Bridging the quality gap: Heart failure
... Heart failure is a debilitating, long-term condition that affects around 900,000 people in the UK. In 2008, 10,000 deaths were attributed to it. Heart failure creates a significant burden, both in terms of compromising patients’ quality of life and economically as, every year, it costs the NHS appro ...
... Heart failure is a debilitating, long-term condition that affects around 900,000 people in the UK. In 2008, 10,000 deaths were attributed to it. Heart failure creates a significant burden, both in terms of compromising patients’ quality of life and economically as, every year, it costs the NHS appro ...
Multiple Defects in Intracellular Calcium Cycling in Whole Failing
... Figure 1. Linescan images showing intracellular Ca2⫹ transients of a multicellular site in control (WKY) and CHF (SHR) hearts. A, Transverse recording in WKY heart in which 15 myocytes are included in this recording site. Basal stimulation at BCL⫽700 ms evokes simultaneous activation of Ca2⫹ transie ...
... Figure 1. Linescan images showing intracellular Ca2⫹ transients of a multicellular site in control (WKY) and CHF (SHR) hearts. A, Transverse recording in WKY heart in which 15 myocytes are included in this recording site. Basal stimulation at BCL⫽700 ms evokes simultaneous activation of Ca2⫹ transie ...
Depolarization wave and mechanics in the paced heart : model and
... function of the heart as a whole. In the heart, a specialized conduction system enables a fast spread of myocyte depolarization. Sometimes, normal depolarization wave propagation is disturbed, by for instance a block in the conduction system and by ventricular pacing. Abnormal ventricular depolariza ...
... function of the heart as a whole. In the heart, a specialized conduction system enables a fast spread of myocyte depolarization. Sometimes, normal depolarization wave propagation is disturbed, by for instance a block in the conduction system and by ventricular pacing. Abnormal ventricular depolariza ...
Pacemaker`s Functional Behaviors in Event-B - HAL
... Pacemaker system and Heart. Our abstract specification includes events modelling pacing modes of single electrode pacemaker. The nature of the refinement that we verified using RODIN [11] proof tools are safety refinement and any behaviour (trace of events) of a refined model must be behaviours of t ...
... Pacemaker system and Heart. Our abstract specification includes events modelling pacing modes of single electrode pacemaker. The nature of the refinement that we verified using RODIN [11] proof tools are safety refinement and any behaviour (trace of events) of a refined model must be behaviours of t ...
Arrythmia recognition
... IST Degree heart block n“P” = n“QRS” ? P-R interval is >0.2 Sec A&E Vinayaka ...
... IST Degree heart block n“P” = n“QRS” ? P-R interval is >0.2 Sec A&E Vinayaka ...
Heart rate as a marker of incidence and prognosis of cardiovascular
... establish a clinical cohort of people with CAD, I consented, recruited and collected anthropometric and biomarker data including RHR from patients attending chest pain clinics and angiography labs in London. ...
... establish a clinical cohort of people with CAD, I consented, recruited and collected anthropometric and biomarker data including RHR from patients attending chest pain clinics and angiography labs in London. ...
Development of Heart Failure and Congenital Septal
... aortic bicuspid valves. The aim of the present study was to additionally investigate the role of eNOS in heart development. Methods and Results—We examined postnatal mortality, cardiac function, and septum defects in eNOS⫺/⫺, eNOS⫹/⫺, and wild-type mice. Postnatal mortality was significantly increas ...
... aortic bicuspid valves. The aim of the present study was to additionally investigate the role of eNOS in heart development. Methods and Results—We examined postnatal mortality, cardiac function, and septum defects in eNOS⫺/⫺, eNOS⫹/⫺, and wild-type mice. Postnatal mortality was significantly increas ...
Pacing mode selection in patients with sick sinus syndrome
... 1. Patients with sinus bradycardia, 2. Patients with sinoatrial conduction block or sinus arrest, and 3. Patients with at least one episode of documented supraventricular tachycardia in addition to sinus bradycardia or sinoatrial block/ sinus arrest (brady-tachy syndrome). Sinus bradycardia is defin ...
... 1. Patients with sinus bradycardia, 2. Patients with sinoatrial conduction block or sinus arrest, and 3. Patients with at least one episode of documented supraventricular tachycardia in addition to sinus bradycardia or sinoatrial block/ sinus arrest (brady-tachy syndrome). Sinus bradycardia is defin ...
Subclinical Atrial Fibrillation and the Risk of Stroke
... trial fibrillation may be asymptomatic and consequently subclinical.1,2 Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.3 About 15% of strokes are attributable to documented atri ...
... trial fibrillation may be asymptomatic and consequently subclinical.1,2 Epidemiologic studies indicate that many patients with atrial fibrillation on screening electrocardiograms had not previously received a diagnosis of atrial fibrillation.3 About 15% of strokes are attributable to documented atri ...
