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Carbon Compounds
Carbon Compounds

... Examples - Fats, oils, waxes, sterols (hormones) Functions • Stored energy (fats) • Structural- part of the cell membrane (phospholipids) • Repel water because they are nonpolar (even distribution of charge across the molecule) Ex- waxes. Helps to ‘waterproof’ a duck’s feathers • Chemical messengers ...
Acting Out the Immune Response - The American Association of
Acting Out the Immune Response - The American Association of

... fight it. The T helper cell, macrophages and other blood components rush to where the bacteria is. 3. The macrophages gobble up some of the bacteria, but can’t get it all. They need help! Only two of the bacteria cells are destroyed. (A discussion of phagocytosis could take place prior to the activi ...
Pset 6 Solutions
Pset 6 Solutions

... During the primary immune response, the memory B cells, against the specific antigen, are generated by the proliferation of the mature B cells that are specific to that antigen. These B cells express surface IgM molecules against the specific antigen. Furthermore, they can also proliferate to form m ...
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Document

... autoimmunity 5. Mediators ...
Micro 532 Exam 1995
Micro 532 Exam 1995

... You have been asked to consult in a clinical diagnostic laboratory. The lab is trying to determine why its new antibody assay system is not accurately detecting protective antibodies in the sera of persons recently exposed to Bonga-Bonga fever virus. This is very frustrating to the laboratory since ...
THE SPLEEN
THE SPLEEN

... The cells and proteins in the blood express antigens which are controlled by polymorphic genes; that is, a specific antigen may be present in some individuals but not in others. A blood transfusion may immunize the recipient against donor antigens that the recipient lacks (alloimmunization), and re ...
Glomerular diseases
Glomerular diseases

... histamine (immediate response)  vascular permeability, airways, hives, conjunctivitis, rhinitis. Later:  leukotriens, prostaglandins, PAF, proteases (late phase)  localized anaphylaxis = atopy (asthma, hay fever, eczema, hives) systemic anaphylaxis – circulatory shock, dyspnea, laryngospasm Ts ...
17 Specific Immune Response
17 Specific Immune Response

... Presentation to Helper T cells 1. After an antigen has been phagocytized by an APC (non-specific response) it is broken down into smaller peptides 2. The digested epitopes (fragments) bind to the MHC Class 2 proteins within an endosome of the APC 3. The epitope-MHC complex is transported to th ...
Cell-mediated (T cells)
Cell-mediated (T cells)

... 2)19% Cytotoxic T cells destroy viral infective & tumor cells 3)Memory Tcells CD4+(lost in AIDs) or CD8+(cytotoxic) subset of antigen T cells that persist long after infection. 4) Regulatory T cells (suppressor T cells) 5)Natural killer (NK) largest T cell.Interferons cause cytotoxic granule release ...
Brief Definitive Report SYSTEMIC AUTOIMMUNE
Brief Definitive Report SYSTEMIC AUTOIMMUNE

... antigens . This can be accomplished using a spot ELISA, in which freshly isolated splenic lymphocytes are cultured in plastic dishes to which specific antigens are adsorbed . Only antibodies binding to the adsorbed antigen remain on the dish when it is washed free of B cells and nonspecific Ig. Thes ...
Foundations in Microbiology
Foundations in Microbiology

... spleen, and GALT where they come into contact with antigens throughout life ...
SCHOLAR ROCK`S NICHE
SCHOLAR ROCK`S NICHE

... members that allows specific antibody binding to them in diseased tissues, because different peptides form complexes with the growth factors in different tissues or disease states. Scholar Rock is exploiting the structural variability of the latency complexes caused by the different binding proteins ...
Natural (Innate) Immunity
Natural (Innate) Immunity

... immunity against smallpox  1885, Louis Pasteur Vaccine against rabies • Other used Inactivated diphtheria toxins as a vaccine against diphtheria (the protective effect were found to be in the serum) • Serum factor called Antibody ...
Innate Immunity
Innate Immunity

... A series of reactions, cascade of proteolytic enzymes (capases); the end result is rapid degradation of the nucleus, and cutting DNA in to ...
1. Hypersensitivity What is Hypersensitivity? Chapter 18: Disorders of the Immune System
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... Transplanted organs and tissues are rejected as foreign by the immune system due mainly to the presence of non-self MHC class I molecules: • human MHC class I molecules are referred to as the HLA (human leukocyte antigen) complex • there are 3 HLA genes resulting in up to 6 different HLA proteins pe ...
Secondary antibody
Secondary antibody

... AIDS Diagnostic Tool ...
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... Ribosome where it pairs with Transfer RNA to put Amino Acids into chains called proteins. • mRNA pairs to tRNA in the ribosomes This protein building is called TRANSLATION. ...
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No Slide Title

... 4) Regulatory T cells (suppressor T cells) 5)Natural killer (NK) largest T cell.Interferons cause cytotoxic granule release 6) Antigen-presenting cell (APC) ...
Immunology
Immunology

... number of afflictions where few mature T cells are present. These patients often have B cells that respond to T-independent antigens, but Candida albicans (yeast) stimulates a poor antibody response. ...
B3 Topic 1 Revision tracker
B3 Topic 1 Revision tracker

... and cancer cells and in treatment of diseases including cancer c the advantages of using monoclonal antibodies to target specific cells compared to drug and radiotherapy treatments 1.1 Demonstrate an understanding that cell metabolism leads to the build-up of waste products in the blood, including c ...
Biology - WordPress.com
Biology - WordPress.com

... cancer cells and in treatment of diseases including cancer c the advantages of using monoclonal antibodies to target specific cells compared to drug and radiotherapy treatments 1.1 Demonstrate an understanding that cell metabolism leads to the build-up of waste products in the blood, including carbo ...
Antibody production
Antibody production

...  Ag recognition stimulates the entry of resting cells into G1 stage of cell cycle  Activated B cells express more MHC-II and B7 and also cytokine receptors ...
Mouse anti- Acetyl CoA Carboxylase 1
Mouse anti- Acetyl CoA Carboxylase 1

... NP_942131), which is identical to chimpanzee. This protein is also 99% similar to Rhesus monkey, 96% similar to pig and bovine and 95% similar to mouse and rat. SPECIFICITY This antibody is specific for human ACC-1(ACC-alpha Biotin carboxylase, COA1_human) protein. On Western blots of human Jurkat c ...
Anti-Hepatitis C Virus Core Antigen antibody [1F6] (Biotin)
Anti-Hepatitis C Virus Core Antigen antibody [1F6] (Biotin)

... protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infecte ...
Purified anti-Nuclear Pore Complex Proteins Antibody
Purified anti-Nuclear Pore Complex Proteins Antibody

... nucleoporins. About half of the nucleoporins typically contain solenoid protein domains—either an alpha solenoid or a beta-propeller fold, or in some cases both as separate structural domains. Each NPC contains at least 456 individual protein molecules and is composed of 30 distinct proteins (nucleo ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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