Effects of Phentermine on Responding Maintained under Multiple
... determine whether DA agonists decrease self-administration by affecting the potency of cocaine. Drug treatment may decrease the reinforcing effects of cocaine. A number of procedures have been used to provide a metric of the reinforcing effects of drugs including progressive-ratio performances, choi ...
... determine whether DA agonists decrease self-administration by affecting the potency of cocaine. Drug treatment may decrease the reinforcing effects of cocaine. A number of procedures have been used to provide a metric of the reinforcing effects of drugs including progressive-ratio performances, choi ...
Electrophysiologic Effects of Chronic Amiodarone Therapy and
... Amiodarone is a widely used antiarrhythmic drug, the mechanisms of action of which remain incompletely understood. Indirect evidence suggests that the class III properties of amiodarone may be mediated by cardiac antithyroid effects. We sought to determine whether the effects of chronic amiodarone o ...
... Amiodarone is a widely used antiarrhythmic drug, the mechanisms of action of which remain incompletely understood. Indirect evidence suggests that the class III properties of amiodarone may be mediated by cardiac antithyroid effects. We sought to determine whether the effects of chronic amiodarone o ...
Document
... 7 of 18 subjects (38.9%) receiving COBI. AEs were predominantly grade 1 or grade 2; there were no grade 3 or grade 4 AEs or SAEs. The most common treatment-emergent AE was headache (4 subjects). Study drug–related AEs were reported for 6 of 18 subjects (33.3%) in this cohort, among which only headac ...
... 7 of 18 subjects (38.9%) receiving COBI. AEs were predominantly grade 1 or grade 2; there were no grade 3 or grade 4 AEs or SAEs. The most common treatment-emergent AE was headache (4 subjects). Study drug–related AEs were reported for 6 of 18 subjects (33.3%) in this cohort, among which only headac ...
Key Considerations in Capsule Filling
... contact parts that have to be cleaned and verified by swabbing after dosing to determine residual API left on the instrument. However, semi-automated filling systems are much simpler to clean, because no substance comes into contact with any other part of the system other than the dosing head and th ...
... contact parts that have to be cleaned and verified by swabbing after dosing to determine residual API left on the instrument. However, semi-automated filling systems are much simpler to clean, because no substance comes into contact with any other part of the system other than the dosing head and th ...
Product Monograph
... RAS, such as ARBs or aliskiren-containing drugs, is generally not recommended in other patients, since such treatment has been associated with an increased incidence of severe hypotension, renal failure, and hyperkalemia (see DRUG INTERACTIONS). Cardiovascular Aortic Stenosis There is concern, on th ...
... RAS, such as ARBs or aliskiren-containing drugs, is generally not recommended in other patients, since such treatment has been associated with an increased incidence of severe hypotension, renal failure, and hyperkalemia (see DRUG INTERACTIONS). Cardiovascular Aortic Stenosis There is concern, on th ...
Evaluation of Naltrexone as a Treatment for Amphetamine
... naltrexone and amphetamine. The results demonstrated that pre-treatment with naltrexone significantly reduces the subjective effects of amphetamine. Pre-treatment with naltrexone had no effect on the physiological and behavioral measures. In the next study, we examined the effect of an acute dose of ...
... naltrexone and amphetamine. The results demonstrated that pre-treatment with naltrexone significantly reduces the subjective effects of amphetamine. Pre-treatment with naltrexone had no effect on the physiological and behavioral measures. In the next study, we examined the effect of an acute dose of ...
03-A922-R2 Erythromycin Tablets PI - 3-25-14
... decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Erythromycin Tablets or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the ant ...
... decrease the effectiveness of the immediate treatment and (2) increase the likelihood that bacteria will develop resistance and will not be treatable by Erythromycin Tablets or other antibacterial drugs in the future. Diarrhea is a common problem caused by antibiotics which usually ends when the ant ...
Alpha-2 Adrenergic Regulation of Melatonin Release in Chick
... and cyclic nucleotide levels (Zatz et al., 1978). Recent evidence indicates that the classic beta-adrenergic effect in the rat is potentiated by postsynaptic alpha- 1 adrenoceptors (Auerbach et al., 198 1; Sugden and Klein, 1984; Sugden et al., 1984). Combined treatment of pineal glands by both alph ...
... and cyclic nucleotide levels (Zatz et al., 1978). Recent evidence indicates that the classic beta-adrenergic effect in the rat is potentiated by postsynaptic alpha- 1 adrenoceptors (Auerbach et al., 198 1; Sugden and Klein, 1984; Sugden et al., 1984). Combined treatment of pineal glands by both alph ...