When Calcium Turns Arrhythmogenic: Intracellular Calcium
... Linking Intracellular Ca2+ Handling to Ventricular Tachyarrhythmias in Hypertrophy and Heart Failure While resting intracellular Ca2+ remains normal in non-failing hypertrophied myocardium (7,14,18), alterations in Ca2+ handling are unlikely to cause arrhythmias directly, unless Ca2+ handling is fur ...
... Linking Intracellular Ca2+ Handling to Ventricular Tachyarrhythmias in Hypertrophy and Heart Failure While resting intracellular Ca2+ remains normal in non-failing hypertrophied myocardium (7,14,18), alterations in Ca2+ handling are unlikely to cause arrhythmias directly, unless Ca2+ handling is fur ...
Original Article
... ejection fraction [LVEF]) LV dilation, hypertrophy, and reduced LVEF when compared with baseline. Mice that consumed 0.12% TMAO exhibited significantly worse cardiac function in all parameters measured after TAC (Figure 2) when compared with mice fed the control diet. An accelerated progression of c ...
... ejection fraction [LVEF]) LV dilation, hypertrophy, and reduced LVEF when compared with baseline. Mice that consumed 0.12% TMAO exhibited significantly worse cardiac function in all parameters measured after TAC (Figure 2) when compared with mice fed the control diet. An accelerated progression of c ...
Chapter 4 Atrial Mechanisms
... and symptoms, and initial emergency care for atrioventricular nodal reentrant tachycardia (AVNRT). Describe the ECG characteristics, possible causes, signs and symptoms, and initial emergency care for atrioventricular reentrant tachycardia (AVRT). Describe the ECG characteristics, possible causes, s ...
... and symptoms, and initial emergency care for atrioventricular nodal reentrant tachycardia (AVNRT). Describe the ECG characteristics, possible causes, signs and symptoms, and initial emergency care for atrioventricular reentrant tachycardia (AVRT). Describe the ECG characteristics, possible causes, s ...
The Effects of /3-Adrenergic Stimulation on the
... important in modulating the electrophysiologic effects of class III antiarrhythmic agents. This study prospectively determined the effects of isoproterenol on the frequency-dependent actions of sematilide (a pure class III agent that selectively blocks the delayed rectifier potassium current) and am ...
... important in modulating the electrophysiologic effects of class III antiarrhythmic agents. This study prospectively determined the effects of isoproterenol on the frequency-dependent actions of sematilide (a pure class III agent that selectively blocks the delayed rectifier potassium current) and am ...
MPS450 - Fluke
... Please note that only serialized products and their accessory items (i.e., products and items bearing a distinct serial number tag) are eligible for partial refund and/or credit. Nonserialized parts and accessory items (e.g., cables, carrying cases, auxiliary modules, etc.) are not eligible for retu ...
... Please note that only serialized products and their accessory items (i.e., products and items bearing a distinct serial number tag) are eligible for partial refund and/or credit. Nonserialized parts and accessory items (e.g., cables, carrying cases, auxiliary modules, etc.) are not eligible for retu ...
Chapter 19
... Heart has unique ability: automaticity • Can contract by itself, independent of any signals or stimulation from body • Contracts in response to an electrical current conveyed by a conduction system • Specialized cells in sinoatrial (SA) node, near superior vena cava initiate an electrical impulse • ...
... Heart has unique ability: automaticity • Can contract by itself, independent of any signals or stimulation from body • Contracts in response to an electrical current conveyed by a conduction system • Specialized cells in sinoatrial (SA) node, near superior vena cava initiate an electrical impulse • ...
Action Potential Dynamics Explain Arrhythmic Vulnerability in
... Until recently, it was thought that TWA is caused by a steep slope (⬎1) of the action potential duration (APD) rateresponse curve (restitution) that, at very rapid rates (3), may lead to APD alternans (4). In the presence of conduction slowing or premature beats, APD alternans may develop an opposit ...
... Until recently, it was thought that TWA is caused by a steep slope (⬎1) of the action potential duration (APD) rateresponse curve (restitution) that, at very rapid rates (3), may lead to APD alternans (4). In the presence of conduction slowing or premature beats, APD alternans may develop an opposit ...
ללא כותרת שקופית
... The third heart sound (S3) occurs 0.12 to 0.20 seconds after S2 in early Diastole. Of the many proposed theories, the most likely explanation is that excessive rapid filling of the ventricle is suddenly halted, causing vibrations that are audible as S3. Pathologic states where an S3 is ...
... The third heart sound (S3) occurs 0.12 to 0.20 seconds after S2 in early Diastole. Of the many proposed theories, the most likely explanation is that excessive rapid filling of the ventricle is suddenly halted, causing vibrations that are audible as S3. Pathologic states where an S3 is ...
