Characterization of novel natural killer (NK)–cell and γδT
... Nasal T/natural killer (NK)–cell lymphoma is a distinct clinicopathologic entity characterized by progressive necrotic lesions in the nasal cavity, nasopharynx, and palate.1 It has been called angiocentric lymphoma, lethal midline granuloma, or polymorphic reticulosis.2 It is a relatively rare disea ...
... Nasal T/natural killer (NK)–cell lymphoma is a distinct clinicopathologic entity characterized by progressive necrotic lesions in the nasal cavity, nasopharynx, and palate.1 It has been called angiocentric lymphoma, lethal midline granuloma, or polymorphic reticulosis.2 It is a relatively rare disea ...
Vaccine immunology - World Health Organization
... strength of the interaction. The avidity is the sum of the epitopespecific affinities for a given antigen. It directly relates to its function. Affinity maturation: Processes through which antigen-specific B cells undergo somatic hypermutation and affinity-based selection, resulting into B cells tha ...
... strength of the interaction. The avidity is the sum of the epitopespecific affinities for a given antigen. It directly relates to its function. Affinity maturation: Processes through which antigen-specific B cells undergo somatic hypermutation and affinity-based selection, resulting into B cells tha ...
fulltext
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...
... antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. Naïve mice have very low amounts of specific an ...
GRA Proteins of Toxoplasma gondii: Maintenance of Host
... possesses a dilysine 'KKXX' endoplasmic reticulum (ER) retrieval motif that rationalizes its association with PVM and possibly the host cell ER. Immunodominant regions encoded by GRA3 (and MIC3) genes on the human B-cell response against T. gondii infection is identified in a panel of recombinant ph ...
... possesses a dilysine 'KKXX' endoplasmic reticulum (ER) retrieval motif that rationalizes its association with PVM and possibly the host cell ER. Immunodominant regions encoded by GRA3 (and MIC3) genes on the human B-cell response against T. gondii infection is identified in a panel of recombinant ph ...
Combined in silico modeling and metabolomics analysis to
... grade, Fisher Scientific) with 0.1% formic acid and finally equilibrated with 0.1% B for 1.5 min. The solvent flow rate was set at 400 mL/min; a column temperature of 308C was used. The eluent from the UPLC system was directed into the MS. Electrospray ionization (ESI) was conducted in both positive an ...
... grade, Fisher Scientific) with 0.1% formic acid and finally equilibrated with 0.1% B for 1.5 min. The solvent flow rate was set at 400 mL/min; a column temperature of 308C was used. The eluent from the UPLC system was directed into the MS. Electrospray ionization (ESI) was conducted in both positive an ...
Lymphatic System These notes are intended as a comprehensive
... dilatation of the microscopic blood vessels in the loose connective tissue. Blood flow therefore increases, and leucocytes and antibodies emerge from the blood vessels to fight the bacteria. The increased blood flow and the efflux of blood components from the vessels changes the appearance of the ti ...
... dilatation of the microscopic blood vessels in the loose connective tissue. Blood flow therefore increases, and leucocytes and antibodies emerge from the blood vessels to fight the bacteria. The increased blood flow and the efflux of blood components from the vessels changes the appearance of the ti ...
440-kD Ankyrins: Structure of the Major
... taken at 0.5-nm intervals with one second response time. Spectra were taken at 40C with protein concentration at 50/~g/ml in 1 mM Tris and 0.4 M NaE pH 7.4. This buffer was selected based on solubility requirements of the control protein, a 43-kD polypeptide derived from the membrane-binding domain ...
... taken at 0.5-nm intervals with one second response time. Spectra were taken at 40C with protein concentration at 50/~g/ml in 1 mM Tris and 0.4 M NaE pH 7.4. This buffer was selected based on solubility requirements of the control protein, a 43-kD polypeptide derived from the membrane-binding domain ...
Protein_Structure_Final_Powerpoint
... positive charge • The residue is located on the surface of the protein structure ...
... positive charge • The residue is located on the surface of the protein structure ...
5 REASONS WHY THE LYMPHATIC SYSTEM IS IMPORTANT TO
... 1. REINFORCEMENT OF THE IMMUNE SYSTEM An important function of the lymphatic system is the manufacturing of antibodies. The production of white blood cells and antibodies to fight invasive bacteria, toxins or disease is also called an immune response. Antibodies defense system: Antibodies can be def ...
