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Comparison of the activities of protein disulphide
Comparison of the activities of protein disulphide

Vanadium-Binding Proteins (Vanabins)
Vanadium-Binding Proteins (Vanabins)

... were highly regular. We used recombinant proteins of these two independent but related vanabins, named as vanabin1 and vanabin2, for metal binding assay and revealed that vanabins can bind to multiple 10 or 20 vanadium(IV) ions with dissociation constants of 2.1 × 10-5 M and 2.3 × 10-5 M, respective ...
Bioinformatics (1) - Computer and Information Sciences
Bioinformatics (1) - Computer and Information Sciences

... – Observation: a lot of living things – Why does Mother nature have this biodiversity? – Answers • Simple classification based on morphological features • Theory: evolution – mutations, natural selection, … ...
The DNA Binding Properties of Saccharomyces cerevisiae Rad51
The DNA Binding Properties of Saccharomyces cerevisiae Rad51

MPN+, a putative catalytic motif found in a subset of MPN domain
MPN+, a putative catalytic motif found in a subset of MPN domain

... In order to gain insight into the functions and evolutionary history of MPN domain proteins such as Rpn11, we performed extended database searches using the general- ...
Carbohydrate-Based Mimetics in Drug Design: Sugar Amino Acids
Carbohydrate-Based Mimetics in Drug Design: Sugar Amino Acids

... molecular recognition. In order to perform these functions, the correct folding of the biopolymers creating the active site is crucial, since any kind of interaction is observed only if the reactive groups are positioned in the correct spatial orientation to each other. Thus, the development of smal ...
An investigation into the composition and nutritional properties of a
An investigation into the composition and nutritional properties of a

... countries. Although malnutrition tends to be more common in these countries, where there are shortages of food, in industrialised countries, more and more people are being diagnosed with malnutrition caused by food allergies. The main approach to managing allergies is to avoid certain foods, which m ...
Formation of Helical Hairpins during Membrane Protein Integration
Formation of Helical Hairpins during Membrane Protein Integration

... Keywords: membrane protein; protein structure; glycosylation; transmembrane helix; helical hairpin ...
Identification of two amino acid residues which - Wiley-VCH
Identification of two amino acid residues which - Wiley-VCH

... The position of the α424Arg residue within the three dimensional structure of the α subunit was examined in order to determine whether the location of the arginine side chain was compatible with a role in neutralizing the charge on the electronegative substrate. A model structure for the Hex A α-sub ...
practice test - WordPress.com
practice test - WordPress.com

... e. nonpolar. ____ 40. In __________ bonds, both atoms exert the same pull on shared electrons. a. nonpolar covalent b. polar covalent c. double covalent d. triple covalent ____ 41. Which of these statements is false concerning covalent bonds? a. Atoms share electrons. b. Proteins possess many covale ...
InterPro Presentation - European Bioinformatics Institute
InterPro Presentation - European Bioinformatics Institute

... Short sequences typically repeated within a protein ...
FtsZ - Cytoskeleton, Inc.
FtsZ - Cytoskeleton, Inc.

... cell division. FtsZ inactivation inhibits cell division, making them attractive targets for novel anti-microbial drugs. Although FtsZ proteins exhibit a degree of homology, inhibitors of the proteins show differential affinities and efficacies. Thus, improved targeting can be achieved by screening s ...
Functional and structural studies of a C
Functional and structural studies of a C

... whereas the large subunit has two RNA chains (23S and 5S rRNA) of about 2904 nt and 120 nt, respectively, packed with 31 different ribosomal proteins. In bacteria, ribosomes synthesize proteins on a continuous basis at an incredible speed of > 15 peptide bonds formed per second. Despite their size d ...
The Metamorphosis of the Aleurone Protein Storage Vacuole
The Metamorphosis of the Aleurone Protein Storage Vacuole

... smaller protein storage vacuoles (Jones and Price, 1970). Several pieces of evidence from electron microscopy studies support this idea. First, protein storage vacuoles are not separate organelles, but are linked by tonoplast connections (Jones and Price, 1970). Second, the large vacuole formed afte ...
Bioinformatics Explained
Bioinformatics Explained

