Pharma. MCQs
... Which of the following statements best describes the mechanism of action of benzodiazepines? a. Benzodiazepines activate GABAB -receptors in the spinal cord. b. They inhibit GABA-transaminase leading to increased levels of GABA. c. They block glutamate receptors in hierarchical neuronal pathways in ...
... Which of the following statements best describes the mechanism of action of benzodiazepines? a. Benzodiazepines activate GABAB -receptors in the spinal cord. b. They inhibit GABA-transaminase leading to increased levels of GABA. c. They block glutamate receptors in hierarchical neuronal pathways in ...
METHYLMERCURY EXCRETION: DEVELOPMEPRAL
... Univ. Ks. Sch. Med.. Kansas City. Kansas 66103 More than sixteen formulas have been devised to allow adjustment of average adult drug doses for infants and children. Clark's rules based on body weight or body surface extrapolation are used most commonly, but they do not take into account the develop ...
... Univ. Ks. Sch. Med.. Kansas City. Kansas 66103 More than sixteen formulas have been devised to allow adjustment of average adult drug doses for infants and children. Clark's rules based on body weight or body surface extrapolation are used most commonly, but they do not take into account the develop ...
Moving from Animal Models to the Clinic
... When determining the maximum recommended starting dose (MRSD) for first-in-human clinical trials of new molecular entities in adult healthy volunteers, the FDA Guidance recommends that researchers first choose the most appropriate mammalian species for making this determination. The default position ...
... When determining the maximum recommended starting dose (MRSD) for first-in-human clinical trials of new molecular entities in adult healthy volunteers, the FDA Guidance recommends that researchers first choose the most appropriate mammalian species for making this determination. The default position ...
Meclizine HCI Tablets, USP Rx Only
... Meclizine HCI is an antihistamine which shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholin ...
... Meclizine HCI is an antihistamine which shows marked protective activity against nebulized histamine and lethal doses of intravenously injected histamine in guinea pigs. It has a marked effect in blocking the vasodepressor response to histamine, but only a slight blocking action against acetylcholin ...
JNC_8-13120583 - Indian Association of Clinical Cardiologists
... with more than one antihypertensive drug to achieve BP control While this recommendation applies only to the choice of the initial antihypertensive drug, panel suggested that any of these 4 classes would be good choices as add-on agents ...
... with more than one antihypertensive drug to achieve BP control While this recommendation applies only to the choice of the initial antihypertensive drug, panel suggested that any of these 4 classes would be good choices as add-on agents ...
Newer Therapies for Chronic Obstructive Pulmonary Disease
... he thick cloud cover over the understanding of pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) is unveiling rapidly and this has contributed significantly to recent drug development and is likely to do so even in the future. Persistent exposure to an inhaled irritant like cigarette s ...
... he thick cloud cover over the understanding of pathophysiology of Chronic Obstructive Pulmonary Disease (COPD) is unveiling rapidly and this has contributed significantly to recent drug development and is likely to do so even in the future. Persistent exposure to an inhaled irritant like cigarette s ...
Parikh, D., et al. (2012)
... mixture. Whilst the intimate mixing of powdered drugs seems an ideal way to formulate two or more active ingredients for dry powder delivery to the lung, it can be difficult to achieve due to complexities of material chemistry and possible interactions between the active components. This can be very ...
... mixture. Whilst the intimate mixing of powdered drugs seems an ideal way to formulate two or more active ingredients for dry powder delivery to the lung, it can be difficult to achieve due to complexities of material chemistry and possible interactions between the active components. This can be very ...
QA53_7_Hypersalivationalternatives
... with oral benzatropine and efficacy was compared with placebo in a double-blind crossover trial (5). Following a one-week baseline assessment, patients received either placebo or benzatropine for 2 weeks with a 1-week washout before crossover. The initial benzatropine dose was 500 microgram to 2mg d ...
... with oral benzatropine and efficacy was compared with placebo in a double-blind crossover trial (5). Following a one-week baseline assessment, patients received either placebo or benzatropine for 2 weeks with a 1-week washout before crossover. The initial benzatropine dose was 500 microgram to 2mg d ...
Read the June 2013 Issue - American Association for Clinical
... and CYP 2A6 are involved in the oxidation of these compounds (phase I) to alcohol and acetic acid products. For example, trichloroethylene and 1,1,1trichloroethane convert to 2,2,2-trichloroethanol and trichloroacetic acid and can be detected in blood and urine. The half-lives of these compounds are ...
