Assessment report on Vitex agnus-castus L., fructus
... Vitex agnus-castus, which grows in the region of the Mediterranean Sea, is a shrub which belongs to the Verbenaceae plant family. The medicinal plant was already mentioned by Dioscurides, a famous pharmacologist of the antiquity. “Agnós” as well as “castus” means “chaste”. The plant, respectively it ...
... Vitex agnus-castus, which grows in the region of the Mediterranean Sea, is a shrub which belongs to the Verbenaceae plant family. The medicinal plant was already mentioned by Dioscurides, a famous pharmacologist of the antiquity. “Agnós” as well as “castus” means “chaste”. The plant, respectively it ...
Caenorhabditis elegans: A versatile platform for drug discovery
... desired targets and reducing effects on unwanted targets. In turn, this will result in an important decrease in the cost of development and in the risk associated with using the drug. The elucidation of drug action mechanisms requires coupling of genetically tractable model systems and highthroughpu ...
... desired targets and reducing effects on unwanted targets. In turn, this will result in an important decrease in the cost of development and in the risk associated with using the drug. The elucidation of drug action mechanisms requires coupling of genetically tractable model systems and highthroughpu ...
ppt
... Induction and regulation of CYP3A (I) A series of xenobiotics have been identified that lead to increased expression of enzymes of the CYP3A family. ...
... Induction and regulation of CYP3A (I) A series of xenobiotics have been identified that lead to increased expression of enzymes of the CYP3A family. ...
Vol. 20, No. 3 Evra Transdermal System
... 150ug/ ethinyl estradiol 20ug). Over 13 cycles, the rate of contraceptive failure was low and not significantly different between the two agents (Evra®:0.5% vs. Mercilon®:0.3%) The second trial compared Evra® ...
... 150ug/ ethinyl estradiol 20ug). Over 13 cycles, the rate of contraceptive failure was low and not significantly different between the two agents (Evra®:0.5% vs. Mercilon®:0.3%) The second trial compared Evra® ...
Inhalation rate of sodium cromoglycate ... plasma pharmacokinetics and protection against
... [23) so that the ability of SCG to inhibit non-myelinated C-fibre activation [6] may also be a factor. Secondly, SCG is highly effective at blocking adenosine- and AMPinduced bronchoconstriction consistent with its action on bronchial mast cells, [20). Thirdly, AMP may be used to provoke reproducibl ...
... [23) so that the ability of SCG to inhibit non-myelinated C-fibre activation [6] may also be a factor. Secondly, SCG is highly effective at blocking adenosine- and AMPinduced bronchoconstriction consistent with its action on bronchial mast cells, [20). Thirdly, AMP may be used to provoke reproducibl ...
Comparison of Inhaled Corticosteroids: An Update
... differences in potency. Other measures, such as improvement in bronchial hyperresponsiveness (BHR) to challenges of exercise, methacholine or adenosine monophosphate, or biomarkers of airway inflammation such as fraction of exhaled nitric oxide and sputum eosinophils, have been posited as more sensi ...
... differences in potency. Other measures, such as improvement in bronchial hyperresponsiveness (BHR) to challenges of exercise, methacholine or adenosine monophosphate, or biomarkers of airway inflammation such as fraction of exhaled nitric oxide and sputum eosinophils, have been posited as more sensi ...
The Artemisinin Project
... Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. The World Health Organization is pressuring manufacturers to stop making the uncompounded drug available to the ...
... Artemisinins can be used alone, but this leads to a high rate of recrudescence (return of parasites) and other drugs are required to clear the body of all parasites and prevent recurrence. The World Health Organization is pressuring manufacturers to stop making the uncompounded drug available to the ...
Impact of membrane transporters polymorphisms on nucleoside-derived drug bioavailability and action
... 1.2 Mechanisms of action Currently used therapeutic nucleoside and nucleotide analogues use the same metabolic pathways as endogenous nucleosides. They enter cells through specific transporters. Once inside the cells, the drug is phosphorylated by a nucleoside kinase and a nucleoside monophosphate k ...
... 1.2 Mechanisms of action Currently used therapeutic nucleoside and nucleotide analogues use the same metabolic pathways as endogenous nucleosides. They enter cells through specific transporters. Once inside the cells, the drug is phosphorylated by a nucleoside kinase and a nucleoside monophosphate k ...
horse and topical anesthetic
... treatments. For each of the 4 drugs evaluated in the present study, the onset of action was rapid; the maximal effect was evident within 5 minutes after administration. Corneal touch threshold values for each treated eye returned to baseline CTT value within 90 minutes after application, regardless ...