Snake venomics of Bothrops punctatus
Snake venomics of Bothrops punctatus

... % ACEi = (Abs Control − Abs sample)/(Abs control − Abs blank). Control absorbance corresponded to hippuric acid formed after the action of ACE, while blank absorbance was enzyme without substrate. Statistical analyses The significance of differences between means was assessed by ANOVA, followed by D ...
Rabbit genome editing with zinc finger nucleases
Rabbit genome editing with zinc finger nucleases

... natively, the Wild-type rabbit from Which the genetically modi?ed rabbit is derived may comprise an ortholog corre sponding to the functional human disease or trait-related pro tein. In this case, the orthologous sequence in the “human ized” rabbit is inactivated such that no functional protein is m ...
a ABBOTT
a ABBOTT

... 25. Kopple JD, Vinton NE, Laidlaw SA et al. Effect of Intmvenous Taurine Supplemenuxion on Plasma, Blood Cells and L-tie Taurine Concentrations in Adults Undergoing bmg-Term Parenteral Nutrition. Am J Clin Nutr 1990; 52:846-53. 26, Roe DA, Wesron MD. Potential Significance of Free Taurine in the Die ...
Keyhole Limpet Hemocyanin ( KLH )
Keyhole Limpet Hemocyanin ( KLH )

... removing divalent cations from a hemocyanin suspension, although divalent cations aid in the formation of larger aggregates. With moderate changes in pH, or ionic strenght, it will reversibly dissociate to subunits, and at pH8.9 will completely dissociate. Each subunit contains oxygen binding sites ...
Identification of a structural motif that confers specific interaction with
Identification of a structural motif that confers specific interaction with

... multiple interacting proteins. To examine the interaction between the COP1 WD40 domain and the HY5, STO and STH proteins, we generated point mutations in the WD40 domain that could interfere speci®cally with the interactions of the domain without affecting its b-propeller structure. To this end, we ...
Regulation of Cytochrome bd Expression in Mycobacterium
Regulation of Cytochrome bd Expression in Mycobacterium

... 1.1 Mycobacteria Mycobacteria are Gram-positive and acid-fast bacteria, belonging to the phylum of Actinobacteria. Mycobacteria possess G + C rich genomes with a content of about 62-70% (24). They are considered to be obligate aerobes and have a rod-shaped appearance of about 0.3 - 0.5 µm in diamete ...
Manipulation of Epitope Function by Modification of Peptide
Manipulation of Epitope Function by Modification of Peptide

Utilisation of Whey
Utilisation of Whey

... attachments (hence the "glyco-" term). Its molecular weight, based on its amino acid content, is about 7,000; however, the carbohydrate units make it behave as if it were somewhat larger. This is important because the ultrafiltration membranes used to prepare whey protein concentrates and whey prote ...
Conclusion - Federal Register of Legislation
Conclusion - Federal Register of Legislation

... expressed at moderate levels in the corn grain, with a mean concentration of 43.6 µg/g fresh weight. The PMI protein is expressed at relatively low levels in the grain, with the mean concentration of 1.9 μg/g fresh weight. The Vip3Aa20 protein is 99.7% identical to the native Vip3Aa1 protein, differ ...
Metabolism of lactic acid bacteria
Metabolism of lactic acid bacteria

... Streptoc occus l a ctis organisms were grown in l actose­ l imite d batch culture and the survival characteristics of washe d organi sms were examine d at the growth temperature . Washe d suspension s had high initial viabilitie s ()9 9 % ) which were maintaine d for varying pe riods depending on th ...
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Protein structure prediction



Protein structure prediction is the prediction of the three-dimensional structure of a protein from its amino acid sequence — that is, the prediction of its folding and its secondary, tertiary, and quaternary structure from its primary structure. Structure prediction is fundamentally different from the inverse problem of protein design. Protein structure prediction is one of the most important goals pursued by bioinformatics and theoretical chemistry; it is highly important in medicine (for example, in drug design) and biotechnology (for example, in the design of novel enzymes). Every two years, the performance of current methods is assessed in the CASP experiment (Critical Assessment of Techniques for Protein Structure Prediction). A continuous evaluation of protein structure prediction web servers is performed by the community project CAMEO3D.
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