Amino Acid Profiling and Nucleic Acid
... protein (single cell protein, SCP) from the mechanically disrupted cells so as to assess the nucleic acid content and essential amino acid profile of the isolates. The suitability of a protein for application within the food industry is dependent on its composition since its nutritional value depend ...
... protein (single cell protein, SCP) from the mechanically disrupted cells so as to assess the nucleic acid content and essential amino acid profile of the isolates. The suitability of a protein for application within the food industry is dependent on its composition since its nutritional value depend ...
IMMUNOREACTIONS INVOLVING PLATELETS. VI. REACTIONS OF
... thrombocytopenia, but their hemoglobin and leukocyte counts were normal and they had no other congenital defects. The four mothers were in good health, had normal platelet levels shortly after parturition, and had no past history of having idiopathic thrombocytopenic purpura or of receiving blood tr ...
... thrombocytopenia, but their hemoglobin and leukocyte counts were normal and they had no other congenital defects. The four mothers were in good health, had normal platelet levels shortly after parturition, and had no past history of having idiopathic thrombocytopenic purpura or of receiving blood tr ...
Introduction to Virology
... Homologues of interferon-regulatory factors block transcription of interferon genes. Viral proteins inhibit activation of interferonstimulated genes. Small viral dsRNAs block activation of dsRNAdependent protein kinase (PKR). Viral proteins that bind to dsRNA reduce activation of PKR. Soluble homolo ...
... Homologues of interferon-regulatory factors block transcription of interferon genes. Viral proteins inhibit activation of interferonstimulated genes. Small viral dsRNAs block activation of dsRNAdependent protein kinase (PKR). Viral proteins that bind to dsRNA reduce activation of PKR. Soluble homolo ...
The Mechanism of Protein Synthesis inthe Developing Chick Embryo
... that either the nuclear or the mitochondrial proteins of the embryo had the highest specific activity, and they suggested that these are the main sites of protein synthesis at some stages of development. In the results described above no support is given to this suggestion. The radioactivity in the ...
... that either the nuclear or the mitochondrial proteins of the embryo had the highest specific activity, and they suggested that these are the main sites of protein synthesis at some stages of development. In the results described above no support is given to this suggestion. The radioactivity in the ...
Mutation Testing: An Artificial Immune System
... there are any antigens present in the system. Properties such as learning and memory now become a result of molecular interactions as opposed to a specific memory pool. In general, regions on an antigen’s surface called epitopes are recognised by paratopes on antibodies. However, antibodies also dis ...
... there are any antigens present in the system. Properties such as learning and memory now become a result of molecular interactions as opposed to a specific memory pool. In general, regions on an antigen’s surface called epitopes are recognised by paratopes on antibodies. However, antibodies also dis ...
Mycobacterium tuberculosis - CBS
... response often require partial or whole proteins, whilst T-cell response can be induced by epitopes. The use of epitopes also avoid potential toxic properties of whole proteins. DNA vaccines may induce both humoral and cellular responses which can be modulated via specific cytokine co-expression [11 ...
... response often require partial or whole proteins, whilst T-cell response can be induced by epitopes. The use of epitopes also avoid potential toxic properties of whole proteins. DNA vaccines may induce both humoral and cellular responses which can be modulated via specific cytokine co-expression [11 ...
Nuclear calcium is required for human T cell activation
... initiated physiologically by the binding of CD80/CD86 receptor on the antigen-presenting cell to the CD28 receptor and can be induced in vitro by the exposure of T cells to either CD28 antibodies or chemical inducers of PKC such as PMA. At the genomic level, the decision between activation and anerg ...
... initiated physiologically by the binding of CD80/CD86 receptor on the antigen-presenting cell to the CD28 receptor and can be induced in vitro by the exposure of T cells to either CD28 antibodies or chemical inducers of PKC such as PMA. At the genomic level, the decision between activation and anerg ...
B Lymphocytes Provide an Infection Niche for Intracellular Bacterium
... were present during the plateau phase of the infection [9]. Moreover, even macrophages (the primary niche) were TGF-β1+ [9]. Because pathogens induce TGF-β1 production by infected host cells as a way to dampen host inflammatory immune responses (reviewed in [10]), this finding raised the possibility t ...
... were present during the plateau phase of the infection [9]. Moreover, even macrophages (the primary niche) were TGF-β1+ [9]. Because pathogens induce TGF-β1 production by infected host cells as a way to dampen host inflammatory immune responses (reviewed in [10]), this finding raised the possibility t ...
