DEVELOPMENT AND EVALUATION OF ANTIFUNGAL TOPICAL NIOSOMAL GEL FORMULATION Research Article
... compared to the stability of conventional dosage forms.3 Niosomes characteristics such as lamellarity, lipid composition and structure4 surface charge and size5 and physiochemical nature of drug itself6 may affect follicular deposition of drugs. Niosomes offer several advantages over liposomes such ...
... compared to the stability of conventional dosage forms.3 Niosomes characteristics such as lamellarity, lipid composition and structure4 surface charge and size5 and physiochemical nature of drug itself6 may affect follicular deposition of drugs. Niosomes offer several advantages over liposomes such ...
MIOSHA Fact Sheet Preventing Exposure to Hazardous Drugs
... exposed. The drugs must be properly labeled according to the requirements of the Federal Drug Administration. Employees must have access to the SDSs and must receive training on the specific hazards posed by each hazardous drug. Part 33 and 433 Personal Protective Equipment (PPE) requires employers ...
... exposed. The drugs must be properly labeled according to the requirements of the Federal Drug Administration. Employees must have access to the SDSs and must receive training on the specific hazards posed by each hazardous drug. Part 33 and 433 Personal Protective Equipment (PPE) requires employers ...
What Are Next Generation Innovative Therapeutic Targets?
... targets have been derived from analysis of disease relevance, functional roles, expression profiles, and loss-of-function genetics between normal and disease states (Ryan and Patterson, 2002; Nicolette and Miller, 2003; Kramer and Cohen, 2004; Austen and Dohrmann, 2005; Jackson and Harrington, 2005; ...
... targets have been derived from analysis of disease relevance, functional roles, expression profiles, and loss-of-function genetics between normal and disease states (Ryan and Patterson, 2002; Nicolette and Miller, 2003; Kramer and Cohen, 2004; Austen and Dohrmann, 2005; Jackson and Harrington, 2005; ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) e-ISSN: 2278-3008, p-ISSN:2319-7676.
... powdered filled capsule, compressed tablet, coated tablet. The main disadvantage of soft gelatin capsules is their high production cost. Therefore, a more recent technique, entitled “powdered solution technology”, has been applied to prepare water-insoluble drugs into rapid-release solid dosage form ...
... powdered filled capsule, compressed tablet, coated tablet. The main disadvantage of soft gelatin capsules is their high production cost. Therefore, a more recent technique, entitled “powdered solution technology”, has been applied to prepare water-insoluble drugs into rapid-release solid dosage form ...
MIOSHA Fact Sheet Preventing Exposure to Hazardous Drugs
... exposed. The drugs must be properly labeled according to the requirements of the Federal Drug Administration. Employees must have access to the SDSs and must receive training on the specific hazards posed by each hazardous drug. Part 33 and 433 Personal Protective Equipment (PPE) requires employers ...
... exposed. The drugs must be properly labeled according to the requirements of the Federal Drug Administration. Employees must have access to the SDSs and must receive training on the specific hazards posed by each hazardous drug. Part 33 and 433 Personal Protective Equipment (PPE) requires employers ...
AMINOPHYLLINE 100 mg Tablets Dear patient, Please
... It is suggested that theophylline exerts these effects by inhibition of phosphodiesterase. AMINOPHYLLINE is used as a bronchodilator in the management of reversible airways obstruction, associated with chronic asthma and other chronic lung diseases such as emphysema and chronic bronchitis. The way t ...
... It is suggested that theophylline exerts these effects by inhibition of phosphodiesterase. AMINOPHYLLINE is used as a bronchodilator in the management of reversible airways obstruction, associated with chronic asthma and other chronic lung diseases such as emphysema and chronic bronchitis. The way t ...
Principles of Pharmacology
... -Blood-brain barrier (cell layer and basement membrane) To penetrate CNS drug must cross BBB, which consists of epithelial and basement membrane cells Are no pores, gaps etc to allow easy penetration of drugs Drug penetration of BBB relates to lipid solubility and ionization Highly lipid soluble non ...
... -Blood-brain barrier (cell layer and basement membrane) To penetrate CNS drug must cross BBB, which consists of epithelial and basement membrane cells Are no pores, gaps etc to allow easy penetration of drugs Drug penetration of BBB relates to lipid solubility and ionization Highly lipid soluble non ...
Section 4.1 Naming Binary Compounds
... compounds of a metal and nonmetal. 2. Use the stock system to predict the names & chemical formulas of binary ionic compounds that contain dblock elements that form 2/more cations with different ...
... compounds of a metal and nonmetal. 2. Use the stock system to predict the names & chemical formulas of binary ionic compounds that contain dblock elements that form 2/more cations with different ...
PHARMACEUTICAL STUDIES ON FLASH TABLETS OFA HIGHLY SOLUBLE METFORMIN HYDROCHLORIDE
... type-2 diabetes [1]. It is used in drug discovery in vivo models to assess the anti-diabetic potential of other drugs. Metformin became commercially available in 1957.Therapeutic doses of metformin do not produce hypoglycemia, and it is a therapeutic advantage when compared with sulfonyl ureas[2].Do ...
... type-2 diabetes [1]. It is used in drug discovery in vivo models to assess the anti-diabetic potential of other drugs. Metformin became commercially available in 1957.Therapeutic doses of metformin do not produce hypoglycemia, and it is a therapeutic advantage when compared with sulfonyl ureas[2].Do ...
High Hazard Chemical Registration Form
... Please provide the Safety Data Sheet (SDS) for this chemical with the registration form. Safety Data Sheets are available from the supplier or maker of this chemical and must be the most current version. As per the Tufts University Chemical Hygiene Plan, work with hazardous substances cannot be carr ...
