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product monograph
product monograph

... with the risk of edema while the marked and prolonged increase in circulating corticosteroid levels that may occur in patients with bilateral adrenal hyperplasia, can cause a severe exacerbation of the symptoms of Cushing's syndrome. On extremely rare occasions, adrenal crisis has supervened during ...
Fexofast Presentation
Fexofast Presentation

... when terfenadine was given at oral doses of up to 300 mg/kg/day throughout organogenesis, which corresponds to levels of systemic fexofenadine exposure fourfold and 32-fold higher, respectively, than those anticipated in clinical use. Decreased pup weight and survival occurred in rats when terfenadi ...
NOACS - West Suffolk Clinical Commissioning Group
NOACS - West Suffolk Clinical Commissioning Group

... • Designed to determine whether rivaroxaban was non-inferior to dose adjusted warfarin (target INR of 2.0 -3.0) in preventing stroke or systemic embolism among patients with non-valvular atrial fibrillation • Primary efficacy endpoint was composite event of stroke and systemic embolism • Primary saf ...
Local Anaesthetic Agents In Clinical Use
Local Anaesthetic Agents In Clinical Use

... Medically compromised (Blood, liver and kidney problems) ...
ANTI- INFLAMMATORY AND ANALGESIC ACTIVITY OF TAMARIX GALLICA  Research Article CHATURVEDI S
ANTI- INFLAMMATORY AND ANALGESIC ACTIVITY OF TAMARIX GALLICA Research Article CHATURVEDI S

... found statistically significant. The extract also caused pronounced reduction in the oedema produced by histamine. This result tends to suggest that the anti-inflammatory activity of the extract is possibly supported by its anti-histamine property. The effect of the extract (100, 200 and 300 mg/kg) ...
Influence of Indomethacin on the Systemic and
Influence of Indomethacin on the Systemic and

... output, indicating that the underlying mechanism was an increase in the systemic vascular resistance. The ventilation and the pulmonary haemodynamics were not affected significantly. This seems to contrast with recent findings in dogs, where indomethacin was reported to increase the pulmonary vascul ...
Trazodone (Desyrel)
Trazodone (Desyrel)

... aggression in patients with Alzheimer’s disease and other brain disorders. Also, at low doses, trazodone has antianxiety effects and may be effective in treating generalized anxiety disorder. These uses for trazodone, however, are outside their indication; trazodone was approved only for the treatme ...
40131
40131

... Voluntary Professor of Family Medicine and Community Health University of Miami Miller School of Medicine ...
Vioxx
Vioxx

... and bleeding than patients taking naproxen, another NSAID, however, the study also showed a greater number of heart attacks in patients taking Vioxx. The VIGOR study was discussed at a February 2001 Arthritis Advisory Committee and the new safety information from this study was added to the labeling ...
Author`s personal copy
Author`s personal copy

... systems are planned to be used with different drugs. However, there are several strategies to modulate drug solubility, e.g. the use of solubilizers described in detail elsewhere [2]. Two compartment osmotic pumps (Fig. 1C) store drug formulation and osmotic agent in two separate compartments. Durin ...
Ranibizumab or bevacizumab in AMD?
Ranibizumab or bevacizumab in AMD?

... Increased incidence of gastrointestinal disorders and endophthalmitis. The adverse effects of drugs are generally evaluated using data from clinical trials primarily designed to demonstrate their efficacy. In such trials, the evaluation of adverse effects is often less rigorous. Signals of adverse e ...
Module 1. General Clinical Pharmacy.Clinical Pharmacy in
Module 1. General Clinical Pharmacy.Clinical Pharmacy in

... C. * Aspiring to the repeated reception of medicine with the purpose of improvement of feel and increase of mood D. Sensibility E. Material accumulation 100. Medicinal dependence shows up A. Only intravenous introduction B. Decreasing of actions at the repeated introduction C. * Place of introductio ...
Each tablet contains 5 mg of aripiprazole
Each tablet contains 5 mg of aripiprazole

