Using DNA Subway in the Classroom Red Line Lesson
... •DNA Subway is a suite of bioinformatics tools which have been placed in simplified workflows. • These tools allow students to work with the same data (DNA or Protein sequence data) used by biologists. • The DNA Subway can be used in the classroom to illustrate the basic principles of molecular bio ...
... •DNA Subway is a suite of bioinformatics tools which have been placed in simplified workflows. • These tools allow students to work with the same data (DNA or Protein sequence data) used by biologists. • The DNA Subway can be used in the classroom to illustrate the basic principles of molecular bio ...
Lecture 6 S - BEHESHTI MAAL
... Mistake during DNA replication, incorrect base incorporated into DNA Three types: 1. Silent mutation: no effect on protein (remember- several codons code for the same amino acid) 2. Missense mutation: codon has changed and different amino acid is incorporated 3. Nonsense mutation: codon has changed ...
... Mistake during DNA replication, incorrect base incorporated into DNA Three types: 1. Silent mutation: no effect on protein (remember- several codons code for the same amino acid) 2. Missense mutation: codon has changed and different amino acid is incorporated 3. Nonsense mutation: codon has changed ...
Gene - Oregon State University
... isolating the messenger RNA, converting to DNA, and sequencing all or part of them – Called ESTs or expressed sequence tags – Many very large databases of them exist – Can compare tissues/cells/environmental treatments to learn about general function ...
... isolating the messenger RNA, converting to DNA, and sequencing all or part of them – Called ESTs or expressed sequence tags – Many very large databases of them exist – Can compare tissues/cells/environmental treatments to learn about general function ...
drug
... polymorphisms (eg. SNPs linked to disease susceptibility…) - study of how human genetic makeup influences drug response (efficacy & toxicity of drugs) - new drug development based on human genomic information … customized drug programs for patients ...
... polymorphisms (eg. SNPs linked to disease susceptibility…) - study of how human genetic makeup influences drug response (efficacy & toxicity of drugs) - new drug development based on human genomic information … customized drug programs for patients ...
microarrays part1
... Massively parallel analysis of gene expression • screen an entire genome at once • find not only individual genes that differ, but groups of genes that differ. • find relative expression level differences Shifting the interest from analysis of single molecules to large complexes and networks Effecti ...
... Massively parallel analysis of gene expression • screen an entire genome at once • find not only individual genes that differ, but groups of genes that differ. • find relative expression level differences Shifting the interest from analysis of single molecules to large complexes and networks Effecti ...
Gene expression pipelining, applications and the wisdom
... The maximum likelihood estimate of θ MAXIMIZES p(y | θ). In some cases it may be hard to find • That’s when EM is useful! EM takes the observed data y, iteratively makes guesses about the complete data x, and then finds the θ that maximizes p(x | θ) over Θ • EM tries to find the maximum likelihood ...
... The maximum likelihood estimate of θ MAXIMIZES p(y | θ). In some cases it may be hard to find • That’s when EM is useful! EM takes the observed data y, iteratively makes guesses about the complete data x, and then finds the θ that maximizes p(x | θ) over Θ • EM tries to find the maximum likelihood ...
Discovering the material for heredity: DNA
... Let’s look at the genetic code again… What tells translation to start and stop? ...
... Let’s look at the genetic code again… What tells translation to start and stop? ...
030612 Yeast, Flies, Worms, and Fish in the Study of Human Disease
... Model organisms provide researchers with a unique the worm by mutation of its orthologue of the humethod of placing genes within a functional path- man gene PRESENILIN. The effects of the mutaway — the so-called modifier screen.9,10 This meth- tion are reversed by overexpression in the worm of od in ...
... Model organisms provide researchers with a unique the worm by mutation of its orthologue of the humethod of placing genes within a functional path- man gene PRESENILIN. The effects of the mutaway — the so-called modifier screen.9,10 This meth- tion are reversed by overexpression in the worm of od in ...
microarrays1
... Microarrays Massively parallel analysis of gene expression • screen an entire genome at once • find not only individual genes that differ, but groups of genes that differ. • find relative expression level differences Shifting the interest from analysis of single molecules to large complexes and net ...
... Microarrays Massively parallel analysis of gene expression • screen an entire genome at once • find not only individual genes that differ, but groups of genes that differ. • find relative expression level differences Shifting the interest from analysis of single molecules to large complexes and net ...
