Amphetamine Paradoxically Augments Exocytotic Dopamine Release and Phasic Dopamine Signals
... Drugs of abuse hijack brain-reward circuitry during the addiction process by augmenting action potential-dependent phasic dopamine release events associated with learning and goal-directed behavior. One prominent exception to this notion would appear to be amphetamine (AMPH) and related analogs, whi ...
... Drugs of abuse hijack brain-reward circuitry during the addiction process by augmenting action potential-dependent phasic dopamine release events associated with learning and goal-directed behavior. One prominent exception to this notion would appear to be amphetamine (AMPH) and related analogs, whi ...
Chemical and Biochemical History of Antimalarials
... low levels or not at all, but where significant transmission has been re-established. The development and spread of drug-resistant strains of malaria parasites has been identified as a key factor in this resurgence and is one of the greatest challenges to malaria control today.2 Although there is cu ...
... low levels or not at all, but where significant transmission has been re-established. The development and spread of drug-resistant strains of malaria parasites has been identified as a key factor in this resurgence and is one of the greatest challenges to malaria control today.2 Although there is cu ...
Clinical pharmacology of dobutamine and dopamine in preterm
... contraction. The chronotropic effect is useful for the treatment of arrhythmias whereas the inotropic effect is useful to augment the myocardial contractility. Dobutamine is about four times as potent as dopamine in stimulating myocardial contractility in low concentrations and increases left ventri ...
... contraction. The chronotropic effect is useful for the treatment of arrhythmias whereas the inotropic effect is useful to augment the myocardial contractility. Dobutamine is about four times as potent as dopamine in stimulating myocardial contractility in low concentrations and increases left ventri ...
Drugs of Abuse - Drug Free Business
... which schedule it should be placed. The threshold issue is whether the drug or other substance has potential for abuse. If a drug does not have a potential for abuse, it cannot be controlled. Although the term “potential for abuse” is not defined in the CSA, there is much discussion of the term in t ...
... which schedule it should be placed. The threshold issue is whether the drug or other substance has potential for abuse. If a drug does not have a potential for abuse, it cannot be controlled. Although the term “potential for abuse” is not defined in the CSA, there is much discussion of the term in t ...
Do Neocortical Pyramidal Neurons Display
... dendritic branches within a radius of 40 µm from the soma. Inside that region there were no excitatory synapses, whereas inhibitory synapses were spread over the whole dendritic tree. B: Vm fluctuations (left) due to synaptic background activity. Poisson-like distributed random inputs without correl ...
... dendritic branches within a radius of 40 µm from the soma. Inside that region there were no excitatory synapses, whereas inhibitory synapses were spread over the whole dendritic tree. B: Vm fluctuations (left) due to synaptic background activity. Poisson-like distributed random inputs without correl ...
Drug-scavenging Liposomes Attenuate the
... irrigation with polyethylene glycol assists in CCB removal from the gastrointestinal tract, especially when sustained release formulations are involved [4]. However, this aggressive intervention can be harmful and its effectiveness is uncertain when patients are already hemodynamically unstable [5]. ...
... irrigation with polyethylene glycol assists in CCB removal from the gastrointestinal tract, especially when sustained release formulations are involved [4]. However, this aggressive intervention can be harmful and its effectiveness is uncertain when patients are already hemodynamically unstable [5]. ...
Drugs of Abuse
... which schedule it should be placed. The threshold issue is whether the drug or other substance has potential for abuse. If a drug does not have a potential for abuse, it cannot be controlled. Although the term “potential for abuse” is not defined in the CSA, there is much discussion of the term in t ...
... which schedule it should be placed. The threshold issue is whether the drug or other substance has potential for abuse. If a drug does not have a potential for abuse, it cannot be controlled. Although the term “potential for abuse” is not defined in the CSA, there is much discussion of the term in t ...
alzheimer disease: treatment of noncognitive behavioral abnormalities
... in outpatients with AD, but the mechanism of treatment efficacy does not appear to be a specific antidepressant effect of imipramine. Petracca et al. (34) randomly assigned 24 patients meet ing criteria for AD with DSM-III-R depression to treatment with either clomipramine or placebo in a randomize ...
