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Nursing 715 Pharmacological Basis of Therapeutics
Nursing 715 Pharmacological Basis of Therapeutics

... Other than by the intravenous route, or for agents designed to have a direct local effect, drugs must first be absorbed into the circulation before they can be distributed to the site of action ...
16ppt
16ppt

... Most MAOIs require avoiding tyramine-containing foods, since tyramine is oxidized by MAO. Inhibition of MAO can result in high levels of tyramine, leading to hypertensive crisis (high blood pressure, often termed the “cheese effect”) ...
Epinephrine
Epinephrine

... inc. blood return to heart, inc. circulation, inc. BP 2. Alpha-2 = inhibits release of norepinephrine dec. in vasoconstriction, dec. BP 3. Beta-1 = inc. in heart rate & force on contraction 4. Beta-2 = relaxation of smooth muscle in bronchi, uterus, peripheral blood vessels Dopaminergic = dilate ves ...
Chapter 17 Antipsychotic Agents
Chapter 17 Antipsychotic Agents

... Several important dopaminergic pathway • Several important dopaminergic pathway are now recognized in the brain. • (1)The first pathway the one most closely related to behavior is the mesolimbic-mesocortical pathway. • (2) Nigrostriatal pathway, involving in the coordination of voluntary自主 movement ...
Pharmacy Technician*s Course. LaGuardia Community College
Pharmacy Technician*s Course. LaGuardia Community College

... called Pancreatic Lipase which is secreted by the pancreas into the bile ducts into the small intestine and catalyzes the reaction in the breakdown of fats to fatty acids and glycerol. The drug Oristat or Xenical ® is a drug that blocks the enzyme pancreatic lipase from working. This will cause the ...
Sedatives
Sedatives

...  Therefore, substitution of buspirone will NOT lessen/prevent benzo withdrawal  If you want to switch to buspirone, need to first withdraw from benzo gradually  Drug free interval between the 2 permits the physician to distinguish between withdrawal effects of benzos and failure of buspirone once ...
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... immune active cells (such as T cells, neutrophils, and eosinophils), “which suggests an important role for H4 receptors in the regulation of immune function”. ...
Direct cholinergic agonists
Direct cholinergic agonists

... The reversible inhibitors include the quaternary amines and the carbamates. They compete with acetylcholine for the active site on the cholinesterase enzyme. This group includes the drugs with names ending in "-stigmine" and "nium." The irreversible inhibitors phosphorylate the enzyme and inactivate ...
Autonomic Nervous System
Autonomic Nervous System

... CNS stimulation followed by depression Decreased cardiovascular response to parasympathetic (vagal) stimulation that slows heart rate. Bronchodilation and decrease respiratory secretions Antispasmodic effects in GI system Change in intra-ocular pressure in patients with glaucoma ...
OPIOID ANALGESICS
OPIOID ANALGESICS

... MOA OF MORPHINE  Certain opioid receptors are located on primary afferent and spinal cord pain transmission neurons(ascending pathways) and on neurons in the midbrain and medulla(descending pathways) that ...
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... We invite submissions under the following headings although this list is not exhaustive: Mind-Brian Relationship. Neuroimaging studies that also examine subjective effects of psychedelic drugs are providing new insights into how changes in brain function can lead to the particular changes in emotion ...
Drugs and the Brain
Drugs and the Brain

... • Some drugs activate chemical receptors in synaptic transmission, others block them • THC and morphine activate specific receptors, which blocks a person from experiencing pain • Caffeine prevents the neurotransmitter adenosine (which has sedative properties), causing stimulation and arousal • LSD ...
Drug Interactions Pharmacolgoy Prof. R. K. Dixit
Drug Interactions Pharmacolgoy Prof. R. K. Dixit

... occurred in patients who are on long-term medication with an inducing drug.  Contraceptive failure and loss of therapeutic effect of many other drugs have occurred due to enzyme induction (Patient taking Rifampicin)  Toxic dose of paracetamol is lower in chronic alcoholics and in those on enzyme i ...
2. Basic Pharmacology
2. Basic Pharmacology

... Agonists activates or enhances cellular activity. triggers a series of biochemical events alteration in function second messengers: biochemicals that initiate these changes ...
drug interactions
drug interactions

... occurred in patients who are on long-term medication with an inducing drug.  Contraceptive failure and loss of therapeutic effect of many other drugs have occurred due to enzyme induction (Patient taking Rifampicin)  Toxic dose of paracetamol is lower in chronic alcoholics and in those on enzyme i ...
Types of Therapy
Types of Therapy

... BIOMEDICAL *Drug Therapy (psychopharmacology) - In the 1950s, biochemists developed Thorazine, a psychoactive drug that helps control symptoms of schizophrenia. This allowed many individuals to leave psychiatric hospitals and live with family, friends, in supportive care facilities, or on their own ...
药效学2
药效学2

... Affinity Intrinsic activity Agonist Yes Antagonist Yes Partial agonist ...
Neuro Pharm Review - UNC School of Medicine
Neuro Pharm Review - UNC School of Medicine

... dopamine in the brain • What are long term dopamine side effects? • chorea, ballismus, & other dyskinesias and mental effects can include depression, anxiety, agitation, ...
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... Found at all autonomic ganglia, somatic neuromuscular junctions and CNS -ligand-gated sodium channels -autonomic ganglia activation of nicotinic receptors produces neuronal excitation leading to the release of neurotransmitters at postganglionic neuroeffector junctions ...
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Drug Discovery Process

... • Patient feels better even if on placebo – Often seen with antidepressants, antianxiety meds ...
Page Selective D3 receptor antagonist The dopamine D3
Page Selective D3 receptor antagonist The dopamine D3

... stronger drug effect observed in those with lower levels of restrained eating. These findings suggest that, in low-restrained eaters, D3 receptor antagonism with GSK598809 reduces selective attention allocated to rewarding food cues. The lack of overall effect of GSK598809 on attentional bias seems ...
UNIVERSITY OF SANTO TOMAS FACULTY OF MEDICINE AND
UNIVERSITY OF SANTO TOMAS FACULTY OF MEDICINE AND

... Environmental causes include MPTP and rotenone as they cause nigral degeneration. Aside from these, atypical forms such as multiple systems atrophy, progressive supranuclear palsy, and corticobasal degeneration may also lead to Parkinson’s. ...
drug 2012 - Dr. Timothy Hain`s Home Page
drug 2012 - Dr. Timothy Hain`s Home Page

... Author’s experience – Useful for motion intolerance and Meniere’s. •Kingma H, Bonink M, Meulenbroeks A, Konijnenberg H. Dose-dependent effect of betahistine on the vestibulo-ocular reflex: a double-blind placebo controlled study in patients with paroxysmal vertigo. Acta Otolaryngologica 117(5):641-6 ...
Adrenergic System Adrenoceptor Blocking Drugs
Adrenergic System Adrenoceptor Blocking Drugs

... (alpha1 effect) to maintain blood pressure is blocked by the drug, and the failure of such response results in Postural (Orthostatic) hypotension. The sympathetic system is further activated to release more and more transmitters (Noradrenaline); this increase would normally be reduced by a negative ...
100908 Gen Pharm History (pt1) 1801KB
100908 Gen Pharm History (pt1) 1801KB

...  Some drugs bind to proteins in blood and remain for prolonged period  Therapeutic effects due to unbound portion of drug in blood  Drug bound to plasma proteins can’t cross ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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