Journal Citation Studies. 46. Physical Chemistry and Chemical
... The 1983 impact factor for a j oumal is the average number of citations received in 1983 by the articles published in that journal in 1981 and 1982. When we first began calculating impact over 10 years ago, we chose to use a 2-year period for articles to equalize the difference between those article ...
... The 1983 impact factor for a j oumal is the average number of citations received in 1983 by the articles published in that journal in 1981 and 1982. When we first began calculating impact over 10 years ago, we chose to use a 2-year period for articles to equalize the difference between those article ...
GPCR endocytosis confers uniformity in responses to chemically
... structure, these drugs also differ in binding affinity and intrinsic efficacy- isoproterenol is classified as a full agonist and salmeterol as a higher affinity partial agonist (January et al., 1998; Nino et al., 2009). Furthermore, they exhibit distinct receptor binding kinetics, with salmeterol ha ...
... structure, these drugs also differ in binding affinity and intrinsic efficacy- isoproterenol is classified as a full agonist and salmeterol as a higher affinity partial agonist (January et al., 1998; Nino et al., 2009). Furthermore, they exhibit distinct receptor binding kinetics, with salmeterol ha ...
cannabis or hashish - KSU Faculty Member websites
... smoking as cigarettes or in pipes or by mixing it with foods or drinks as observed in some parts of India. The most used parts of the plant are the bracts, flowers, leaves and the resin which covers these parts [28]. During the last few decades millions of youth throughout the world have been attrac ...
... smoking as cigarettes or in pipes or by mixing it with foods or drinks as observed in some parts of India. The most used parts of the plant are the bracts, flowers, leaves and the resin which covers these parts [28]. During the last few decades millions of youth throughout the world have been attrac ...
NIDA Research Report - MDMA
... sessions and reportedly allowed users to achieve insights about their problems. It was also during this time that MDMA first started becoming available on the street. In 1985, the U.S. Drug Enforcement Administration (DEA) banned the drug, placing it on its list of Schedule I drugs, corresponding to ...
... sessions and reportedly allowed users to achieve insights about their problems. It was also during this time that MDMA first started becoming available on the street. In 1985, the U.S. Drug Enforcement Administration (DEA) banned the drug, placing it on its list of Schedule I drugs, corresponding to ...
Drug Prior Authorization Attachment AIS
... ISO+: EXTENDED ISO UNITS CODES ..........................................................................................................68 ...
... ISO+: EXTENDED ISO UNITS CODES ..........................................................................................................68 ...
DANGERS OF PHARMACEUTICAL SUBSTITUTES FOR NICOTINE
... We are still not clear on how substituting one addiction for another is therapy…. Nicotine Nasal Spray Nicotine nasal spray (Nicotrol NS®) is an aqueous solution of nicotine delivering approximately 0.5 mg of nicotine to the nasal mucosa with each spray. Nasal irritation is common, affecting 80% to ...
... We are still not clear on how substituting one addiction for another is therapy…. Nicotine Nasal Spray Nicotine nasal spray (Nicotrol NS®) is an aqueous solution of nicotine delivering approximately 0.5 mg of nicotine to the nasal mucosa with each spray. Nasal irritation is common, affecting 80% to ...
27 Gastrointestinal drugs
... and citrate (Shohl’s) solution died due to hyperaluminaemia.2 When these cases were compared with another 34 renal patients, it was found that the fatalities had occurred in patients who had taken more aluminium hydroxide, more citrate, and who were older. When both groups were considered together, ...
... and citrate (Shohl’s) solution died due to hyperaluminaemia.2 When these cases were compared with another 34 renal patients, it was found that the fatalities had occurred in patients who had taken more aluminium hydroxide, more citrate, and who were older. When both groups were considered together, ...
Chapter-3 Drug and excipients profile
... magnesium hydroxide carries away much of the body's supply of potassium, and failure to take extra potassium may lead to muscle cramps. Magnesium hydroxide is also used as an antiperspirant armpit deodorant. Milk of magnesia is useful against canker sores (aphthous ulcer) when used topically. Milk o ...