... and CYP 2A6 are involved in the oxidation of these compounds (phase I) to alcohol and acetic acid products. For example, trichloroethylene and 1,1,1trichloroethane convert to 2,2,2-trichloroethanol and trichloroacetic acid and can be detected in blood and urine. The half-lives of these compounds are ...
pharmaceutical aerosols – enhancing the metered dose
... MDIs, the interfacial chemistry of the suspended drug particles tends to be a dominating factor. Surfactants are required to disperse the particles in their biologically preferred aerodynamic size of 1–5 microns. In many instances, the surfactants that are permissible for inhalation drug formulation ...
... MDIs, the interfacial chemistry of the suspended drug particles tends to be a dominating factor. Surfactants are required to disperse the particles in their biologically preferred aerodynamic size of 1–5 microns. In many instances, the surfactants that are permissible for inhalation drug formulation ...
Cefakliman mono
... If patients, suffering from estrogen-dependent tumours, are/were in medical care, Cefakliman® mono must not be used as it is not known if Cimicifuga rootstock extracts support estrogen-dependent tumours or if they do not have any influence. There has not been sufficient research for the application ...
... If patients, suffering from estrogen-dependent tumours, are/were in medical care, Cefakliman® mono must not be used as it is not known if Cimicifuga rootstock extracts support estrogen-dependent tumours or if they do not have any influence. There has not been sufficient research for the application ...
Guideline on Pulmonary Arterial Hypertension - EMA
... drug and to determine the appropriate therapeutic range including dose-concentration-response relationship. It is recommended to establish the optimal therapeutic dose before starting the confirmatory therapeutic studies. These studies could be placebo-controlled, investigating the efficacy of at le ...
... drug and to determine the appropriate therapeutic range including dose-concentration-response relationship. It is recommended to establish the optimal therapeutic dose before starting the confirmatory therapeutic studies. These studies could be placebo-controlled, investigating the efficacy of at le ...
Drug prescribing pattern of topical corticosteroids
... (BNF) divides the topical corticosteroids into four groups, whereas American system divides them into seven classes,[7] where class I represents super potent or ultrapotent drugs and class VII the least potent. The physicians must have a complete knowledge of the drugs in each class; however, they m ...
... (BNF) divides the topical corticosteroids into four groups, whereas American system divides them into seven classes,[7] where class I represents super potent or ultrapotent drugs and class VII the least potent. The physicians must have a complete knowledge of the drugs in each class; however, they m ...
ProposalForMedsAllergiesLabsSDWG_WG_2012_10_4
... classifications that can identify drug concepts intended for specific therapeutic uses and thereby potentially not only identify drugs missed in RxNorm based extensional value sets but also suppress reporting on patients that are on same ingredient drugs that do not meet the therapeutic intent (such ...
... classifications that can identify drug concepts intended for specific therapeutic uses and thereby potentially not only identify drugs missed in RxNorm based extensional value sets but also suppress reporting on patients that are on same ingredient drugs that do not meet the therapeutic intent (such ...
Angiotensin receptor blockers provide better stroke protection than
... prematurely due to the great disparity in outcomes between the two treatment arms, although there was no difference in systolic and diastolic blood pressure between the two treatment groups for the 12 month treatment period. Another small study in 24 post-stroke hypertensive patients without occlusi ...
... prematurely due to the great disparity in outcomes between the two treatment arms, although there was no difference in systolic and diastolic blood pressure between the two treatment groups for the 12 month treatment period. Another small study in 24 post-stroke hypertensive patients without occlusi ...
Structural biology and drug discovery
... Identifying ligand binding regions As structural genomics projects produce more 3D structures, with many of the proteins recognized only from their gene sequences, it is becoming increasingly important to develop computational methods that will identify sites involved in productive intermolecular in ...
... Identifying ligand binding regions As structural genomics projects produce more 3D structures, with many of the proteins recognized only from their gene sequences, it is becoming increasingly important to develop computational methods that will identify sites involved in productive intermolecular in ...
