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Preface (PDF, 24 Pages, 5.7 MB)
Preface (PDF, 24 Pages, 5.7 MB)

... ­permission, in this textbook appear on the appropriate page within the text or on p. P-1. Copyright © 2016, 2010, 2006 Pearson Education, Inc. All rights reserved. Manufactured in the United States of America. This publication is protected by Copyright, and p ­ ermission should be obtained from the ...
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Final Exam Review Packet
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Nucleophilic acyl substitution



Nucleophilic acyl substitution describe a class of substitution reactions involving nucleophiles and acyl compounds. In this type of reaction, a nucleophile – such as an alcohol, amine, or enolate – displaces the leaving group of an acyl derivative – such as an acid halide, anhydride, or ester. The resulting product is a carbonyl-containing compound in which the nucleophile has taken the place of the leaving group present in the original acyl derivative. Because acyl derivatives react with a wide variety of nucleophiles, and because the product can depend on the particular type of acyl derivative and nucleophile involved, nucleophilic acyl substitution reactions can be used to synthesize a variety of different products.
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