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Gene Section CLIC4 (chloride intracellular channel 4)  Atlas of Genetics and Cytogenetics
Gene Section CLIC4 (chloride intracellular channel 4) Atlas of Genetics and Cytogenetics

... CLIC4 has been shown to regulate TGF-beta signaling. It has been shown to translocate to the nucleus in a Schnurri-2 dependent manner and nuclear CLIC4 has been shown to subsequently stabilise phospho- Smad2 and Smad3. CLIC4 has been implicated in angiogenesis. It has been shown to be involved in ac ...
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... and include base deletion and base substitution. Due to the degenerate nature of the genetic code, not all base substitutions cause a change in the sequence of encoded amino acids. Mutagenic agents can increase the rate of gene mutation. Mutations in the number of chromosomes can arise spontaneously ...
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... Brief history of bioinformatics: Databases • The first biological database - Protein Identification Resource was established in 1972 by Margaret Dayhoff • Dayhoff and co-workers organized the proteins into families and superfamilies based on degree of sequence similarity • Idea of sequence alignmen ...
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Endogenous retrovirus



Endogenous retroviruses (ERVs) are endogenous viral elements in the genome that closely resemble and can be derived from retroviruses. They are abundant in the genomes of jawed vertebrates, and they comprise up to 5–8% of the human genome (lower estimates of ~1%). ERVs are a subclass of a type of gene called a transposon, which can be packaged and moved within the genome to serve a vital role in gene expression and in regulation. Researchers have suggested that retroviruses evolved from a type of transposable gene called a retrotransposon, which includes ERVs; these genes can mutate and instead of moving to another location in the genome they can become exogenous or pathogenic. This means that all ERVs may not have originated as an insertion by a retrovirus but that some may have been the source for the genetic information in the retroviruses they resemble.
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