dna sequence information independent technologies for
... CAMBIA'S genomics program has developed two new technologies. The first, the Transgenomics Initiative (TGI), offers a novel paradigm for biotechnological intervention and is a complement to the dominant sequence-based paradigm. This program concentrates on developing novel traits and agriculturally ...
... CAMBIA'S genomics program has developed two new technologies. The first, the Transgenomics Initiative (TGI), offers a novel paradigm for biotechnological intervention and is a complement to the dominant sequence-based paradigm. This program concentrates on developing novel traits and agriculturally ...
BRCA genes inherited breast and ovarian cancer
... What if a relative with breast/ovarian/prostate cancer is not available for testing, can I be tested even if I have never had cancer? Testing can be difficult to interpret if we don’t know exactly which mutation is present in a family. If we test a person who has not had cancer and the test does no ...
... What if a relative with breast/ovarian/prostate cancer is not available for testing, can I be tested even if I have never had cancer? Testing can be difficult to interpret if we don’t know exactly which mutation is present in a family. If we test a person who has not had cancer and the test does no ...
Supplementary Figure and Table Legend (doc 44K)
... competitive microarray comparing CD44+/CD24- fraction versus ‘rest’ fraction of NBLE cells. (b) Validation of competitive microarray comparing CD44+/CD24- fraction versus ‘rest’ fraction of CB272 cells. (The inset tables show fold changes observed in the respective microarray data). Supplementary Fi ...
... competitive microarray comparing CD44+/CD24- fraction versus ‘rest’ fraction of NBLE cells. (b) Validation of competitive microarray comparing CD44+/CD24- fraction versus ‘rest’ fraction of CB272 cells. (The inset tables show fold changes observed in the respective microarray data). Supplementary Fi ...
Mutations are any changes in the genetic material
... 1. The diagram shows the normal sequence of genes in a particular chromosome. Which chromosomes could have resulted from a deletion that occurred in this chromosome? ...
... 1. The diagram shows the normal sequence of genes in a particular chromosome. Which chromosomes could have resulted from a deletion that occurred in this chromosome? ...
of gene expression - Université d`Ottawa
... red = expressed at higher levels in test than in control green = expressed at lower levels in test yellow = expressed at same level in both ...
... red = expressed at higher levels in test than in control green = expressed at lower levels in test yellow = expressed at same level in both ...
genetic testing
... Role-Play Sheet for Martha Bioinformatics Researcher at a Pharmaceutical Company (Expertise—genetic and DNA analysis) Bioinformatics is a new field of study that combines biology and information technology. It is used to analyze large databases of information, such as those resulting from the Human ...
... Role-Play Sheet for Martha Bioinformatics Researcher at a Pharmaceutical Company (Expertise—genetic and DNA analysis) Bioinformatics is a new field of study that combines biology and information technology. It is used to analyze large databases of information, such as those resulting from the Human ...
Abigail Rousseau
... Represses transcription of EBNA1 (essential for replication of EBV genome) EBV- related genetic susceptibility?? ...
... Represses transcription of EBNA1 (essential for replication of EBV genome) EBV- related genetic susceptibility?? ...
Assembling and Annotating the Draft Human Genome
... • Processed pseudogenes can be identified by: – Lack of introns (but ~20% of real genes lack introns) – Not being the best place in genome an mRNA aligns (be careful not to filter out real paralogs) – Being inserted from another chromosome since ...
... • Processed pseudogenes can be identified by: – Lack of introns (but ~20% of real genes lack introns) – Not being the best place in genome an mRNA aligns (be careful not to filter out real paralogs) – Being inserted from another chromosome since ...
Complex Patterns of Inheritance
... • Involves methylation (-CH3) (turns genes OFF) or demethylation (turns genes on) of cytosine nucleotides Several hundred mammalian genes, many critical for development, may be subject to imprinting. ...
... • Involves methylation (-CH3) (turns genes OFF) or demethylation (turns genes on) of cytosine nucleotides Several hundred mammalian genes, many critical for development, may be subject to imprinting. ...