... 1. REINFORCEMENT OF THE IMMUNE SYSTEM An important function of the lymphatic system is the manufacturing of antibodies. The production of white blood cells and antibodies to fight invasive bacteria, toxins or disease is also called an immune response. Antibodies defense system: Antibodies can be def ...
Epstein-Barr Virus (EBV) Infections in Patients
... this and other data, several items need to be considered. One, which came first? Is it the EBV infection causing the chronic fatigue shown in many of these patients (and, possibly lymphoma), or is it the depressed immunity in the lymphoma and chronically ill patients allowing the opportunistic EBV t ...
... this and other data, several items need to be considered. One, which came first? Is it the EBV infection causing the chronic fatigue shown in many of these patients (and, possibly lymphoma), or is it the depressed immunity in the lymphoma and chronically ill patients allowing the opportunistic EBV t ...
Role of the ubiquitinselective CDC48UFD1/NPL4 chaperone
... oleic (18:1) acids by the introduction of a single double bond between carbon 9 and carbon 10 of the respective carbon chains (Mitchell and Martin, 1995). Yeast cells are not able to synthesize polyunsaturated fatty acids, but they can take up these compounds from the environment and incorporate the ...
... oleic (18:1) acids by the introduction of a single double bond between carbon 9 and carbon 10 of the respective carbon chains (Mitchell and Martin, 1995). Yeast cells are not able to synthesize polyunsaturated fatty acids, but they can take up these compounds from the environment and incorporate the ...
Immunopathogenesis of chronic periapical
... I through 9 (Cl is actually a combination of three of the eleven proteins). The complement proteins are present in normal blood serum. The complement system can be activated in two ways, the classic pathway and the alternate pathway. The classic pathway of complement system is activated when foreign ...
... I through 9 (Cl is actually a combination of three of the eleven proteins). The complement proteins are present in normal blood serum. The complement system can be activated in two ways, the classic pathway and the alternate pathway. The classic pathway of complement system is activated when foreign ...
Functional and quantitative proteomics using SILAC
... labelling is very high — quantitation is straightforward. SILAC does require adapting one’s cell line to dialyzed serum, and further steps might have to be taken if cells don’t adapt well. However, this step can be checked without labelled amino acids. The SILAC approach is not necessarily expensive ...
... labelling is very high — quantitation is straightforward. SILAC does require adapting one’s cell line to dialyzed serum, and further steps might have to be taken if cells don’t adapt well. However, this step can be checked without labelled amino acids. The SILAC approach is not necessarily expensive ...
NLRC5 regulates MHC class I antigen presentation in host defense
... to negatively regulate the NF-κB and type I interferonproducing signaling pathways by targeting the IKK complex and RIG-I/MDA5, respectively [12]. A subsequent report showed that NLRC5 suppressed LPS-mediated inflammatory responses [13]. However, two other studies reported the contradictory result t ...
... to negatively regulate the NF-κB and type I interferonproducing signaling pathways by targeting the IKK complex and RIG-I/MDA5, respectively [12]. A subsequent report showed that NLRC5 suppressed LPS-mediated inflammatory responses [13]. However, two other studies reported the contradictory result t ...
9 Innate and acquired immunity
... Granulocytes are short-lived cells, days, compared to macrophages, which may survive for months or years. They are classified as neutrophils, eosinophils and basophils on the basis of their histochemical staining. The mature forms have a multilobed nucleus and many granules. Neutrophils constitute 60 ...
... Granulocytes are short-lived cells, days, compared to macrophages, which may survive for months or years. They are classified as neutrophils, eosinophils and basophils on the basis of their histochemical staining. The mature forms have a multilobed nucleus and many granules. Neutrophils constitute 60 ...
Autoimmune Disorders: an Overview of Molecular and Cellular
... susceptibility genes have been identified. Certain environmental influences, such as cigarette smoke, ultraviolet light, or infectious agents, may interplay with this genetic predisposition to initiate the disease process. Silica exposure and its role in systemic lupus erythematosus (SLE) have been ...
... susceptibility genes have been identified. Certain environmental influences, such as cigarette smoke, ultraviolet light, or infectious agents, may interplay with this genetic predisposition to initiate the disease process. Silica exposure and its role in systemic lupus erythematosus (SLE) have been ...
