Structure-based drug design - Biomolecular Structure Center
... how a new compound will change the delicate balance of all metabolic, transport and signalling pathways in the human body is simply impossible, no matter how much pharmacological and toxicological knowhow has been invested in tailoring of the compound for use in humans. Hence, many promising compoun ...
... how a new compound will change the delicate balance of all metabolic, transport and signalling pathways in the human body is simply impossible, no matter how much pharmacological and toxicological knowhow has been invested in tailoring of the compound for use in humans. Hence, many promising compoun ...
antibiotics
... In order to be selectively toxic, a chemotherapeutic agent must interact with some microbial function or microbial structure that is either not present or is substantially different from that of the host. In treating infections caused by prokaryotic bacteria, the agent may inhibit peptidoglycan synt ...
... In order to be selectively toxic, a chemotherapeutic agent must interact with some microbial function or microbial structure that is either not present or is substantially different from that of the host. In treating infections caused by prokaryotic bacteria, the agent may inhibit peptidoglycan synt ...
The Basics of Alzheimer`s Disease
... Signs and Symptoms Memory problems are typically one of the first signs of cognitive impairment related to Alzheimer’s disease. Some people with memory problems have a condition called mild cognitive impairment (MCI). In MCI, people have more memory problems than normal for their age, but their sym ...
... Signs and Symptoms Memory problems are typically one of the first signs of cognitive impairment related to Alzheimer’s disease. Some people with memory problems have a condition called mild cognitive impairment (MCI). In MCI, people have more memory problems than normal for their age, but their sym ...
Serotonergic Modulation of Inspiratory Hypoglossal Motoneurons in
... and depression of hypoglossal activity are closely linked. Increased levels of 5-HT are released during wakefulness, when raphe neurons are active, and may increase HMN activity, whereas withdrawal of 5-HT, in particular during REM sleep when raphe neurons are inactive, may decrease HMN activity. Th ...
... and depression of hypoglossal activity are closely linked. Increased levels of 5-HT are released during wakefulness, when raphe neurons are active, and may increase HMN activity, whereas withdrawal of 5-HT, in particular during REM sleep when raphe neurons are inactive, may decrease HMN activity. Th ...
Breakthrough Seizures—Approach to Prevention
... there are many potential concerns with doing this, largely around the topic of bioequivalence. Generic agents need to fall within a range of equivalence of 80–125% to the branded version before they receive US Food and Drug Administration (FDA) approval, and the substitution of a branded medication ...
... there are many potential concerns with doing this, largely around the topic of bioequivalence. Generic agents need to fall within a range of equivalence of 80–125% to the branded version before they receive US Food and Drug Administration (FDA) approval, and the substitution of a branded medication ...
Adverse Effects
... taken twice daily was compared with oral erythromycin 250 mg four times a day for 7 to 14 days.The most frequently isolated organisms were S. aureus and S. pyogenes • Clinical success was seen in 96% of the clarithromycin-treated patients compared with 94% in erythromycin-treated patients ...
... taken twice daily was compared with oral erythromycin 250 mg four times a day for 7 to 14 days.The most frequently isolated organisms were S. aureus and S. pyogenes • Clinical success was seen in 96% of the clarithromycin-treated patients compared with 94% in erythromycin-treated patients ...
Behavioral and psychological disturbances in Alzheimer disease
... patients prescribed atypical neuroleptics had a 1.6 greater death rate than those taking placebos. They also reminded physicians that quetiapine and olanzapine are not approved for treating behavioral disorders in elderly patients with dementia. Risperidone is approved for the short-term treatment ...
... patients prescribed atypical neuroleptics had a 1.6 greater death rate than those taking placebos. They also reminded physicians that quetiapine and olanzapine are not approved for treating behavioral disorders in elderly patients with dementia. Risperidone is approved for the short-term treatment ...
Antidepressants
... Understand the Pain Processing Loop (pre-synaptic, post synaptic dorsal horn neurons and decending pain control pathways ...
... Understand the Pain Processing Loop (pre-synaptic, post synaptic dorsal horn neurons and decending pain control pathways ...
Pharmacology of Muscarinic Receptor Blockade
... Therapeutic Uses of Muscarinic Antagonists (5) • Posioning by inhibitors of acetylcholinesterase • Mushroom poisoning due to muscarine • In conjunction with inhibitors of acetylcholinesterase when they are used to promote recovery from neuromuscular blockade after surgery • Injudicious use of choli ...
... Therapeutic Uses of Muscarinic Antagonists (5) • Posioning by inhibitors of acetylcholinesterase • Mushroom poisoning due to muscarine • In conjunction with inhibitors of acetylcholinesterase when they are used to promote recovery from neuromuscular blockade after surgery • Injudicious use of choli ...
Intranasal delivery bypasses the blood
... (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic administration ...
... (BBB) to deliver therapeutic agents to the brain and spinal cord. This technology allows drugs that do not cross the BBB to be delivered to the central nervous system within minutes. It also directly delivers drugs that do cross the BBB to the brain, eliminating the need for systemic administration ...
Memorandum 1 18 4 '03 MAR 13 PC48 s.
... Department ofPharmaceutical Technology, Jadavpur University after a prolonged and rigorous R&D spanning more than 7 years. During the research work, very large base of pre-clinical studies and post-clinical observations were carried out to reveal non-toxic effect of the medicine with high therapeuti ...
... Department ofPharmaceutical Technology, Jadavpur University after a prolonged and rigorous R&D spanning more than 7 years. During the research work, very large base of pre-clinical studies and post-clinical observations were carried out to reveal non-toxic effect of the medicine with high therapeuti ...
