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Mechanisms of Sleep Control - UCLA Integrative Center for
Mechanisms of Sleep Control - UCLA Integrative Center for

... by a widespread reduction in brain activity and energy usage correlated with EEG voltage increases and by a maintenance of autonomic regulation. However, there are a few very important exceptions to this general rule of reduced brain activity during NREM sleep, as described below. WHERE IS NREM SLEE ...
Obstructive sleep apnea and driving
Obstructive sleep apnea and driving

... The CTS-CSS working group conducted an environmental scan of all existing Canadian provincial guidelines for driving in patients with OSA. In addition to the environmental scan, the working group used the Medical Expert Panel (MEP) Recommendations on Obstructive Sleep Apnea and Commercial Motor Vehi ...
PRACTICE PARAMETERS FOR THE USE OF LIGHT THERAPY IN THE...
PRACTICE PARAMETERS FOR THE USE OF LIGHT THERAPY IN THE...

... the period January 1994 to December 1997. Evidence is presented by grade and level. Recommendations are identified as standards, guidelines, or options. Recommendations are provided for delayed sleep phase syndrome (DSPS), advanced sleep phase syndrome (ASPS), non-24-hour sleep-wake syndrome, jet la ...
Circadian Rhythm Abnormalities
Circadian Rhythm Abnormalities

... (SCN), located in the anterior hypothalamus.1 These rhythms control a variety of biological processes, such as sleepwake cycle, body temperature, feeding, ...
Menopause Related Sleep Disorders
Menopause Related Sleep Disorders

... study in which estrogen replacement (ERT) and non ERT patients were stressed by having blood drawn during the night.27 Although there was no difference at baseline between the 2 groups in polysomnography (PSG) parameters, following a stress challenge, the non ERT patients had more total wake time, l ...
SOP paper
SOP paper

... burden. Sleep disorders such as insomnia, sleep-related breathing disorders and sleep-related movement disorders are prevalent. In addition, sleep disorders are associated with other chronic diseases (and occasionally can be even the first manifestation of, e.g. Parkinson"s disease and depression), ...
Mammalian Sleep
Mammalian Sleep

... be concentrated in a single period each day in adult humans and the great apes, although the latter and people in many cultures take a midday nap. In most mammals, however, sleep is polyphasic, with sleep episodes interrupted by periods of wakefulness. Species also vary in the degree of responsivene ...
Understanding Sleep Disorders treatment guide
Understanding Sleep Disorders treatment guide

... Often the first signs of OSA are recognized not by the patient, but by the bed partner. They may include snoring, daytime sleepiness or fatigue, restlessness during sleep, sudden awakenings with gasping or choking, dry mouth or sore throat upon awakening, trouble concentrating, forgetfulness, irrita ...
State transitions between wake and sleep, and within the
State transitions between wake and sleep, and within the

... sleep promoting neurons. The role of the hypothalamus in the regulation of sleep and wake states has been recognised as early as 1930,35,36 but it is only in recent years that a population of sleep promoting neurons localised in the ventrolateral preoptic (VLPO) area of the hypothalamus has been ide ...
Recent Advances in the Understanding of Narcolepsy: Diagnosis
Recent Advances in the Understanding of Narcolepsy: Diagnosis

... 1.  Episodes of cataplexy, defined as either (a) or (b), occurring at least a few times per month: a. In individuals with long-standing disease, brief (seconds to minutes) episodes of sudden bilateral loss of muscle tone with maintained consciousness that are precipitated by laughter or joking. b. I ...
Hypoglossal nerve stimulation for sleep apnoea
Hypoglossal nerve stimulation for sleep apnoea

... Airway Stimulation system. The study was conducted in two stages: in the first stage, patients were enrolled based on broad selection criteria (n=22); while additional patients were recruited for the second stage based on the outcomes of stage one (n=9). Patients who met the inclusion criteria (stag ...
Chapter 12 – Sleep Disorders - American Academy of Neurology
Chapter 12 – Sleep Disorders - American Academy of Neurology

... AAN.com ©2013 American Academy of ...
Attended Polysomnography for Evaluation of Sleep Disorders
Attended Polysomnography for Evaluation of Sleep Disorders

... Epworth Sleepiness Scale (ESS): The ESS is an 8-item questionnaire which is used to determine the level of a person’s daytime sleepiness. The ESS is based on the patient’s assessment of the likelihood of falling asleep in certain situations commonly encountered in daily life. See the following websi ...
Evaluation of an individualised programme to
Evaluation of an individualised programme to

