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Clinical Implications of Chirality and Stereochemistry in
Clinical Implications of Chirality and Stereochemistry in

... suggest that dexmethylphenidate has similar or slightly greater efficacy than methylphenidate in attention-deficit/hyperactivity disorder (ADHD), with a lower propensity for adverse effects and can be given in half the dosage of racemic methylphenidate. Amphetamine products are available as dextroam ...
No Slide Title
No Slide Title

... at a time. The shape of the suppository ensures that it will stay in the rectal orifice in direct contact with the hemorrhoid. The mold also features an air vent for each suppository, enabling the dosage form to stay in the body for up to six hours. The air vent is created using a removable metal pl ...
IntelGenx Technologies Corp. (Form: 8-K, Received
IntelGenx Technologies Corp. (Form: 8-K, Received

... Institute of Molecular Regenerative Medicine at the Paracelsus Medical University in Salzburg, Austria. Dr. Aigner has made major contributions in the field of brain and spinal cord regeneration over the last 25 years. He was the first to develop tools to visualize neurogenesis in living animals and ...
Rexulti (b
Rexulti (b

... Rexulti pregnancy exposure registry: Monitors pregnancy outcomes in women exposed to brexpiprazole during pregnancy; for more information contact the National Pregnancy Registry for Atypical Antipsychotics at 1-866-961-2388 or visit http://womensmentalhealth.org/clinical-and-researchprograms/pregnan ...
as a PDF
as a PDF

... been found after long-term treatment with various antidepressants 3°. These findings have led to the suggestion that an excess of 5-HT at some receptors, probably the 5-HT 2 type, could be involved in depressive illness. The 5-HT1A agonist 8-OH-DPAT has been found to selectively reduce brain 5-HT sy ...
Barbiturates (ex. phenobarbital)
Barbiturates (ex. phenobarbital)

...  Opiates bind to specific receptors (mu, kappa, delta and sigma) found throughout the body but notably in the brain, spinal cord and GI tract  Mu receptor activation:   pain (analgesia)   CNS dopamine action which produces a state of euphoria and relaxation ...
The Medical Effects Of Marijuana On the Brain
The Medical Effects Of Marijuana On the Brain

... Until 1988, when specific cannabinoid receptors were found in the brain, the mode of cannabinoid action in the human body was not at all clear. There was little biochemical or neurological proof to link these type of behavioral disorders with the actions of specific mechanisms. Pharmaceuticals that ...
73 Post-polio syndrome and amyotrophic lateral sclerosis
73 Post-polio syndrome and amyotrophic lateral sclerosis

... u Inflammatory B cells infiltrates, often perivascular u Neuronal inclusions are not typical features, spheroids were seen occasionally (3) The main pathology is similar to late period of poliomyelitis ...
slides - ISCTM
slides - ISCTM

Acute dystonia with concomitant use of amitriptyline and paroxetine
Acute dystonia with concomitant use of amitriptyline and paroxetine

... of angle of mouth, slurring of speech, and up rolling of eyeballs for last two days and admitted in the critical care unit. She was diagnosed as major depressive disorder before three years and on regular treatment from psychiatry unit as per the informant and available records. She was receiving pa ...
Pharmacokinetics (Excretion of Drugs and factors affecting Excretion
Pharmacokinetics (Excretion of Drugs and factors affecting Excretion

... • Hair ...
Pain Management clinical protocol MMC.docx
Pain Management clinical protocol MMC.docx

... Murray Medical Centre Mandurah will adopt the following guidelines from the RACGP: 1. Medical Care of older persons in Residential Aged Care facilities: pain management. NOTE: References to the prescription and administration of Schedule 8 medication in any of these protocols are outside the scope o ...
November Newsletter
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... Abbott Laboratories and FDA notified healthcare professionals and patients about the voluntary withdrawal of Meridia (Sibutramine), an obesity drug, from the market because of clinical trial data indicating an increased risk of heart attack and stroke, after reviewing the data from the Sibutramine C ...
Chapter 16 Cholinesterase Inhibitors
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... Increase the activity of CNS neurons Enhance neuronal excitation; a few suppress neuronal inhibition In sufficient doses, all can cause convulsions Limited clinical applications ...
Inhibitors of angiotensin
Inhibitors of angiotensin

... of the cardiac output and the peripheral vascular resistance • BP is maintained by moment-to-moment regulation of cardiac output and peripheral vascular resistance, exerted at four anatomic sites: arterioles, postcapillary venules (capacitance vessels), heart, & the kidney ...
Glutamine: Ubiquitous and Overlooked
Glutamine: Ubiquitous and Overlooked

... for a long time. The brain's major excitatory neurotransmitter, this simple amino acid is responsible for nearly half of all brain activity. Neurologists learned to understand it as the culprit in traumatic brain disease many years ago, when it was realized that much of the damage done to the brain ...
Drugs used in Hypertension
Drugs used in Hypertension

... • The loss of HCO3-  metabolic acidosis  the effects of the drug becomes self-limiting as the [HCO3-]blood falls. • The incr Na+ delivery to the distal nephron incr K+ secretion. • Acetazolamide used to treat glaucoma to decr intraocular P (decr the secretion of HCO3- and assoc H2O into the AH. ...
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09. antiamoebic drug..

... Luminal amoebicides ...
HypertenDiur
HypertenDiur

... • The loss of HCO3-  metabolic acidosis  the effects of the drug becomes self-limiting as the [HCO3-]blood falls. • The incr Na+ delivery to the distal nephron incr K+ secretion. • Acetazolamide used to treat glaucoma to decr intraocular P (decr the secretion of HCO3- and assoc H2O into the AH. ...
RAYMOND GEORGE RESEARCH SYNOPSIS
RAYMOND GEORGE RESEARCH SYNOPSIS

... The laboratory is on track to an Investigational New Drug (IND) Application regarding novel drug(s) that target brain serotonin receptors for treatment of neuropsychiatric disorders, including, autism spectrum disorder, obsessive-compulsive disorders (binge eating, attention deficit-hyperactivity di ...
Management of overdose and poisoning
Management of overdose and poisoning

... I.V. (preferred), I.M., intratracheal, SubQ: 0.4-2 mg every 2-3 minutes as needed Lower doses in opiate dependence Elimination half-life of naloxone is only 60 to 90 minutes ...
Levsin Tablet PI RA - Meda Pharmaceuticals
Levsin Tablet PI RA - Meda Pharmaceuticals

... Levsin® inhibits specifically the actions of acetylcholine on structures innervated by postganglionic cholinergic nerves and on smooth muscles that respond to acetylcholine but lack cholinergic innervation. These peripheral cholinergic receptors are present in the autonomic effector cells of the smo ...
Zofran (Ondansetron)
Zofran (Ondansetron)

... • You are treating a 6 y/o child with nausea and vomiting. The patients weight is 40 lbs. What would the appropriate dose of Zofran be for this child? ...
Pharmacology - Pemberton Counseling
Pharmacology - Pemberton Counseling

... Contraindicated in in patients with hypertension, hyperthyroidism, cardiac disease or glaucoma. It is not recommended for psychotic patients ot patients with a history of substance abuse. ...
Epinephrine
Epinephrine

... Methodology and Rationale 1. Apex of turtle’s heart was attached to a kymograph set up 2. Baseline rate and amplitude were obtained for 1 minute. 3. Drugs were directly instilled to the heart muscle (1 mL in 1 minute). 4. Rate and amplitude of contraction were recorded for three minutes ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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