Interdependence of Modulated Dispersion and Tissue Structure in
... modulating spatial gradients of ventricular repolarization (ie, modulated dispersion). However, it is not clear if such changes in arrhythmia vulnerability can be attributed to the formation of an electrophysiological substrate for unidirectional block and what the potential role is of tissue struct ...
... modulating spatial gradients of ventricular repolarization (ie, modulated dispersion). However, it is not clear if such changes in arrhythmia vulnerability can be attributed to the formation of an electrophysiological substrate for unidirectional block and what the potential role is of tissue struct ...
EHRA/HRS Expert Consensus on Catheter Ablation of
... evolved rapidly and is a work in progress. Ablation is often a sole therapy of VT in patients without structural heart disease and is commonly combined with an implantable cardioverter-defibrillator (ICD) and/or antiarrhythmic therapy for scar-related VTs associated with structural heart disease. As ...
... evolved rapidly and is a work in progress. Ablation is often a sole therapy of VT in patients without structural heart disease and is commonly combined with an implantable cardioverter-defibrillator (ICD) and/or antiarrhythmic therapy for scar-related VTs associated with structural heart disease. As ...
How Harmful is Conventional Right Ventricular Apical Pacing
... of complete LBBB (QRS >140 ms) has been shown [22]. Risk remains significant even after adjusting for age, underlying cardiac disease, indicators of HF severity, and HF medications. The VEST Study [23] demonstrated that QRS duration was found to be an independent predictor of mortality. Patients wit ...
... of complete LBBB (QRS >140 ms) has been shown [22]. Risk remains significant even after adjusting for age, underlying cardiac disease, indicators of HF severity, and HF medications. The VEST Study [23] demonstrated that QRS duration was found to be an independent predictor of mortality. Patients wit ...
Pacing Therapies for Heart Failure (PDF Available)
... activation nearly simultaneous throughout the ventricles. This rapid conduction, and simultaneous activation of the right and left ventricles, results in the narrow QRS complex seen on a normal ECG. If an impulse is transmitted throughout the ventricle without using the His-Purkinje system, it takes ...
... activation nearly simultaneous throughout the ventricles. This rapid conduction, and simultaneous activation of the right and left ventricles, results in the narrow QRS complex seen on a normal ECG. If an impulse is transmitted throughout the ventricle without using the His-Purkinje system, it takes ...
Spiral wave dynamics and ventricular arrhythmias
... both. There are many different types of cardiac arrhythmias. The so-called reentrant arrhythmias that are caused by abnormal reentrant propagation of excitation waves are a frequently occurring and dangerous category. Reentrant arrhythmias in the atria include atrial tachycardia, atrial flutter and ...
... both. There are many different types of cardiac arrhythmias. The so-called reentrant arrhythmias that are caused by abnormal reentrant propagation of excitation waves are a frequently occurring and dangerous category. Reentrant arrhythmias in the atria include atrial tachycardia, atrial flutter and ...
Rate control in Atrial fibrillation Groenveld, Hessel Folkert
... gave it the term ‘delirium cordis’, due to the irregular arterial pulse.26 In 1908 the first electrocardiogram of AF was published.27 Treatment options at that time were limited. To reduce the ventricular rate digoxin was given; the reduction of ventricular rate due to digoxin was already discovered ...
... gave it the term ‘delirium cordis’, due to the irregular arterial pulse.26 In 1908 the first electrocardiogram of AF was published.27 Treatment options at that time were limited. To reduce the ventricular rate digoxin was given; the reduction of ventricular rate due to digoxin was already discovered ...
Acute Effects of Right Ventricular Apical Pacing on Left Ventricular
... Background—Chronic right ventricular (RV) apical pacing has a detrimental effect on left ventricular (LV) function. However, the acute effects of RV apical pacing on LV mechanics remain unclear. The purpose of the study was to assess the acute impact of RV apical pacing on global LV function, evalua ...
... Background—Chronic right ventricular (RV) apical pacing has a detrimental effect on left ventricular (LV) function. However, the acute effects of RV apical pacing on LV mechanics remain unclear. The purpose of the study was to assess the acute impact of RV apical pacing on global LV function, evalua ...
Isolated Heart Perfusion Systems
... The modular nature of the IH-Series allows for initial integration or later upgrade with the Working Heart (also known as Ejecting Heart) perfusion pathway*. This enables orthograde perfusion: entering the left atrium, flowing through the left ventricle and exiting the aorta. In this way, a more phy ...
... The modular nature of the IH-Series allows for initial integration or later upgrade with the Working Heart (also known as Ejecting Heart) perfusion pathway*. This enables orthograde perfusion: entering the left atrium, flowing through the left ventricle and exiting the aorta. In this way, a more phy ...