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Serotonin syndrome - Exeter Headache Clinic
Serotonin syndrome - Exeter Headache Clinic

... were lost to follow-up, 10 patients failed to achieve 50% reduction, 6 stopped because of side-effects and 3 withdrew. DVP-26/51(51%) of patients had greater than 50% reduction.8 were lost to follow-up, 3 failed to achieve a 50% reduction and 10 stopped due to side-effects and 4 withdrew. From this ...
Prion Diseases - Winona State University
Prion Diseases - Winona State University

... Disease causing prion is a modified form of a normal cellular protein known as PrPc. This normal form is protease sensitive so it does not accumulate. The modified prion is known as PrPsc (for scrapie) which is relatively resistant to proteases and accumulates in cytoplasmic vesicles of diseased ind ...
T HE   C HE MIS T R Y ... IS CHOCOLATE AN APHRODISIAC?
T HE C HE MIS T R Y ... IS CHOCOLATE AN APHRODISIAC?

... T HE C HE MIS T R Y OF C HO C OL AT E IS CHOCOLATE AN APHRODISIAC? NH2 ...
Bath Salts - Commonwealth Prevention Alliance
Bath Salts - Commonwealth Prevention Alliance

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introduction to drug discovery
introduction to drug discovery

Abstinence-based treatment
Abstinence-based treatment

... Category: Health issues and physiology Definition: The term addiction does not appear in the diagnostic criteria of substance abuse problems outlined by the American Psychiatric Association, in part because of the concern that words like addiction and addict are pejorative and could result in unnece ...
5-Antifungal Chemotherapy
5-Antifungal Chemotherapy

... Exploring Mech. of Resistance from Mech. of Actions • A gene coding an enzyme that synthesizes a particular fungal cell wall polysaccharide is mutated. A fungal pathogen might, in this way, develop resistance to which of the following agents? • A fungal pathogen has been found accumulating low ergo ...
Substance Classifications, Effects, and Associated
Substance Classifications, Effects, and Associated

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Developmental and Pathophysiological Studies of Vestibular
Developmental and Pathophysiological Studies of Vestibular

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Pharmacological Evidence of Hypotensive Activity of Somina
Pharmacological Evidence of Hypotensive Activity of Somina

... blood pressure, diastolic blood pressure and mean arterial pressure in normotensive rats. Literature has shown that agents lower blood pressure by interfering either the inhibition of the sympathetic nervous system which decrease the arterial pressure [11] or parasympathetic stimulation results in h ...
NUH list of critical drugs which should not be omitted or delayed
NUH list of critical drugs which should not be omitted or delayed

... To make sure that drugs are most effective and to prevent patients from suffering harm, it is important for some drugs to be administered at specific times. The following list of drugs are considered critical and must never be omitted or delayed without a clinical reason which has been discussed wit ...
Simon Zheng - A Critical Review of Natural Language Processing Approaches to Discovering Drug-Drug Interactions from Medical Literatur
Simon Zheng - A Critical Review of Natural Language Processing Approaches to Discovering Drug-Drug Interactions from Medical Literatur

... set to score three times that many randomly chosen drug-gene relationships. Each relationship was scored leaving out knowledge of the relationship during training. In performing this external validation, Pharmspresso found many relationships that do not appear in PharmGKB but had high scores from t ...
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Pharmacology and Clinical Pharmacology
Pharmacology and Clinical Pharmacology

... particular interest in cannabinoid receptors, their signalling interactions with other GPCRs and their contribution to neuroprotection or neurodegeneration in diseases such as Huntington’s disease. Our work focuses on using cell models to understand receptor signalling and cross talk, as well as uti ...
Section-20 - Cowmedical
Section-20 - Cowmedical

... matter it is known as polioencephalomalacia while necrosis of neurons in white matter is called as leukoencephalomalacia. There are three types of scavenger cells in nervous system known as microglial, oligodendroglial and astrocytes. Microlial cells surround the necrotic neurons and are known as sa ...
Step 2. Transfection of plasmid into human neuronal cells
Step 2. Transfection of plasmid into human neuronal cells

... Confirm enzyme function by screening for 5-HTP protein using western blotting using 5-HTP antibody (ab8890, Abcam) ...
Ch. 5 - Quia
Ch. 5 - Quia

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new recreational drug use
new recreational drug use

... Structurally related to the psychostimulant metamfetamine and the hallucinogen mescaline (figure 1), MDMA produces a mixture of stimulant and mild psychedelic effects. In the developed world, use of the compound is increasing at a rate higher than that of most other recreational drugs.5,6 With colle ...
Calcium channel blockers and drug interactions
Calcium channel blockers and drug interactions

... should be used with caution in patients with impaired renal or hepatic function. Any drug that affects hepatic Row will undoubtedly alter the half-life and pharmacokinetics of the calcium blockers. A classic example of a drug that decreases blood flow to the liver is cimetidine. Since both cimetidin ...
Misuse of amphetamines and related drugs
Misuse of amphetamines and related drugs

... This article discusses the misuse of drugs which act as stimulants, an effect mainly produced by enhancement of the central transmission of catecholamines, particularly dopamine. Stimulant misuse is extremely widespread in the UK and elsewhere, but primary users of such drugs present relatively rare ...
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Adverse effects

... or heavier, with more or less time in between – Hot flashes and/or night sweats – Trouble sleeping – Vaginal dryness – Mood swings – Trouble focusing – Less hair on head, more on face ...
Epilepsy 101: Getting Started
Epilepsy 101: Getting Started

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Nicotine: The Brain and Body Background Information
Nicotine: The Brain and Body Background Information

What`s New on the Streets
What`s New on the Streets

... first time it seems possible to “overdose” on cannabis. While still not lethal, taking more than your personal limit of dabs can lead to uncomfortable highs and, in some cases, passing out. After all of the chanting that “you can’t overdose on marijuana,” concentrates could be undermining advocates’ ...
In vivo and in vitro metabolism studies of glaucine, a new
In vivo and in vitro metabolism studies of glaucine, a new

... human main phase I metabolites in vitro, to identify the involved CYP isoenzyme using heterologically expressed single CYPs, to determine the Michaelis-Menten constants Km, and Vmax in human liver microsomes, and finally, to investigate the detectability by the authors standard urine screening appro ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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