Butorphanol-Mediated Antinociception in Mice: Partial Agonist
... Received for publication November 20, 1996. ...
... Received for publication November 20, 1996. ...
Effexor ℞
... Clinical Worsening and Suicide Risk Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant ...
... Clinical Worsening and Suicide Risk Patients with major depressive disorder (MDD), both adult and pediatric, may experience worsening of their depression and/or the emergence of suicidal ideation and behavior (suicidality) or unusual changes in behavior, whether or not they are taking antidepressant ...
PRODUCT MONOGRAPH
... It is not known whether this drug is excreted in human milk. In parturition and lactation studies with rats, no evidence of impaired parturition or of toxic effects to suckling pups was observed when chlorhexidine gluconate was administered to dams at doses that were over 100 times greater than the ...
... It is not known whether this drug is excreted in human milk. In parturition and lactation studies with rats, no evidence of impaired parturition or of toxic effects to suckling pups was observed when chlorhexidine gluconate was administered to dams at doses that were over 100 times greater than the ...
Cefepime for Injection, USP
... Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standardized procedure. Standardized procedures are based on a dilution ...
... Quantitative methods are used to determine antimicrobial minimum inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standardized procedure. Standardized procedures are based on a dilution ...
PRILOSEC (omeprazole) (omeprazole magnesium) DELAYED-RELEASE CAPSULES
... antibacterial agents. For more information specific to antibacterial agents (clarithromycin and amoxicillin) indicated for use in combination with PRILOSEC, refer to WARNINGS and PRECAUTIONS sections of those package inserts. 5.4 Interaction with Clopidogrel Avoid concomitant use of PRILOSEC with cl ...
... antibacterial agents. For more information specific to antibacterial agents (clarithromycin and amoxicillin) indicated for use in combination with PRILOSEC, refer to WARNINGS and PRECAUTIONS sections of those package inserts. 5.4 Interaction with Clopidogrel Avoid concomitant use of PRILOSEC with cl ...
SCIENTIFIC DISCUSSION
... carbamazepine was two to 3-fold more potent than zonisamide in causing behavioural disturbances. However, rapid high loading of zonisamide at doses of 10, 25 or 40 mg/kg may inhibit spontaneous activity in the rat, whereas gradual dosing had no unfavourable effects on spontaneous activity. This obse ...
... carbamazepine was two to 3-fold more potent than zonisamide in causing behavioural disturbances. However, rapid high loading of zonisamide at doses of 10, 25 or 40 mg/kg may inhibit spontaneous activity in the rat, whereas gradual dosing had no unfavourable effects on spontaneous activity. This obse ...
A Descriptive Study of Adverse Events from
... from 2 regional poison centers for human exposures to clenbuterol. Data collected after individual chart review, including review of individual case notes fields, included demographics, substances involved including coingestatants if known, reason for exposure/use of clenbuterol, dose, clinical effe ...
... from 2 regional poison centers for human exposures to clenbuterol. Data collected after individual chart review, including review of individual case notes fields, included demographics, substances involved including coingestatants if known, reason for exposure/use of clenbuterol, dose, clinical effe ...
1.3.1 LEVITRA-Annotated PM dated 06-Mar-2015
... There are no controlled clinical data on the efficacy and safety of LEVITRA in known hereditary degenerative retinal disorders such as retinitis pigmentosa; its use is therefore not recommended until further information is available. Otologic Sudden decrease or loss of hearing has been reported in a ...
... There are no controlled clinical data on the efficacy and safety of LEVITRA in known hereditary degenerative retinal disorders such as retinitis pigmentosa; its use is therefore not recommended until further information is available. Otologic Sudden decrease or loss of hearing has been reported in a ...
Epinephrine increases facility of outflow and cyclic AMP
... AMP Content in the Human Eye in Vitro Kristine A. Erickson-Lamy* and James A. NathansonjThe physiologic mechanism that underlies the epinephrine-induced increase in facility of outflow (C) in glaucomatous human eyes and normal primate eyes is not completely understood. In this study, a recently deve ...
... AMP Content in the Human Eye in Vitro Kristine A. Erickson-Lamy* and James A. NathansonjThe physiologic mechanism that underlies the epinephrine-induced increase in facility of outflow (C) in glaucomatous human eyes and normal primate eyes is not completely understood. In this study, a recently deve ...
