NIDA Research Report - MDMA
... properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and all-night party scene, but its use has now spread to a wide range of settings and demographic subgroups. According ...
... properties, is often taken for the feelings of well-being, stimulation, and the distortions in time and sensory perceptions that it produces. MDMA first became popular in the “rave” and all-night party scene, but its use has now spread to a wide range of settings and demographic subgroups. According ...
GUIDE TO INDIVIDUAL CASE SAFETY REPORTING
... diseases, vaccines and contraceptives are examples of classes of medicinal products where lack of efficacy should be considered for reporting. It is important to provide batch numbers for vaccines and biological medicinal products. Judgment should be applied when considering if cases of lack of effi ...
... diseases, vaccines and contraceptives are examples of classes of medicinal products where lack of efficacy should be considered for reporting. It is important to provide batch numbers for vaccines and biological medicinal products. Judgment should be applied when considering if cases of lack of effi ...
PRODUKTRESUMÉ
... Before cabergoline administration, pregnancy should be excluded and after treatment pregnancy should be prevented for at least one month. As cabergoline has an elimination half-life of 79-115 hours in hyperprolactinaemic patients, once regular ovulatory cycles have been achieved women seeking pregna ...
... Before cabergoline administration, pregnancy should be excluded and after treatment pregnancy should be prevented for at least one month. As cabergoline has an elimination half-life of 79-115 hours in hyperprolactinaemic patients, once regular ovulatory cycles have been achieved women seeking pregna ...
Tree-structured gatekeeping procedures for multiple objectives in
... serves as a gatekeeper for the families later in the sequence, this testing approach is commonly known as the gatekeeping testing approach. Several types of gatekeeping procedures for clinical trials with ordered objectives have been proposed in the literature. Westfall and Krishen [1], Maurer et al ...
... serves as a gatekeeper for the families later in the sequence, this testing approach is commonly known as the gatekeeping testing approach. Several types of gatekeeping procedures for clinical trials with ordered objectives have been proposed in the literature. Westfall and Krishen [1], Maurer et al ...
Lecture-1-Opioids - Kentucky Academy of Family Physicians
... MD. CDC. CDC Vital Signs. Prescription Painkiller Overdoses. Use and abuse of methadone as a painkiller. 2012. FDA. Questions and Answers: FDA approves a Risk Evaluation and Mitigation Strategy for Extended-Release and Long-Acting Opioid Analgesics. www.fda.gov/Drugs/DrugSafety/InformationbyDrugClas ...
... MD. CDC. CDC Vital Signs. Prescription Painkiller Overdoses. Use and abuse of methadone as a painkiller. 2012. FDA. Questions and Answers: FDA approves a Risk Evaluation and Mitigation Strategy for Extended-Release and Long-Acting Opioid Analgesics. www.fda.gov/Drugs/DrugSafety/InformationbyDrugClas ...
Abstracts
... reactions (HR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions (SCAR) and anaphylaxis. Currently, two different concepts provide rational explanations how a drug can initiate a drug HR by activating human T c ...
... reactions (HR) with various clinical pictures from minor affections like maculopapular exanthema (MPE) and urticaria to severe cutaneous adverse reactions (SCAR) and anaphylaxis. Currently, two different concepts provide rational explanations how a drug can initiate a drug HR by activating human T c ...
A European Respiratory Review on ...
... to develop long-acting beta-agonists. The pharmacology of these agents has been extensively reviewed in this journal [5). A thoroughly investigated long acting beta-agonists is salmeterol. Pharmacological development of this molecule, led by Or R Brittain of Glaxo Group Research, was on the rational ...
... to develop long-acting beta-agonists. The pharmacology of these agents has been extensively reviewed in this journal [5). A thoroughly investigated long acting beta-agonists is salmeterol. Pharmacological development of this molecule, led by Or R Brittain of Glaxo Group Research, was on the rational ...
PK/PD - Physiologie et Thérapeutique Ecole Véto Toulouse (ENVT)
... Classical PK/PD indices vs. semimechanistic models • However, they also predict that when the AM half-life is short, the best predictor is always T>MIC and when the half-life is long, the best predictor is always AUC/MIC whatever the antibiotic. • These kind of results are very important for veteri ...
