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06_20_cancer_age.jpg
06_20_cancer_age.jpg

... Mistakes during DNA replication can also alter genetic information Replication errors are extremely rare, generally occurring once per 109 base pairs The rate of replication errors is kept low due to correction or ‘proofreading’ activity, which reduces the error rate to one in 106 bases copied by D ...
TUMOR-SUPPRESSOR GENES
TUMOR-SUPPRESSOR GENES

... competitively antagonize myc function. The function of myc may also be antagonized by the formation of max-max homodimers which antagonize transcription. Other oncogenes coding for sequence-specific DNA binding proteins include myb and ets. ...
Document
Document

1. Translation
1. Translation

... 2. Activators, repressors, effectors For activator or repressor proteins to do their job, each must be able to exist in two states: one that can bind its DNA targets and one that cannot. The binding state must be in accord with the cellular environment; that is, be appropriate for a given set of ph ...
CS 5263 Bioinformatics - Department of Computer Science
CS 5263 Bioinformatics - Department of Computer Science

... Transcription (also called expression) mRNA mRNA degradation ...
Differences between DNA and RNA • Ribonucleic acid is similar to
Differences between DNA and RNA • Ribonucleic acid is similar to

... DNA, but has a few differences • Firstly, RNA is single-stranded, whereas DNA is double-stranded ...
Document
Document

... RNA processing mRNA transport mRNA degradation and storage 5. Translation 6. Posttranslational modulation of protein activity ...
Chapter 17 Presentation
Chapter 17 Presentation

... 1. It can H-bond to other nucleic acids. 2. It can form a specific 3D shape by Hbonding on itself. 3. It has functional groups that allow it to act as a catalyst. ...
From DNA to Protein
From DNA to Protein

... proteins as the parent cell. A skin cell should be able to produce skin proteins, a hair follicle cell hair proteins. The linear polymer DNA with all the information about proteins can be easily duplicated in cell division. How does it work? To make new proteins, the living cell uses the genetic cod ...
Analysis of Microarray Gene Expression Data Using a
Analysis of Microarray Gene Expression Data Using a

... expression. The permutation tests give a more conservative estimate than the bootstrap. 3. For p-value of interest of 0.10, the PTP, PFP, PFN and EDR are consistent across all tests. All these values are in optimal ranges for the information sought in this data. ...
Distinguish between mRNA, rRNA, and tRNA. What molecule does
Distinguish between mRNA, rRNA, and tRNA. What molecule does

... tRNA - adaptor, binds amino acids and rRNA and translates between mRNA and protein. Each tRNA also carries the amino acid corresponding to the mRNA codon to which it binds. Transfer RNA translates the language of nucleotides into the language of amino acids. ...
Week 2
Week 2

... the lipid membrane – These receptor proteins then create a cascade of reactions called the signaling pathway through phosphorylation or dephosphorylation reactions – The signal eventually reaches the nucleus, triggering the cell’s response by changing its protein composition ...
Recombinant Human Platelet-Derived Growth Factor BB PDGF
Recombinant Human Platelet-Derived Growth Factor BB PDGF

Transcription
Transcription

... 5. The DNA chain acting as template for RNA synthesis has the following order of bases, AGCTTCGA. What will be the order of bases in mRNA? ...
DNA structure
DNA structure

... • Each strand of original DNA serves as a template • Nucleotides match to template according to base pairing rules (complementary strand) • 1 ‘parent’ DNA strand produces 2 new ‘daughter’ strands • Occurs rapidly, both strands simultaneously – Humans with 6 billion pairs a few hours, with only about ...
Molecular Pathology - Fahd Al
Molecular Pathology - Fahd Al

... find correlations between therapeutic responses to drugs and the genetic profiles of patients. Expression screening. The focus of most current microarray-based studies is the monitoring of RNA expression levels which can be done by using either cDNA clone microarrays or gene-specific oligonucleotide ...
Foundations of Biology
Foundations of Biology

... In addition to promoters, enhancers also influence the expression of genes Control of gene expression in eukaryotes involves many more factors than control in prokaryotes This allows much finer control of gene expression ©2000 Timothy G. Standish ...
Reverse Transcriptase PCR
Reverse Transcriptase PCR

... DNA digested with restriction enzymes, by isolation of the entire repeat on a single fragment of about 11 kilobase pairs from a genomic DNA library constructed in bacteriophage lambda and by characterization of three cloned EcoRI fragments which span the entire repeat. The segments encoding both the ...
12.3 DNA, RNA, and Protein
12.3 DNA, RNA, and Protein

... • Transcription is catalyzed by RNA polymerase. – RNA polymerase and other proteins form a transcription complex. – The transcription complex recognizes the start of a gene and unwinds a segment of it. ...
Slide 1
Slide 1

... examples include nucleus, telomere, and RNA polymerase II holoenzyme ...
L_ARG
L_ARG

Final Report
Final Report

... Noxo1. Noxo1 (NOX Organizer 1) is a protein that serves as an “organizer” in a multiprotein enzyme complex that is involved in a wide range of cellular functions. Aberrant function of these enzyme complexes leads to an array of diseases, including vascular disease and certain cancers. Noxo1’s role ...
DNA Structure
DNA Structure

... Understand that the nucleus of a cell contains chromosomes on which genes are located ...
Assessment Schedule – 2005 Biology: Describe gene expression
Assessment Schedule – 2005 Biology: Describe gene expression

... Describes how alleles are involved. Explains relationship between alleles and different enzymes. Eg: Eg: • They are multiple alleles, any one cat can only have two. This gene has multiple alleles, each with their own enzyme product. The • C allows intermediate substance intermediate substance is onl ...
Jeopardy!!
Jeopardy!!

... free floating in the cytoplasm In Eukaryotes, the DNA is safely contained within the nucleus ...
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Silencer (genetics)

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