Phloem RNA-binding proteins as potential components of the long
... of the ribonucleotide complexes that function to regulate RNA transport or metabolism. eIF5A contains a KOW motif (acronym of the authors surname, Kyrpides et al., 1996) characterized by the presence of an invariant glycine residue and five alternating blocks of hydrophilic and hydrophobic residues ( ...
... of the ribonucleotide complexes that function to regulate RNA transport or metabolism. eIF5A contains a KOW motif (acronym of the authors surname, Kyrpides et al., 1996) characterized by the presence of an invariant glycine residue and five alternating blocks of hydrophilic and hydrophobic residues ( ...
Macromolecules
... sort of like the 4-helix bundle, but with just two helices. Originally it was thought that the leucyl residues interdigitated (hence the name, "leucine zipper"), but it is now believed that they face each other (reality in the form of x-ray crystallography strikes again). In any case, the symmetric ...
... sort of like the 4-helix bundle, but with just two helices. Originally it was thought that the leucyl residues interdigitated (hence the name, "leucine zipper"), but it is now believed that they face each other (reality in the form of x-ray crystallography strikes again). In any case, the symmetric ...
Molecular Biology
... • RNA polymerase II (Pol II; also known as RNAP II). It transcribes protein-encoding genes into mRNA (and also the snRNA genes). • RNA polymerase III (Pol III). It transcribes the 5S rRNA genes and all the tRNA genes. ...
... • RNA polymerase II (Pol II; also known as RNAP II). It transcribes protein-encoding genes into mRNA (and also the snRNA genes). • RNA polymerase III (Pol III). It transcribes the 5S rRNA genes and all the tRNA genes. ...
Document
... Chemical Structure of Proteins ◦ Proteins are built from amino acids held together by peptide bonds. The amino acids confer shape and properties to the protein. ◦ Two or more polypeptide chains may associate to form a protein complex. Each cell type has characteristic proteins associated with its fu ...
... Chemical Structure of Proteins ◦ Proteins are built from amino acids held together by peptide bonds. The amino acids confer shape and properties to the protein. ◦ Two or more polypeptide chains may associate to form a protein complex. Each cell type has characteristic proteins associated with its fu ...
The orphan histidine protein kinase SgmT is a cdiGMP receptor and
... A fundamental property of bacterial cells is their ability to respond to changes in the extracellular and intracellular environments. In this context, specific inputs are coupled to specific outputs by dynamically interacting signalling proteins organized in regulatory pathways. In order to ensure a ...
... A fundamental property of bacterial cells is their ability to respond to changes in the extracellular and intracellular environments. In this context, specific inputs are coupled to specific outputs by dynamically interacting signalling proteins organized in regulatory pathways. In order to ensure a ...
Primary and secondary metabolism, and post
... mycelium typically begins to produce the various antibiotics. Before the genome sequencing project began, S. coelicolor was known to produce four antibiotics (one of them plasmid determined), two of which, actinorhodin (Act) and undecylprodigiosin (Red), are pigmented, and a polyketide spore pigment ...
... mycelium typically begins to produce the various antibiotics. Before the genome sequencing project began, S. coelicolor was known to produce four antibiotics (one of them plasmid determined), two of which, actinorhodin (Act) and undecylprodigiosin (Red), are pigmented, and a polyketide spore pigment ...
Chapter 11 Transcription and RNA Processing
... ( stability and protection) A poly(A) tail (a 20-200 nucleotide polyadenosine tract, As) is added to the 3’ end of the transcript. The 3’ end is generated by cleavage rather than by termination. (stability and protection) When present, intron sequences are spliced out of the transcript. (stabili ...
... ( stability and protection) A poly(A) tail (a 20-200 nucleotide polyadenosine tract, As) is added to the 3’ end of the transcript. The 3’ end is generated by cleavage rather than by termination. (stability and protection) When present, intron sequences are spliced out of the transcript. (stabili ...
RNA Structure and the Versatility of RNA
... • Largest class of small non-coding RNA molecules expressed in animal cells. • RNA-protein complexes through interactions with piwi proteins. • These piRNA complexes have been linked to both epigenetic and post-transcriptional gene silencing of retrotransposons and other genetic elements in germ lin ...
... • Largest class of small non-coding RNA molecules expressed in animal cells. • RNA-protein complexes through interactions with piwi proteins. • These piRNA complexes have been linked to both epigenetic and post-transcriptional gene silencing of retrotransposons and other genetic elements in germ lin ...
