LIPOSOMES FOR THE DELIVERY OF NUCLEIC ACID DRUGS A
... effective when used to transfect cells in culture but has relatively poor performance in vivo. Upon systemic administration, lipoplex systems are rapidly cleared from the blood, accumulating in the capillary bed of first-pass organs such as the lung. LIPOSOMAL FORMULATIONS FOR NUCLEIC ACID DELIVERY: ...
... effective when used to transfect cells in culture but has relatively poor performance in vivo. Upon systemic administration, lipoplex systems are rapidly cleared from the blood, accumulating in the capillary bed of first-pass organs such as the lung. LIPOSOMAL FORMULATIONS FOR NUCLEIC ACID DELIVERY: ...
THE ROLE OF CYP3A4/5 IN ALPRAZOLAM METABOLISM
... The cytochrome P450s can be functionally categorized based particular on endogenous substances such as fatty acids, steroids and prostaglandins and those that are responsible in the metabolism of exogenous substances such as drugs, environmental chemicals and pollutants, and natural plant products ...
... The cytochrome P450s can be functionally categorized based particular on endogenous substances such as fatty acids, steroids and prostaglandins and those that are responsible in the metabolism of exogenous substances such as drugs, environmental chemicals and pollutants, and natural plant products ...
For effective and well-tolerated treatment
... occur any time after transplantation (greatest risk is within first few months following transplantation) ...
... occur any time after transplantation (greatest risk is within first few months following transplantation) ...
Natural Flavonoids Isolated From the Leaves of Enhydra
... torpidity of liver (Chopra et al., 2000). The plant possesses nutritional value, and its methanol extract has been reported to have antidiarrheal activity (Uddin et al., 2005). Recently, the free-radical scavenging potential of crude extract and different fractions have been reported (Sannigrahi et ...
... torpidity of liver (Chopra et al., 2000). The plant possesses nutritional value, and its methanol extract has been reported to have antidiarrheal activity (Uddin et al., 2005). Recently, the free-radical scavenging potential of crude extract and different fractions have been reported (Sannigrahi et ...
Lidocaine HCI 2% and Epinephrine 1:50,000 Injection Lidocaine
... Many drugs used during the conduct of anesthesia are considered potential triggering agents for familial malignant hyperthermia. Since it is not known whether amide-type local anesthetics may trigger this reaction, and since the need for supplemental general anesthesia cannot be predicted in advance ...
... Many drugs used during the conduct of anesthesia are considered potential triggering agents for familial malignant hyperthermia. Since it is not known whether amide-type local anesthetics may trigger this reaction, and since the need for supplemental general anesthesia cannot be predicted in advance ...
Report - The Endocrine Society of Australia
... means of secondary prevention in patients with known atherosclerosis (3). In Australia, type 2 diabetes is the major cause of renal failure. Of new patients starting dialysis in Australia in 2011, 35% had diabetes as the primary cause of their renal failure, with more patients having diabetes as a c ...
... means of secondary prevention in patients with known atherosclerosis (3). In Australia, type 2 diabetes is the major cause of renal failure. Of new patients starting dialysis in Australia in 2011, 35% had diabetes as the primary cause of their renal failure, with more patients having diabetes as a c ...
1.1. An overview of reports on agomelatine Introduction
... yet to be determined [2]. Since Valdoxan has obtained a market authorization from EMA, there has been some discussion regarding the risk-benefit balance of this drug. According to a recently published article, several international experts are not convinced agomelatine has additional value in the tr ...
... yet to be determined [2]. Since Valdoxan has obtained a market authorization from EMA, there has been some discussion regarding the risk-benefit balance of this drug. According to a recently published article, several international experts are not convinced agomelatine has additional value in the tr ...
Normal Thermoregulatory Responses to 3-iodothyronamine, Trace Amines and Amphetamine-like Psychostimulants in
... cryogenic agent has made determining the mechanism of action of T1AM as well as its biological role a relevant goal of recent experimental work. Central to recent studies of T1AM is the speculation of the involvement of trace amine associated receptor 1 (TAAR1) in its mechanism of action. TAAR1 is a ...