... in outpatients with AD, but the mechanism of treatment efficacy does not appear to be a specific antidepressant effect of imipramine. Petracca et al. (34) randomly assigned 24 patients meet ing criteria for AD with DSM-III-R depression to treatment with either clomipramine or placebo in a randomize ...
NEFAZODONE
... • Often best to try another antidepressant monotherapy prior to resorting to augmentation strategies to treat side effects • Many side effects cannot be improved with an augmenting agent • Many side effects are dose-dependent (i.e., they increase as dose increases, or they ...
... • Often best to try another antidepressant monotherapy prior to resorting to augmentation strategies to treat side effects • Many side effects cannot be improved with an augmenting agent • Many side effects are dose-dependent (i.e., they increase as dose increases, or they ...
GlucoNorm PM
... skipped. Given the preprandial dosing regimen, patients taking GlucoNorm® can adjust dosing according to their changing meal patterns, thereby reducing the risk of hypoglycemia when meals are missed. Hypoglycemia is also more likely to occur after strenuous or prolonged exercise, when alcohol is ing ...
... skipped. Given the preprandial dosing regimen, patients taking GlucoNorm® can adjust dosing according to their changing meal patterns, thereby reducing the risk of hypoglycemia when meals are missed. Hypoglycemia is also more likely to occur after strenuous or prolonged exercise, when alcohol is ing ...
Internal Medicine Morning Report
... • Initial plasma glucose-lowering effect similar to growth hormone ...
... • Initial plasma glucose-lowering effect similar to growth hormone ...
Temperature and pH Responsive Microfibers for Controllable and
... been successfully applied to cancer treatments and tissue engineering with a better improved efficacy.[3-5] However, there are still two major challenges to overcome 1) reducing initial burst effects and 2) realizing a programmable drug delivery.[6, 7] In the past decade, multiple technologies have ...
... been successfully applied to cancer treatments and tissue engineering with a better improved efficacy.[3-5] However, there are still two major challenges to overcome 1) reducing initial burst effects and 2) realizing a programmable drug delivery.[6, 7] In the past decade, multiple technologies have ...
Metabolism and drug interactions of 3-hydroxy-3
... 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase inhibitors (statins) represent the most ecient drugs for the treatment of hypercholesterolaemia. Plasma cholesterol is lowered due to the inhibition of endogenous cholesterol synthesis and the subsequent increased expression of the low-densit ...
... 3-Hydroxy-3-methylglutaryl coenzyme A (HMG-CoA)reductase inhibitors (statins) represent the most ecient drugs for the treatment of hypercholesterolaemia. Plasma cholesterol is lowered due to the inhibition of endogenous cholesterol synthesis and the subsequent increased expression of the low-densit ...
MIC - Physiologie et Thérapeutique Ecole Véto Toulouse (ENVT)
... cefquinome was achieved in horses using a jet nebulizer, but cefquinome was not detectable after 4 h in the majority of horses – This is likely true for any drug that was not specifically developed for inhalation (e.g. dexamethasone) because pulmonary absorption is very fast due to a very high blood ...
... cefquinome was achieved in horses using a jet nebulizer, but cefquinome was not detectable after 4 h in the majority of horses – This is likely true for any drug that was not specifically developed for inhalation (e.g. dexamethasone) because pulmonary absorption is very fast due to a very high blood ...
The Řie-Tozer Model of Drug D
... fluids, Eq. 1 or 2, respectively), and linearity of the underlying pharmacokinetic processes (i.e., lack of saturation of processes of drug transport between the pools, protein binding, and elimination). The scheme of the 3-pool model of drug distribution is shown in Figure 1. Equation 2 has been de ...
... fluids, Eq. 1 or 2, respectively), and linearity of the underlying pharmacokinetic processes (i.e., lack of saturation of processes of drug transport between the pools, protein binding, and elimination). The scheme of the 3-pool model of drug distribution is shown in Figure 1. Equation 2 has been de ...
The Treatment Of Leukemia
... people very commonly, many people were not candidates for bone marrow transplant. Today however, we are in a wonderful era because chronic myeloid leukemia is the leukemia for which there was one of the best examples of a targeted therapy that has been developed. It is a drug called imatinib known b ...
... people very commonly, many people were not candidates for bone marrow transplant. Today however, we are in a wonderful era because chronic myeloid leukemia is the leukemia for which there was one of the best examples of a targeted therapy that has been developed. It is a drug called imatinib known b ...