... treatments. For each of the 4 drugs evaluated in the present study, the onset of action was rapid; the maximal effect was evident within 5 minutes after administration. Corneal touch threshold values for each treated eye returned to baseline CTT value within 90 minutes after application, regardless ...
Macrolides and associated antibiotics based on similar mechanism
... The effects of associations, such as azithromycin–chloroquine and azithromycin–quinine, were additive on sensitive chloroquine strains and synergistic on resistant strains [40]. Other associations were examined, showing effectiveness, associating azithromycin with a rapidly acting schizonticidal com ...
... The effects of associations, such as azithromycin–chloroquine and azithromycin–quinine, were additive on sensitive chloroquine strains and synergistic on resistant strains [40]. Other associations were examined, showing effectiveness, associating azithromycin with a rapidly acting schizonticidal com ...
Publicly funded Practice-oriented Clinical Trials
... Bimetra.be), Patrick Galloo (president of former Technische Raad Implantaten), André Scheen (comité Médicopharmaceutique CHU Liège; member of CRM), Katelijne De Nys (Head of Clinical Trial Centre UZ Leuven) Other possible interests that could lead to a potential or actual conflict of interest: Katel ...
... Bimetra.be), Patrick Galloo (president of former Technische Raad Implantaten), André Scheen (comité Médicopharmaceutique CHU Liège; member of CRM), Katelijne De Nys (Head of Clinical Trial Centre UZ Leuven) Other possible interests that could lead to a potential or actual conflict of interest: Katel ...
Pharmacological Treatment of Urinary Incontinence C 14
... and stress incontinence), and failure to empty can lead to urinary retention, which may result in overflow incontinence. A disturbed filling/storage function can, at least theoretically, be improved by agents which decrease detrusor activity, increase bladder capacity, and/or increase outlet resista ...
... and stress incontinence), and failure to empty can lead to urinary retention, which may result in overflow incontinence. A disturbed filling/storage function can, at least theoretically, be improved by agents which decrease detrusor activity, increase bladder capacity, and/or increase outlet resista ...
avodart - Urological Sciences Research Foundation
... Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5α-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human a ...
... Dutasteride is a competitive and specific inhibitor of both type 1 and type 2 5α-reductase isoenzymes, with which it forms a stable enzyme complex. Dissociation from this complex has been evaluated under in vitro and in vivo conditions and is extremely slow. Dutasteride does not bind to the human a ...
In vitro and in vivo studies of artemisinin endoperoxides
... conducted to assess potential inhibitory effects of artemisinin, ARM, ARS and DHA (Papers I and II). Results were extrapolated to evaluate the risk of drug-drug interactions (DDIs) in vivo. An LC-MS/MS method was optimized and validated for the quantification of ARS and DHA in human plasma and saliv ...
... conducted to assess potential inhibitory effects of artemisinin, ARM, ARS and DHA (Papers I and II). Results were extrapolated to evaluate the risk of drug-drug interactions (DDIs) in vivo. An LC-MS/MS method was optimized and validated for the quantification of ARS and DHA in human plasma and saliv ...
Mykofenolatmofetil Actavis film
... recommended dose in renal transplant patients is 1 g administered twice daily (2 g daily dose). Paediatric population aged 2 to 18 years The recommended dose of mycophenolate mofetil is 600 mg/m2 administered orally twice daily (up to a maximum of 2 g daily). Mykofenolatmofetil Actavis tablets shoul ...
... recommended dose in renal transplant patients is 1 g administered twice daily (2 g daily dose). Paediatric population aged 2 to 18 years The recommended dose of mycophenolate mofetil is 600 mg/m2 administered orally twice daily (up to a maximum of 2 g daily). Mykofenolatmofetil Actavis tablets shoul ...
FULL PRESCRIBING INFORMATION: CONTENTS*
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Attention Deficit Hyperactivity Diso ...
... Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Attention Deficit Hyperactivity Diso ...
Factrel® Injection
... Injection and FTAI was conducted 24 or 17 hours later, respectively. For control cows FTAI was performed 72 hours after the LUTALYSE Injection dose was administered. All treatment groups had significantly greater pregnancy rates to FTAI than cows administered LUTALYSE Injection alone, and were 17.1, ...