Chlamydia trachomatis RNA polymerase major sigma subunit
... a gap of 63 amino acids and an additional 16 amino acids at the carboxyl terminus, which may play some role in modifying the U-DNA interaction, such that a promoter sequence unique to C. trachomatis is recognized. Monoclonal antibodies specific for E. coli U” were used to probe for homologous struct ...
... a gap of 63 amino acids and an additional 16 amino acids at the carboxyl terminus, which may play some role in modifying the U-DNA interaction, such that a promoter sequence unique to C. trachomatis is recognized. Monoclonal antibodies specific for E. coli U” were used to probe for homologous struct ...
| Specific antigen(s) in sarcoidosis: a link to autoimmunity?
... This work has several implications and raises numerous questions. First of all, the current and the preceding publications of the Karolinska group demonstrate an autoantigenic component in the pathogenesis of sarcoidosis. However, the current report involves only patients with Löfgren syndrome and i ...
... This work has several implications and raises numerous questions. First of all, the current and the preceding publications of the Karolinska group demonstrate an autoantigenic component in the pathogenesis of sarcoidosis. However, the current report involves only patients with Löfgren syndrome and i ...
Role of complement in health and disease
... • Lectins are proteins that bind to specific carbohydrate targets. • Lectin activating complement binds to mannose residues; present on surface of various bacterial cells, fungi and viruses, so also called as MBL (mannan‐binding lectin pathway) • Human cells have sialic acid residues covering su ...
... • Lectins are proteins that bind to specific carbohydrate targets. • Lectin activating complement binds to mannose residues; present on surface of various bacterial cells, fungi and viruses, so also called as MBL (mannan‐binding lectin pathway) • Human cells have sialic acid residues covering su ...
Analysis of Cell-Mediated Immune Responses in Support of Dengue
... Rothman, A. L., Currier, J. R., Friberg, H. L., & Mathew, A. (2015). Analysis of cell-mediated immune responses in support of dengue ...
... Rothman, A. L., Currier, J. R., Friberg, H. L., & Mathew, A. (2015). Analysis of cell-mediated immune responses in support of dengue ...
Model Description Sheet
... 6 carry clusters of D antigen epitopes while loops 1, 2, and 5 do not play a major role in RhD antigenicity due to their sequence identity with RhCE. The RHD gene arose from gene duplication of the RHCE gene and has 93.8% homology. Along with RhAG (Rh associated glycoprotein) both RhD and RhCE are p ...
... 6 carry clusters of D antigen epitopes while loops 1, 2, and 5 do not play a major role in RhD antigenicity due to their sequence identity with RhCE. The RHD gene arose from gene duplication of the RHCE gene and has 93.8% homology. Along with RhAG (Rh associated glycoprotein) both RhD and RhCE are p ...
Porphyrin ring source can alter the outer membrane protein profile of
... and, although the reason for this is unclear, it may represent a failure of antibody induction, possibly due to a lack of antigen expression. The inconsistent resolution of the 84-Kda doublet prevents the use of the immunoblotting procedure to discern whether a single component of the doublet, or bo ...
... and, although the reason for this is unclear, it may represent a failure of antibody induction, possibly due to a lack of antigen expression. The inconsistent resolution of the 84-Kda doublet prevents the use of the immunoblotting procedure to discern whether a single component of the doublet, or bo ...
Guidelines on evaluation of monoclonal antibodies as similar
... Monoclonal antibodies (mAbs) are a major class of recombinant deoxyribonucleic acid (rDNA) technology-derived biotherapeutic products that have achieved outstanding success in treating many life-threatening and chronic diseases. Some of these targeted therapy products are ranked in the top 10 lists ...
... Monoclonal antibodies (mAbs) are a major class of recombinant deoxyribonucleic acid (rDNA) technology-derived biotherapeutic products that have achieved outstanding success in treating many life-threatening and chronic diseases. Some of these targeted therapy products are ranked in the top 10 lists ...
Immune responses to vaccines involving a combined antigen
... better tolerated and regarded as safer alternatives to traditional vaccines, they are usually poorly immunogenic when used alone and therefore require exogenous adjuvants to augment resultant immune responses [3e5]. Alum is a conventional adjuvant and the only one widely licensed for human use. Desp ...
... better tolerated and regarded as safer alternatives to traditional vaccines, they are usually poorly immunogenic when used alone and therefore require exogenous adjuvants to augment resultant immune responses [3e5]. Alum is a conventional adjuvant and the only one widely licensed for human use. Desp ...
Pertussis is a highly contagious infectious disease of the respiratory
... Pertussis is a highly contagious infectious disease of the respiratory tract which is caused by Bordetella pertussis. Before widespread introduction of vaccination against pertussis, almost every child contracted pertussis. The disease is most severe in neonates and children under the age of 1. Intr ...
