Sedative hypnotic
... “Z Drugs” are a group of nonbenzodiazepine drugs with effects similar to benzodiazepines which are used in the treatment of insomnia and whose names mostly start with the letter “Z”. ...
... “Z Drugs” are a group of nonbenzodiazepine drugs with effects similar to benzodiazepines which are used in the treatment of insomnia and whose names mostly start with the letter “Z”. ...
Drug and Alcohol Use, Abuse and Prevention Information
... o Mescaline: derived from peyote cactus. Ceremonial drug of Native Americans. Generates an LSD effect with some amphetamine properties. Can last 12 hrs. o Psilocybin/Psilocin: psychoactive ingredient in Psilocybe mexicana (magic mushrooms). Acts on the brain for ~2-4 hours. o MDMA (ecstasy)—hallucin ...
... o Mescaline: derived from peyote cactus. Ceremonial drug of Native Americans. Generates an LSD effect with some amphetamine properties. Can last 12 hrs. o Psilocybin/Psilocin: psychoactive ingredient in Psilocybe mexicana (magic mushrooms). Acts on the brain for ~2-4 hours. o MDMA (ecstasy)—hallucin ...
anxiety
... CONCLUSIONS: Benzodiazepine exposure in the elderly increases the risk of hip fractures. This is true even with modest dosage, short-acting agents and short-term exposures. Clinicians should prescribe benzodiazepines judiciously with the elderly to minimize drug-related hip fractures. ...
... CONCLUSIONS: Benzodiazepine exposure in the elderly increases the risk of hip fractures. This is true even with modest dosage, short-acting agents and short-term exposures. Clinicians should prescribe benzodiazepines judiciously with the elderly to minimize drug-related hip fractures. ...
SCHIZOPHRENIA2001
... Clozapine =atypical neuroleptic - improves performance of chronic PCP monkeys in object retrieval task -increases basal dopamine concentration in frontal cortex ...
... Clozapine =atypical neuroleptic - improves performance of chronic PCP monkeys in object retrieval task -increases basal dopamine concentration in frontal cortex ...
The Role of Neuroimaging in Clinical Trials and Drug Discovery In
... et al, 2000). Although clozapine and quetiapine seem to be exceptions, this rule also applies for most of the secondgeneration, 'atypical' antipsychotics (Nyberg et al, 1999). When their doses are raised above a certain threshold, striatal (and potentially extrastriatal) D2 DA occupancy increases to ...
... et al, 2000). Although clozapine and quetiapine seem to be exceptions, this rule also applies for most of the secondgeneration, 'atypical' antipsychotics (Nyberg et al, 1999). When their doses are raised above a certain threshold, striatal (and potentially extrastriatal) D2 DA occupancy increases to ...
Depression
... cause or alleviate symptoms of depression and their known neurochemical effects on monoaminergic transmission in the brain • The monoamine hypothesis of depression suggests that depression is related to a deficiency in the amount or function of cortical and limbic serotonin (5-HT), norepinephrine (N ...
... cause or alleviate symptoms of depression and their known neurochemical effects on monoaminergic transmission in the brain • The monoamine hypothesis of depression suggests that depression is related to a deficiency in the amount or function of cortical and limbic serotonin (5-HT), norepinephrine (N ...
AADC Gene Therapy for Parkinson`s Disease
... a gene, AADC (aromatic amino acid decarboxylase) into the brains of people with moderately advanced Parkinson’s disease. In this study, the AADC gene will be delivered to a specific area of the brain and it may increase dopamine production in the brain. It is the third study of its kind. The study w ...
... a gene, AADC (aromatic amino acid decarboxylase) into the brains of people with moderately advanced Parkinson’s disease. In this study, the AADC gene will be delivered to a specific area of the brain and it may increase dopamine production in the brain. It is the third study of its kind. The study w ...
Drugs acting on digestive system
... cortex, and perhaps secondarily inhibits the hunger center. However, due to the fact that amphetamine refers to the active psychoactive drugs and has a pronounced peripheral sympathomimetic properties when applied arise anxiety, insomnia, tachycardia, increased blood pressure may develop physical dr ...
