Branched-chain amino acids alter neurobehavioral function in rats
... obesity epidemic, including in the US, where more than 34% of adults are obese (44, 45). Given the high prevalence of obesity and mood disorders, there is an increasing interest in the relationship of these two conditions (2, 17, 25, 33, 42, 58, 62) and in the concept that overnutrition may have a d ...
... obesity epidemic, including in the US, where more than 34% of adults are obese (44, 45). Given the high prevalence of obesity and mood disorders, there is an increasing interest in the relationship of these two conditions (2, 17, 25, 33, 42, 58, 62) and in the concept that overnutrition may have a d ...
SBT202 - SibTech, Inc.
... Functional activity in tissue culture: The ability of EGF/Si to bind to and activate EGF receptor was tested in two tissue culture assays: stimulation of EGFR tyrosine autophosphorylation and competition with EGF-toxin fusion protein (SibTech product # SBT076.012) for binding to EGFR expressed on MD ...
... Functional activity in tissue culture: The ability of EGF/Si to bind to and activate EGF receptor was tested in two tissue culture assays: stimulation of EGFR tyrosine autophosphorylation and competition with EGF-toxin fusion protein (SibTech product # SBT076.012) for binding to EGFR expressed on MD ...
The Enzymes of Ammonia Assimilation and their
... The activities of GS, NADP-GOGAT and NADP-GDH in extracts of members of the ‘herbicola’, ‘carotovora’ and ‘amylovora’ clusters, grown with different sources of nitrogen, are shown in Table 1. NAD-GOGAT, NAD-GDH and corresponding amidotransferases and dehydrogenases (both NAD- and NADP-linked) able t ...
... The activities of GS, NADP-GOGAT and NADP-GDH in extracts of members of the ‘herbicola’, ‘carotovora’ and ‘amylovora’ clusters, grown with different sources of nitrogen, are shown in Table 1. NAD-GOGAT, NAD-GDH and corresponding amidotransferases and dehydrogenases (both NAD- and NADP-linked) able t ...
Kinetic analysis of retroviral proteases by HELGA EIZERT
... retroviruses that can easily immortalize or transform target cells. The lentiviruses are viruses associated with neurological and immunosuppressive diseases. Spumaviruses, represented by the human foamy virus (HFV), cause a distinct cytopathological effect but do not seem to cause clinical diseases. ...
... retroviruses that can easily immortalize or transform target cells. The lentiviruses are viruses associated with neurological and immunosuppressive diseases. Spumaviruses, represented by the human foamy virus (HFV), cause a distinct cytopathological effect but do not seem to cause clinical diseases. ...
Pseudouridine at position 55 in tRNA controls the contents of other
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
... hypothetically proposed by others. To confirm this idea, we replaced the truB gene in the genome with mutant genes, which express TruB proteins with very weak or no enzymatic activity. However the growth retardation at 50 C was not rescued by these mutant proteins. Nucleoside analysis revealed that ...
PKU
... Clinics used to think that after age 6 phe would not hurt your brain. Now we know differently. ...
... Clinics used to think that after age 6 phe would not hurt your brain. Now we know differently. ...
DOCTORAL THESIS
... shape and structure while affording mechanical strength to the plant. The cell wall dictates plant cell morphology and as a consequence it is responsible for the final plant shape. Plant cells treated with cell-wall degrading enzymes, which effectively removed the cell wall, are invariably spherical ...
... shape and structure while affording mechanical strength to the plant. The cell wall dictates plant cell morphology and as a consequence it is responsible for the final plant shape. Plant cells treated with cell-wall degrading enzymes, which effectively removed the cell wall, are invariably spherical ...
Disposition of Glutathione Conjugates in Rats by a Novel Glutamic
... column (Waters Symmetry C18, 7.8 ⫻ 300 mm, 7 m). The solvent system consisted of a mixture of acetonitrile and 0.05% TFA. The solvent composition was maintained at 5% acetonitrile for the first 5 min, followed by a linear ramp to 15% acetonitrile in the next 8 min. The percentage organic was increa ...
... column (Waters Symmetry C18, 7.8 ⫻ 300 mm, 7 m). The solvent system consisted of a mixture of acetonitrile and 0.05% TFA. The solvent composition was maintained at 5% acetonitrile for the first 5 min, followed by a linear ramp to 15% acetonitrile in the next 8 min. The percentage organic was increa ...
Glucosinolates, isothiocyanates and indoles
... imol/g dry weight. After several backcrosses, isothiocyanate-enriched broccoli was developed from these initial hybrids (Mithen et al., 2003). Some of the quantitative trait loci important in enhancing the glucosinolate concentration of broccoli are in positions in the genome similar to those that d ...
... imol/g dry weight. After several backcrosses, isothiocyanate-enriched broccoli was developed from these initial hybrids (Mithen et al., 2003). Some of the quantitative trait loci important in enhancing the glucosinolate concentration of broccoli are in positions in the genome similar to those that d ...