Humulin R (U-500) - Eli Lilly and Company
... hypoglycemia can cause seizures, may be life-threatening or cause death. Severe hypoglycemia may develop as long as 18 to 24 hours after an injection of HUMULIN R U-500. Hypoglycemia can impair concentration ability and reaction time; this may place an individual and others at risk in situations whe ...
... hypoglycemia can cause seizures, may be life-threatening or cause death. Severe hypoglycemia may develop as long as 18 to 24 hours after an injection of HUMULIN R U-500. Hypoglycemia can impair concentration ability and reaction time; this may place an individual and others at risk in situations whe ...
Identification of the date-rape drug GHB and its precursor GBL by
... Gamma-hydroxybutyric acid (GHB) (Fig. 1), known colloquially as ‘liquid ecstasy’ or ‘liquid X’[1] is a Class C drug of abuse[2] that also occurs naturally in mammalian tissues in very small amounts (5 mg/L).[3] The drug has recently become associated with drug-facilitated sexual assaults or ‘date ra ...
... Gamma-hydroxybutyric acid (GHB) (Fig. 1), known colloquially as ‘liquid ecstasy’ or ‘liquid X’[1] is a Class C drug of abuse[2] that also occurs naturally in mammalian tissues in very small amounts (5 mg/L).[3] The drug has recently become associated with drug-facilitated sexual assaults or ‘date ra ...
PHARMACEUTICAL BENEFITS ADVISORY COMMITTEE (PBAC
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
... circumstances, consumers will be able to comment on items in other sections of the agenda. The submissions for which input is sought will be listed in alphabetical order by drug name. There is no provision for consumer comments to the PBAC on agenda item 8 which relates to pricing matters. Pharmaceu ...
The Impact of Probiotics on the Gastrointestinal
... when specific pathogen free bacteria were inoculated in these animals’ intestines. They also noticed that the motility of intestines became normal when probiotics were inoculated instead of doing so with commensal bacteria. Actually gastrointestinal motility and microorganisms in the tracts are mutu ...
... when specific pathogen free bacteria were inoculated in these animals’ intestines. They also noticed that the motility of intestines became normal when probiotics were inoculated instead of doing so with commensal bacteria. Actually gastrointestinal motility and microorganisms in the tracts are mutu ...
Nasal Drug Delivery
... because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate impl ...
... because of the high permeability of the nasal epithelium, rapid drug absorption across this membrane and avoidance of hepatic first-pass metabolism. The main objective of this thesis was to investigate factors influencing the permeability of the nasal mucosa to various compounds and to evaluate impl ...
Process Redesign of Pharma Synthesis
... • Purity and yield • 7-11 years between development and manufacture – Regulatory steps (Phase I-III) ...
... • Purity and yield • 7-11 years between development and manufacture – Regulatory steps (Phase I-III) ...
Protocol - The EMMES Corporation
... Eligible patients are up to 66.00 years of age, have acute leukemia, myelodysplasia, chronic myeloid leukemia, or other myeloproliferative disorders, adequate organ function, a 6/6 or 5/6 HLA-A, B and DRB1 matched unrelated donor, and are able to give signed informed consent prior to enrollment. Don ...
... Eligible patients are up to 66.00 years of age, have acute leukemia, myelodysplasia, chronic myeloid leukemia, or other myeloproliferative disorders, adequate organ function, a 6/6 or 5/6 HLA-A, B and DRB1 matched unrelated donor, and are able to give signed informed consent prior to enrollment. Don ...
see Warnings and - Boehringer Ingelheim
... been reported in both children and adults in association with oxcarbazepine use. Such serious skin reactions may be life threatening, and some patients have required hospitalization with very rare reports of fatal outcome. The median time of onset for reported cases was 19 days after treatment initi ...
... been reported in both children and adults in association with oxcarbazepine use. Such serious skin reactions may be life threatening, and some patients have required hospitalization with very rare reports of fatal outcome. The median time of onset for reported cases was 19 days after treatment initi ...
APTIVUS ® Soft Capsules APTIVUS ® Oral Solution (tipranavir)
... Distribution: Tipranavir is extensively bound to plasma proteins (>99.9%) in vitro. It binds to both human serum albumin and α-1-acid glycoprotein. From clinical samples of healthy volunteers and HIV-positive subjects who received APTIVUS without ritonavir the mean fraction of tipranavir unbound in ...