... patients on their symptoms prior to hospital discharge may assist health care providers to identify patients who could be at risk for having more difficulty with physical functioning and physical activity during the first 6 months after surgery (Zimmerman et al. 2010). Symptoms of pain, fatigue and ...
Ictal SPECT in patients with rapid eye movement
Ictal SPECT in patients with rapid eye movement

... convert within 10–15 years after onset to neurodegenerative disease such as Parkinson’s disease, multisystem atrophy, or dementia of the Lewy bodies (Schenck et al., 2013). Patients with idiopathic REM sleep behaviour disorder frequently show signs and symptoms associated with an increased risk of d ...
Sleep duration varies as a function of glutamate and GABA in rat
Sleep duration varies as a function of glutamate and GABA in rat

... and wakefulness. In numerous brain regions, levels of glutamate are highest during wakefulness or rapid eye movement (REM) sleep (Azuma et al. 1996; Kodama et al. 1998; Kodama and Honda 1999; Léna et al. 2005; LopezRodriguez et al. 2007; John et al. 2008; Dash et al. 2009). One exception is the tha ...
cheyne-stokes, apneas complejas y centrales uso de la ventilación
cheyne-stokes, apneas complejas y centrales uso de la ventilación

... this revolution in the state of his breathing occupied about a minute during which there were about thirty acts of respiration...” ...
Ciccarelli 4: Consciousness
Ciccarelli 4: Consciousness

... All rights reserved. ...
Management of Sleep Disturbances Following Concussion/Mild
Management of Sleep Disturbances Following Concussion/Mild

... classified as mild traumatic brain injury (mTBI), also known as concussion.1 While symptoms are common in the immediate post-concussive period, most people who sustain a concussion completely recover within days to weeks. However, a small subset of individuals, most notably those with pre-existing a ...
The Ups and Downs of Bi-level Pressure Therapy in Sleep
The Ups and Downs of Bi-level Pressure Therapy in Sleep

... CPAP titration is safe without previous diagnostic polysomnogram to establish the diagnosis of OSA ™ Other nocturnal breathing disorders like central sleep apnea, chronic hypoventilation due to emphysema or other diseases cannot be recognized with automatic CPAP ™ Patients are at risk for mask leak ...
Clinical Update on Epidemiology, Pathogenesis, and
Clinical Update on Epidemiology, Pathogenesis, and

... stress, poorer mood, greater coping difficulties, decreased memory and concentration, impaired psychomotor performance, less ability to complete tasks, decreased productivity, occupational difficulties, greater tendency to suffer work-related or traffic accidents, greater impairment of family or soc ...
Sleep Health and Appropriate Use of OTC Sleep
Sleep Health and Appropriate Use of OTC Sleep

... Insomnia should be distinguished from sleep disturbance. “Insomnia” is a disorder defined by (a) having difficulty sleeping (difficulty falling asleep or staying asleep, or not feeling rested after sleeping), (b) which occurs despite adequate opportunity and circumstance for sleep, (c) which is asso ...
Standard Polysomnography - Log
Standard Polysomnography - Log

... requirements for recording respiration signals will vary according to equipment specifications, but should adhere as closely as possible to AASM standards. Because apneas, hypopneas and RERA’s frequently trigger arousals and interrupt the normal sleep cycle, it is important that respiratory effort a ...
Introduction - Sleep Centres of Australia
Introduction - Sleep Centres of Australia

... patients with OSA than without OSA, and may have a greater impact on morbidity and mortality than the cardiovascular sequelae of OSA. All patients should be warned about an increased risk of accidents associated with untreated OSA and the potential consequences of driving or operating other dangerou ...
Click here for handout
Click here for handout

... science/ ...
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Sleep deprivation



Sleep deprivation is the condition of not having enough sleep; it can be either chronic or acute. A chronic sleep-restricted state can cause fatigue, daytime sleepiness, clumsiness and weight loss or weight gain. It adversely affects the brain and cognitive function. However, in a subset of cases sleep deprivation can, paradoxically, lead to increased energy and alertness and enhanced mood; it has even been used as a treatment for depression (see below). Few studies have compared the effects of acute total sleep deprivation and chronic partial sleep restriction. Complete absence of sleep over long periods has not been seen in humans (unless they suffer from fatal familial insomnia); it appears that brief microsleeps cannot be avoided. Long-term total sleep deprivation has caused death in lab animals.
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