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The discovery of the structure and function of the genetic substance
The discovery of the structure and function of the genetic substance

... • James Watson and Francis Crick began working on the structure of DNA in 1950 • Watson saw Franklin’s Bform photo and described it to Crick • Crick who was a ...
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CHK Tachyphylaxis Brochure_Layout 1
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Untitled

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The origin of the RNA world: Co-evolution of genes and metabolism
The origin of the RNA world: Co-evolution of genes and metabolism

... about pre-biotic pathways, at least for the synthesis of the fundamental building blocks that must have been synthesized abiotically before life could emerge. We do not suppose a perfect correspondence between primordial and extant pathways. For example, steps in which NH3 is delivered via glutamine ...
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Genetic code



The genetic code is the set of rules by which information encoded within genetic material (DNA or mRNA sequences) is translated into proteins by living cells. Biological decoding is accomplished by the ribosome, which links amino acids in an order specified by mRNA, using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries.The code defines how sequences of these nucleotide triplets, called codons, specify which amino acid will be added next during protein synthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. Because the vast majority of genes are encoded with exactly the same code (see the RNA codon table), this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact some variant codes have evolved. For example, protein synthesis in human mitochondria relies on a genetic code that differs from the standard genetic code.While the genetic code determines the protein sequence for a given coding region, other genomic regions can influence when and where these proteins are produced.
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