... Distribution: Tipranavir is extensively bound to plasma proteins (>99.9%) in vitro. It binds to both human serum albumin and α-1-acid glycoprotein. From clinical samples of healthy volunteers and HIV-positive subjects who received APTIVUS without ritonavir the mean fraction of tipranavir unbound in ...
Morphine Sulfate Extended-Release Tablets
... taken in its prescription and patients should be instructed against use by individuals other than the patient for whom it was prescribed, as this may have severe medical consequences for that individual. General Morphine sulfate extended-release tablets are intended for use in patients who require m ...
... taken in its prescription and patients should be instructed against use by individuals other than the patient for whom it was prescribed, as this may have severe medical consequences for that individual. General Morphine sulfate extended-release tablets are intended for use in patients who require m ...
Sulfato de Atropina. Monografia.
... To avoid excessive systemic absorption, the lacrimal sac should be compressed by digital pressure for 2-3 minutes after instillation. To avoid inducing angle closure glaucoma, an estimation of the depth of the angle of the anterior chamber should be made. Administration of atropine in infants requir ...
... To avoid excessive systemic absorption, the lacrimal sac should be compressed by digital pressure for 2-3 minutes after instillation. To avoid inducing angle closure glaucoma, an estimation of the depth of the angle of the anterior chamber should be made. Administration of atropine in infants requir ...
Attachment: Product Information: Atazanavir
... not affect the AUC of atazanavir relative to fasting conditions and the Cmax was within 11% of fasting values. The 24-hour concentration following a high-fat meal was increased by approximately 33% due to delayed absorption; the median Tmax increased from 2.0 to 5.0 hours. Coadministration of REYATA ...
... not affect the AUC of atazanavir relative to fasting conditions and the Cmax was within 11% of fasting values. The 24-hour concentration following a high-fat meal was increased by approximately 33% due to delayed absorption; the median Tmax increased from 2.0 to 5.0 hours. Coadministration of REYATA ...
Activity and Enzyme Kinetics of Human UDP
... To understand the substrate selectivity of human UGTs, we also studied the glucuronidation of 4-hydroxyindole, a chemically simpler analog of psilocin which lacks the N,Ndimethylaminoethyl side chain. We successfully prevented the oxidative degradation of psilocin, a problem we encountered early in ...
... To understand the substrate selectivity of human UGTs, we also studied the glucuronidation of 4-hydroxyindole, a chemically simpler analog of psilocin which lacks the N,Ndimethylaminoethyl side chain. We successfully prevented the oxidative degradation of psilocin, a problem we encountered early in ...
full document
... patient safety and decreasing the workload of the anesthesiologist [Hemmerling et al., 2010], [Liu et al., 2006], [Struys et al., 2001]. It might also reduce the variability in drug dosing between anesthesiologists [Mackey, 2012]. This has been confirmed by several studies, as mentioned in Section 1 ...
... patient safety and decreasing the workload of the anesthesiologist [Hemmerling et al., 2010], [Liu et al., 2006], [Struys et al., 2001]. It might also reduce the variability in drug dosing between anesthesiologists [Mackey, 2012]. This has been confirmed by several studies, as mentioned in Section 1 ...
Low Impulsive Action, but not Impulsive Choice, Predicts
... blocks of 12 trials (Zeeb et al, 2010). The first 2 trials were forced choice, in which only one lever was extended. Both levers were extended for the following 10 trials. A trial began when the houselight turned on and lever(s) extended 2 s later. A response on one lever immediately delivered a sma ...
... blocks of 12 trials (Zeeb et al, 2010). The first 2 trials were forced choice, in which only one lever was extended. Both levers were extended for the following 10 trials. A trial began when the houselight turned on and lever(s) extended 2 s later. A response on one lever immediately delivered a sma ...
Effects of Phentermine on Responding Maintained under Multiple
... determine whether DA agonists decrease self-administration by affecting the potency of cocaine. Drug treatment may decrease the reinforcing effects of cocaine. A number of procedures have been used to provide a metric of the reinforcing effects of drugs including progressive-ratio performances, choi ...
... determine whether DA agonists decrease self-administration by affecting the potency of cocaine. Drug treatment may decrease the reinforcing effects of cocaine. A number of procedures have been used to provide a metric of the reinforcing effects of drugs including progressive-ratio performances, choi ...