Inquiry into Life Twelfth Edition
... Upstream Elements • Upstream promoter elements are usually found upstream of class II core promoters • Differ from core promoters in binding to relatively gene-specific transcription factors – GC boxes bind transcription factor Sp1 – CCAAT boxes bind CTF (CCAAT-binding transcription ...
... Upstream Elements • Upstream promoter elements are usually found upstream of class II core promoters • Differ from core promoters in binding to relatively gene-specific transcription factors – GC boxes bind transcription factor Sp1 – CCAAT boxes bind CTF (CCAAT-binding transcription ...
The Predicted Candidates of Arabidopsis Plastid Inner Envelope
... make use of certain features of plastid-targeted proteins. The plastid genome itself encodes only about 120 single-copy genes and, therefore, must rely on proteins from the nucleus. The protein constituents that are encoded in the nuclear genome are synthesized in the cytoplasm as higher Mr precurso ...
... make use of certain features of plastid-targeted proteins. The plastid genome itself encodes only about 120 single-copy genes and, therefore, must rely on proteins from the nucleus. The protein constituents that are encoded in the nuclear genome are synthesized in the cytoplasm as higher Mr precurso ...
Comparative analysis of proteins with a mucus
... To create domains of a uniform size would require either merging of every second repeat of the Lb. plantarum mucusbinding protein with its neighbour or splitting the Lb. reuteri domain in two. However, our sequence analysis suggests that the mucus-binding building blocks of the mucusbinding proteins ...
... To create domains of a uniform size would require either merging of every second repeat of the Lb. plantarum mucusbinding protein with its neighbour or splitting the Lb. reuteri domain in two. However, our sequence analysis suggests that the mucus-binding building blocks of the mucusbinding proteins ...
lecture1.pps
... What is Glycobiology? ¶ Study of the structure, biosynthesis and biology of saccharides (sugar chains or “glycans”) in nature. ¶ Glycobiology is an integrative science, crossing all subfields of chemistry, biology and medicine. ¶ Chemical analysis and biochemistry dominated the field in the early p ...
... What is Glycobiology? ¶ Study of the structure, biosynthesis and biology of saccharides (sugar chains or “glycans”) in nature. ¶ Glycobiology is an integrative science, crossing all subfields of chemistry, biology and medicine. ¶ Chemical analysis and biochemistry dominated the field in the early p ...
8-Cell and Molecular Biology (Transcription)
... While proteins that have little to do with each other in the cells, their genes are adjacent Therefore, in brief decoding genomes is not a simple matter Even with the aid of powerful computers, it is still difficult for researchers • to locate definitively the beginning and end of genes in the ...
... While proteins that have little to do with each other in the cells, their genes are adjacent Therefore, in brief decoding genomes is not a simple matter Even with the aid of powerful computers, it is still difficult for researchers • to locate definitively the beginning and end of genes in the ...
PDF - Bentham Open
... Using 2-D liquid separation and an ESI-TOF MS-based mass mapping technique, we examined the differences in the proteomic profiles of the permafrost bacterium E. sibiricum 255-15 grown at two temperatures (4oC and 25oC) and two media (liquid broth and agar surface) before freeze-thawing treatments. I ...
... Using 2-D liquid separation and an ESI-TOF MS-based mass mapping technique, we examined the differences in the proteomic profiles of the permafrost bacterium E. sibiricum 255-15 grown at two temperatures (4oC and 25oC) and two media (liquid broth and agar surface) before freeze-thawing treatments. I ...
Polymer scaling laws of unfolded and intrinsically disordered
... enough to determine ρ0 independently, we fixed lp (but not ρ0 ) to this value of 0.40 nm. For comparison, a free fit of the length scaling of RG for 10,905 folded proteins selected from the Protein Data Bank results in ν ¼ 0.34 and a persistence length of lp ¼ 0.53 nm (Fig. 2) (35), but even usi ...
... enough to determine ρ0 independently, we fixed lp (but not ρ0 ) to this value of 0.40 nm. For comparison, a free fit of the length scaling of RG for 10,905 folded proteins selected from the Protein Data Bank results in ν ¼ 0.34 and a persistence length of lp ¼ 0.53 nm (Fig. 2) (35), but even usi ...
PDF
... enough to determine ρ0 independently, we fixed lp (but not ρ0 ) to this value of 0.40 nm. For comparison, a free fit of the length scaling of RG for 10,905 folded proteins selected from the Protein Data Bank results in ν ¼ 0.34 and a persistence length of lp ¼ 0.53 nm (Fig. 2) (35), but even usi ...