Important Safety Information
... incidence of somnolence, sedation or fatigue was 21% and 8% in patients treated with 100 mg of Addyi at bedtime and placebo, respectively. The risk of CNS depression is increased if Addyi is taken during waking hours, or if Addyi is taken with alcohol or other CNS depressants, or with medications th ...
... incidence of somnolence, sedation or fatigue was 21% and 8% in patients treated with 100 mg of Addyi at bedtime and placebo, respectively. The risk of CNS depression is increased if Addyi is taken during waking hours, or if Addyi is taken with alcohol or other CNS depressants, or with medications th ...
The Treatment of Hyperkalemia - Georgia Society of Health
... • I, Dwayne Pierce, have nothing to disclose concerning possible financial or personal relationships with commercial entities (or their competitors) mentioned in this presentation • There will be discussion of off-label uses of certain pharmaceutical agents and the use of agents not yet approved by ...
... • I, Dwayne Pierce, have nothing to disclose concerning possible financial or personal relationships with commercial entities (or their competitors) mentioned in this presentation • There will be discussion of off-label uses of certain pharmaceutical agents and the use of agents not yet approved by ...
Dictionary of Herbal Remedies Used by Migrant Farmworkers
... Many modern medications, such as digoxin, warfarin, and vinca alkaloids, are derived from plant sources. These examples of herbs highlight the fact that many herbs are not innocuous, and they should not be ignored. While some herbs have positive therapeutic effects, there are some which cause advers ...
... Many modern medications, such as digoxin, warfarin, and vinca alkaloids, are derived from plant sources. These examples of herbs highlight the fact that many herbs are not innocuous, and they should not be ignored. While some herbs have positive therapeutic effects, there are some which cause advers ...
... Teenagers may refer to AAS as "pumpers," "gym candy," or "juice." Trade names for AAS are Dianabol, Anadrol, Deca Durabolin, Parabolin, and Winstrol. AAS are often used with nutritional supplements like creatine, niultivitamins, and energy drinks, in the belief that these regimens will make the user ...
Pereda 2014
... Box 1 | The debate over the nature of synaptic transmission S. Ramón y Cajal and C. Sherrington, the fathers of modern neuroscience, established that networks of multiple elementary units, called ‘neurons’, communicate with each other through functional specializations called ‘synapses’. Their semin ...
... Box 1 | The debate over the nature of synaptic transmission S. Ramón y Cajal and C. Sherrington, the fathers of modern neuroscience, established that networks of multiple elementary units, called ‘neurons’, communicate with each other through functional specializations called ‘synapses’. Their semin ...
Kratom Did you know? - Maryland Poison Center
... Kratom Kratom (Mitragyna speciosa) is a plant/tree indigenous to Thailand and Southeast Asia whose leaves have been used for their psychoactive properties since the 19th century in that part of the world. The Maryland Poison Center was consulted on three cases of toxicity from kratom abuse this mont ...
... Kratom Kratom (Mitragyna speciosa) is a plant/tree indigenous to Thailand and Southeast Asia whose leaves have been used for their psychoactive properties since the 19th century in that part of the world. The Maryland Poison Center was consulted on three cases of toxicity from kratom abuse this mont ...
Self-administration of psychoactive substances by the monkey
... + Present Address : Central Institute for Experimental Animals, 1433, Nogawa, Kawasaki, Japan. ...
... + Present Address : Central Institute for Experimental Animals, 1433, Nogawa, Kawasaki, Japan. ...
PDF
... The risk of gastrointestinal bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation (see section 2: “Do not take Fasdol”), and in elderly patients. These patients should commence the ...
... The risk of gastrointestinal bleeding, ulceration or perforation is higher with increasing NSAID doses, in patients with a history of ulcer, particularly if complicated with haemorrhage or perforation (see section 2: “Do not take Fasdol”), and in elderly patients. These patients should commence the ...
Traumatic brain injury: Current endeavours and trends for
... also appeared in one of our previous papers, dedicated to neuroprotection in spinal cord injury (SCI), published in 2009, the October issue of Spinal Cord journal. We will further discuss some of these therapeutic drugs and procedures. Our color code serves to achieve a balanced, selective approach; ...
... also appeared in one of our previous papers, dedicated to neuroprotection in spinal cord injury (SCI), published in 2009, the October issue of Spinal Cord journal. We will further discuss some of these therapeutic drugs and procedures. Our color code serves to achieve a balanced, selective approach; ...