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Hyoscyamine Sulfate Tablets, USP
Hyoscyamine Sulfate Tablets, USP

... Reported clinical experience has not identified differences in safety between patients aged 65 and over and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepat ...
OTHER DIURETICS
OTHER DIURETICS

... spironolactone at low doses (12.5 – 50 mg daily). BHS recommendations include low dose spironolactone as a step 4 treatment option i.e. in patients with blood pressure above target despite a combination of A + C + D. Eplerenone might be considered as an alternative to spironolactone to avoid non-spe ...
English  - International Journal of Psychology and
English - International Journal of Psychology and

... was acquired on the trial affected by anisomycin would be effectively erased. Thus, it was predicted that recovery from cSNC in anisomycin-treated animals would start on the trial after anisomycin administration as if the previous trial had not occurred. Anisomycin is an antibiotic derived from the ...
Paediatric Advanced Life Support
Paediatric Advanced Life Support

... as it might because the variations in guidelines for different age groups cause confusion to providers, and therefore poor performance. Most of the changes in paediatric guidelines for 2005 have been made for simplification and to minimise differences between adult and paediatric protocols. It is ho ...
SINAREST Tablet/Syrup
SINAREST Tablet/Syrup

... in conjunction with other Paracetamol containing products. SINAREST Tablet/Syrup should be used with caution in patients with renal or hepatic dysfunction, diabetes mellitus, hyperthyroidism, cardiovascular problems, epilepsy and closed angle glaucoma. It is advisable not to drive or operate machine ...
RITALIN 10 / RITALIN LA
RITALIN 10 / RITALIN LA

... crossover clinical study conducted in a laboratory classroom setting, demonstrated that a single dose of 20 mg Ritalin LA had a rapid onset of effect and was statistically superior to placebo in improving classroom behaviour and cognitive responses. After administration of Ritalin LA, the improvemen ...
Predicting Drug Metabolism - Cambridge Repository
Predicting Drug Metabolism - Cambridge Repository

... forms are expressed predominantly in the liver, but also in a whole variety of other organs at lower expression levels (Figure 1). Hence liver, or liver-derived in vitro systems are often the most convenient, interesting and important experimental model systems for metabolism studies, e.g. when cons ...
(PSD) March 2015 PBAC meeting
(PSD) March 2015 PBAC meeting

... therapeutic equivalence data has been provided to and accepted by the Therapeutic Goods Administration. It would thus be expected that these brands may be interchanged without differences in clinical effect. For other brands of an item, i.e., those not indicated as above, it is unknown whether or no ...
ritalin®10 / ritalin®la
ritalin®10 / ritalin®la

... crossover clinical study conducted in a laboratory classroom setting, demonstrated that a single dose of 20 mg Ritalin LA had a rapid onset of effect and was statistically superior to placebo in improving classroom behaviour and cognitive responses. After administration of Ritalin LA, the improvemen ...
Amiodarone for Atrial Fib 2007
Amiodarone for Atrial Fib 2007

... daily dose may be used when sinus- or atrioventricular-node dysfunction is a concern. It is relatively safe to initiate treatment with amiodarone in the ambulatory setting.23 Electrocardiographic monitoring (with 12-lead electrocardiography or an event recorder) should be performed at least once dur ...
committee for veterinary medicinal products
committee for veterinary medicinal products

... the clinical documentation on the compound is very extensive, but no adverse effects on reproductive function are reported. The general consensus that paromomycin is free from side effects on reproductive system is supported by the extensive clinical use in pregnant women, in children and infants an ...
Buspirone and Pindolol Effects on the EEG Frequency Spectrum in
Buspirone and Pindolol Effects on the EEG Frequency Spectrum in

... Conclusions ...
Amiodarone for Atrial Fibrillation
Amiodarone for Atrial Fibrillation