... cryogenic agent has made determining the mechanism of action of T1AM as well as its biological role a relevant goal of recent experimental work. Central to recent studies of T1AM is the speculation of the involvement of trace amine associated receptor 1 (TAAR1) in its mechanism of action. TAAR1 is a ...
Improving Medicines for Children in Canada
... on children’s use of drugs, either prescription or over-the-counter, is lacking. As a result, any discussion of the issue is necessarily imprecise. Nonetheless, children’s need for medicines is clear. Yet few drugs available in Canada are approved for use in children. Manufacturers are neither requi ...
... on children’s use of drugs, either prescription or over-the-counter, is lacking. As a result, any discussion of the issue is necessarily imprecise. Nonetheless, children’s need for medicines is clear. Yet few drugs available in Canada are approved for use in children. Manufacturers are neither requi ...
Liquid Chromatography/Tandem Mass Spectrometry Detection of
... phase was isolated and washed three times with a mixture of chloroform/ isopropanol (3:1 v/v) to remove excess NAPQI and lipophilic side products. The water phase was subsequently dried overnight by nitrogen stream. The residue was taken up in 1 ml of 10% acetonitrile and applied to preparative high ...
... phase was isolated and washed three times with a mixture of chloroform/ isopropanol (3:1 v/v) to remove excess NAPQI and lipophilic side products. The water phase was subsequently dried overnight by nitrogen stream. The residue was taken up in 1 ml of 10% acetonitrile and applied to preparative high ...
Pfizer Inc All Rights Reserved
... – May leverage multivariate methods (i.e. PCA) to simplify data analysis. Joseph Kushner IV. (2013) Utilizing quantitative certificate of analysis data to assess the amount of excipient lot-to-lot variability sampled during drug product development. Pharm Dev Tech, 18(2):333-342. ...
... – May leverage multivariate methods (i.e. PCA) to simplify data analysis. Joseph Kushner IV. (2013) Utilizing quantitative certificate of analysis data to assess the amount of excipient lot-to-lot variability sampled during drug product development. Pharm Dev Tech, 18(2):333-342. ...
research
... the effects of previously administered benzodiazepines. It has been pointed out however that there are several problems in comparing results from such studies as they typically differ in the doses of benzodiazepines and flumazenil used; method of drug administration; selection of appropriate memory ...
... the effects of previously administered benzodiazepines. It has been pointed out however that there are several problems in comparing results from such studies as they typically differ in the doses of benzodiazepines and flumazenil used; method of drug administration; selection of appropriate memory ...
product information
... over 2 hours on day 1 every 3 weeks); 942 patients were randomised to bolus 5-FU and leucovorin. In the primary analysis (ITT population), median observation time was 57 months for DFS and 59 months for OS. XELOX group had a statistical significant improvement in DFS compared to 5-FU/LV (HR=0.80, 95 ...
... over 2 hours on day 1 every 3 weeks); 942 patients were randomised to bolus 5-FU and leucovorin. In the primary analysis (ITT population), median observation time was 57 months for DFS and 59 months for OS. XELOX group had a statistical significant improvement in DFS compared to 5-FU/LV (HR=0.80, 95 ...
studies comparing in vivo:in vitro metabolism of three
... number of different hepatocyte preparations from different animals. ...
... number of different hepatocyte preparations from different animals. ...
274 Antibacterials
... Children. Due to the possible difficulty of evaluating changes in visual acuity that may be induced in children receiving ethambutol, the BNFC advises that it should be used with caution in children under 5 years of age and unable to report visual changes accurately, whereas in the USA licensed prod ...
... Children. Due to the possible difficulty of evaluating changes in visual acuity that may be induced in children receiving ethambutol, the BNFC advises that it should be used with caution in children under 5 years of age and unable to report visual changes accurately, whereas in the USA licensed prod ...
... Patients with moderate to severe asthma (forced expiratory volume in one second (FEV1) ≤70% predicted despite high-dose inhaled GC therapy) were characterized clinically as sensitive or resistant to oral GC therapy according to their FEV1 response to orally administered prednisolone [10, 22]. After ...
O A
... in this group. It is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. It's bioavailability in cat with rectal administration is %43.5±61 and in human with oral administration is %20±7. This drug has some side effects such as hypertension, histamine rele ...
