R. Prabhakar - Emerson Center for Scientific Computation
... Computational Modeling of Reaction Mechanisms, Drugs and Biomaterials Rajeev Prabhakar Department of Chemistry, University of Miami, Coral Gables, FL 33146 Theoretical and computational techniques are used to study complex processes that are required in a wide range of biological, biotechnological a ...
... Computational Modeling of Reaction Mechanisms, Drugs and Biomaterials Rajeev Prabhakar Department of Chemistry, University of Miami, Coral Gables, FL 33146 Theoretical and computational techniques are used to study complex processes that are required in a wide range of biological, biotechnological a ...
L1 - Enzymes and Biological Regulation
... • Most enzymes are proteins. • Enzymes are specific in the type of reactions they catalyze. 1. Absolute specificity – acts only on one substance. 2. Relative specificity – acts on structurally related substances. 3. Stereochemical specificity – distinguishes between stereoisomers. ...
... • Most enzymes are proteins. • Enzymes are specific in the type of reactions they catalyze. 1. Absolute specificity – acts only on one substance. 2. Relative specificity – acts on structurally related substances. 3. Stereochemical specificity – distinguishes between stereoisomers. ...
Presentation1
... Peanut Butter and Jelly Salmonella X Our research question was to try to determine why salmonella can survive and grow in less than ideal conditions, such as a jar of Peter Pan peanut butter. In the bacterium Pseudomonas aeruginosa, a lipase enzyme has been isolated from a strain which is capable of ...
... Peanut Butter and Jelly Salmonella X Our research question was to try to determine why salmonella can survive and grow in less than ideal conditions, such as a jar of Peter Pan peanut butter. In the bacterium Pseudomonas aeruginosa, a lipase enzyme has been isolated from a strain which is capable of ...
Zecture #24
... ‧ We’ll look at the proposed mechanism of peptide bond formation; this model has changed dramatically since 2000! ‧ Use proteases as a mechanistic model system. ...
... ‧ We’ll look at the proposed mechanism of peptide bond formation; this model has changed dramatically since 2000! ‧ Use proteases as a mechanistic model system. ...
Document
... 2DG competes with the glucose intermediate against the active site of enzyme 2. If plenty of glucose or glucose intermediate is supplied, the inhibition can be minimized and the reaction rate can be restored to the original level. ...
... 2DG competes with the glucose intermediate against the active site of enzyme 2. If plenty of glucose or glucose intermediate is supplied, the inhibition can be minimized and the reaction rate can be restored to the original level. ...
South Pasadena • AP Chemistry
... The chemical elements are the building blocks of matter, which can be understood in terms of arrangements of atoms. Molecules & elements Chemical analysis The mole Electron configuration Periodicity Quantum mechanical model Atomic models Mass spectrometry Light & matter Conservat ...
... The chemical elements are the building blocks of matter, which can be understood in terms of arrangements of atoms. Molecules & elements Chemical analysis The mole Electron configuration Periodicity Quantum mechanical model Atomic models Mass spectrometry Light & matter Conservat ...
Enzymes: “Helper” Protein molecules
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
Enzymes: “Helper” Protein molecules
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
Chapter 2 Outline
... steroid based e.g. testosterone, progesterone C. Proteins – structural building blocks of the body 1. composed of amino acid monomers 2. Chemical composition CHON 3. Enzymes are protein catalysts a. Substrate – material enzyme is working on b. Binding site (active site) – place where substrate bonds ...
... steroid based e.g. testosterone, progesterone C. Proteins – structural building blocks of the body 1. composed of amino acid monomers 2. Chemical composition CHON 3. Enzymes are protein catalysts a. Substrate – material enzyme is working on b. Binding site (active site) – place where substrate bonds ...
Collision Theory
... • Before atoms/molecules/ions can react, they must first collide • An effective collision between two species puts enough energy to break key bonds • The activation energy (Ea) is the minimum energy that must be supplied by collisions to trigger a reaction • A certain fraction of all molecules in a ...
... • Before atoms/molecules/ions can react, they must first collide • An effective collision between two species puts enough energy to break key bonds • The activation energy (Ea) is the minimum energy that must be supplied by collisions to trigger a reaction • A certain fraction of all molecules in a ...
Enzymes: “Helper” Protein molecules
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
... Enzymes aren’t used up Enzymes are not changed by the reaction used only temporarily re-used again for the same reaction with other molecules very little enzyme needed to help in many reactions ...
2.4 Chemical Reactions
... ! "Bonds break and form during chemical reactions. •" Chemical reactions change substances into different ones by breaking and forming chemical bonds. –" Reactants are changed during a chemical reaction. –" Products are made by a chemical reaction. ...
... ! "Bonds break and form during chemical reactions. •" Chemical reactions change substances into different ones by breaking and forming chemical bonds. –" Reactants are changed during a chemical reaction. –" Products are made by a chemical reaction. ...
Enzyme catalysis
Enzyme catalysis is the increase in the rate of a chemical reaction by the active site of a protein. The protein catalyst (enzyme) may be part of a multi-subunit complex, and/or may transiently or permanently associate with a Cofactor (e.g. adenosine triphosphate). Catalysis of biochemical reactions in the cell is vital due to the very low reaction rates of the uncatalysed reactions. A key driver of protein evolution is the optimization of such catalytic activities via protein dynamics.The mechanism of enzyme catalysis is similar in principle to other types of chemical catalysis. By providing an alternative reaction route the enzyme reduces the energy required to reach the highest energy transition state of the reaction. The reduction of activation energy (Ea) increases the amount of reactant molecules that achieve a sufficient level of energy, such that they reach the activation energy and form the product. As with other catalysts, the enzyme is not consumed during the reaction (as a substrate is) but is recycled such that a single enzyme performs many rounds of catalysis.