Number 52, 2005 11 Robert L. M etzenberg
... routinely. They could equally well be called "self-adjusting knockdowns" of essential genes. Such minimally-sheltered knockouts could give results in microarray analysis that would be less subject to artifact than results with heterokaryons or with homokaryons sheltered with an inducible wild-type a ...
... routinely. They could equally well be called "self-adjusting knockdowns" of essential genes. Such minimally-sheltered knockouts could give results in microarray analysis that would be less subject to artifact than results with heterokaryons or with homokaryons sheltered with an inducible wild-type a ...
Chromosomal assignment of seven genes on canine chromosomes
... Another idiogram for the canine chromosomes has been proposed by Selden and coworkers (1975). In the case of the loci studied in this paper, it is possible to assign chromosome numbers based on Selden’s idiogram as well: Chr 4 is the same in both idiograms, and Chr 2, 3, and 5 would be 6, 5, and 7 r ...
... Another idiogram for the canine chromosomes has been proposed by Selden and coworkers (1975). In the case of the loci studied in this paper, it is possible to assign chromosome numbers based on Selden’s idiogram as well: Chr 4 is the same in both idiograms, and Chr 2, 3, and 5 would be 6, 5, and 7 r ...
Slide 1
... The upper image shows a cancerous tumour on the edge of an outstretched tongue while the lower image shows a healthy tongue. Tobacco can damage cells in the lining of the oral cavity. Mouth cancer occurs when cells in your mouth mutate and grow out of control. Cancer often appears as lumps and swell ...
... The upper image shows a cancerous tumour on the edge of an outstretched tongue while the lower image shows a healthy tongue. Tobacco can damage cells in the lining of the oral cavity. Mouth cancer occurs when cells in your mouth mutate and grow out of control. Cancer often appears as lumps and swell ...
Mitochondrial and other neuromuscular disorders
... Another cause of energy crisis of the muscle cell is defective glycogen metabolism, since glycogen is important for storage of carbohydrates used for energy production. We have identified two new diseases, which lead to inability of the muscle cell to produce glycogen. We study the disease mechanis ...
... Another cause of energy crisis of the muscle cell is defective glycogen metabolism, since glycogen is important for storage of carbohydrates used for energy production. We have identified two new diseases, which lead to inability of the muscle cell to produce glycogen. We study the disease mechanis ...
chapter 15 section 3 notes
... No individual is exactly like any other genetically—except for identical twins, who share the same genome. Chromosomes contain many regions with repeated DNA sequences that do not code for proteins. These vary from person to person. Here, one sample has 12 repeats between genes A and B, while the se ...
... No individual is exactly like any other genetically—except for identical twins, who share the same genome. Chromosomes contain many regions with repeated DNA sequences that do not code for proteins. These vary from person to person. Here, one sample has 12 repeats between genes A and B, while the se ...
L11_SUMMARY_DE
... • The empirical Bayes estimate of variance is closer to the mean variance, more often than the sample variance, which means that the moderated t-score is more likely to have a moderate (not very small, not very large) value than a true t-score. • The tails of the moderated t distribution are fairly ...
... • The empirical Bayes estimate of variance is closer to the mean variance, more often than the sample variance, which means that the moderated t-score is more likely to have a moderate (not very small, not very large) value than a true t-score. • The tails of the moderated t distribution are fairly ...
Gene Section ANXA1 (annexin A1) Atlas of Genetics and Cytogenetics
... mutations, hyper-methylation of the promoter with subsequent loss of transcription, and alterations in the post-translation processing (e.g. phosphorylation) of the protein involved in annexins regulation (de Coupade et al., 2000; Rodrigues-Lisoni et al., 2006; Alves et al., 2008). Lindgren et al. ( ...
... mutations, hyper-methylation of the promoter with subsequent loss of transcription, and alterations in the post-translation processing (e.g. phosphorylation) of the protein involved in annexins regulation (de Coupade et al., 2000; Rodrigues-Lisoni et al., 2006; Alves et al., 2008). Lindgren et al. ( ...
Positive Control and Catabolite Repression
... interact with other sequences and affect the transcription and translation of these sequences • Regulatory elements: DNA sequences that are not transcribed but play a role in regulating other nucleotide sequences ...
... interact with other sequences and affect the transcription and translation of these sequences • Regulatory elements: DNA sequences that are not transcribed but play a role in regulating other nucleotide sequences ...
Document
... recombination to integrate the DNA into the recipient cell • can map genes by the frequency of co-transduction (frequency of simultaneous transfer of two genes) ...
... recombination to integrate the DNA into the recipient cell • can map genes by the frequency of co-transduction (frequency of simultaneous transfer of two genes) ...
Evaluation of TMPRSS2-ERG Fusion Protein in
... prostate cancer, and its exquisite specificity, this ERG mouse mAb may be a valuable tool for the clear diagnosis of adenocarcinoma in the prostate by IHC. Furthermore, the robust presence of ERG in prostatic adenocarcinoma and its absence in a wide-variety of other tissues, may make ERG an excellen ...