... Pertussis is a highly contagious infectious disease of the respiratory tract which is caused by Bordetella pertussis. Before widespread introduction of vaccination against pertussis, almost every child contracted pertussis. The disease is most severe in neonates and children under the age of 1. Intr ...
Transfusion Support Issues in Hematopoietic Stem Cell
... patient to be dependent on RBC and platelet transfusions until engraftment of those cell lines occurs. Although granulocyte progenitor cells are also destroyed, granulocyte-colony stimulating factor may be given because granulocyte transfusions are reserved for specific scenarios. The need for plasm ...
... patient to be dependent on RBC and platelet transfusions until engraftment of those cell lines occurs. Although granulocyte progenitor cells are also destroyed, granulocyte-colony stimulating factor may be given because granulocyte transfusions are reserved for specific scenarios. The need for plasm ...
SUMMARY AND EXPLANATION OF THE TEST
... could be performed at point of care or in the laboratory. Recent studies have shown that the BTA stat test, which qualitatively detects bladder tumor associated antigen can be extremely useful in this regard.6,7 The BTA stat test is a single-step, antibody based test which is performed in only 5 min ...
... could be performed at point of care or in the laboratory. Recent studies have shown that the BTA stat test, which qualitatively detects bladder tumor associated antigen can be extremely useful in this regard.6,7 The BTA stat test is a single-step, antibody based test which is performed in only 5 min ...
What are vaccines made of? - Vermont Coalition for Vaccine Choice
... Antibiotics are present in some vaccines to prevent bacterial contamination during the manufacturing process. Yeast proteins are added during the creation of hepatitis B vaccine and one brand of the human papillomavirus (HPV) vaccine (Gardasil®). Yeast proteins do not cause an allergic reaction in p ...
... Antibiotics are present in some vaccines to prevent bacterial contamination during the manufacturing process. Yeast proteins are added during the creation of hepatitis B vaccine and one brand of the human papillomavirus (HPV) vaccine (Gardasil®). Yeast proteins do not cause an allergic reaction in p ...
"Autoimmune Disease". - University of St Andrews
... reaction of the immune system against one or more of the organism’s own tissues. It does not necessarily imply any tissue damage or dysfunction. When there is tissue infiltration, damage and/or dysfunction, the condition is termed autoimmune disease. The purpose of the body’s immune system is to fight ...
... reaction of the immune system against one or more of the organism’s own tissues. It does not necessarily imply any tissue damage or dysfunction. When there is tissue infiltration, damage and/or dysfunction, the condition is termed autoimmune disease. The purpose of the body’s immune system is to fight ...
Antibody-Selected Mimics of Hepatitis C Virus Hypervariable Region
... preventing the replication of escape mutants by eliciting a T- and B-cell repertoire directed against many viral variants. The hypervariable region 1 (HVR1) of the putative envelope 2 protein that presents B and T epitopes shown to induce protective immunity against hepatitis C virus (HCV), might be ...
... preventing the replication of escape mutants by eliciting a T- and B-cell repertoire directed against many viral variants. The hypervariable region 1 (HVR1) of the putative envelope 2 protein that presents B and T epitopes shown to induce protective immunity against hepatitis C virus (HCV), might be ...
Functional Anatomy of Lymphatic System
... aid in defense and white blood cell formation located along length of lymphatic vessels scattered throughout the body usually in clusters ...
... aid in defense and white blood cell formation located along length of lymphatic vessels scattered throughout the body usually in clusters ...
Author`s personal copy
... The observation that onset of plasma leakage occurs up to several days following significant reduction or clearance of viremia suggests that, instead of the proposed antibodydependent enhancement due to viral burden, an immunemediated mechanism may be responsible for the extreme capillary permeabili ...
... The observation that onset of plasma leakage occurs up to several days following significant reduction or clearance of viremia suggests that, instead of the proposed antibodydependent enhancement due to viral burden, an immunemediated mechanism may be responsible for the extreme capillary permeabili ...
Review Article Distinct Functions of Specialized
... apoptosis in CD11c+ plaque-macrophages with subsequent proinflammatory effects on atherosclerosis [27], or prevailing effects of other cell subsets (Zernecke et al., unpublished observations). The constitutive cell-specific expression of a suicide gene in CD11c+ DCs entailed the development of a mye ...
... apoptosis in CD11c+ plaque-macrophages with subsequent proinflammatory effects on atherosclerosis [27], or prevailing effects of other cell subsets (Zernecke et al., unpublished observations). The constitutive cell-specific expression of a suicide gene in CD11c+ DCs entailed the development of a mye ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.