... Aripiprazole was excreted in the milk of treated rats during lactation. It is not known whether aripiprazole is excreted in human milk. Patients should be advised not to breast feed if they are taking aripiprazole. ...
Flagyl Prescribing Information
Flagyl Prescribing Information

... doses up to five times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to metronidazole. No fetotoxicity was observed when metronidazole was administered orally to pregnant mice at 20 mg/kg/day, approximately one and a half times the most frequently recomm ...
View Contents - Pharmacophore
View Contents - Pharmacophore

... its gastric residence time and increase its bioavailability as it has good solubility at low pH values. Melt granulation technique was used for preparing the floating tablets using polyethylene glycol 6000 as bioadhesive hydrophilic meltable polymer and different viscosity grades of direct compressi ...
Fixed Dose Combinations & Rational Pharmacotherapeutics DR
Fixed Dose Combinations & Rational Pharmacotherapeutics DR

... over individual drugs despite the claim that Serratiopeptidase promotes more rapid resolution of inflammation. Pts exposed to greater risk of GI irritation and bleeding from peptic ulceration. • FDCs of Quinolones + Nitroimidazoles (e.g. Norfloxacin + ...
phentermine informed consent - Ultimate Weight Loss Solutions
phentermine informed consent - Ultimate Weight Loss Solutions

... swelling in your ankles or feet; pounding heartbeats or fluttering in your chest;  confusion or irritability, unusual thoughts or behavior; feelings of extreme happiness or sadness; or  dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety,  confusion, chest ...
terbutaline sulfate injection usp
terbutaline sulfate injection usp

... aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the ...
Probenecid
Probenecid

... Use with caution in patients with a history of peptic ulcer. The appearance of hypersensitivity reactions requires cessation of probenecid therapy. If probenecid is given with methotrexate, the dosage of methotrexate should be reduced and serum levels may need to be monitored. Haematuria, renal coli ...
Acetaminophen and Your Liver
Acetaminophen and Your Liver

... Most people are only at risk for liver toxicity if they take more than the normal recommended amount of acetaminophen. Most cases of liver damage occur in people who have taken at least 10-15 grams – (the maximum recommended dose is 4 grams a day in a person without cirrhosis). Many of the emergency ...
Determining the subjective and physiological effects
Determining the subjective and physiological effects

... the stimulant-like effects of BZP. To date, there is very little data published about the subjective effects of BZP other than that produced by Campbell and Bye and that reported anecdotally by individuals on drug culture-related websites such as Erowid (http://www.erowid.org). Research has shown th ...
Product Monograph
Product Monograph

... NSAIDs inhibiting prostaglandin biosynthesis interfere with platelet function to varying degrees; patients who may be adversely affected by such an action, such as those on anti-coagulants or suffering from haemophilia or platelet disorders should be carefully observed when NAPROSYN is administered. ...
Antiarrhythmic therapy in patients with atrial fibrillation
Antiarrhythmic therapy in patients with atrial fibrillation

... atrial flutter (14, 15). Among the significant adverse events observed in patients, who were treated with vernakalant, compared with patients receiving placebo, the most commonly observed (5-7%) were transient hypotension, bradycardia, which, however, did not cause the need of drug withdrawal and sh ...
Data Sheet
Data Sheet

... should be used with caution in patients with traumatised mucosa and/or sepsis in the region of the proposed application. The oropharyngeal use of topical anaesthetic agents may interfere with swallowing and thus enhance the danger of aspiration. Numbness of the tongue or buccal mucosa may increase t ...
AusPAR: Lixisenatide - Therapeutic Goods Administration
AusPAR: Lixisenatide - Therapeutic Goods Administration

... patients with T2DM, mean apparent half-life generally ranged from 1.5 to 4.5 h and the mean apparent clearance ranged from 20 to 67 L/h at steady state. The same test method, a ligand binding assay designated DOH0498, was used for the determination of lixisenatide in Studies BDR6864 and BEQ11094. Ho ...
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