... cortex, and perhaps secondarily inhibits the hunger center. However, due to the fact that amphetamine refers to the active psychoactive drugs and has a pronounced peripheral sympathomimetic properties when applied arise anxiety, insomnia, tachycardia, increased blood pressure may develop physical dr ...
Biopsychology of Psychiatric Disorders - U
... – Reserpine was known to be a dopamine antagonist (it depleted the brain of dopamine by causing them to leak from their vessicles) – Stimulants, which are agonists of dopamine trigger schizophrenic episodes in healthy subjects at high doses (cocaine psychosis and amphetamine psychosis) ...
... – Reserpine was known to be a dopamine antagonist (it depleted the brain of dopamine by causing them to leak from their vessicles) – Stimulants, which are agonists of dopamine trigger schizophrenic episodes in healthy subjects at high doses (cocaine psychosis and amphetamine psychosis) ...
Using Drugs to Promote Health
... Regardless of whether the medicine you are taking is a prescription or an over the counter drug, you should read all of the warnings and dosage information to ensure that you do not have any unwanted side effects. ...
... Regardless of whether the medicine you are taking is a prescription or an over the counter drug, you should read all of the warnings and dosage information to ensure that you do not have any unwanted side effects. ...
Designer and look
... neurotransmitter (chemical that carries signals between nerve cells) called serotonin. The rise in serotonin levels causes many users to experience changes in mood or mental outlook. Some users report that the drug triggers a feeling of euphoria or exhilaration, along with increased compassion and ...
... neurotransmitter (chemical that carries signals between nerve cells) called serotonin. The rise in serotonin levels causes many users to experience changes in mood or mental outlook. Some users report that the drug triggers a feeling of euphoria or exhilaration, along with increased compassion and ...
The Mechanistic Classification of Addictive Drugs
... Figure 1. The Dominant Targets Involved in Increasing Dopamine for the Major Types of Addictive Drugs G, Gi/o-coupled receptors; i, ionotropic receptors/ion channels; T, monoamine transporters ...
... Figure 1. The Dominant Targets Involved in Increasing Dopamine for the Major Types of Addictive Drugs G, Gi/o-coupled receptors; i, ionotropic receptors/ion channels; T, monoamine transporters ...
Nat Genet
... (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. Analysis of ...
... (ALS). The mRNA targets of TDP-43 in the human brain and its role in RNA processing are largely unknown. Using individual nucleotide-resolution ultraviolet cross-linking and immunoprecipitation (iCLIP), we found that TDP-43 preferentially bound long clusters of UG-rich sequences in vivo. Analysis of ...
Mechanisms of action of antiepileptic drugs
... been proposed that the slow inactivation pathway is more prominent during prolonged depolarisation, as might be expected during epileptiform discharges. Calcium channels. Voltage-gated calcium channels represent another important target for several antiepileptic agents. The efficacy of ethosuximide ...
... been proposed that the slow inactivation pathway is more prominent during prolonged depolarisation, as might be expected during epileptiform discharges. Calcium channels. Voltage-gated calcium channels represent another important target for several antiepileptic agents. The efficacy of ethosuximide ...
A Dual-Mechanism Drug for Vitreoretinal Diseases
... in ophthalmic commercial use; however, that may soon change. Two anti-integrin agents are in US clinical trials for ophthalmic use: lifitegrast (Shire), a compound with the potential to treat ocular surface inflammation that is nearing US Food and Drug Administration (FDA) approval, and ALG-1001 (Lu ...
... in ophthalmic commercial use; however, that may soon change. Two anti-integrin agents are in US clinical trials for ophthalmic use: lifitegrast (Shire), a compound with the potential to treat ocular surface inflammation that is nearing US Food and Drug Administration (FDA) approval, and ALG-1001 (Lu ...
