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Psychoactive substance = any substance that has an effect on the
Psychoactive substance = any substance that has an effect on the

... substance and features disturbances of consciousness, perception, mood, behaviour, and physiological functions Substance withdrawal = substance-specific syndrome that occurs on reduction or cessation of substance that has usually been used repeatedly in high doses, for a prolonged period (one of cri ...
PPT, 6.99MB
PPT, 6.99MB

... and in urgent situations is given orally as a loading dose of 300 mg followed by maintenance dosing of 75 mg once daily. • It is a prodrug and is converted into its active sulfhydryl metabolite by CYP enzymes in the liver including CYP2C19. • Poor metabolisers are at increased risk of therapeutic fa ...
testosterone
testosterone

... a. What’s the primary use of diuretics in medicine today? a. Control of high blood pressure. Many patients, especially over the age of 50, need blood pressure control and diuretic agents are usually looked to first by physicians. b. Dr. Pillion looks at the kidney as a river system that flows down t ...
Trichiuris trichiura
Trichiuris trichiura

...  increase colonic phase segmenting activity > prolongs transit time of fecal mass → allows more time for absorption of water and electrolytes from the intestinal lumen  decrease mass colonic movements  decrease the gastrocolic reflex Disadvantage: dependence when used for prolonged periods ...
Rozerem - Takeda
Rozerem - Takeda

... The data described in this section reflect exposure to ROZEREM in 5373 subjects, including 722 exposed for 6 months or longer, and 448 subjects for one year. Six percent of the 5373 individual subjects exposed to ROZEREM in clinical studies discontinued treatment owing to an adverse event, compared ...
Title 17-A - Maine Legislature
Title 17-A - Maine Legislature

... reflects changes made through the Second Regular Session of the 127th Maine Legislature and is current through October 1, 2016. The text is subject to change without notice. It is a version that has not been officially certified by the Secretary of State. Refer to the Maine Revised Statutes Annotate ...
Drugs Hanson 7 - Lackawanna College
Drugs Hanson 7 - Lackawanna College

... Alcohol as a Drug (continued) • Alcohol is an addictive substance. Of the approximately 2 million receiving treatment for drug abuse, 64% are being treated for alcoholism. • Social psychologists refer to the perception of alcohol as a social lubricant. • Four reasons why many people view alcohol as ...
THC - Department of Psychology
THC - Department of Psychology

... Budder: Processed hashish oil that is reported as being anywhere between 82-100% THC. ...
Structure-based drug design strategies in medicinal
Structure-based drug design strategies in medicinal

... Hits can be identified through the docking of smallmolecule ligands (selected from databases of chemical structures) into protein active sites or by using receptorbased pharmacophore models. Furthermore, drug candidates can be designed de novo by improving the complementary binding properties of lea ...
Vasoconstrictors: Myths and Realities
Vasoconstrictors: Myths and Realities

... homeostasis within the affected cells. Beta-blocker tachyphylaxis involves binding and stabilizing receptors, as well as inhibiting a cell’s ability to remove receptors from its surface.5 As early as 1946, there were reports of the adverse rebound effects of nasal vasoconstrictor use.6 In fact, most ...
Restoril™ (temazepam) Capsules USP Rx only DESCRIPTION
Restoril™ (temazepam) Capsules USP Rx only DESCRIPTION

... Sleep disturbance may be the presenting manifestation of an underlying physical and/or psychiatric disorder. Consequently, a decision to initiate symptomatic treatment of insomnia should only be made after the patient has been carefully evaluated. The failure of insomnia to remit after 7 to 10 days ...
Tricyclic Antidepressants
Tricyclic Antidepressants

... Recently we have discussed the place of TCAs in the treatment of depression in the elderly. In the treatment of depression, SSRIs are more commonly used, than TCAs as first-line agents in most situations. TCAs may also cause problematic adverse effects especially in the elderly. In this article we p ...
Therapeutic Parenteral Drug Administration and In
Therapeutic Parenteral Drug Administration and In

... powder or 10 mg as sub-mucosal injection (group C ) unilaterally. The contralateral site served as control and did not receive any steroid administration. Facial edema, trismus and pain perception were evaluated at the 2nd and 7th postoperative day. A multivariate analysis revealed that treatment an ...
Facts about Alcoholism and Alcohol Abuse
Facts about Alcoholism and Alcohol Abuse

