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- Experimental Neurobiology
- Experimental Neurobiology

... the wrong time or in the wrong place. Involvement of genetic and environmental factors in the onset of depression was investigated in relation to epigenetics. When mice with the disrupted in schizophrenia 1 (DISC1) abnormal gene received isolated rearing stress, depression-like abnormal behaviors an ...
Basic Concepts in Medicinal Chemistry - Review
Basic Concepts in Medicinal Chemistry - Review

... heterocyclic rings, the designation of aromatic ring positions and steroid nomenclature, while the second chapter focuses on the chemical characteristics of functional groups and the roles they play in drug action. The following chapters identify those functional groups that are acidic or basic, rev ...
Antiparasitic Agents
Antiparasitic Agents

... Pentamidine was originally developed as an antitrypanosomal drug. It is the safest of the diamidine group of antiprotozoals although it still has significant toxicity. The mechanism is unclear, but in trypanosomes it appears to bind to DNA. II. USES a.) Treatment and prophylaxis (aerosolized form) o ...
PDF
PDF

Combination therapy for HYPERTENSION
Combination therapy for HYPERTENSION

... formulations have however been widely used in the treatment of other conditions such as Parkinson’s disease or bacterial infection. The use of multiple drug classes has also been widely accepted in the management of other chronic conditions such as angina, which resulted in a renewed interest in the ...
assembly committee on public safety
assembly committee on public safety

... effects of alcohol. Certain generalizations can be made: high doses generally have a larger effect than small doses; well-learned tasks are less affected than novel tasks; and certain variables, such as prior exposure to a drug, can either reduce or accentuate expected effects, depending on circumst ...
Hypertension - Webstercare
Hypertension - Webstercare

... likely to contribute to varying degrees in these effects. Multiple medications may allow lower doses of each drug and minimise these adverse effects. Lower body weight and frailty increase the risk of these side effects. Sartans are generally used in people who cannot tolerate the persistent dry cou ...
U4C3L1 - lecjrotc
U4C3L1 - lecjrotc

... Think about the word drug for a moment. It can bring many images to mind from over-the-counter aspirin to stop a headache, a news report about someone who was arrested for cocaine possession, a prescription for antibiotics from your doctor, a drug-related death covered on the front page of the paper ...
Medication Assisted Treatment in Adolescents
Medication Assisted Treatment in Adolescents

...  Efficacy v. Effectiveness  Thus far, none approved for cannabis or stimulants ...
MORPHINE
MORPHINE

... until 1925. It is a narcotic which numbs senses, reduces pain, and induces sleep. Pharmacology and Metabolism ...
Oscar-Della-Pasqua-P..
Oscar-Della-Pasqua-P..

... per group and dose level) for paediatric patients with supraventricular tachycardia. Lines indicate 50% and more than 95% efficacy. (B) Patient fraction with 50% and more than 95% probability of arrhythmia suppression. Arrows indicate start and target doses. ...
Full U.S. Prescribing Information
Full U.S. Prescribing Information

... and DOSAGE AND ADMINISTRATION), it is important to use the lowest possible effective dose. Elderly patients are especially at risk. Some of these changes may be characterized by decreased inhibition, e.g., aggressiveness and extroversion that seem out of character, similar to that seen with alcohol. ...
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets
Serex Film Coated Tablets 25-100-200-300 mg, 30 tablets

... As in with other antipsychotics, quetiapine also should be used carefully in patients that have seizures or potential to decrease the seizure threshold like Alzheimer’s disease. In clinic studies performed with quetiapine, approximately 20 % reduction was observed in total and free thyroxin levels ( ...
Bio-Diuretic - MBi Nutraceuticals
Bio-Diuretic - MBi Nutraceuticals

... bowels by adding undigested fiber to fecal bulk. This nutrient-dense herb contains a variety of constituents, including potassium, fiber, vitamin B6, vitamin A, vitamin C, and thiamin, and is also high in folic acid, which is essential for the body to produce new red blood cells. Camellia Sinensis, ...
Aerosols
Aerosols

... while insulin dry powder inhaler is presently in the final stages of development and submitted to the Food and Drug Administration for review. ...
Pharmacists and Medical Malpractice
Pharmacists and Medical Malpractice

... dispensed Prostin suppositories believing it was the same drug. Tragically, Prostin is a cervical ripening agent which is sometimes used for abortion procedures and which provides the complete opposite clinical effect of the drug that was ordered. The labor and delivery nurse did not identify the er ...
Drug Shortage
Drug Shortage

... – Importation—very controversial – Biologics—ASHP is working to change that ...
Drugs of Abuse: Marijuana/Cannabis
Drugs of Abuse: Marijuana/Cannabis

... and refilled with marijuana, sometimes in combination with another drug. Marijuana is also mixed with foods or brewed as a tea. What is its effect on the mind? When marijuana is smoked, the THC passes from the lungs and into the bloodstream, which carries the chemical to the organs throughout the bo ...
Instructions for the Medical Use of Arbidol
Instructions for the Medical Use of Arbidol

... children 2 – 6, 50 mg; children 6 –12, 100 mg; children over 12 – adult, 200 mg 48 hours before the procedure, then from 2 to 5 days after the procedure. For treatment of illness: For influenza, or other uncomplicated RSV, children 2 – 6, 50 mg; children 6 – 12, 100 mg, and children over 12 and adul ...
Eating disorders - Royal Society of Chemistry
Eating disorders - Royal Society of Chemistry

... the mid-1960s, LSD and other psychedelics were being used as recreational drugs, triggering a regulatory backlash. In 1965, a law was passed in the US making it illegal to manufacture, compound, process or sell any hallucinogenic drugs. Medical research was eligible for a permit excluding it from th ...
Alprazolam - Drs. Foster and Smith
Alprazolam - Drs. Foster and Smith

... Not for use in animals who are hypersensitive (allergic) to it or other benzodiazepine medications such as diazepam (Valium). ...
The Translational Research Cycle – Example in Infectious Diseases
The Translational Research Cycle – Example in Infectious Diseases

... but does not activate, a nuclear receptor called the ‘Pregnane X-Receptor’ (PXR, also called SXR or NR1I2). SFN appeared to tightly, perhaps irreversibly, bind to the ligand binding site of the receptor, thus preventing other ligands from binding and activating the receptor. Ligand activation of PXR ...
From Morphine to Methadone: Maintenance Drugs in The Treatment
From Morphine to Methadone: Maintenance Drugs in The Treatment

... individual and society than drug use.or addicti
PMB Dept of Internal medicine : Presentation: ARV Therapy
PMB Dept of Internal medicine : Presentation: ARV Therapy

... Drug interactions are complex, and clinically important – More than two simultaneous non-linear bidirectional drug-drug interactions are more than hard to predict, and may be managed empirically or avoided – PI’s are all CYP450 3A4 substrate, blocker and inducers to different degrees • Ritonavir is ...
Parkinson`s Medications
Parkinson`s Medications

... What are the side effects of Parkinson’s drugs? The most common reactions (which occur within the first several days of a new treatment) include nausea, vomiting, dizziness (drop in blood pressure), sleepiness and visual hallucinations. In the last few years, levodopa and dopamine agonists in partic ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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