Variable expression of immunoreactive surface proteins of
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
... Despite accumulating data implicating Propionibacterium acnes in a variety of diseases, its precise role in infection remains to be determined. P. acnes antigen-specific CD4+ T cells are present in early inflamed acne lesions and may be involved in the inflammatory response; however, little is known ...
Innate responses of B cells
... (CIA) [72]. In all these cases the B cells involved were activated and consequently produced IL-10. How this B cell-derived IL-10 production mediates these effects has not been determined but the induction of a Treg population seems most likely. In relation to this, Gray et al. [73] have recently li ...
... (CIA) [72]. In all these cases the B cells involved were activated and consequently produced IL-10. How this B cell-derived IL-10 production mediates these effects has not been determined but the induction of a Treg population seems most likely. In relation to this, Gray et al. [73] have recently li ...
Fig. 9.1. Basic concepts for electrolyte and H2O movements into and
... Fig. 9.5. Gastric or abomasal secretion of H+ and Cl-. H+ and HCO3- are formed from the combination of OH- (from H2O) and CO2 in a reaction catalyzed by carbonic anhydrase. H+ (from H2O) is secreted into the lumen via a H+—K+-ATPase pump. The generated HCO3- is transported to the ECF via a Cl--HCO3- ...
... Fig. 9.5. Gastric or abomasal secretion of H+ and Cl-. H+ and HCO3- are formed from the combination of OH- (from H2O) and CO2 in a reaction catalyzed by carbonic anhydrase. H+ (from H2O) is secreted into the lumen via a H+—K+-ATPase pump. The generated HCO3- is transported to the ECF via a Cl--HCO3- ...
投影片 1
... b-catenin in Wnt pathway. Using a yeast two-hybrid screen, we identified a novel protein, GSK3b interaction protein (GSKIP), which binds to GSK3beta. We have defined a 25-aminoacid residues region in the C-terminal of GSKIP that is highly similar to the GSK3beta interaction domain (GID) of Axin. Usi ...
... b-catenin in Wnt pathway. Using a yeast two-hybrid screen, we identified a novel protein, GSK3b interaction protein (GSKIP), which binds to GSK3beta. We have defined a 25-aminoacid residues region in the C-terminal of GSKIP that is highly similar to the GSK3beta interaction domain (GID) of Axin. Usi ...
Recent progress in vaccines
... we are now on the threshold of clinical development for some vaccines against fungal pathogens. Major drivers of the rather sharp change in perspective regarding antifungal vaccines are considered in Box 1. It is difficult to weight the importance of any single factor for the shift in emphasis but i ...
... we are now on the threshold of clinical development for some vaccines against fungal pathogens. Major drivers of the rather sharp change in perspective regarding antifungal vaccines are considered in Box 1. It is difficult to weight the importance of any single factor for the shift in emphasis but i ...
Relationship between Protein Synthesis and Secretion in Liver Cells
... over the entire incubation period. The concentration of ATP in the cells had been decreased by adding fructose up to a concentration of 10 mM. A half-maximal incorporation of L-[1-14C]leucine into protein was observed at about 1·05 fLmol ATP per g cells, wet weight. The relationships between protein ...
... over the entire incubation period. The concentration of ATP in the cells had been decreased by adding fructose up to a concentration of 10 mM. A half-maximal incorporation of L-[1-14C]leucine into protein was observed at about 1·05 fLmol ATP per g cells, wet weight. The relationships between protein ...
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... antigen and re-presented it [6]. Figure 2C shows results of a T cell recognition experiment using LCL targets derived from donor 1. In this case the more lytic wild-type LCL was diluted with the DBZLF1 LCL to give equivalent numbers of lytic targets in the assay. When CD8+ T cells specific for the i ...
... antigen and re-presented it [6]. Figure 2C shows results of a T cell recognition experiment using LCL targets derived from donor 1. In this case the more lytic wild-type LCL was diluted with the DBZLF1 LCL to give equivalent numbers of lytic targets in the assay. When CD8+ T cells specific for the i ...
Cellular profile and cytokine production at prosthetic interfaces
... tissues surrounding revised joint prostheses may further elucidate the biological processes of loosening and osteolysis and suggest preventative or therapeutic methods which may favourably affect the survival of the implant. Our aim in this prospective study was to determine the major cell types and ...
... tissues surrounding revised joint prostheses may further elucidate the biological processes of loosening and osteolysis and suggest preventative or therapeutic methods which may favourably affect the survival of the implant. Our aim in this prospective study was to determine the major cell types and ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.