Aalborg Universitet Molecular Pathogenesis of Spondyloarthritis Carlsen, Thomas Gelsing
... predominantly of the IgG1 subclass. Therefore, based on the ELISA results, crossreaction between bacterial and human HSP60 could not be supported as a pathogenic mechanism for SpA disease in our study. However, a weak correlation between anti-human HSP60 IgG3 and one of the several disease parameter ...
... predominantly of the IgG1 subclass. Therefore, based on the ELISA results, crossreaction between bacterial and human HSP60 could not be supported as a pathogenic mechanism for SpA disease in our study. However, a weak correlation between anti-human HSP60 IgG3 and one of the several disease parameter ...
Isolation of infectious HIV-1
... magnetic isolation of infectious HIV-1 virions from culturederived HIV-1, human plasma or serum, and other bodily fluids, e.g. cerebral spinal fluid or cervical lavage. It has been determined that CD44, expressed on all leukocytes, is the most effective host cell marker for the general labeling and cap ...
... magnetic isolation of infectious HIV-1 virions from culturederived HIV-1, human plasma or serum, and other bodily fluids, e.g. cerebral spinal fluid or cervical lavage. It has been determined that CD44, expressed on all leukocytes, is the most effective host cell marker for the general labeling and cap ...
IMMUNOLOGY
... jointly to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning the activation of innate immunity" and the other half to Ralph M. Steinman "for his discovery of the dendritic cell and its role in adaptive immunity". ...
... jointly to Bruce A. Beutler and Jules A. Hoffmann "for their discoveries concerning the activation of innate immunity" and the other half to Ralph M. Steinman "for his discovery of the dendritic cell and its role in adaptive immunity". ...
Vaccinations - e-Bug
... inactivated by being killed or denatured by heat, radiation or other harmful conditions. The antigen is the same but the microorganism can no longer cause the infectious disease. Vaccines provide immunity by stimulating the immune system to produce antibodies to fight a particular infection or preve ...
... inactivated by being killed or denatured by heat, radiation or other harmful conditions. The antigen is the same but the microorganism can no longer cause the infectious disease. Vaccines provide immunity by stimulating the immune system to produce antibodies to fight a particular infection or preve ...
T Cells
... • makes the gamma globulin portion of blood proteins • Are soluble proteins secreted by activated B cells and plasma cells in response to an antigen • Are capable of binding specifically with that antigen • There are five classes of antibodies: IgD, IgM, IgG, IgA, and IgE • Antibodies themselves do ...
... • makes the gamma globulin portion of blood proteins • Are soluble proteins secreted by activated B cells and plasma cells in response to an antigen • Are capable of binding specifically with that antigen • There are five classes of antibodies: IgD, IgM, IgG, IgA, and IgE • Antibodies themselves do ...
Logic of the Immune System - Cancer Immunology Research
... displayed MHC–peptide complexes, and thus serve as a guidance system for the incoming immune attack. Not only that, antigen-presenting cells also carry receptors involved in innate immunity: double-stranded RNA, unmethylated DNA, peptidoglycan, lipopolysaccharides, and other pathogen-derived materia ...
... displayed MHC–peptide complexes, and thus serve as a guidance system for the incoming immune attack. Not only that, antigen-presenting cells also carry receptors involved in innate immunity: double-stranded RNA, unmethylated DNA, peptidoglycan, lipopolysaccharides, and other pathogen-derived materia ...
NAP57, a Mammalian Nucleolar Protein with a Putative Homolog
... appears to shuttle between the nucleolus and the cytoplasm (Borer et al., 1989; Meier and Blobel, 1992). It is likely that these proteins function in ribosomal subunit assembly and in nucleocytoplasmic transport. Noppl40, a nucleolar phosphoprotein of 140 kD, is a representative of the shuttling var ...
... appears to shuttle between the nucleolus and the cytoplasm (Borer et al., 1989; Meier and Blobel, 1992). It is likely that these proteins function in ribosomal subunit assembly and in nucleocytoplasmic transport. Noppl40, a nucleolar phosphoprotein of 140 kD, is a representative of the shuttling var ...