... enough to determine ρ0 independently, we fixed lp (but not ρ0 ) to this value of 0.40 nm. For comparison, a free fit of the length scaling of RG for 10,905 folded proteins selected from the Protein Data Bank results in ν ¼ 0.34 and a persistence length of lp ¼ 0.53 nm (Fig. 2) (35), but even usi ...
The role of cytosolic proteins in the insertion of tail
... Membrane proteins are generally inserted into the endoplasmic reticulum (ER) membrane by a co-translational mechanism, which begins with the association of signal recognition particle (SRP) to a hydrophobic sequence within the nascent polypeptide chain. This is followed by binding of the ribosome–na ...
... Membrane proteins are generally inserted into the endoplasmic reticulum (ER) membrane by a co-translational mechanism, which begins with the association of signal recognition particle (SRP) to a hydrophobic sequence within the nascent polypeptide chain. This is followed by binding of the ribosome–na ...
sv-lncs - School of Mathematical and Computer Sciences
... A series of studies attempting to reveal the modules in cellular networks, ranging from metabolic,[5] to protein networks,[6, 7] strongly support the proposal that modular architecture is one of the principles underlying biological organisation. The modular nature of the cellular networks, including ...
... A series of studies attempting to reveal the modules in cellular networks, ranging from metabolic,[5] to protein networks,[6, 7] strongly support the proposal that modular architecture is one of the principles underlying biological organisation. The modular nature of the cellular networks, including ...
Central Dogma of Genetics
... – Enzyme moves back one or more nucleotides, cleaves RNA, then resumes synthesis in forward direction. ...
... – Enzyme moves back one or more nucleotides, cleaves RNA, then resumes synthesis in forward direction. ...
DNA-Bound Fos Proteins Activate Transcription in Yeast
... bind to the promoter regions of specific genes and activate or repress their transcription. There is some evidence that supports this idea. Both Fos and Myc proteins reportedly cause “transactivation,” respectively stimulating transcription of transiently expressed transfected mouse al collagen and ...
... bind to the promoter regions of specific genes and activate or repress their transcription. There is some evidence that supports this idea. Both Fos and Myc proteins reportedly cause “transactivation,” respectively stimulating transcription of transiently expressed transfected mouse al collagen and ...
MODERN METHODS in BIOCHEMISTRY
... Many vectors are now engineered with DNA sequences encoding a specific peptide (purification tag) that, when fused to the expressed protein, may be used for one-step purification of the recombinant protein by high-affinity binding. That is molecular biologists design expression systems such that the ...
... Many vectors are now engineered with DNA sequences encoding a specific peptide (purification tag) that, when fused to the expressed protein, may be used for one-step purification of the recombinant protein by high-affinity binding. That is molecular biologists design expression systems such that the ...
041118-SusanWong
... Will provide 35 million doses for young people, schoolchildren, women and all those at particular risk through their work. Assist countries in making the transition to self sustained programs. ...
... Will provide 35 million doses for young people, schoolchildren, women and all those at particular risk through their work. Assist countries in making the transition to self sustained programs. ...
SR protein
SR proteins are a conserved family of proteins involved in RNA splicing. SR proteins are named because they contain a protein domain with long repeats of serine and arginine amino acid residues, whose standard abbreviations are ""S"" and ""R"" respectively. SR proteins are 50-300 amino acids in length and composed of two domains, the RNA recognition motif (RRM) region and the RS binding domain. SR proteins are more commonly found in the nucleus than the cytoplasm, but several SR proteins are known to shuttle between the nucleus and the cytoplasm.SR proteins were discovered in the 1990s in Drosophila and in amphibian oocytes, and later in humans. In general, metazoans appear to have SR proteins and unicellular organisms lack SR proteins.SR proteins are important in constitutive and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA by preferentially selecting different splice sites on the pre-mRNA strands to create multiple mRNA transcripts from one pre-mRNA transcript. Once splicing is complete the SR protein may or may not remain attached to help shuttle the mRNA strand out of the nucleus. As RNA Polymerase II is transcribing DNA into RNA, SR proteins attach to newly made pre-mRNA to prevent the pre-mRNA from binding to the coding DNA strand to increase genome stabilization. Topoisomerase I and SR proteins also interact to increase genome stabilization. SR proteins can control the concentrations of specific mRNA that is successfully translated into protein by selecting for nonsense-mediated decay codons during alternative splicing. SR proteins can alternatively splice NMD codons into its own mRNA transcript to auto-regulate the concentration of SR proteins. Through the mTOR pathway and interactions with polyribosomes, SR proteins can increase translation of mRNA.Ataxia telangiectasia, neurofibromatosis type 1, several cancers, HIV-1, and spinal muscular atrophy have all been linked to alternative splicing by SR proteins.