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answer key for cracking the code of life
answer key for cracking the code of life

... 48) Alyssa and Lori and Melanie (younger sister who died of ovarian cancer). Died in 1983. - Alyssa then got breast cancer at age 34. She did well, but then found another lump in 1996. - There are links b/t breast and ovarian cancer – brca1 and brca2 are perfectly healthy normal genes that we all ha ...
Sample Questions from Previous Problem Sets in MCB 240 Here
Sample Questions from Previous Problem Sets in MCB 240 Here

... wild-type XX animals by the cell death machinery. The reporter pkd-2::gfp is expressed in the CEMs of males, and the genetic screen identified mutations that caused the reporter to be expressed in XX animals. Three dominant X-linked mutations, xy1, xy2, and xy3, caused CEM survival in hermaphrodites ...
MYH-associated polyposis fact sheet
MYH-associated polyposis fact sheet

... but who do not have a mutation in the APC gene. Since the clinical features of MAP are similar to those of FAP/AFAP, FAP/AFAP should first be ruled out by testing for a mutation in APC. If no mutation is found in APC, then testing for MYH mutations can be pursued. There are two common MYH mutations ...
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MCS Grade 7 Science Curriculum Map
MCS Grade 7 Science Curriculum Map

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Environmental Skin Cancer: Mechanisms
Environmental Skin Cancer: Mechanisms

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Researchers Find Highly Active Gene in Aggressive Human Lung

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Classification of Genetic disorders:

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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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