Of mice and (wo)men: genotype–phenotype
... genotype–phenotype correlations. A more recent and comprehensive study of a cohort of 356 families characterized by protein-truncating mutations further confirmed this correlation (6). Here, families with mutations 30 of nt 4191 (codon 1358), i.e. in between the boundaries described in the two above ...
... genotype–phenotype correlations. A more recent and comprehensive study of a cohort of 356 families characterized by protein-truncating mutations further confirmed this correlation (6). Here, families with mutations 30 of nt 4191 (codon 1358), i.e. in between the boundaries described in the two above ...
Mechanism of the Inhibitory Action of Linoleic Acid on
... measured by monitoring the incorporation of [2-14C]thymidine, [5-SH]uracil, [2-3H]glycine, L - [ U - ~ ~ C ] phenylalanine and [2-3H]glycerol,respectively, into material precipitated by ice-cold 5 % (w/v) trichloroacetic acid (TCA). Since glycine is incorporated into both cell wall and protein, but ...
... measured by monitoring the incorporation of [2-14C]thymidine, [5-SH]uracil, [2-3H]glycine, L - [ U - ~ ~ C ] phenylalanine and [2-3H]glycerol,respectively, into material precipitated by ice-cold 5 % (w/v) trichloroacetic acid (TCA). Since glycine is incorporated into both cell wall and protein, but ...
glucuronidation of opioids, carboxylic acid
... in the endoplasmic reticulum and participate in the metabolic elimination of many endogenous compounds and xenobiotics (1). Compounds with a wide variety of chemical moieties, such as amines, hydroxylated compounds, and carboxylic acids, are substrates for UGT isoforms. UGTs that are members of the ...
... in the endoplasmic reticulum and participate in the metabolic elimination of many endogenous compounds and xenobiotics (1). Compounds with a wide variety of chemical moieties, such as amines, hydroxylated compounds, and carboxylic acids, are substrates for UGT isoforms. UGTs that are members of the ...
Analysis of the Molecular Basis of Flowering Time Variation in
... (Karlsson et al., 1993; Nordborg and Bergelson, 1999), but the F1 plants from the crosses to Col flowered even later, suggesting that Kondara and Kz-9 FRI alleles are fully functional and confer very late flowering in the presence of the strong Col FLC allele. Given the identical amino acid sequence ...
... (Karlsson et al., 1993; Nordborg and Bergelson, 1999), but the F1 plants from the crosses to Col flowered even later, suggesting that Kondara and Kz-9 FRI alleles are fully functional and confer very late flowering in the presence of the strong Col FLC allele. Given the identical amino acid sequence ...
Mechanistic Studies Of Drug Resistance Conferred By An ABC
... First and for most, I would like to thank my mentor Dr. Parjit Kaur, without whom this work could never be done. I am grateful for her well-rounded guidance and support throughout all these years’ Ph.D studies. Her understanding, sincerity and patience have encouraged me to overcome the obstacles an ...
... First and for most, I would like to thank my mentor Dr. Parjit Kaur, without whom this work could never be done. I am grateful for her well-rounded guidance and support throughout all these years’ Ph.D studies. Her understanding, sincerity and patience have encouraged me to overcome the obstacles an ...
Chemical Composition of Phloem Sap from the Uppermost Internode
... Demonstrable gradients of solutes occurred only between the crease sieve tubes and the endosperm cavity, not along the transport pathways from the peduncle to the crease of the wheat ear, as reported by Fisher and Gifford (1986). In the present experiments, no gradient in the concentration of sucros ...
... Demonstrable gradients of solutes occurred only between the crease sieve tubes and the endosperm cavity, not along the transport pathways from the peduncle to the crease of the wheat ear, as reported by Fisher and Gifford (1986). In the present experiments, no gradient in the concentration of sucros ...
Complete comparative genomic analysis of two field isolates of
... 2002; Li et al., 2002a), eight ORFs have amino acid substitutions in their encoded products. These include me53, lef-1, tlp-20, lef-8, lef-9, orf80, odv-e66 (orf144) and ie-1. Five of 12 ORFs that are unique to v90/2 and v90/4, orf5, orf10, orf18, orf23 and orf64 (Li et al., 2002b), have amino acid ...
... 2002; Li et al., 2002a), eight ORFs have amino acid substitutions in their encoded products. These include me53, lef-1, tlp-20, lef-8, lef-9, orf80, odv-e66 (orf144) and ie-1. Five of 12 ORFs that are unique to v90/2 and v90/4, orf5, orf10, orf18, orf23 and orf64 (Li et al., 2002b), have amino acid ...
