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Cocaine`s Actions
Cocaine`s Actions

... • MANY drug approaches have been tried with little success: • Substitute DA agents • Antidepressants (multiple types) • Alternative stimulants • New approaches under development: keep the drug out of the brain • Enhancing metabolic enzymes • Cocaine vaccine – antibody attaches to cocaine making it t ...
Document
Document

... Nomenclature / Drug Names (cont.) Trade Name ...
Marijuana Harmless?
Marijuana Harmless?

... Prescription Opioid Abuse: A First Step to Heroin Use? Prescription opioid pain medications such as Oxycontin and Vicodin can have effects similar to heroin when taken in doses or in ways other than prescribed, and they are currently among the most commonly abused drugs in the United States. Rese ...
Drug Treatment Choice in Older Adults with Urinary Incontinence
Drug Treatment Choice in Older Adults with Urinary Incontinence

... 3 week RCT Comparing Darifenacin, Oxybutynin ER and Placebo ...
Street Drugs - Centegra Health System
Street Drugs - Centegra Health System

... labels “NOT FOR HUMAN CONSUMPTION” but in reality they are marketed purely for human consumption.. The boom of Spice/K2 knockoffs is growing incredibly, with the newer products not even bothering to label their product “NOT FOR HUMAN CONSUMPTION.” Synthetic cannabinoids are a structurally diverse cl ...
Diapro MR Prescribing Information
Diapro MR Prescribing Information

... A transitional period is not generally necessary. A starting dose of 30 mg should be used  and this should be adjusted to suit the patient's blood glucose response, as described  above.   When switching from a hypoglycaemic sulphonylurea with a prolonged half‐life, a  treatment free period of a few  ...
TransMolecular Receives Orphan Drug Designation for 131I
TransMolecular Receives Orphan Drug Designation for 131I

... “The receipt of our third Orphan Drug Designation is a result of our robust regulatory and clinical development strategy for the TM601 tumor-targeting platform,” said Michael Egan, President and Chief Executive Officer of TransMolecular. “We are pleased that this designation represents another step ...
Low efficacy diuretics
Low efficacy diuretics

... Gynecomastia in male and menstrual irregularities in female (similar to sex steroid structures) → acts at receptors in other organs. So it will not be given in large doses on a chronic basis. At low doses, can be used chronically with few side effects. Hyperkalemia, nausea, lethargy and mental confu ...
Discovery of `mini-brains` could change
Discovery of `mini-brains` could change

... "We don't yet know how the system works, but the are an interesting step in advancing scientists' machinery is definitely in place to allow the understanding of the mechanisms underpinning peripheral system to interpret and modify the tactile pain perception. We are committed to supporting informati ...
Barbiturates
Barbiturates

... – Certain barbiturates are also used to induce anesthesia for short surgical procedures or at the beginning of longer ones – Because of the risks associated with barbiturate abuse, and because new and safer drugs such as the benzodiazepines are now available, barbiturates are less frequently prescri ...
4.4 Special warnings and precautions for use
4.4 Special warnings and precautions for use

... Interaction with other medicinal products and other forms of interaction ▪ The pharmacological gastrointestinal effects of lanreotide may reduce the intestinal absorption of co-administered drugs including cyclosporin. Concomitant administration of cyclosporine with lanreotide may decrease the relat ...
Anithypertensive_drugs_and_its_classifications
Anithypertensive_drugs_and_its_classifications

... ◦ amiloride, triamterene ...
Table 1 Cholesterol Med Chart
Table 1 Cholesterol Med Chart

... Avoid in females of childbearing age. If used, discontinue when pregnancy is contemplated. Well tolerated for mild hypercholesterolemia. Simvastatin is the most potent on a milligram basis. ...
Generic Drugs - CN Pensioners` Association
Generic Drugs - CN Pensioners` Association

... brand name product. Generic drugs contain the same active medicinal ingredient and are considered therapeutically equivalent to the brand name product although they may differ in shape and colour when compared to the brand name product. The most important thing to know is that the active ingredients ...
Effects of the putative dopamine D receptor antagonist PNU 99194A
Effects of the putative dopamine D receptor antagonist PNU 99194A

... potential role of this receptor subtype in mediating emotional behavior. Previous studies in habituated rats have shown that the putative dopamine D 3 receptor antagonist 5,6-dimethoxy-2-Ždi-n-propylamino.indan ŽPNU 99194A. increased locomotor behavior. The present study examined the effects PNU 991 ...
Narcotics
Narcotics

... that dulled the senses and relieved pain. term originally applied to all compounds that produce insensibility to external stimuli through depression of the central nervous system, but now applied primarily to the drugs known as opiates— compounds extracted from the opium poppy and their chemical der ...
LSD
LSD

... The physical effects include dilated pupils, higher body temperature, increased heart rate and blood pressure, sweating, loss of appetite, sleeplessness, dry mouth, and tremors. Sensations may seem to "cross over" for the user, giving the feeling of hearing colors and seeing sounds. If taken in a la ...
Drug Interactions
Drug Interactions

... Drug Interactions at Excretion Level The renal excretion of active drug can also be affected by concurrent drug therapy.  The renal excretion of certain drugs that are weak acids or weak bases may be influenced by other drugs that affect urinary pH.  This is due to changes in ionization of the dr ...
Document
Document

...  Alters the activity of chemical messengers, which enable nerve cells in the brain to communicate with one another.  It interferes with the body’s ability to control its temperature (severe medical consequences, death).  Contains a number of other harmful drugs in it (caffeine, cough suppressants ...
Drug Development Process
Drug Development Process

... defraud in drug misbranding cases (fraudulent claims). • Provided standards and safe tolerances. • Authorized factory inspections. ...
Jay Williams, PhD`s Blog
Jay Williams, PhD`s Blog

... At the 2014 annual meeting of the American College of Gastroenterologists, Dr. James Ehrlich presented data proving that 38% BPF significantly improved liver structure and function in patients with both metabolic syndrome and fatty liver disease. The study involved authors from 3 continents and was ...
Dopamine D1-like Receptors and Reward-related
Dopamine D1-like Receptors and Reward-related

... In the above studies, reporting that SCH 23390 blocked place conditioning, control experiments showed that the same doses of SCH 23390 given alone did not produce a place aversion. However, a number of studies have found that SCH 23390 or the D1-like antagonist A69024, at some doses, can produce a p ...
456 PHG
456 PHG

... B- Biologics related to human food e.g., human albumin, anti-heamophilic factor. ...
Drug interaction of plasma protein binding
Drug interaction of plasma protein binding

... Adverse reactions Dangerous factors: ...
No Slide Title
No Slide Title

... Gabapentin (Neurontin) • Binds to Gabapentin-binding protein • Blocks calcium channels • Increases GABA synthesis ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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