... functions tend to decline, including hearing, vision, and reaction time. These combined factors make older people more likely to have alcohol-related falls, auto accidents, and other kinds of accidents. Alcohol abuse can also lead to major depression in the elderly. In addition, older people tend to ...
The neural basis of drug craving: an incentive
The neural basis of drug craving: an incentive

... repeated use of addictive drugs produces incremental neuroadaptations in this neural system, rendering it increasingly and perhaps permanently, hypersensitive (‘sensitized’) to drugs and drug-associated stimuli. The sensitization of dopamine systems is gated by associative learning, which causes exc ...
malaria
malaria

... On the day of admission, the patient had shaking chills followed by temperature elevation to 104°F (40°C). Physical examination revealed a well-developed man who appeared ill. There is some left upper quadrant tenderness but no organomegaly; blood pressure,126/90; pulse, 120; and respirations, 22. ...
Carbinoxamine Maleate
Carbinoxamine Maleate

... As many other antihistamines, carbinoxamine maleate has an atropine-like action and, therefore, should be used with caution in patients with: increased intraocular pressure, hyperthyroidism, cardiovascular disease, hypertension. Antihistamines such as carbinoxamine maleate should not be used to trea ...
Antimicrobials: Drugs that Weaken the Cell Wall I
Antimicrobials: Drugs that Weaken the Cell Wall I

... Cephalosporins: Interactions • Probenecid: delays renal excretion • Alcohol: three drugs that interfere with Vit K metabolism may induce ETOH intolerance • Anti-coagulants ...
Principles of early drug discovery
Principles of early drug discovery

... that a small molecule or larger biologicals and upon binding, elicit a biological response which may be measured both in vitro and in vivo. It is now known that certain target classes are more amenable to small molecule drug discovery, for example, G-protein-coupled receptors (GPCRs), whereas antibo ...
File
File

... chemicals and transmit messages into cells—as marijuana does and produces a similar “high. ...
is there an interaction?
is there an interaction?

... Triptans and selective serotonin/noradrenaline re-uptake inhibitors (SSRIs/SNRIs) are commonly used to treat migraine and depression, respectively. As migraine and depression often occur together, there is significant potential to co-prescribe these agents [1]. Both triptans and SSRIs/SNRIs have ser ...
Information Guide ot Antidepressants | March 2009
Information Guide ot Antidepressants | March 2009

... switching to escitalopram at 25% of the citalopram dose. Venlafaxine is detectable in the serum and associated with less weight gain in breast-fed infants. Less information is available about burpropion, mirtazepine and trazodone, although the concentrations in breast milk infant serum are low. The ...
carbidopa/levodopa (kar-bi-doe-pa/lee-voe-doe-pa) - DavisPlus
carbidopa/levodopa (kar-bi-doe-pa/lee-voe-doe-pa) - DavisPlus

... ● For orally disintegrating tablets, just prior to administration remove tablet from bottle with dry hands. Immediately place tablet on top of tongue. Tablet will dis- ...
AVAPRO (irbesartan) tablets
AVAPRO (irbesartan) tablets

... management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management, see published guideline ...
Eleventh Specialty Pharma Newsletter (December 2009)
Eleventh Specialty Pharma Newsletter (December 2009)

... FDA Approves Pomalyst for Advanced Multiple Myeloma. The U.S. Food and Drug Administration today approved Pomalyst (pomalidomide) to treat patients with multiple myeloma whose disease progressed after being treated with other cancer drugs. ...
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Neuropharmacology

Neuropharmacology is the study of how drugs affect cellular function in the nervous system, and the neural mechanisms through which they influence behavior. There are two main branches of neuropharmacology: behavioral and molecular. Behavioral neuropharmacology focuses on the study of how drugs affect human behavior (neuropsychopharmacology), including the study of how drug dependence and addiction affect the human brain. Molecular neuropharmacology involves the study of neurons and their neurochemical interactions, with the overall goal of developing drugs that have beneficial effects on neurological function. Both of these fields are closely connected, since both are concerned with the interactions of neurotransmitters, neuropeptides, neurohormones, neuromodulators, enzymes, second messengers, co-transporters, ion channels, and receptor proteins in the central and peripheral nervous systems. Studying these interactions, researchers are developing drugs to treat many different neurological disorders, including pain, neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease, psychological disorders, addiction, and many others.
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