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Answers to the Topic Pre
Answers to the Topic Pre

... Well, you don't need to do this further than recognising that phylogenetic classification using molecular differences places these organisms in the eukarya. What features would you expect protozoan cells to have? Genetic material enclosed in a nucleus and membrane bound organelles. Write down the 4 ...
Nervous System
Nervous System

... amino acids) using an mRNA template.  mRNA = copy of gene  Every 3 letters on mRNA = codon = codes for a specific amino acid (a.a.). e.g.: the codon AUG codes for methionine (“met”)  Amino acids will be bonded together in a specific sequence. Correct a.a. sequence is critical to the protein bein ...
A green chapter in the book of life.
A green chapter in the book of life.

... a huge number of books can be written by linking these words together in different ways, so the diversity of life depends to a certain extent on how the genes are coupled together into pathways, with selection resulting in shades of meaning that denote speciesspecific function. During 1.6 billion ye ...
Effect of HDGF on Hepatic Stellate Cells
Effect of HDGF on Hepatic Stellate Cells

... Release of free radicals and signaling cytokines HSC activation ...
Varicella-Zoster Virus Specifies a Thymidylate Synthetase
Varicella-Zoster Virus Specifies a Thymidylate Synthetase

... present in both uninfected and infected cells. The additional polypeptide, present only in infected cells, had an apparent molecular weight of 32 500, and thus corresponded in size to the ternary complex of VZV TS expressed in E. coli. Varicella-zoster virus and HVS, the only two herpesviruses shown ...
Big Idea 3
Big Idea 3

... other cases, mutations can alter levels of gene expression or simply be silent. In order for information in DNA to direct cellular processes, information must be transcribed (DNA'RNA) and, in many cases, translated (RNA->protein). The products of transcription and translation play an important role ...
22(L)/S/O - India Environment Portal
22(L)/S/O - India Environment Portal

... proteins from DNA to ribosomes and helps in assembling the desired protein molecules. Recent discoveries have substantially changed, if not overturned, this belief. Now it has been found that besides doing this, RNA molecules regulate many important processes, including shutting off the blue-print c ...
cytoskeleton
cytoskeleton

... – Intermediate filaments are built from a diverse class of subunits from a family of proteins called keratins. • Intermediate filaments are more permanent fixtures of the cytoskeleton than are the other two classes. • They reinforce cell shape and fix organelle location. • NOT conserved: not found i ...
DNA technology the study of sequence, expression, and function of
DNA technology the study of sequence, expression, and function of

... Transgenic animals are made by introducing genes from one species into the genome of another animal Transgenic animals are pharmaceutical “factories,” producers of large amounts of otherwise rare substances for medical use “Pharm” plants are also being developed to make human proteins for medical us ...


... constitutively expressed from the p(luxR) promoter and gfplva is expressed from the p(luxI) promoter. In architecture b, luxR is constitutively expressed from the p(luxR) promoter and luxI and gfplva are expressed from the p(luxI) promoter. Modeling suggests that exchanging the placement of luxI and ...
Supplemental Material 1 Simultaneous isolation of mRNA, miRNA
Supplemental Material 1 Simultaneous isolation of mRNA, miRNA

... target islands are penalized because they may introduce spurious predictions. Second, it rewards instances that maximize the minimum distance between the same MREs. The MREs that are targeted by miR-n must be spaced out enough that miR-n+RISC can sit on the mRNA target without steric interference by ...
Lesson 1 Introduction to virulence factors
Lesson 1 Introduction to virulence factors

... Virulence factors are proteins and/or molecules produced by a pathogen that contribute to the ability of the microbe to cause disease. These are factors that are necessary for the organism to successfully (1) encounter a host, (2) invade a host, (3) colonize a host, (4) evade detection by the immune ...
Document
Document

... TBP: TATA box binding protein Promoter upstream of real starting sequence of transcription TFIIH open DNA double helix and phosphorylate C-tail of polymerase and allow the release and transcription ...
DNA methyltransferases and DNA methylation in the pea aphid.
DNA methyltransferases and DNA methylation in the pea aphid.

... Look for genes that we would ‘like’ to be methylated • Juvenile hormone esterase • Juvenile hormone binding protein ...
Cystic Fibrosis
Cystic Fibrosis

... Cystic fibrosis is a genetic disease that affects many different parts of the body. There are approximately 30,000 Americans with cystic fibrosis. The most serious problem is the production of extremely thick, sticky mucus that clogs up the bronchial tubes in the lungs and the passageways in the pan ...
Document
Document

... Two of the subclones were ruled out by linkage analysis, and a third was a pseudogene (gene-like sequence lacking expression signals). ...
Mutation Reading--How the Gene for Sickle Cell Hemoglobin
Mutation Reading--How the Gene for Sickle Cell Hemoglobin

