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Personalized medicine - Pitt Department of Biomedical Informatics
Personalized medicine - Pitt Department of Biomedical Informatics

Developmental Gene Expression Part II
Developmental Gene Expression Part II

... Warm-Up (1/7) On the piece of white paper from the back, answer the following question. ...
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... Caenorhabditis elegans (biological model nematode) Arabidopsis thaliana (biological model mustard plant) ...
Final Exam Study Guide
Final Exam Study Guide

... The material covered on Exams I and II, such that you could correctly answer these same questions or variations of these questions when they appear on Exam III. Definitions for genomics, proteomics and bioinformatics The two approaches taken for sequencing the human genome Microarray experiments (ho ...
inFORMAtiOn FOR wOMen ABOUt FAMily
inFORMAtiOn FOR wOMen ABOUt FAMily

Communication - Miss Hanson's Biology Resources
Communication - Miss Hanson's Biology Resources

...  insertion ...
08 Bacterial Transformation Lab Part1 Fa08
08 Bacterial Transformation Lab Part1 Fa08

... The unique plasmid we use encodes the gene for the Green Fluorescent Protein (GFP) and a gene for resistance to the antibiotic, ampicillin. The plasmid also incorporates a special gene regulation system, which can be used to control expression of the fluorescent protein in transformed cells. The ge ...
Name: Date: ______ Hour: ______ 8th Grade Science: Heredity and
Name: Date: ______ Hour: ______ 8th Grade Science: Heredity and

... 10. In seeds, a round seed (R) is dominant over a wrinkled seed (r). I want to study offspring that have a 50% chance of being round seeds and a 50% chance of being wrinkled seeds. *Create a Punnett square(s) to show the possible cross(es) that would yield my desired results. ...
Mutations - GK-12 Program at the University of Houston
Mutations - GK-12 Program at the University of Houston

Chromosomes, DNA, and Genes
Chromosomes, DNA, and Genes

... Disease-Associated Mutations Alter Protein Function ...
Gene Expression-Based Assays for Cancers of Unknown Primary
Gene Expression-Based Assays for Cancers of Unknown Primary

... origin. The test was developed by Pathwork Diagnostics, but was later purchased by Response Genetics, Inc. MiRview® mets (Rosetta Genomics, Philadelphia, PA) is another microarray technology which uses microRNAs (miRNA), small non-coding, single-stranded RNA molecules that regulate genes post-transc ...
ppt
ppt

... • Mutations may also depend on the environment • The molecular clock (MC) hypothesis state that evolution is working in a similar rate for all lineages Relative rate test: O ...
Genetic Control of Metabolism
Genetic Control of Metabolism

12 transgenic mice
12 transgenic mice

... species is pigmented, it is easy to see which offspring are chimeric. This technology is used to generate knock out mice, where all copies of a specific gene are knocked out or made non functional. This method is more efficient than injection into pronuclei . How is this done? ...
Biosketch - UNC School of Medicine - UNC
Biosketch - UNC School of Medicine - UNC

Luria/Delbrück
Luria/Delbrück

... If bacteriophage T1 caused T1 resistance, then the variance in the two procedures should be the same. If, however, the event leading to T1 resistance was random, then it might occur at different times in different cultures, leading to different final proportions of T1-resistant cells in different c ...
PCB 6528 Exam – Organelle genomes and gene expression
PCB 6528 Exam – Organelle genomes and gene expression

... some similar features and exhibit some interesting differences. Indicate whether each of the features below pertain to plastid genomes, plant mitochondrial genomes, both genomes or neither genome. Genome Feature ...
Gene Mapping - University of Delaware
Gene Mapping - University of Delaware

... Use Polymerase Chain Reaction (PCR). Primers based upon: • random sequence • expressed sequence tag ...
Chapter 20: DNA Technology and Genomics
Chapter 20: DNA Technology and Genomics

... fragments); and (3) DNA sequencing of each small fragment, followed by assembly of the overall sequence. The Celera whole-genome shotgun approach omitted the first two stages. Each chromosome was cut into small fragments, which were cloned in plasmid or phage vectors. The sequence of each fragment w ...
Genome Shock in Polyploid Plants
Genome Shock in Polyploid Plants

Chapter 7 Genes and Protein Synthesis
Chapter 7 Genes and Protein Synthesis

... Flexibility with third nucleotide Aminoacylation – process of adding an AA to a tRNA ...
Research News
Research News

... strong phylogenetic signals. They consider that a fundamental change in current practices is required: (1) bootstrap support should not be used for concatenation analyses of large data sets; (2) the signal in individual genes and trees derived from them should be carefully examined; and (3) internod ...
notes - Southington Public Schools
notes - Southington Public Schools

... important) this discovery led to a Nobel Prize in medicine (Shimomura, Chalfie, Tsien 2008) since the gene is tacked on to other GM attempts, allowing visual proof that cells in a sample or organism got the new gene being studied. The Human Genome Genome = the complete set of genes for an organism. ...
Stem Cells and cell division
Stem Cells and cell division

... • An advantage of multicellular organisms is that not every cell needs to perform every function. • Allows the formation of specialization – tissues. • For specialization to be successful, the behavior of one type of cell must be integrated with the behavior of other cells. ...
Homeotic genes - Monroe County Schools
Homeotic genes - Monroe County Schools

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Oncogenomics



Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.
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