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Endothelin-1 plasma levels are not elevated in patients with F. Grimpen
Endothelin-1 plasma levels are not elevated in patients with F. Grimpen

... from systemic hypertension which was treated in all cases (calcium antagonist in one, angiotensin converting enzyme inhibitor in six, diuretics in five, and b-blockers in six patients). No changes in any of these medications were made for the duration of the study. In 22 cases there was no clinical ...
Secondary insomnia: diagnostic challenges and intervention
Secondary insomnia: diagnostic challenges and intervention

... cold or hot, leg cramps and dreams. Higher rates of medical illness in older adults increase their risk of insomnia due to both the illness itself and the medication used in its treatment. There are normal age-related physiological changes that retard drug absorption, distribution, metabolism and el ...
Author`s personal copy - Sleep, Stress, and Memory Lab
Author`s personal copy - Sleep, Stress, and Memory Lab

... Fig. 3B). Critically, another group of subjects was sleep deprived on the first night after training. These subjects were allowed 2 full nights of recovery sleep before being retested 3 days later. The subjects failed to show any residual learning, suggesting that performance enhancements depend on ...
MSLT perameter.qxp - American Academy of Sleep Medicine
MSLT perameter.qxp - American Academy of Sleep Medicine

... occurs in association with disorders and conditions such as narcolepsy, idiopathic hypersomnia, and sleep deprivation. It may occur due to the obstructive sleep apnea syndrome, periodic limb movement disorder, a variety of other medical and neurological disorders, or medication side effects. Excessi ...
abstract - National University of Natural Medicine
abstract - National University of Natural Medicine

... B.1.1. Insomnia impacts daily functioning. Since insomnia includes not only sleep dysfunctions, but significant problems during waking hours as well, it creates an enormous burden for the individual. Dysphoria is significantly related to insomnia, as is also decreased quality of life to an extent ev ...
Parasomnias and Their Mimics
Parasomnias and Their Mimics

... American Academy of Sleep Medicine; 2005. ...
Defi nitions of Narcolepsy
Defi nitions of Narcolepsy

... et al3b–3f discovered that the canine narcolepsy was due to a mutation of the hypocretin receptor 2 gene, and hypocretin 1 was found to be reduced or absent in the cerebrospinal fluid (CSF) of patients with narcolepsy. Narcolepsy was the first primary sleep disorder to be identified and characterize ...
complex sleep apnea
complex sleep apnea

... definitely interrelationships between heart disease and all forms of sleep-disordered breathing so this is an area many will be looking into further. What role do concomitant medications such as serotonin-reuptake-inhibitors and diuretics play in producing an under-damped ventilatory control? There ...
incorporating sleep apnea appliances into
incorporating sleep apnea appliances into

... • Balanced by neurotransmitters in the brain and brainstem • Affected by light and daily natural rhythms ...
Sleep apnoea - Best of Health BMJ
Sleep apnoea - Best of Health BMJ

... You have a stroke when the blood supply to a part of your brain is cut off. This damages your brain and can cause symptoms like weakness or numbness on one side of your body. You may also find it hard to speak if you've had a stroke. high blood pressure Your blood pressure is considered to be high w ...
Practice Parameters for Clinical Use of the Multiple Sleep
Practice Parameters for Clinical Use of the Multiple Sleep

... occurs in association with disorders and conditions such as narcolepsy, idiopathic hypersomnia, and sleep deprivation. It may occur due to the obstructive sleep apnea syndrome, periodic limb movement disorder, a variety of other medical and neurological disorders, or medication side effects. Excessi ...
Understanding Sleep Disorders
Understanding Sleep Disorders

... apnea and who do not have problems affecting the heart, lungs and/or nervous system. (See sidebar on HST for details.) How is sleep apnea treated? Conservative treatment may be all that is needed for milder cases of sleep apnea. Lifestyle changes may include losing weight (if overweight), avoiding a ...
Sleep Health and the Appropriate Use of OTC Sleep Aids in Older
Sleep Health and the Appropriate Use of OTC Sleep Aids in Older

... While occasional sleeplessness lasting a few weeks is common, many people have sleep problems that persist for much longer. Chronic insomnia can last for months or years.12 Ohayon et al. performed a meta-analysis of 65 sleep studies, which revealed that most individuals who develop sleep disturbance ...
What Keeps Us Awake: the Neuropharmacology of Stimulants and
What Keeps Us Awake: the Neuropharmacology of Stimulants and