... in this group. It is a suitable injectable anesthetic in human and animal that has a low intestinal absorption rate. It's bioavailability in cat with rectal administration is %43.5±61 and in human with oral administration is %20±7. This drug has some side effects such as hypertension, histamine rele ...
Lipid mediators of tumor necrosis factor-alpha-induced uveitis.
... right eye; the left eye received an equal volume of sterile vehicle that consisted of phosphate-buffered saline that contained 0.1 % low-endotoxin bovine serum albumin (Fraction V; Sigma Chemical Co., St. Louis, MO). Injections were made through a 30-g needle that was attached to a syringe, approxim ...
... right eye; the left eye received an equal volume of sterile vehicle that consisted of phosphate-buffered saline that contained 0.1 % low-endotoxin bovine serum albumin (Fraction V; Sigma Chemical Co., St. Louis, MO). Injections were made through a 30-g needle that was attached to a syringe, approxim ...
METHOD DEVELOPMENT AND VALIDATION FOR THE SIMULTANEOUS ESTIMATION of
... secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus. Novartis has since withdrawn its intent to submit vildagliptin to the FDA, as of July ...
... secretion of insulin in the beta cells and suppress glucagon release by the alpha cells of the islets of Langerhans in the pancreas. Vildagliptin has been shown to reduce hyperglycemia in type 2 diabetes mellitus. Novartis has since withdrawn its intent to submit vildagliptin to the FDA, as of July ...
Product Monograph Template - Standard
... Thioridazine: Thioridazine administration alone produces prolongation of the QTc interval, which is associated with serious ventricular arrhythmias, such as torsade de pointes-type arrhythmias, and sudden death. This effect appears to be dose-related. An in vivo study suggests that drugs which inhib ...
... Thioridazine: Thioridazine administration alone produces prolongation of the QTc interval, which is associated with serious ventricular arrhythmias, such as torsade de pointes-type arrhythmias, and sudden death. This effect appears to be dose-related. An in vivo study suggests that drugs which inhib ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... weight, relative liver/ kidney weight and liver/ kidney microanatomy in healthy Swiss mice. The salient findings in this study were that bromocriptine did not significantly change the mean percent body weight but caused a dose dependent increase in mean relative liver/kidney weight and liver/kidney ...
... weight, relative liver/ kidney weight and liver/ kidney microanatomy in healthy Swiss mice. The salient findings in this study were that bromocriptine did not significantly change the mean percent body weight but caused a dose dependent increase in mean relative liver/kidney weight and liver/kidney ...
Antihistamines in the treatment of asthma J . B
... of the airways. It is, therefore, suggested that antihistamines will be more effective in patients with mild asthma and in the younger asthmatics. In perennial asthma, rhinitis and conjunctivitis are not always severe and nasal or ocular treatments are not required by most patients. Anti-inflammator ...
... of the airways. It is, therefore, suggested that antihistamines will be more effective in patients with mild asthma and in the younger asthmatics. In perennial asthma, rhinitis and conjunctivitis are not always severe and nasal or ocular treatments are not required by most patients. Anti-inflammator ...
Commentary: Reproductive Risks of Leflunomide (ArravaR
... In vitro, after mitogen stimulation, the active metabolite of leflunomide, inhibits T cell proliferation, DNA synthesis, and expression of certain cell surface and nuclear antigens directly involved in T cell activation and proliferation. It inhibits mitogen-stimulated proliferation of human periphe ...
... In vitro, after mitogen stimulation, the active metabolite of leflunomide, inhibits T cell proliferation, DNA synthesis, and expression of certain cell surface and nuclear antigens directly involved in T cell activation and proliferation. It inhibits mitogen-stimulated proliferation of human periphe ...
New oral anticoagulants for stroke prevention in atrial fibrillation
... We are at the dawn of a new era in oral anticoagulant therapy. For the past 65 years, the only available oral anticoagulants were the vitamin K antagonists, such as warfarin [1] . Although effective, these agents are difficult to administer because the dose varies from patient to patient reflecting, ...
... We are at the dawn of a new era in oral anticoagulant therapy. For the past 65 years, the only available oral anticoagulants were the vitamin K antagonists, such as warfarin [1] . Although effective, these agents are difficult to administer because the dose varies from patient to patient reflecting, ...