PPT
... – Cancer is a disease of the cell cycle. – Cancer cells do not respond normally to the cell cycle control system. ...
... – Cancer is a disease of the cell cycle. – Cancer cells do not respond normally to the cell cycle control system. ...
PDF
... • Radiation therapy, which damages DNA and disrupts cell division. • Chemotherapy, which uses drugs that disrupt cell division. ...
... • Radiation therapy, which damages DNA and disrupts cell division. • Chemotherapy, which uses drugs that disrupt cell division. ...
Gene-and-Chromosome-Mutations
... usually detectable under the microscope during cell division. • They usually occur during crossing over when the number or sequence of genes may be altered. • When a chromosome is broken it has a sticky end which can join onto other chromosomes. • Therefore, the structure of a chromosome can be alte ...
... usually detectable under the microscope during cell division. • They usually occur during crossing over when the number or sequence of genes may be altered. • When a chromosome is broken it has a sticky end which can join onto other chromosomes. • Therefore, the structure of a chromosome can be alte ...
Genetics
... Relate the concept of the gene to the sequences of nucleotides in DNA Sequence the steps involving protein synthesis Categorize the different kinds of mutations that can occur in DNA Compare the effects of different kinds of mutations on cells and organisms. ...
... Relate the concept of the gene to the sequences of nucleotides in DNA Sequence the steps involving protein synthesis Categorize the different kinds of mutations that can occur in DNA Compare the effects of different kinds of mutations on cells and organisms. ...
Gene Section FRZB (frizzled related protein) -
... signalling (Loughlin et al., 2004). Additionally, an association analysis confirmed that the R324G variant of the FRZB gene is involved in osteoarthritis and indicates a role of this variant in several generalized OA phenotypes (Min et al., 2005). Next, evidence was found for a differential associat ...
... signalling (Loughlin et al., 2004). Additionally, an association analysis confirmed that the R324G variant of the FRZB gene is involved in osteoarthritis and indicates a role of this variant in several generalized OA phenotypes (Min et al., 2005). Next, evidence was found for a differential associat ...
research description
... microbiota remains a poorly understood ecosystem, in need of further research. We study the human microbiota using metagenomic techniques, and analyze samples from both healthy individuals and patients with gastric reflux disease, inflammatory bowel diseases and several types of cancer, to try and e ...
... microbiota remains a poorly understood ecosystem, in need of further research. We study the human microbiota using metagenomic techniques, and analyze samples from both healthy individuals and patients with gastric reflux disease, inflammatory bowel diseases and several types of cancer, to try and e ...
TUESDAY, 17TH FEBRUARY 2015 Over the weekend there were
... that provides new evidence on the use of Hormone Replacement Therapy (HRT) and the risk of developing the two most common types of ovarian cancer. The report, which is based on an analysis of 52 studies involving 20,000 women from several countries, including Australia, estimated that for women star ...
... that provides new evidence on the use of Hormone Replacement Therapy (HRT) and the risk of developing the two most common types of ovarian cancer. The report, which is based on an analysis of 52 studies involving 20,000 women from several countries, including Australia, estimated that for women star ...
2nd problem set
... a) ______________ : a sequence that immediately precedes a gene and indicates the start of transcription. b) ______________ : a protein that synthesizes a new strand of DNA. c) ______________: a molecule which can terminate a growing DNA strand. 7. Which one of the following molecules is NOT found i ...
... a) ______________ : a sequence that immediately precedes a gene and indicates the start of transcription. b) ______________ : a protein that synthesizes a new strand of DNA. c) ______________: a molecule which can terminate a growing DNA strand. 7. Which one of the following molecules is NOT found i ...
Testing the Effects of Epilepsy Genes in Human Neuronal Progenitor
... only in the world to have identified genetic loci that contribute to susceptibility to juvenile myoclonic epilepsy, the most common epilepsy of adolescent onset. One of our highest priorities is to understand how variation in these genes affects both the development and the normal molecular processe ...
... only in the world to have identified genetic loci that contribute to susceptibility to juvenile myoclonic epilepsy, the most common epilepsy of adolescent onset. One of our highest priorities is to understand how variation in these genes affects both the development and the normal molecular processe ...
Brian Nguyen - Neurofibromatosis (Type 2)
... S Tumors also develop on other parts of nervous system, including brain ...
... S Tumors also develop on other parts of nervous system, including brain ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.