REQUIP®
... Ropinirole has moderate in vitro affinity for opioid receptors. Ropinirole and its metabolites have negligible in vitro affinity for dopamine D1, 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, alpha1-, alpha2-, and beta-adrenoreceptors. The precise mechanism of action of Requip as a treatment for P ...
... Ropinirole has moderate in vitro affinity for opioid receptors. Ropinirole and its metabolites have negligible in vitro affinity for dopamine D1, 5-HT1, 5-HT2, benzodiazepine, GABA, muscarinic, alpha1-, alpha2-, and beta-adrenoreceptors. The precise mechanism of action of Requip as a treatment for P ...
Hematopoietic Stem Cell Transplantation for Chronic Myelogenous
... routine cytogenetics, or by detection of abnormal BCR-ABL products by fluorescence in situ hybridization or molecular studies, in the setting of persistent unexplained leukocytosis. Conventional-dose chemotherapy regimens used for chronic-phase disease can induce multiple remissions and delay the on ...
... routine cytogenetics, or by detection of abnormal BCR-ABL products by fluorescence in situ hybridization or molecular studies, in the setting of persistent unexplained leukocytosis. Conventional-dose chemotherapy regimens used for chronic-phase disease can induce multiple remissions and delay the on ...
Shimadzu Journal Vol. 3, issue 3
... 2: Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA. ...
... 2: Department of Anesthesiology, College of Physicians and Surgeons of Columbia University, New York, New York 10032, USA. ...
Sample Chapter
... Birth defects, together with deformations and chromosomal abnormalities, are a leading cause of neonatal and postneonatal deaths and carry a high social and economic impact. According to the most recent analysis in 1992, the estimated lifetime cost for all infants with one or more of the 18 most c ...
... Birth defects, together with deformations and chromosomal abnormalities, are a leading cause of neonatal and postneonatal deaths and carry a high social and economic impact. According to the most recent analysis in 1992, the estimated lifetime cost for all infants with one or more of the 18 most c ...
Heavy metal-Lead
... Cases of paint ingestion have increased markedly. Children are apparently attracted to the paint because of the sweet taste of lead acetate found in these paints. Inhalation of dust, fumes, mists or vapours. In industry (e.g., smelting, battery production etc.), inhalation is more common than inges ...
... Cases of paint ingestion have increased markedly. Children are apparently attracted to the paint because of the sweet taste of lead acetate found in these paints. Inhalation of dust, fumes, mists or vapours. In industry (e.g., smelting, battery production etc.), inhalation is more common than inges ...
Lecture 13, Inhibitors - Cal State LA
... mimic of the substrate or the transition state. Lecture on Protein targets listed some examples of reversible inhibitors as drugs 1. Transition state mimic for adenosine deaminase (enzyme which degrades anticancer drugs) ...
... mimic of the substrate or the transition state. Lecture on Protein targets listed some examples of reversible inhibitors as drugs 1. Transition state mimic for adenosine deaminase (enzyme which degrades anticancer drugs) ...
Vernacular Name
... Volatile oil: These compounds are formed from an alcohol and a hydrocarbon Protein: Higly complex, nitrogenous compounds, found in all animal and vegetable tissues Carbohydrates: These compounds are formed in plants as a result of photosynthesis Fat: An oil which may be of animal or plant origin, an ...
... Volatile oil: These compounds are formed from an alcohol and a hydrocarbon Protein: Higly complex, nitrogenous compounds, found in all animal and vegetable tissues Carbohydrates: These compounds are formed in plants as a result of photosynthesis Fat: An oil which may be of animal or plant origin, an ...
Sound-Alike/Look-Alike Drugs for Hospital
... Potentially serious mix-ups between metronidazole and metformin have been linked to look-alike packaging (both bulk bottles and unit-dose packages). Metformin is contraindicated in certain clinical situations where use might contribute to lactic acidosis. Administration of intravenous iodinated cont ...
... Potentially serious mix-ups between metronidazole and metformin have been linked to look-alike packaging (both bulk bottles and unit-dose packages). Metformin is contraindicated in certain clinical situations where use might contribute to lactic acidosis. Administration of intravenous iodinated cont ...