METRONIDAZOLE INTRAVENOUS INFUSION
... adverse reactions have involved the gastrointestinal tract, particularly nausea, sometimes accompanied by headache, anorexia and occasionally vomiting, diarrhoea, epigastric distress and abdominal cramping; constipation and oral mucositis have also been reported. A metallic, sharp unpleasant taste i ...
... adverse reactions have involved the gastrointestinal tract, particularly nausea, sometimes accompanied by headache, anorexia and occasionally vomiting, diarrhoea, epigastric distress and abdominal cramping; constipation and oral mucositis have also been reported. A metallic, sharp unpleasant taste i ...
Product Monograph - AstraZeneca Canada
... commonly (≥1% - <10%) with quetiapine in clinical trials. Occasional reports of diabetes, have also been observed in clinical trials with quetiapine (see ADVERSE REACTIONS, Abnormal Hematologic and Clinical Chemistry Findings). Assessment of the relationship between atypical antipsychotic use and gl ...
... commonly (≥1% - <10%) with quetiapine in clinical trials. Occasional reports of diabetes, have also been observed in clinical trials with quetiapine (see ADVERSE REACTIONS, Abnormal Hematologic and Clinical Chemistry Findings). Assessment of the relationship between atypical antipsychotic use and gl ...
Product Monograph May 6, 2016
... anaphylaxis requiring emergency medical attention. Instruct patients to discontinue TRAMACET® immediately and seek medical care if they experience these symptoms. Do not prescribe TRAMACET® to patients with acetaminophen allergy. Drug Abuse, Addiction and Dependence Tramadol has the potential to cau ...
... anaphylaxis requiring emergency medical attention. Instruct patients to discontinue TRAMACET® immediately and seek medical care if they experience these symptoms. Do not prescribe TRAMACET® to patients with acetaminophen allergy. Drug Abuse, Addiction and Dependence Tramadol has the potential to cau ...
TABLE OF CONTENTS Introduction Contacts
... resistance mechanism is conferred through efflux of erythromycin out of the cell through specific pumps (encoded by the msrA gene). Staphylococcal isolates carrying the MsrA efflux pump are resistant only to erythromycin and not clindamycin. If a S. aureus isolate is resistant to erythromycin and su ...
... resistance mechanism is conferred through efflux of erythromycin out of the cell through specific pumps (encoded by the msrA gene). Staphylococcal isolates carrying the MsrA efflux pump are resistant only to erythromycin and not clindamycin. If a S. aureus isolate is resistant to erythromycin and su ...
The Use of Midazolam in Paediatric Dentistry: A Review of the
... Another study on the use of oral midazolam for sedation of child patients reported that the technique was well tolerated by children and their parents. However, some children became upset in recovery due to the numb sensation of their lip caused by local anaesthtics. Oral midazolam sedation was ment ...
... Another study on the use of oral midazolam for sedation of child patients reported that the technique was well tolerated by children and their parents. However, some children became upset in recovery due to the numb sensation of their lip caused by local anaesthtics. Oral midazolam sedation was ment ...
(Foscan®, 5,10,15,20-Tetra(m- hydroxyphenyl)chlorin)
... the 1H-, 13C- and 15N-NMR spectra have been clarified (46) and mass spectrometric studies undertaken (47). To enable research into kinetic phenomena of the radical type I mechanism, ESR experiments observing mTHPC with and without stable free radicals (e.g., di-tert-butyl nitroxide) have been undert ...
... the 1H-, 13C- and 15N-NMR spectra have been clarified (46) and mass spectrometric studies undertaken (47). To enable research into kinetic phenomena of the radical type I mechanism, ESR experiments observing mTHPC with and without stable free radicals (e.g., di-tert-butyl nitroxide) have been undert ...
Baclofen Intoxication
... serum half-life of up to 34 hours has been estimated after overdose. Animal experiments with radiolabeled baclofen indicate that concentrations in nerve tissue and brain are lower than in blood, but the apparent elimination rate of 24 hours from nerve tissue is much slower. This might explain why pr ...
... serum half-life of up to 34 hours has been estimated after overdose. Animal experiments with radiolabeled baclofen indicate that concentrations in nerve tissue and brain are lower than in blood, but the apparent elimination rate of 24 hours from nerve tissue is much slower. This might explain why pr ...
STAXYN PRODUCT MONOGRAPH
... erection or if they have an undesirable effect as vardenafil in film-coated tablets are available in other strengths. Patients should be counselled about the importance of notifying their physicians about other medications they have been prescribed, including STAXYN. Physicians should counsel patien ...