Cardiovascular Expert Questions
... Jugular venous distension, hepatojugular reflux and peripheral edema s/o right sided CCF. Investigations Electrocardiography Published consensus guidelines establish a goal that the initial 12-lead ECG be obtained and integrated within 10 min of presentation for patients with acute chest pain or o ...
... Jugular venous distension, hepatojugular reflux and peripheral edema s/o right sided CCF. Investigations Electrocardiography Published consensus guidelines establish a goal that the initial 12-lead ECG be obtained and integrated within 10 min of presentation for patients with acute chest pain or o ...
Treatment for uterine fibroids: Searching for effective drug therapies
... at N1 plays a very important role in binding potency and increasing the number of alkyl chains in this substituent group from methyl to ethyl or isopropyl (8) improved the binding affinity 7- and 5-fold, respectively. The functional activities follow this same trend. Mifepristone is a 19-nortestoste ...
... at N1 plays a very important role in binding potency and increasing the number of alkyl chains in this substituent group from methyl to ethyl or isopropyl (8) improved the binding affinity 7- and 5-fold, respectively. The functional activities follow this same trend. Mifepristone is a 19-nortestoste ...
Mechanism of Action
... Treatment of drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. As an OTC hypnotic Minimal gastrointestinal side effects ...
... Treatment of drug-induced extrapyramidal symptoms as well as to treat mild cases of Parkinson's disease. As an OTC hypnotic Minimal gastrointestinal side effects ...
Extended-Release Injectable Parasiticide 5% Sterile
... The macrocyclic lactones have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels that are present in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions ...
... The macrocyclic lactones have a unique mode of action. Compounds of this class bind selectively and with high affinity to glutamate-gated chloride ion channels that are present in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions ...
ESTIMATION AND VALIDATION OF STABILITY INDICATING UV SPECTROPHOTOMETRIC
... Objective: The objective of present study is to develop and validate stability indicating method to generate reliable and accurate data regardless of whether it is for acceptance, release, stability or pharmacokinetic study. Method: The UV spectrum was scanned between 200 to 400 nm and 273 nm was se ...
... Objective: The objective of present study is to develop and validate stability indicating method to generate reliable and accurate data regardless of whether it is for acceptance, release, stability or pharmacokinetic study. Method: The UV spectrum was scanned between 200 to 400 nm and 273 nm was se ...
Antibody-Drug Conjugates (ADCs) – Biotherapeutic bullets
... The critical factor in the manufacture of ADCs is choosing the right linker to attach the cytotoxic drug to the MAb (37,38). Currently, the development of linker technology is central to biopharma ADC programmes, with the main emphasis on targeting cancer cells. Incorporating the right linker will i ...
... The critical factor in the manufacture of ADCs is choosing the right linker to attach the cytotoxic drug to the MAb (37,38). Currently, the development of linker technology is central to biopharma ADC programmes, with the main emphasis on targeting cancer cells. Incorporating the right linker will i ...
Print PDF - CiplaMed
... Citicoline has been investigated as a therapy for stroke patients. Three mechanisms are postulated: (1) ability to repair neuronal membranes via increased synthesis of phosphatidylcholine; (2) repair of damaged cholinergic neurons via potentiation of acetylcholine production; and, (3) reduction of f ...
... Citicoline has been investigated as a therapy for stroke patients. Three mechanisms are postulated: (1) ability to repair neuronal membranes via increased synthesis of phosphatidylcholine; (2) repair of damaged cholinergic neurons via potentiation of acetylcholine production; and, (3) reduction of f ...
Evalulation of Azelaic Acid for Non
... Disease State Classification • Defined by American Academy of Dermatology – Mild Acne • A few to several papules or pustules ...
... Disease State Classification • Defined by American Academy of Dermatology – Mild Acne • A few to several papules or pustules ...
... The Plegridy Pen Injector provides Peginterferon beta-la, which is one of the new disease modifying drugs approved by the Food and Drug Administration (FDA) in 2014 for the treatment of RRMS. Peginterferon beta-la is a drug that belongs to the same interferon class as several medications that have b ...
Research Chemicals - KFx Drug Consultancy Initiative
... and it was dubbed “mephedrone.” Again this wasn’t a standardized name. It’s just some people involved in the drug thought the name was a fair summary of the drugs structure and name and it stuck. Others thought it was a lousy name, and argued, unheeded for more “accurate” names, such as 4MMC were su ...
... and it was dubbed “mephedrone.” Again this wasn’t a standardized name. It’s just some people involved in the drug thought the name was a fair summary of the drugs structure and name and it stuck. Others thought it was a lousy name, and argued, unheeded for more “accurate” names, such as 4MMC were su ...
Inhibition of Human Aldehyde Oxidase Activity by Diet
... new chemical entities, leading to an increased number of AO drug substrates during drug development (Pryde et al., 2010; Hutzler et al., 2013). In parallel with increasing candidate AO substrates is an impetus to identify AO inhibitors, elucidate the mechanism of inhibition, and understand clinical ...
... new chemical entities, leading to an increased number of AO drug substrates during drug development (Pryde et al., 2010; Hutzler et al., 2013). In parallel with increasing candidate AO substrates is an impetus to identify AO inhibitors, elucidate the mechanism of inhibition, and understand clinical ...
Blue Shield Reference Guide
... Home delivery service is a standard component of our prescription drug benefit. Members may call the Member Service telephone number on their identification card to obtain a home delivery order form. Advantages of using the home delivery service Members may prefer to use the home delivery prescripti ...
... Home delivery service is a standard component of our prescription drug benefit. Members may call the Member Service telephone number on their identification card to obtain a home delivery order form. Advantages of using the home delivery service Members may prefer to use the home delivery prescripti ...