12-1 Chromosomes and Inheritance patterns
... Y) is a sex-determining gene on the Y chromosome in humans and other primates. • One of the most controversial uses of this discovery was as a means for gender verification at the Olympic Games, • Athletes with a SRY gene were not permitted to participate as females, although all athletes in whom th ...
... Y) is a sex-determining gene on the Y chromosome in humans and other primates. • One of the most controversial uses of this discovery was as a means for gender verification at the Olympic Games, • Athletes with a SRY gene were not permitted to participate as females, although all athletes in whom th ...
Gene Section PDCD6 (programmed cell death 6) Atlas of Genetics and Cytogenetics
... results indicate that inhibition of PDCD6 expression reduces cellular viability. Several target proteins, which interact with PDCD6 in a calcium dependent fashion have been found. Most prominent are AIP1/Alix, an adaptor protein involved in apoptosis, endocytosis, adhesion and cytokinesis as well as ...
... results indicate that inhibition of PDCD6 expression reduces cellular viability. Several target proteins, which interact with PDCD6 in a calcium dependent fashion have been found. Most prominent are AIP1/Alix, an adaptor protein involved in apoptosis, endocytosis, adhesion and cytokinesis as well as ...
Gramene: A Resource for Comparative Grass Genomics
... Ontologies can be indexed “objectively” by a computer.\ Computers can infer new knowledge ...
... Ontologies can be indexed “objectively” by a computer.\ Computers can infer new knowledge ...
DNA Sequencing: Importance
... • Molecular medicine Improved diagnosis of disease – Disease gene identification will lead to more accurate diagnosis Earlier detection of genetic predispositions to disease – Will be able to assess risk for certain diseases, e.g. cancer, Type II diabetes, heart disease Rational drug design ...
... • Molecular medicine Improved diagnosis of disease – Disease gene identification will lead to more accurate diagnosis Earlier detection of genetic predispositions to disease – Will be able to assess risk for certain diseases, e.g. cancer, Type II diabetes, heart disease Rational drug design ...
Genetics and genomics in wildlife studies: Implications for
... ecological, evolutionary, and conservation genetics research. The current revolution in next generation sequencing (NGS) technologies is destined to add a genomic dimension to biological diversity studies. Twelve leading researchers were invited to give talks on the application of genomic tools to a ...
... ecological, evolutionary, and conservation genetics research. The current revolution in next generation sequencing (NGS) technologies is destined to add a genomic dimension to biological diversity studies. Twelve leading researchers were invited to give talks on the application of genomic tools to a ...
DNA (Gene) Mutations
... Change in the nucleotide sequence of a gene May only involve a single nucleotide May be due to copying errors, chemicals, viruses, etc. ...
... Change in the nucleotide sequence of a gene May only involve a single nucleotide May be due to copying errors, chemicals, viruses, etc. ...
Heredity and the Origin of Life
... mother and one from father • Today, Mendel’s “factors” are called “Genes” which are made of DNA ...
... mother and one from father • Today, Mendel’s “factors” are called “Genes” which are made of DNA ...
The pathogenesis of neoplasia
... in the body so that the final outcome depends on the balance between the factors and the extent of the changes in the initiated cells. This explains why preneoplastic, or even apparently fully transformed tumors, can be found but do not appear to be growing, and sometimes even regress (3,5). The who ...
... in the body so that the final outcome depends on the balance between the factors and the extent of the changes in the initiated cells. This explains why preneoplastic, or even apparently fully transformed tumors, can be found but do not appear to be growing, and sometimes even regress (3,5). The who ...
Document
... – The discovery of a defective gene and the development of a screening test. – The importance of counselling. ...
... – The discovery of a defective gene and the development of a screening test. – The importance of counselling. ...
Chapter 6 - VU Research Portal
... In Chapter 3 we studied the cell-type specific effects of intron 2 mutations and found a potential explanation for this selective vulnerability in LBSL. The magnitude of the effect of the intron 2 mutations differed depending on the cell type. The largest effect was observed in cells derived from th ...
... In Chapter 3 we studied the cell-type specific effects of intron 2 mutations and found a potential explanation for this selective vulnerability in LBSL. The magnitude of the effect of the intron 2 mutations differed depending on the cell type. The largest effect was observed in cells derived from th ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.