... Injection and FTAI was conducted 24 or 17 hours later, respectively. For control cows FTAI was performed 72 hours after the LUTALYSE Injection dose was administered. All treatment groups had significantly greater pregnancy rates to FTAI than cows administered LUTALYSE Injection alone, and were 17.1, ...
PRODUCT MONOGRAPH Pr ZYLOPRIM® Allopurinol Tablets USP
... Since ZYLOPRIM® and its metabolites are excreted only by the kidney, accumulation of the drug can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine cl ...
... Since ZYLOPRIM® and its metabolites are excreted only by the kidney, accumulation of the drug can occur in renal failure and the dose of ZYLOPRIM® should consequently be reduced. With a creatinine clearance of 20 to 10 mL/min, a daily dosage of 200 mg of ZYLOPRIM® is suitable. When the creatinine cl ...
Prescribing Information
... observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Attention Deficit Hyperactivity Disorder ...
... observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Attention Deficit Hyperactivity Disorder ...
PRODUCT INFORMATION NUELIN SR TABLETS
... shown in several studies to reduce the half-life of theophylline substantially, even when absorption has been completed. The recommended dose is 1 g/kg every 4-6 hours (or 10 g/hour) until the theophylline level has plateaued or commenced falling or is below 55 µmol/L. (This depends on the experienc ...
... shown in several studies to reduce the half-life of theophylline substantially, even when absorption has been completed. The recommended dose is 1 g/kg every 4-6 hours (or 10 g/hour) until the theophylline level has plateaued or commenced falling or is below 55 µmol/L. (This depends on the experienc ...
Project: Abbott Course Title: REDUCTIL Module title/ID: Competition
... children. NICE clinical guideline 43. National Institute for Health and Clinical Excellence. Issue date: December 2006.) stated that orlistat should be prescribed only as part of an overall plan for managing obesity in adults who meet one of the following criteria: ...
... children. NICE clinical guideline 43. National Institute for Health and Clinical Excellence. Issue date: December 2006.) stated that orlistat should be prescribed only as part of an overall plan for managing obesity in adults who meet one of the following criteria: ...
1.1. Oxaliplatin and laryngospasm Introduction Oxaliplatin (Eloxatin
... platinum salt can induce a cascade of reactions leading to cytokines of forming a major histocompatibility complex (MHC) [3]. ...
... platinum salt can induce a cascade of reactions leading to cytokines of forming a major histocompatibility complex (MHC) [3]. ...
Erectile Dysfunction Drugs Changed the Protein Expressions and
... among them are the onset and duration of action providing treatment options for men with ED [3, 4]. The cytochrome P450s (CYPs) are superfamily of hemoproteins, which metabolise various compounds. The currently known CYPs in humans are classified into 18 different families and 44 subfamilies accordi ...
... among them are the onset and duration of action providing treatment options for men with ED [3, 4]. The cytochrome P450s (CYPs) are superfamily of hemoproteins, which metabolise various compounds. The currently known CYPs in humans are classified into 18 different families and 44 subfamilies accordi ...
Product Monograph FLONASE Corticosteroid for nasal use
... mucosa, the mechanism of which is not yet completely defined. The onset of action is not immediate, and two to three days treatment may be required before maximum relief is obtained. This is because the anti-inflammatory activities of glucocorticoids are related to specific steroid effects, which in ...
... mucosa, the mechanism of which is not yet completely defined. The onset of action is not immediate, and two to three days treatment may be required before maximum relief is obtained. This is because the anti-inflammatory activities of glucocorticoids are related to specific steroid effects, which in ...
Serotonergic Modulation of Rat Pineal Gland Activity: In Vivo
... Ci/mmol), and unlabeled melatonin (Sigma Chemical Co.). We assayed 500-l duplicate aliquots, comparing results directly against a standard curve prepared in assay buffer (0.1 mol/l tricine, pH 7.4, containing 9 g of NaCl and 1 g of gelatin per liter). The reaction mixtures were incubated for 18 h a ...
... Ci/mmol), and unlabeled melatonin (Sigma Chemical Co.). We assayed 500-l duplicate aliquots, comparing results directly against a standard curve prepared in assay buffer (0.1 mol/l tricine, pH 7.4, containing 9 g of NaCl and 1 g of gelatin per liter). The reaction mixtures were incubated for 18 h a ...