... inhaler. They were used (and are still used) by the United States military as antifatigue medications, and they currently are legally available for medical use as adjuncts for short-term weight control, in attention-deficit/hyperactivity disorder, and in narcolepsy. Oral and intravenous doses of amp ...
Surgeries for Snoring and Obstructive Sleep Apnea Syndrome in
Surgeries for Snoring and Obstructive Sleep Apnea Syndrome in

... According to the American Academy of Sleep Medicine, the following AHI/RDI levels are used for the diagnosis of OSA:[2] ...
What Is Central Sleep Apnea?
What Is Central Sleep Apnea?

... use proprietary algorithms to maintain ventilation relatively constant during fluctuations in patient effort) in the treatment of breathing abnormalities during sleep in CHF patients. If these newer devices are effective at eliminating CSB, then one might anticipate improvement in outcome if CSB its ...
Why We Sleep: The Temporal Organization of
Why We Sleep: The Temporal Organization of

... increased sleep (sleep rebound) after sleep deprivation. During NREM sleep recovery, delta power decreases exponentially with time, tracking the dissipation of the behavioral sleep debt. REM sleep is also homeostatically regulated. has been proposed [1,19,23]: rapid reversibility (as opposed to hibe ...
Consciousness - AP Psychology
Consciousness - AP Psychology

... • Sleep deprivation: any significant loss of sleep – results in irritability and problems with ...
Spontaneous Spike Activity of Spinoreticular Tract Neurons During
Spontaneous Spike Activity of Spinoreticular Tract Neurons During

... Division of Pharmacology & Toxicology, Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, BC, V6T 1Z3, Canada Abstract: Sleep mentation studies infer that pain sensation in humans may be reduced during active REM sleep. However, to provide a mechanistic explanation fo ...
69516 Inside.indd - National Sleep Foundation
69516 Inside.indd - National Sleep Foundation

... with a disruption of circadian rhythms sleep is actually an active physiological ...
Characteristics of sleep
Characteristics of sleep

... -more tired: shorter 1st period of paradoxical (REM) sleep -as the person rest –REM periods become longer 4. Life-styles: -Person who does shift work & changes shifts --- must arrange activities so that the person is ready to sleep at the right time -Moderate activities – usually is conducive to sle ...
Sleep Apnea in Spinal Cord Injury: A Systematic Review
Sleep Apnea in Spinal Cord Injury: A Systematic Review

... already high prevalence of OSA, while at the same time leaving hypoventilation underestimated and potentially under-treated. Also relevant to this point is that continuous monitoring of pCO2 was not done in any of these studies. Symptoms suggesting sleep disordered breathing would be fairly standar ...
Sleep and Sleep Disorders
Sleep and Sleep Disorders

... 1. Have severe chronic fatigue for at least 6 months or longer that is not relieved by rest and not due to medical or psychiatric conditions associated with fatigue as excluded by clinical diagnosis; and 2. Concurrently have four or more of the following symptoms: o self-reported impairment in short ...
Sleep Apnea in the Elderly, World Sleep Day
Sleep Apnea in the Elderly, World Sleep Day

... • Since the prevalence of central sleep apnea appears to be increased in the elderly, it is possible that factors which promote the development of central apnea may be enhanced by aging. For example, an increased ventilatory response to hypercapnia can promote the development of sleep apnea by desta ...
States of Consciousness
States of Consciousness

... asleep for at least three nights a week over a month’s time) (Roth, 2007). Individuals who do rotating shift work are also likely to experience disruptions in circadian cycles. Rotating shift work refers to a work schedule that changes from early to late on a daily or weekly basis. For example, a pe ...
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Sleep deprivation



Sleep deprivation is the condition of not having enough sleep; it can be either chronic or acute. A chronic sleep-restricted state can cause fatigue, daytime sleepiness, clumsiness and weight loss or weight gain. It adversely affects the brain and cognitive function. However, in a subset of cases sleep deprivation can, paradoxically, lead to increased energy and alertness and enhanced mood; it has even been used as a treatment for depression (see below). Few studies have compared the effects of acute total sleep deprivation and chronic partial sleep restriction. Complete absence of sleep over long periods has not been seen in humans (unless they suffer from fatal familial insomnia); it appears that brief microsleeps cannot be avoided. Long-term total sleep deprivation has caused death in lab animals.
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