... prostate cancer, and its exquisite specificity, this ERG mouse mAb may be a valuable tool for the clear diagnosis of adenocarcinoma in the prostate by IHC. Furthermore, the robust presence of ERG in prostatic adenocarcinoma and its absence in a wide-variety of other tissues, may make ERG an excellen ...
CH 13: Regulation of Gene Expression
... Gene Rearrangements • Gene rearrangements are mutations that move an entire __________ gene to a new location on a chromosome – This may affect a gene’s expression because it is exposed to different _____________ regulatory proteins – It could be comparable to moving to France but speak not being ab ...
... Gene Rearrangements • Gene rearrangements are mutations that move an entire __________ gene to a new location on a chromosome – This may affect a gene’s expression because it is exposed to different _____________ regulatory proteins – It could be comparable to moving to France but speak not being ab ...
File
... appeared to be “linked” together in ways that, at first glance, seemed to violate the principle of independent assortment. For example, a fly with reddish-orange eyes and miniature wings, like the one shown in Figure 11–18, was used in a series of crosses. The results showed that the genes for those ...
... appeared to be “linked” together in ways that, at first glance, seemed to violate the principle of independent assortment. For example, a fly with reddish-orange eyes and miniature wings, like the one shown in Figure 11–18, was used in a series of crosses. The results showed that the genes for those ...
Open questions: What has genetics told us about autism spectrum disorders?
... drive for sameness and predictability (which is an important part of the restricted interests and obsessive behaviors phenotype), and this leads to a secondary social withdrawal; after all, people are the least predictable objects in a developing child’s environment. Another possibility is that the ...
... drive for sameness and predictability (which is an important part of the restricted interests and obsessive behaviors phenotype), and this leads to a secondary social withdrawal; after all, people are the least predictable objects in a developing child’s environment. Another possibility is that the ...
Charles G. Kurland
... proteome is in fact not made up of bacterial descendents. They are eukaryotic proteins with no allignable homologues in bacteria or in archaea. Some of the characteristic organelle-specific functions such as ATP export are carried out by such eukaryotic add-ons to the mitochondrial proteome. The lab ...
... proteome is in fact not made up of bacterial descendents. They are eukaryotic proteins with no allignable homologues in bacteria or in archaea. Some of the characteristic organelle-specific functions such as ATP export are carried out by such eukaryotic add-ons to the mitochondrial proteome. The lab ...
human gene testing - National Academy of Sciences
... Genetic Errors Cause Disease The precise arrangement (sequence) of A, C, G, and T bases on a DNA strand is the recipe that encodes the exact sequence of a protein. If the recipes have extra bases or misspelled bases or if some are deleted, the cell can make a wrong protein or too much or too little ...
... Genetic Errors Cause Disease The precise arrangement (sequence) of A, C, G, and T bases on a DNA strand is the recipe that encodes the exact sequence of a protein. If the recipes have extra bases or misspelled bases or if some are deleted, the cell can make a wrong protein or too much or too little ...
Answers to test 2
... 15. You construct an F1 from the cross of two pure breeding lines of plants carrying two genes that are on the same chromosome but for which at least one crossover always occurs between these genes (A and B). The initial cross is AABB x aabb. You then self an F1 plant and grow just two progeny. What ...
... 15. You construct an F1 from the cross of two pure breeding lines of plants carrying two genes that are on the same chromosome but for which at least one crossover always occurs between these genes (A and B). The initial cross is AABB x aabb. You then self an F1 plant and grow just two progeny. What ...
Oncogenomics
Oncogenomics is a relatively new sub-field of genomics that applies high throughput technologies to characterize genes associated with cancer. Oncogenomics is synonymous with ""cancer genomics"". Cancer is a genetic disease caused by accumulation of mutations to DNA leading to unrestrained cell proliferation and neoplasm formation. The goal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide new insights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies. The success of targeted cancer therapies such as Gleevec, Herceptin, and Avastin raised the hope for oncogenomics to elucidate new targets for cancer treatment.Besides understanding the underlying genetic mechanisms that initiates or drives cancer progression, one of the main goals of oncogenomics is to allow for the development of personalized cancer treatment. Cancer develops due to an accumulation of mutations in DNA. These mutations accumulate randomly, and thus, different DNA mutations and mutation combinations exist between different individuals with the same type of cancer. Thus, identifying and targeting specific mutations which have occurred in an individual patient may lead to increased efficacy of cancer therapy.The completion of the Human Genome Project has greatly facilitated the field of oncogenomics and has increased the abilities of researchers to find cancer causing genes. In addition, the sequencing technologies now available for sequence generation and data analysis have been applied to the study of oncogenomics. With the amount of research conducted on cancer genomes and the accumulation of databases documenting the mutational changes, it has been predicted that the most important cancer-causing mutations, rearrangements, and altered expression levels will be cataloged and well characterized within the next decade.Cancer research may look either on the genomic level at DNA mutations, the epigenetic level at methylation or histone modification changes, the transcription level at altered levels of gene expression, or the protein level at altered levels of protein abundance and function in cancer cells. Oncogenomics focuses on the genomic, epigenomic, and transcript level alterations in cancer.