Are sperm-binding proteins among two closely related frog species
... classified as a pre-zygotic block to fertilization (versus post-zygotic mechanisms that occur due to genetic incompatibilities after zygote formation). It is thought that rapid changes in the egg's sperm-binding protein, termed ZPC or ZP3 in vertebrate species (discussed in more detail later), could ...
... classified as a pre-zygotic block to fertilization (versus post-zygotic mechanisms that occur due to genetic incompatibilities after zygote formation). It is thought that rapid changes in the egg's sperm-binding protein, termed ZPC or ZP3 in vertebrate species (discussed in more detail later), could ...
AHAS herbicide resistance endowing mutations: effect on AHAS
... (AHAS) gene have been identified to date that confer target-site resistance to AHAS-inhibiting herbicides in biotypes of field-evolved resistant weed species. However, the effect of resistance mutations on AHAS functionality and plant growth has been investigated for only a very few mutations. This ...
... (AHAS) gene have been identified to date that confer target-site resistance to AHAS-inhibiting herbicides in biotypes of field-evolved resistant weed species. However, the effect of resistance mutations on AHAS functionality and plant growth has been investigated for only a very few mutations. This ...
A 5000-Fold Increase in the Specificity of a Bacterial
... Phosphotriesterases (PTEs) have been isolated from a range of bacterial species, including Agrobcaterium radiobacter (PTEAr), and are efficient enzymes with broad substrate ranges. The turnover rate of PTEAr for the common organophosphorous insecticide malathion is lower than expected based on its p ...
... Phosphotriesterases (PTEs) have been isolated from a range of bacterial species, including Agrobcaterium radiobacter (PTEAr), and are efficient enzymes with broad substrate ranges. The turnover rate of PTEAr for the common organophosphorous insecticide malathion is lower than expected based on its p ...
CELLULAR ENERGY METABOLISM DURING FETAL
... that of calf heart mitochondria . As seen in a polarographic experiment with calf heart mitochondria (Fig. 1 a), the addition of carnitine to the medium containing palmityl-CoA resulted in an increase in oxidative rate from 25 n atoms oxygen/ mg/min to 80 n atoms/mg/min . There was generally a lag p ...
... that of calf heart mitochondria . As seen in a polarographic experiment with calf heart mitochondria (Fig. 1 a), the addition of carnitine to the medium containing palmityl-CoA resulted in an increase in oxidative rate from 25 n atoms oxygen/ mg/min to 80 n atoms/mg/min . There was generally a lag p ...
Single Processing Center Models for Human Dicer and Bacterial
... Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins. Dicer contains two domains related to the bacterial dsRNAspecific endonuclease, RNase III, which is known ...
... Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins. Dicer contains two domains related to the bacterial dsRNAspecific endonuclease, RNase III, which is known ...
Recombination in large RNA viruses: Coronaviruses
... came with a vengeance, as murine coronaviruses were quickly shown to recombine at very high frequency under a variety of natural and experimental conditions. The capacity to recombine has now been demonstrated in several different coronaviruses. Recombination is an important mechanism contribut- ...
... came with a vengeance, as murine coronaviruses were quickly shown to recombine at very high frequency under a variety of natural and experimental conditions. The capacity to recombine has now been demonstrated in several different coronaviruses. Recombination is an important mechanism contribut- ...
Evaluation of Corn Distillers Grains and Ruminally Protected Lysine
... Milk protein percentages and yields when cows were fed wet CDG were similar ( 2 5 ) or reduced ( 3 ) compared with milk protein percentages and yields when cows were fed SBM. Increased milk protein percentages and yields have occurred in several studies in which cows were fed RPLM (7, 19, 20, 22). B ...
... Milk protein percentages and yields when cows were fed wet CDG were similar ( 2 5 ) or reduced ( 3 ) compared with milk protein percentages and yields when cows were fed SBM. Increased milk protein percentages and yields have occurred in several studies in which cows were fed RPLM (7, 19, 20, 22). B ...
Genetic code
The genetic code is the set of rules by which information encoded within genetic material (DNA or mRNA sequences) is translated into proteins by living cells. Biological decoding is accomplished by the ribosome, which links amino acids in an order specified by mRNA, using transfer RNA (tRNA) molecules to carry amino acids and to read the mRNA three nucleotides at a time. The genetic code is highly similar among all organisms and can be expressed in a simple table with 64 entries.The code defines how sequences of these nucleotide triplets, called codons, specify which amino acid will be added next during protein synthesis. With some exceptions, a three-nucleotide codon in a nucleic acid sequence specifies a single amino acid. Because the vast majority of genes are encoded with exactly the same code (see the RNA codon table), this particular code is often referred to as the canonical or standard genetic code, or simply the genetic code, though in fact some variant codes have evolved. For example, protein synthesis in human mitochondria relies on a genetic code that differs from the standard genetic code.While the genetic code determines the protein sequence for a given coding region, other genomic regions can influence when and where these proteins are produced.