Using Dynamical Systems to Model Human Heading Perception Oliver Layton, PhD
... abundance of approaches to mathematically model the primate brain, few simultaneously incorporate temporal dynamics, make mechanistic predictions about how populations of neurons interact to give rise to behavior, link the activity of neurons to our perceptual experience, and quantatively simulate c ...
... abundance of approaches to mathematically model the primate brain, few simultaneously incorporate temporal dynamics, make mechanistic predictions about how populations of neurons interact to give rise to behavior, link the activity of neurons to our perceptual experience, and quantatively simulate c ...
1 The Neuromuscular Junction: Pharmacology
... 4. Drugs affecting Action: a. Inhibitors (antagonists) This is the main area of neuromuscular synaptic pharmacology. The binding of ACh to its receptors at NMJ epitomises the general equation: A+RARAR*, with the ‘starred’ state of the agonist-receptor (AR) complex corresponding to the open-pore st ...
... 4. Drugs affecting Action: a. Inhibitors (antagonists) This is the main area of neuromuscular synaptic pharmacology. The binding of ACh to its receptors at NMJ epitomises the general equation: A+RARAR*, with the ‘starred’ state of the agonist-receptor (AR) complex corresponding to the open-pore st ...
Interactions, Chronic Effects & Nonspecific Factors
... Types of Tolerance Pharmacodynamic Tolerance decreased NT synthesis Down-regulation of receptors Behavioral Tolerance Volitional vs. Associative Cross Tolerance tolerance to 1 drug also to a 2d e.g., alcohol & phenobarbitol ~ ...
... Types of Tolerance Pharmacodynamic Tolerance decreased NT synthesis Down-regulation of receptors Behavioral Tolerance Volitional vs. Associative Cross Tolerance tolerance to 1 drug also to a 2d e.g., alcohol & phenobarbitol ~ ...
Pharmacology Objectives 5
... 2) Understand the major mechanisms through which genetic variation can alter responses to drugs. The most common type of variation change is a change in a single nucleotide pair termed a single nucleotide polymorphism or SNP. If SNPs occur in the coding region of a gene they can have qualitative eff ...
... 2) Understand the major mechanisms through which genetic variation can alter responses to drugs. The most common type of variation change is a change in a single nucleotide pair termed a single nucleotide polymorphism or SNP. If SNPs occur in the coding region of a gene they can have qualitative eff ...
Central Nervous Stimulants
... Respiratory Stimulants (Analeptics) • Used to antagonize respiratory depression caused by overdosage with CNS depressants; Doxapram • Act on respiratory center in the brain stem as well as on peripheral carotid chemoreceptors to increase the depth and rate of respiration • Doxapram: use/reversal of ...
... Respiratory Stimulants (Analeptics) • Used to antagonize respiratory depression caused by overdosage with CNS depressants; Doxapram • Act on respiratory center in the brain stem as well as on peripheral carotid chemoreceptors to increase the depth and rate of respiration • Doxapram: use/reversal of ...
Document
... • drug X is equally efficacious to drug Y. drug X is more potent than drug Y. both drug X and drug Y produce a 100% response, but drug X reaches that response at a lower dose. Those curves positioned to the left are more potent than those positioned to the right. drug Z is more potent than drug Y, an ...
... • drug X is equally efficacious to drug Y. drug X is more potent than drug Y. both drug X and drug Y produce a 100% response, but drug X reaches that response at a lower dose. Those curves positioned to the left are more potent than those positioned to the right. drug Z is more potent than drug Y, an ...
February 2007 Toxtidbits
... dietary supplements are also often adulterated with other drugs, sometimes containing prescription drugs not listed on the label. Some of these undisclosed drugs can result in toxicity from high doses or drug interactions. Report all cases of suspected adulterated drugs to the Maryland Poison Center ...
... dietary supplements are also often adulterated with other drugs, sometimes containing prescription drugs not listed on the label. Some of these undisclosed drugs can result in toxicity from high doses or drug interactions. Report all cases of suspected adulterated drugs to the Maryland Poison Center ...