... Classical PK/PD indices vs. semimechanistic models • However, they also predict that when the AM half-life is short, the best predictor is always T>MIC and when the half-life is long, the best predictor is always AUC/MIC whatever the antibiotic. • These kind of results are very important for veteri ...
Treatment of Tics and Tourette Syndrome | SpringerLink
... etiology for TS is controversial. Finally, it is important to note that most patients with tic disorders have few difficulties secondary to their tics; parents are often more concerned about tics than their affected child. Decisions regarding the treatment of tics need to be individualized, especial ...
... etiology for TS is controversial. Finally, it is important to note that most patients with tic disorders have few difficulties secondary to their tics; parents are often more concerned about tics than their affected child. Decisions regarding the treatment of tics need to be individualized, especial ...
Aprepitant Emend™ — Merck Frosst Canada Ltd.
... Outcomes were reported as acute (within the first 24 hours of chemotherapy), delayed (>24 hours after chemotherapy) or overall (during day one to five). ...
... Outcomes were reported as acute (within the first 24 hours of chemotherapy), delayed (>24 hours after chemotherapy) or overall (during day one to five). ...
Effects of terbutaline and atenolol ... airways in asthmatic patients J.W.J. Lammers, Folgering,
... parameters derived from MEFV curves when breathing air and for density dependence of expiratory airflow. By measurement of MEFV curves when the patients were breathing air alone, it was not possible to determine whether there is a difference in the bronchoconstrictor effect of atenolol between large ...
... parameters derived from MEFV curves when breathing air and for density dependence of expiratory airflow. By measurement of MEFV curves when the patients were breathing air alone, it was not possible to determine whether there is a difference in the bronchoconstrictor effect of atenolol between large ...
Inhibition of Multidrug and Toxin Extrusion (MAT
... been shown that cisplatin plasma concentrations are increased, and renal accumulation is higher, in Mate1 (-/-) mice (versus wild-type animals) (Nakamura et al., 2010). Unlike mice, however, genotype-phenotype associations in humans are more complex because of the expression of two forms of MATE (MA ...
... been shown that cisplatin plasma concentrations are increased, and renal accumulation is higher, in Mate1 (-/-) mice (versus wild-type animals) (Nakamura et al., 2010). Unlike mice, however, genotype-phenotype associations in humans are more complex because of the expression of two forms of MATE (MA ...
Can methylphenidate be used for adults with attention deficit
... A Cochrane systematic review (11 trials, n=474) which evaluated the efficacy and tolerability of IR methylphenidate versus placebo in the treatment of adults with ADHD showed that IR methylphenidate decreased hyperactivity, impulsivity and inattentiveness compared to placebo. Subgroup analysis compa ...
... A Cochrane systematic review (11 trials, n=474) which evaluated the efficacy and tolerability of IR methylphenidate versus placebo in the treatment of adults with ADHD showed that IR methylphenidate decreased hyperactivity, impulsivity and inattentiveness compared to placebo. Subgroup analysis compa ...
Sinemet® CR Product Monograph
... used for determination of ketonuria. False-negative tests may result with the use of glucoseoxidase methods of testing for glucosuria. Caution should be exercised when interpreting the plasma and urine levels of catecholamines and their metabolites in patients on levodopa or levodopa-carbidopa thera ...
... used for determination of ketonuria. False-negative tests may result with the use of glucoseoxidase methods of testing for glucosuria. Caution should be exercised when interpreting the plasma and urine levels of catecholamines and their metabolites in patients on levodopa or levodopa-carbidopa thera ...
... we planned to develop a European list of PIM for older people consented by experts from seven European countries, namely the European Union (EU)(7)-PIM list. We had the opportunity to work together with two researchers who had been previously involved in the development of the PRISCUS list (41), a P ...
EA_QA47.7Methylphenidateinadults
... A Cochrane systematic review (11 trials, n=474) which evaluated the efficacy and tolerability of IR methylphenidate versus placebo in the treatment of adults with ADHD showed that IR methylphenidate decreased hyperactivity, impulsivity and inattentiveness compared to placebo. Subgroup analysis compa ...
... A Cochrane systematic review (11 trials, n=474) which evaluated the efficacy and tolerability of IR methylphenidate versus placebo in the treatment of adults with ADHD showed that IR methylphenidate decreased hyperactivity, impulsivity and inattentiveness compared to placebo. Subgroup analysis compa ...