... magnesium hydroxide carries away much of the body's supply of potassium, and failure to take extra potassium may lead to muscle cramps. Magnesium hydroxide is also used as an antiperspirant armpit deodorant. Milk of magnesia is useful against canker sores (aphthous ulcer) when used topically. Milk o ...
DEVELOPMENT AND VALIDATION OF SPECTROPHOTOMETRIC METHOD OF
... tablet dosage form. The λmax was found to be 283 nm. Beer’s law was obeyed in the concentration range of 3-18 µg/ml. The regression equation was y = 0.064 x + 0.013 with value of R2 as 0.996. The method showed good linearity, accuracy and reproducibility. Accuracy was determined using standard addit ...
... tablet dosage form. The λmax was found to be 283 nm. Beer’s law was obeyed in the concentration range of 3-18 µg/ml. The regression equation was y = 0.064 x + 0.013 with value of R2 as 0.996. The method showed good linearity, accuracy and reproducibility. Accuracy was determined using standard addit ...
achieving success in the sustained regeneration form of corporate
... proficiency with the complexities of managing a portfolio of advanced NPD projects. Further, low levels of product advancement could be associated with low launch rates for firms who initiate many products only to discontinue development when additional information reveals that the investment is not ...
... proficiency with the complexities of managing a portfolio of advanced NPD projects. Further, low levels of product advancement could be associated with low launch rates for firms who initiate many products only to discontinue development when additional information reveals that the investment is not ...
Diversity and Versatility of Actinomycetes and its Role in Antibiotic
... many of which have been successfully isolated and turned into useful drugs and other organic chemicals. Microbial pathogens are becoming increasingly resistant to available treatments so new antibiotics are needed, but the channel of compounds under development is scarce. There is frantic need of ne ...
... many of which have been successfully isolated and turned into useful drugs and other organic chemicals. Microbial pathogens are becoming increasingly resistant to available treatments so new antibiotics are needed, but the channel of compounds under development is scarce. There is frantic need of ne ...
On-site testing of saliva and sweat with Drugwipe and determination
... of abuse [8–13]. Particular interest has been expressed by law enforcement agencies for roadside testing of potentially intoxicated drivers [14–16]. The presence of certain drugs of abuse or their metabolites in urine can be interpreted as evidence of relatively recent exposure, except for cannabis. ...
... of abuse [8–13]. Particular interest has been expressed by law enforcement agencies for roadside testing of potentially intoxicated drivers [14–16]. The presence of certain drugs of abuse or their metabolites in urine can be interpreted as evidence of relatively recent exposure, except for cannabis. ...
Chemistry 2009-to-2004 Standards Crosswalk
... Objective 4.03 not addressed, it is an enrichment topic and may be used to differentiate the honors course. Objective 5.05 not addressed, it is an enrichment topic and may be used to differentiate the honors course. ...
... Objective 4.03 not addressed, it is an enrichment topic and may be used to differentiate the honors course. Objective 5.05 not addressed, it is an enrichment topic and may be used to differentiate the honors course. ...
Salvia Divinorum
... Neither Salvia divinorum nor its active constituent salvinorin A has an approved medical use in the U.S. Chemistry and Pharmacology ...
... Neither Salvia divinorum nor its active constituent salvinorin A has an approved medical use in the U.S. Chemistry and Pharmacology ...
Pharmacokinetics Warfarin
... • A patient taking Cefdinir may experience a lowering of her INR due to the gut flora being altered. False (INR would be increased) • The interaction of aspirin and warfarin is due to warfarin being displaced from protein binding sites causing an increased INR. False (It doesn’t displace binding sit ...
... • A patient taking Cefdinir may experience a lowering of her INR due to the gut flora being altered. False (INR would be increased) • The interaction of aspirin and warfarin is due to warfarin being displaced from protein binding sites causing an increased INR. False (It doesn’t displace binding sit ...
Non-respiratory functions of the lung
... to uric acid. This selectivity of the lung seems to imply that it acts as a metabolic filter removing certain locally important vasoactive substances, while substances important to systemic regulation pass unaffected. It also implies that vasoactive substances normally removed by the lung may have p ...