... daily dose may be used when sinus- or atrioventricular-node dysfunction is a concern. It is relatively safe to initiate treatment with amiodarone in the ambulatory setting.23 Electrocardiographic monitoring (with 12-lead electrocardiography or an event recorder) should be performed at least once dur ...
Effect of `Mentat` on the pharmacokinetics of single and multiple
Effect of `Mentat` on the pharmacokinetics of single and multiple

... at 0800 hour for 7 days. On day 7, blood samples of 1 ml each were collected at 0, 1, 2, 3, 4, 5, 6, 9, 12 and 24 hours after drug treatment in heparinized tubes. Plasma was separated and kept at -20oC until analysis could be performed. From day 8 to 14 the rabbits were treated with phenytoin (60 mg ...
Design and physicochemical characterisation of novel
Design and physicochemical characterisation of novel

... formulation for dissolving microneedles containing ibuprofen sodium (B). Texture Analyser/light microscopy set-up for investigation of physical properties of microneedles (C) and Franz cell set-up for in vitro transdermal drug release studies (D). Indication of biological testing of microneedles in ...
phenytoin [see Drug Interactions (7)].
phenytoin [see Drug Interactions (7)].

... interactions must be considered prior to and during therapy with KALETRA. Review of other medications taken by patients and monitoring of patients for adverse effects is recommended during therapy with KALETRA. See Tables 3 and 9 for listing of drugs that are contraindicated for use with KALETRA du ...
choice of sedation for critically ill patients: a rational approach
choice of sedation for critically ill patients: a rational approach

... medicine must be used to determine or choose a sedative regimen for patients; however, this can be difficult. Few randomized control studies have been conducted comparing different sedative agents. In some cases, the results of these studies have been unconvincing, as pharmacology of the drugs tends ...
Regulation of Subsequent Entry Biologics
Regulation of Subsequent Entry Biologics

... efficacy.2 Accordingly, the EMA definition includes a requirement that the biosimilar have a safety and efficacy profile similar to that of the reference product. Likewise, in the US, a biosimilar is defined as a biologic that is “highly similar” to a reference product, with no clinically meaningful ...
influence of oxcarbazepine on the antinociceptive action of
influence of oxcarbazepine on the antinociceptive action of

... channels by administration of ATP-dependent potassium channel blockers may lead to attenuation or abolition of antinociception (26), and their opening ñ to induction or enhancement of antinociceptive effect (27-29). The enhancement of morphineinduced effect by oxcarbazepine may have a character of a ...
Structure-Guided Discovery of (S)-3
Structure-Guided Discovery of (S)-3

... Plasma protein binding range 4-13% ...
P-RMS
P-RMS

... Concomitant treatment with alpha-antagonists may produce or aggravate hypotension. The combination of diltiazem with an alpha-antagonist should be considered only with the strict monitoring of the blood pressure. Amiodarone, digoxin: Increased risk of bradycardia: Caution is required when these are ...
Immunogenicity Bioassay Summit 2014 and
Immunogenicity Bioassay Summit 2014 and

... tolerated drug in the assay ...
Reinforcing behavioral variability: An analysis of dopamine
Reinforcing behavioral variability: An analysis of dopamine

... performed for each dependent variable for each drug, with dose and component as the within-subjects factors. When a dose X component interaction was significant, post hoc tests were performed using the Sidak adjustment for multiple comparisons. A p value of 0.05 or less was considered statistically s ...
Lipofen - Kowa Pharmaceuticals America, Inc.
Lipofen - Kowa Pharmaceuticals America, Inc.

... cholelithiasis and cholecystitis requiring surgery between the two groups (3.0% vs. 1.8%). In a study conducted by the World Health Organization (WHO), 5000 subjects without known coronary artery disease were treated with placebo or clofibrate for 5 years and followed for an additional one year. The ...
FLOVENT DISKUS (fluticasone propionate inhalation
FLOVENT DISKUS (fluticasone propionate inhalation

... fatal course in susceptible children or adults using corticosteroids. In such children or adults who have not had these diseases or been properly immunized, particular care should be taken to avoid exposure. How the dose, route, and duration of corticosteroid administration affect the risk of develo ...
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