Transplantation Immunology
... To suppress the activity of subpopulation of T-cells. To block co-stimulatory signals. Ab to the CD3 molecule of TCR (T cell receptor) complex results in a rapid depletion of mature T-cells from the circulation. Ab specific for the high-affinity IL-2 receptor is expressed only on activated T ...
... To suppress the activity of subpopulation of T-cells. To block co-stimulatory signals. Ab to the CD3 molecule of TCR (T cell receptor) complex results in a rapid depletion of mature T-cells from the circulation. Ab specific for the high-affinity IL-2 receptor is expressed only on activated T ...
PDF
... CDR-H3 sequences that lack identifiable DH sequence and are created by V, J, and N sequence alone appear indistinguishable from similar sequences created in wild-type (WT) mice (Figures S1 and S2 in Supplementary Material). The DRG peptide sequence characteristic of the dominant Ox1 Id is an example ...
... CDR-H3 sequences that lack identifiable DH sequence and are created by V, J, and N sequence alone appear indistinguishable from similar sequences created in wild-type (WT) mice (Figures S1 and S2 in Supplementary Material). The DRG peptide sequence characteristic of the dominant Ox1 Id is an example ...
Ch6PROTEIN
... Proteins in the body and diet are long polypeptides (100s of amino acids) DENATURING of PROTEINS Acid, alkaline, heat, alcohol, and agitation can disrupt the chemical forces that stabilize proteins can cause them to lose their shape (denature) Denaturing of proteins happens during food preparation ( ...
... Proteins in the body and diet are long polypeptides (100s of amino acids) DENATURING of PROTEINS Acid, alkaline, heat, alcohol, and agitation can disrupt the chemical forces that stabilize proteins can cause them to lose their shape (denature) Denaturing of proteins happens during food preparation ( ...
D (+)-Glucose, anhydrous
... metabolism, glucose is also involved in maintaining reduced environment inside the cells. Metabolism of glucose via the oxidative branch of the pentose phosphate pathway provides the reducing power needed to maintain the pool of NADPH. Cells in vitro are subjected to oxidative stress and their abili ...
... metabolism, glucose is also involved in maintaining reduced environment inside the cells. Metabolism of glucose via the oxidative branch of the pentose phosphate pathway provides the reducing power needed to maintain the pool of NADPH. Cells in vitro are subjected to oxidative stress and their abili ...
Preparation of Vaccines
... – Even though they are harmless, they still contain recognizable antigens on their surface – Because the microbe does not multiply, a weaker immune response is stimulated vs. live vaccines – larger doses and more boosters are required. – Example:Polio virus ...
... – Even though they are harmless, they still contain recognizable antigens on their surface – Because the microbe does not multiply, a weaker immune response is stimulated vs. live vaccines – larger doses and more boosters are required. – Example:Polio virus ...
Chapter 19, Section 2 The Body’s Defenses
... • HIV spreads from one person to another only if body fluids from an infected person come in contact with an uninfected person. – Sexual contact, sharing needles, in utero, transfusion are examples. ...
... • HIV spreads from one person to another only if body fluids from an infected person come in contact with an uninfected person. – Sexual contact, sharing needles, in utero, transfusion are examples. ...
Receptors
... • not every antigen is immunogenic • Antigen is a molecule recognised by immune system • non-immunogenic molecules (haptens) can be bound on immunogen (called carrier) ...
... • not every antigen is immunogenic • Antigen is a molecule recognised by immune system • non-immunogenic molecules (haptens) can be bound on immunogen (called carrier) ...
S1 Methods.
... Purification of ASC specks. HEK293T cells were transfected with ASC encoding plasmids by calcium phosphate method. 24 h after transfection, cells were lysed by sonication. ASC specks were sepearated from soluble proteins and enriched by repeated low speed centrifugation cycles at 200 g. Antibodies. ...