... Different versions of the same gene are called different alleles. These different alleles share the same general sequence of nucleotides, but they differ in at least one nucleotide in the sequence. Different alleles can result in different characteristics as follows: Differences in the nucleotide se ...
here
here

... Paralogs: “deepest” bifurcation in molecular tree reflects gene duplication. The study of paralogs and their distribution in genomes provides clues on the way genomes evolved. Gen and genome duplication have emerged as the most important pathway to molecular innovation, including the evolution of de ...
fulltext - DiVA portal
fulltext - DiVA portal

... research. Ideally, such database searches should be part of the routine experimental design and validation, similar to making a literature search. However, the scale and complexity of many repositories often acts as a barrier to their use by basic researchers. For example, finding relevant experimen ...
Ex2 answers
Ex2 answers

... protein occurs post-translationally and is thus still an option for regulation. #3 is NOT possible because there is mRNA produced from Hrt1 in both heart and liver cells, so this Hrt1 gene is not regulated at the level of transcription. #4 is possible because all that you know is that mRNA is made i ...
Honors Biology Chapter 3 – The Process of Science: Studying
Honors Biology Chapter 3 – The Process of Science: Studying

... 2. genetic markers can even show up in noncoding (intron) sections of a person’s genome a. these are the ones used in court cases – least likely to be shared with any other person ...
RNA 8.4 Transcription TEKS 4B, 6C, 9C
RNA 8.4 Transcription TEKS 4B, 6C, 9C

... TEKS 4B, 6C, 9C ...
MBch15
MBch15

... Perceiving order in the makeup of the code The genetic code might have evolved in a way to minimize deleterious effects of mutations. 1. Codons with pyrimidines in the 2nd position mostly specify hydrophobic amino acids; while those with purines in the 2nd ...
3 - Rudner Lab - Harvard University
3 - Rudner Lab - Harvard University

... is coupled to the completion of landmark morphological events. We refer to this dependence on morphogenesis for gene expression as “morphological coupling.” Three examples of morphological coupling in prokaryotes are reviewed in which the activation of a transcription factor is tied to the assembly ...
Transcription
Transcription

... site; those extending in the opposite direction are upstream. The σ70 subunit binds to specific sequences near the −10 and −35 positions in the promoter. The α subunits lie close to the DNA in the upstream direction. The β and β′ subunits associate with the start site ...
< 1 ... 169 170 171 172 173 174 175 176 177 ... 320 >

Gene regulatory network



A gene regulatory network or genetic regulatory network (GRN) is a collection of regulators thatinteract with each other and with other substances in the cell to govern the gene expression levels of mRNA and proteins.The regulator can be DNA, RNA, protein and their complex. The interaction can be direct or indirect (through their transcribed RNA or translated protein).In general, each mRNA molecule goes on to make a specific protein (or set of proteins). In some cases this protein will be structural, and will accumulate at the cell membrane or within the cell to give it particular structural properties. In other cases the protein will be an enzyme, i.e., a micro-machine that catalyses a certain reaction, such as the breakdown of a food source or toxin. Some proteins though serve only to activate other genes, and these are the transcription factors that are the main players in regulatory networks or cascades. By binding to the promoter region at the start of other genes they turn them on, initiating the production of another protein, and so on. Some transcription factors are inhibitory.In single-celled organisms, regulatory networks respond to the external environment, optimising the cell at a given time for survival in this environment. Thus a yeast cell, finding itself in a sugar solution, will turn on genes to make enzymes that process the sugar to alcohol. This process, which we associate with wine-making, is how the yeast cell makes its living, gaining energy to multiply, which under normal circumstances would enhance its survival prospects.In multicellular animals the same principle has been put in the service of gene cascades that control body-shape. Each time a cell divides, two cells result which, although they contain the same genome in full, can differ in which genes are turned on and making proteins. Sometimes a 'self-sustaining feedback loop' ensures that a cell maintains its identity and passes it on. Less understood is the mechanism of epigenetics by which chromatin modification may provide cellular memory by blocking or allowing transcription. A major feature of multicellular animals is the use of morphogen gradients, which in effect provide a positioning system that tells a cell where in the body it is, and hence what sort of cell to become. A gene that is turned on in one cell may make a product that leaves the cell and diffuses through adjacent cells, entering them and turning on genes only when it is present above a certain threshold level. These cells are thus induced into a new fate, and may even generate other morphogens that signal back to the original cell. Over longer distances morphogens may use the active process of signal transduction. Such signalling controls embryogenesis, the building of a body plan from scratch through a series of sequential steps. They also control and maintain adult bodies through feedback processes, and the loss of such feedback because of a mutation can be responsible for the cell proliferation that is seen in cancer. In parallel with this process of building structure, the gene cascade turns on genes that make structural proteins that give each cell the physical properties it needs.It has been suggested that, because biological molecular interactions are intrinsically stochastic, gene networks are the result of cellular processes and not their cause (i.e. cellular Darwinism). However, recent experimental evidence has favored the attractor view of cell fates.
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