Dextromethorphan (DXM)
... opiate as it does not bind to opiate receptors. When DMX is used recreationally, one of the key mechanisms of action is its ability to act as an NMDA receptor antagonist. This, in turn, suppresses glutamate, a central nervous system agonist. This can also cause central nervous system depression. Imp ...
... opiate as it does not bind to opiate receptors. When DMX is used recreationally, one of the key mechanisms of action is its ability to act as an NMDA receptor antagonist. This, in turn, suppresses glutamate, a central nervous system agonist. This can also cause central nervous system depression. Imp ...
HIGHLIGHTS OF PRESCRIBING INFORMATION
... JANUVIA. These reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Onset of these reactions occurred within the first 3 months after initiation of treatment with JANUVIA, with some reports occurring after the first dose. If a hypersensitivit ...
... JANUVIA. These reactions include anaphylaxis, angioedema, and exfoliative skin conditions including Stevens-Johnson syndrome. Onset of these reactions occurred within the first 3 months after initiation of treatment with JANUVIA, with some reports occurring after the first dose. If a hypersensitivit ...
drug-supplement interactions: a counter-offensive
... human experiments. Others, like resveratrol, only inhibit the function of platelets that are washed ex vivo and have no effect on platelets suspended in whole blood, rendering any clinical effect unlikely68. Dietary supplements that inhibit human platelet function after oral administration are liste ...
... human experiments. Others, like resveratrol, only inhibit the function of platelets that are washed ex vivo and have no effect on platelets suspended in whole blood, rendering any clinical effect unlikely68. Dietary supplements that inhibit human platelet function after oral administration are liste ...
ZOCOR - Merck.com
... dose of ZOCOR should be reduced by 50% if initiating lomitapide. ZOCOR dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken ZOCOR 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. 2.5 Adolescents (10-1 ...
... dose of ZOCOR should be reduced by 50% if initiating lomitapide. ZOCOR dosage should not exceed 20 mg/day (or 40 mg/day for patients who have previously taken ZOCOR 80 mg/day chronically, e.g., for 12 months or more, without evidence of muscle toxicity) while taking lomitapide. 2.5 Adolescents (10-1 ...
Actavis v ICOS
... An important part of the context in this case relates to the famous drug VIAGRA. By the relevant priority dates (1999/2000), Pfizer had launched the compound sildenafil citrate under the brand name VIAGRA as a treatment for erectile dysfunction. It had attracted enormous public attention as well as ...
... An important part of the context in this case relates to the famous drug VIAGRA. By the relevant priority dates (1999/2000), Pfizer had launched the compound sildenafil citrate under the brand name VIAGRA as a treatment for erectile dysfunction. It had attracted enormous public attention as well as ...
Acta okl1-2014.cdr - Polskie Towarzystwo Farmaceutyczne
... AGNIESZKA MICHALAK* and GRAØYNA BIA£A Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodüki 4A, 20-093 Lublin, Poland Abstract: The consequences of alcohol dependence concern serious health care, social and economic problems. The scope of many studies is to ...
... AGNIESZKA MICHALAK* and GRAØYNA BIA£A Chair and Department of Pharmacology and Pharmacodynamics, Medical University of Lublin, Chodüki 4A, 20-093 Lublin, Poland Abstract: The consequences of alcohol dependence concern serious health care, social and economic problems. The scope of many studies is to ...
EFAVIRENZ RAT MODEL Research Article
... Drugs that inhibit CYP450 enzymes, generally lead to decreased metabolism of other drugs metabolized by the same enzyme. The decreased metabolism can result in higher drug levels and increased potential for toxicity. When drugs that induce CYP450 enzymes are administered to a ...
... Drugs that inhibit CYP450 enzymes, generally lead to decreased metabolism of other drugs metabolized by the same enzyme. The decreased metabolism can result in higher drug levels and increased potential for toxicity. When drugs that induce CYP450 enzymes are administered to a ...
Amantadine Hydrochloride Capsules, USP - Upsher
... and such changes has not been established. Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease ...
... and such changes has not been established. Melanoma: Epidemiological studies have shown that patients with Parkinson’s disease have a higher risk (2- to approximately 6-fold higher) of developing melanoma than the general population. Whether the increased risk observed was due to Parkinson’s disease ...