... Purification of ASC specks. HEK293T cells were transfected with ASC encoding plasmids by calcium phosphate method. 24 h after transfection, cells were lysed by sonication. ASC specks were sepearated from soluble proteins and enriched by repeated low speed centrifugation cycles at 200 g. Antibodies. ...
Functional subsets of lymphocytes
... There are more complete data on the use of two suggests that JRA patients with detectable autodifferent types of antisera to distinguish T cell sub- antibody lack circulating suppressor cells (Schlosssets. Schlossman and his colleagues have investigated man et al., 1978). Rapid progress may be expec ...
... There are more complete data on the use of two suggests that JRA patients with detectable autodifferent types of antisera to distinguish T cell sub- antibody lack circulating suppressor cells (Schlosssets. Schlossman and his colleagues have investigated man et al., 1978). Rapid progress may be expec ...
Beta 1-adrenergic receptor-directed autoimmunity as a cause of
... immune system may then engender an autoimmune response [7,9,10,16]. To serve as an autoantigen, (endogenous) myocyte membrane receptors must be degraded by proteolysis to small fragments (oligopeptides), and one or several of the generated fragments must be able to form a complex with one of the maj ...
... immune system may then engender an autoimmune response [7,9,10,16]. To serve as an autoantigen, (endogenous) myocyte membrane receptors must be degraded by proteolysis to small fragments (oligopeptides), and one or several of the generated fragments must be able to form a complex with one of the maj ...
Video: Understanding Viruses - Hutchison
... 20 million people died of the epidemic, but 1 in 5 people contracted the disease. Most deaths occurred within days of contracting the disease. 4. Edward Jenner developed the first vaccine, a vaccine for small pox. Describe how he developed the vaccine and what was a bit controversial (and ethically ...
... 20 million people died of the epidemic, but 1 in 5 people contracted the disease. Most deaths occurred within days of contracting the disease. 4. Edward Jenner developed the first vaccine, a vaccine for small pox. Describe how he developed the vaccine and what was a bit controversial (and ethically ...
Health, Gnotobiology and Infectious Diseases
... and a receptor molecule • Processing – transmission of the received signal from the receptor to other molecules and cells – mediated by cytokines • Response ...
... and a receptor molecule • Processing – transmission of the received signal from the receptor to other molecules and cells – mediated by cytokines • Response ...
Blood Physiology – Part 1
... Figure 1. The development of plasma cells in response to antigen binding on the B cell surface T Lymphocytes These cells differentiate in the thymus, hence are named T cells. Similar to B cells they also pass between the circulation and the spleen/lymph nodes. Macrophages and dendritic cells present ...
... Figure 1. The development of plasma cells in response to antigen binding on the B cell surface T Lymphocytes These cells differentiate in the thymus, hence are named T cells. Similar to B cells they also pass between the circulation and the spleen/lymph nodes. Macrophages and dendritic cells present ...
Blood Physiology Part 1 - e-SAFE
... Figure 1. The development of plasma cells in response to antigen binding on the B cell surface T Lymphocytes These cells differentiate in the thymus, hence are named T cells. Similar to B cells they also pass between the circulation and the spleen/lymph nodes. Macrophages and dendritic cells present ...
... Figure 1. The development of plasma cells in response to antigen binding on the B cell surface T Lymphocytes These cells differentiate in the thymus, hence are named T cells. Similar to B cells they also pass between the circulation and the spleen/lymph nodes. Macrophages and dendritic cells present ...
Monoclonal antibody
Monoclonal antibodies (mAb or moAb) are monospecific antibodies that are made by identical immune cells that are all clones of a unique parent cell, in contrast to polyclonal antibodies which are made from several different immune cells. Monoclonal antibodies have monovalent affinity, in that they bind to the same epitope.Given almost any substance, it is possible to produce monoclonal antibodies that specifically bind to that substance; they can then serve to detect or purify that substance. This has become an important tool in biochemistry, molecular biology and medicine. When used as medications, the non-proprietary drug name ends in -mab (see ""Nomenclature of monoclonal antibodies""), and many immunotherapy specialists use the word mab anacronymically.