... to uric acid. This selectivity of the lung seems to imply that it acts as a metabolic filter removing certain locally important vasoactive substances, while substances important to systemic regulation pass unaffected. It also implies that vasoactive substances normally removed by the lung may have p ...
Alzheimers consultee and commentator comments
... • As many as one in five people with early Alzheimer’s disease experience depression that could be identified and treated by a GP. Treatment of depression improves cognitive function and self care. This is likely to improve quality of life and probably reduce the level of required support and hence ...
... • As many as one in five people with early Alzheimer’s disease experience depression that could be identified and treated by a GP. Treatment of depression improves cognitive function and self care. This is likely to improve quality of life and probably reduce the level of required support and hence ...
Tutorial Planner - Collegiate Medical Centre
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
... outpatients who are unable to absorb oral agents because of gastric atony or vomiting. Injectables are used in the emergency room or inpatient settings. The new agents are used when all else fails. Some antihistamines commonly used as vestibular suppressants have significant antiemetic properties (e ...
Diagnostic pitfalls of drug-induced immune hemolytic anemia
... drug-induced immune destruction of cells. Although complement-mediated cell destruction is understood quite well, many aspects of the more common extravascular destruction of blood cells are still not understood. Over the last four decades, we have learned that important factors such as immunoglobul ...
... drug-induced immune destruction of cells. Although complement-mediated cell destruction is understood quite well, many aspects of the more common extravascular destruction of blood cells are still not understood. Over the last four decades, we have learned that important factors such as immunoglobul ...
navigating the regulatory landscape
... that is generally recognized by consumers or a chemical or other technical name.9 In this case, the labeling declaration requirements on the finished cosmetic could raise an issue of proper identification with respect to the synthetic biology squalane because there is no recognized or accepted stand ...
... that is generally recognized by consumers or a chemical or other technical name.9 In this case, the labeling declaration requirements on the finished cosmetic could raise an issue of proper identification with respect to the synthetic biology squalane because there is no recognized or accepted stand ...
Dissolution Stability of Cephalexin Extemporaneous Suspensions
... dissolution behavior throughout its life, which is known as Dissolution Stability (19). This concept is a critical biopharmaceutical parameter because of the potential impact it may have on the bioavailability of the product. Therefore, it is essential that the dissolution characteristics of a pharm ...
... dissolution behavior throughout its life, which is known as Dissolution Stability (19). This concept is a critical biopharmaceutical parameter because of the potential impact it may have on the bioavailability of the product. Therefore, it is essential that the dissolution characteristics of a pharm ...
ELECTRICALLY ASSISTED TRANSDERMAL DELIVERY OF ESCIN
... chloride reagent was prepared immediately before use by dissolving 75 mg of ferric chloride in 100 phosphate buffer containing 10% sulfuric acid while shaking and cooling. Preparation of the electric circuit used in the in vitro permeation studies An electric circuit was custom designed 26 using 220 ...
... chloride reagent was prepared immediately before use by dissolving 75 mg of ferric chloride in 100 phosphate buffer containing 10% sulfuric acid while shaking and cooling. Preparation of the electric circuit used in the in vitro permeation studies An electric circuit was custom designed 26 using 220 ...
Foundation - The Learning Oasis
... published a list of commonly used drugs. The most notable of these is the one created in Great Britain, Martindale’s Pharmacopoeia. It was also during this time that pharmacists began to be recognized as healthcare providers. In North America, during the colonial period (from the 1600s to the 1700s) ...
... published a list of commonly used drugs. The most notable of these is the one created in Great Britain, Martindale’s Pharmacopoeia. It was also during this time that pharmacists began to be recognized as healthcare providers. In North America, during the colonial period (from the 1600s to the 1700s) ...
PHARMACOLOGY/THERAPEUTICS I - Stritch School of Medicine
... Warfarin also produces necrosis (Coumadin® induced necrosis). This is basically due to the impairment of the functionality of protein C. This protein also requires - carboxylation of glutamic acid for functionality. ...
... Warfarin also produces necrosis (Coumadin® induced necrosis). This is basically due to the impairment of the functionality of protein C. This protein also requires - carboxylation of glutamic acid for functionality. ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.