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Chapter 16
Chapter 16

... An antigen is a substance that stimulates cells to produce antibodies. An allergen is a foreign substance capable of stimulating an allergic reaction. 42. Describe how an immediate-reaction allergic response may occur. In an immediate-reaction allergy, the individuals have an inherited ability to sy ...
Vaksin dan sera
Vaksin dan sera

... •Inactivated, therefore cannot replicate in the host and cause disease. •Local reactions at the site of injection may occur. 3. Stability •Efficacy of the vaccine does not rely on the viability of the organisms. •These vaccines tend to be able to withstand more adverse storage conditions. 4. Expense ...
Protein Purification - University of San Diego Home Pages
Protein Purification - University of San Diego Home Pages

... – derived from single cell - hybrid of mouse spleen and a immortal cell line (lymphocyte and myeloma) – inject mice then can grow cell in a dish – antibodies purified from cell culture media – single epitope, very specific – unlimited production of antibodies ...
Proteins
Proteins

... Receptor proteins - Communication Maintain fluid balance (blood) Structural proteins – support Contractile proteins - movement Transport proteins – in cell membrane, hemoglobin • Antibodies – immune system • Hormones (communication) • Biological catalysts (speed up chemical reactions) - ENZYMES ...
The Immune System - John Burroughs Middle School
The Immune System - John Burroughs Middle School

... called an opsonin (antibodies are an example) ...
Rotation Final Report
Rotation Final Report

... the B cell is activated and begins to engulf the pathogen; the pathogen gets digested and the resulting peptides are presented on the cell surface using MHC (Major Histocompatibility complex) class II proteins. These MHC proteins are important for the activation of other immune responses. Before the ...
By: Diana Marzulli, Sony Abraham and
By: Diana Marzulli, Sony Abraham and

... blood supply causes the redness, heat, and associated with inflammation.  This increased blood flow delivers antimicrobial proteins and other healing elements to the site.  The body may also initiate a systemic response in which a fever or increase in white blood cell count. The most severe of sys ...
lectyre1-Introductio..
lectyre1-Introductio..

... – Immunity: The state of protection from infectious disease • The study of mechanisms that humans and other animals use to defend their bodies from invading organisms such as bacteria, viruses, fungi, parasites and toxins ...
Immune System Study Guide
Immune System Study Guide

... 20. A disease in which the body’s immune system does not recognize its own body cells as being part of “self” is called a(n) ____________________ disease. 21. If you receive an organ transplant, you must take drugs that ____________________ the immune system so the transplanted organ is not attacked ...
IOTest CD25-APC-Alexa Fluor 700
IOTest CD25-APC-Alexa Fluor 700

... The high affinity IL-2 receptor (IL-2R) is a trimeric complex composed of three polypeptides chains, α (IL-2Rα, Tac, p55, or CD25), β (IL-2Rβ, p75, or CD122), and γ (IL2Rγ or p64). T lymphocytes express an intermediate-affinity IL-2 receptor that comprises β /γ or α/γ chain complex. IL-2Rβ and IL-2R ...
BD Pharmingen™ FITC Rat Anti-Mouse Vβ 11 T
BD Pharmingen™ FITC Rat Anti-Mouse Vβ 11 T

... derived from gated events based on the forward and side light-scattering of viable lymphocytes. Flow cytometry was performed on a FACScan™. ...
Tumor Immunology
Tumor Immunology

... response Animals can be immunized against tumors Immunity is transferable from immune to naïve animals Tumor specific antibodies and cell have been detected in humans with some malignancies ...
Immunopathology I
Immunopathology I

... number of different pharmacologic activities. Very little IgE is present in the plasma or blood circulation though; all of the IgE is bound to tissue cells. b. Like other types of immunoglobulin, IgE comes from B-cells that are induced with specific antigens and CD4 T-Cell help. IL4, in particular, ...
Understanding the Immune System
Understanding the Immune System

... – T-Cells (Thymus derived) Natural Killer Cells (Innate Immunity)  CD4+ T-Cells (helper cells)  CD8+ T-Cells (cytotoxic cells) ...
Updated - PeproTech Posters
Updated - PeproTech Posters

... glutathione, which is critical for cellular protection against mitochondrial-derived reactive oxygen species (ROS). Consequently, TIGAR expression modulates p53-induced apoptosis in response to ROS-associated DNA damage. Since elevated levels of F-2-6-BP are required for cell growth and Continued on ...
Multiple Choice. Answer all questions. _____1. When comparing
Multiple Choice. Answer all questions. _____1. When comparing

... _____20. Which of the following statements about steroid hormones is true? A) Steroid hormones cause the production of cAMP. B) Steroid hormones are polar molecules that cannot pass through the cell membrane. C) Steroid hormones activate a transcription factor. D) Steroid hormones bind to specific ...
Immunity B1 1.9
Immunity B1 1.9

... (a) White blood cells have a type of memory. (b)Small amounts of dead or inactive pathogen are injected into the body. (c) If you encounter a live version of the pathogen, your white blood cells rapidly make antibodies to destroy it. (d) The antigens in the vaccine stimulate the white blood cell to ...
Immune System
Immune System

... the environment. IgE binds to mast cells and is involved with inflammation. ...
Immune System
Immune System

... - Slows down the body by causing it to ache - Signals reinforcement to help fight infection and starts specific defenses Interleukin-21 ...
Supplementary Data (doc 82K)
Supplementary Data (doc 82K)

... Luminex-100 XYP System (Luminex Corporation, Austin, TX). A two-fold or higher increase in cytokine production in the postvaccine sample as compared with negative controls was considered to be a positive response. Negative controls included PBMC alone and prevaccine PBMC reactivity against Id/KLH. T ...
Using antibody catalysis to study the outcome of multiple
Using antibody catalysis to study the outcome of multiple

... and the light chains were expressed from two CMV promoters to give an IgG1 hybrid antibody with a human kappa constant region and human ␥1 constant region (C.R. and C.F.B., unpublished data). The antibodies were expressed in a human cell line and were secreted into the cell culture medium, from whic ...
Proposed the "selective theory" to explain the origin of serum antibody
Proposed the "selective theory" to explain the origin of serum antibody

... C. never result in autoreactive specificities. D. exploit imprecise joining of multiple gene segments to afford diversity. 21. In designing a monoclonal blocking antibody to IgE (anti-IgE) to be used in treating or preventing allergic reactions, one would target the monoclonal antibody to which stru ...
The Immune System and Its Functioning
The Immune System and Its Functioning

... Another type of immune response is passive immunity. The antibodies functioning in passive immunity were produced somewhere other than your own body. Infants have passive immunity because they are born with antibodies that were transferred through their mother’s placenta. These antibodies will not r ...
Introduction to Immunology BIOS 486A/586A
Introduction to Immunology BIOS 486A/586A

... T cells are activated by foreign peptides trapped and displayed by dendritic cells in lymph nodes. B cells directly bind immunogens and proliferate with the help of T cell-derived growth factors. ...
Presentation 2
Presentation 2

... engulf pathogens • WBC then adheres to the pathogen via binding of cell membrane components • This process can be facilitated by opsonization- antibodies or other proteins (complement) mark the pathogen for death by sticking to it ...
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Monoclonal antibody



Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.
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