... erection or if they have an undesirable effect as vardenafil in film-coated tablets are available in other strengths. Patients should be counselled about the importance of notifying their physicians about other medications they have been prescribed, including STAXYN. Physicians should counsel patien ...
Opioid Receptors and Legal Highs - The Salvia divinorum Research
... Hallucinations occur rapidly after administration and are typically very vivid (27). Salvia divinorum produces synesthesia as its characteristic psychotropic effect; many users report a confusion of the senses, like hearing colors or smelling sounds (27). Hallucinogenic effects are typically brief, ...
... Hallucinations occur rapidly after administration and are typically very vivid (27). Salvia divinorum produces synesthesia as its characteristic psychotropic effect; many users report a confusion of the senses, like hearing colors or smelling sounds (27). Hallucinogenic effects are typically brief, ...
Product Monograph
... The safety of DIFLUCAN in children has been established in 577 children ages 1 day to 17 years who received doses ranging from 1 to 15 mg/kg/day for 1 to 1616 days (see ADVERSE REACTIONS). Efficacy of DIFLUCAN has not been established in infants less than 6 months of age. A small number of patients ...
... The safety of DIFLUCAN in children has been established in 577 children ages 1 day to 17 years who received doses ranging from 1 to 15 mg/kg/day for 1 to 1616 days (see ADVERSE REACTIONS). Efficacy of DIFLUCAN has not been established in infants less than 6 months of age. A small number of patients ...
Fentanyl Grünenthal sublingual tablet ENG SmPC
... management of opioid therapy in cancer patients. Physicians should keep in mind the potential of abuse of fentanyl. Patients should be instructed not to use two different formulations of fentanyl concurrently for the treatment of breakthrough pain, and to dispose of any fentanyl product prescribed f ...
... management of opioid therapy in cancer patients. Physicians should keep in mind the potential of abuse of fentanyl. Patients should be instructed not to use two different formulations of fentanyl concurrently for the treatment of breakthrough pain, and to dispose of any fentanyl product prescribed f ...
1
... Patients with left ventricular outflow obstruction, (e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors. The following groups of patients with cardiovascular disease were not included in clinical safety and ...
... Patients with left ventricular outflow obstruction, (e.g., aortic stenosis and idiopathic hypertrophic subaortic stenosis) can be sensitive to the action of vasodilators, including PDE5 inhibitors. The following groups of patients with cardiovascular disease were not included in clinical safety and ...
DILT-XR - Apotex
... In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals. In exercise tolerance studies in patients with ischemic heart disease, diltiazem reduces the d ...
... In man, diltiazem prevents spontaneous and ergonovine-provoked coronary artery spasm. It causes a decrease in peripheral vascular resistance and a modest fall in blood pressure in normotensive individuals. In exercise tolerance studies in patients with ischemic heart disease, diltiazem reduces the d ...
Adverse_Events_White_Paper
... (AEs) in tables, figures, and listings (TFLs), with a focus on Phase 2-4 clinical trials and integrated summary documents. The intent is to begin the process of developing a common standard for analysis and reporting of collected information that is used across clinical trials and across therapeutic ...
... (AEs) in tables, figures, and listings (TFLs), with a focus on Phase 2-4 clinical trials and integrated summary documents. The intent is to begin the process of developing a common standard for analysis and reporting of collected information that is used across clinical trials and across therapeutic ...
A Guide to Aerosol Delivery Devices for Respiratory Therapists
... While the “art” of aerosol delivery is much more abstract than the science, it is as equally important to the appropriate delivery of respiratory medications for optimal outcomes. For aerosol therapy, the interaction between technology and human interaction is where “art” comes into play. There is a ...
... While the “art” of aerosol delivery is much more abstract than the science, it is as equally important to the appropriate delivery of respiratory medications for optimal outcomes. For aerosol therapy, the interaction between technology and human interaction is where “art” comes into play. There is a ...
Paracetamol use (and/or misuse)
... A greater percentage of the caregivers gave paracetamol to their children via the oral route. Whereas Remsing [16] and co-workers in their series noted that parenteral paracetamol had a more rapid onset of action, however, oral formulations are safe, well absorbed and equally efficacious and should ...
... A greater percentage of the caregivers gave paracetamol to their children via the oral route. Whereas Remsing [16] and co-workers in their series noted that parenteral paracetamol had a more rapid onset of action, however, oral formulations are safe, well absorbed and equally efficacious and should ...