... Please provide the Safety Data Sheet (SDS) for this chemical with the registration form. Safety Data Sheets are available from the supplier or maker of this chemical and must be the most current version. As per the Tufts University Chemical Hygiene Plan, work with hazardous substances cannot be carr ...
FDA Advisory Panel Recommends Approval of Tysabri
... more; it could be less," he said. "What I would like to see are numbers in the hundreds of thousands." SUPERB CLINICAL OUTCOMES Even though neurologists have different opinions about the benefit-risk ratio and the long-term patient outcomes, many have been quick to state that natalizumab has been as ...
... more; it could be less," he said. "What I would like to see are numbers in the hundreds of thousands." SUPERB CLINICAL OUTCOMES Even though neurologists have different opinions about the benefit-risk ratio and the long-term patient outcomes, many have been quick to state that natalizumab has been as ...
Click Here to View
... Chronic use of Suboxone and Subutex can cause dependence similar to Opioids. Abrupt use of the medicine can cause withdrawal symptoms, although symptoms may be milder and delayed in onset Due to presence of Naloxone, if suboxone is administered in the presence of Opioids in the system, it can cause ...
... Chronic use of Suboxone and Subutex can cause dependence similar to Opioids. Abrupt use of the medicine can cause withdrawal symptoms, although symptoms may be milder and delayed in onset Due to presence of Naloxone, if suboxone is administered in the presence of Opioids in the system, it can cause ...
SUSTAINED RELEASE AEROSOL FOR PULMONARY DRUG DELIVERY SYSTEM: A REVIEW
... solubility and liphophilicity. Both hydrophilic and lipophilic drugs are absorbed through the lung. Low molecular substances such as nicotine and its derivatives are well absorbed in lung. The gastrointestinal route difficulties such as poor solubility, low bioavailability, unwanted metabolites, foo ...
... solubility and liphophilicity. Both hydrophilic and lipophilic drugs are absorbed through the lung. Low molecular substances such as nicotine and its derivatives are well absorbed in lung. The gastrointestinal route difficulties such as poor solubility, low bioavailability, unwanted metabolites, foo ...
110 EXAM Review MATERIALTro
... b. Heterogeneous mixture has 2 or more physically distinct phases. Examples: ...
... b. Heterogeneous mixture has 2 or more physically distinct phases. Examples: ...
(continued): Many commercially available liquid preparations are
... Sublingual and Buccal Medications: Sublingual and buccal tablets are placed under the tongue or between the gum and cheek, respectively. These products are meant to dissolve quickly in the mouth for rapid absorption through a large supply of blood vessels in the oral mucosa. Drugs are often given vi ...
... Sublingual and Buccal Medications: Sublingual and buccal tablets are placed under the tongue or between the gum and cheek, respectively. These products are meant to dissolve quickly in the mouth for rapid absorption through a large supply of blood vessels in the oral mucosa. Drugs are often given vi ...
Photostability
... involved and the intensity of the light sources used. For development and validation purposes, it is appropriate to limit exposure and end the studies if extensive decomposition occurs. For photostable materials, studies may be terminated after an appropriate exposure level has been used. The design ...
... involved and the intensity of the light sources used. For development and validation purposes, it is appropriate to limit exposure and end the studies if extensive decomposition occurs. For photostable materials, studies may be terminated after an appropriate exposure level has been used. The design ...
Review on shilajit used in traditional Indian medicine
... Currently, there are three major theories explaining the origin of shilajit namely biological, geological and bio-mineralogical. Accordingly, the biological hypothesis of shilajit represents as a product of biological conversion occurring under certain physiochemical conditions of dead plant residue ...
... Currently, there are three major theories explaining the origin of shilajit namely biological, geological and bio-mineralogical. Accordingly, the biological hypothesis of shilajit represents as a product of biological conversion occurring under certain physiochemical conditions of dead plant residue ...
Advanced Cellular Respiration Worksheet
... 13. The former diet drug dinitrophenol (DNP) makes the membrane of the mitochondrian leaky to hydrogen ions. What effect would this have on ATP production? What specific component of ATP production is affected by this effect? If you were told that sometimes people die of “overheating” when on this d ...
... 13. The former diet drug dinitrophenol (DNP) makes the membrane of the mitochondrian leaky to hydrogen ions. What effect would this have on ATP production? What specific component of ATP production is affected by this effect? If you were told that sometimes people die of “overheating” when on this d ...
Cytochrome P450
... be measured by difference spectrometry and is referred to as the "type I" difference spectrum (see inset graph in figure). Some substrates cause an opposite change in spectral properties, a "reverse type I" spectrum, by processes that are as yet unclear. Inhibitors and certain substrates that bind ...
... be measured by difference spectrometry and is referred to as the "type I" difference spectrum (see inset graph in figure). Some substrates cause an opposite change in spectral properties, a "reverse type I" spectrum, by processes that are as yet unclear. Inhibitors and certain substrates that bind ...
Chapter 2 power point
... because the components are mixed as individual atoms, ions, and/or molecules. A homogeneous mixture is also called a solution. Solutions in which water is the solvent are called aqueous solutions. ...
... because the components are mixed as individual atoms, ions, and/or molecules. A homogeneous mixture is also called a solution. Solutions in which water is the solvent are called aqueous solutions. ...
Naming Binary Molecular Compounds
... Yes, even though there are no metals present, the ammonium ion is a common polyatomic cation. Are there any monoatomic ions? No, the cation and anion are both polyatomic. Which elements have specific rules? H = +1 because it is attached to a non-metal (N) O = -2 Which elements do not have a specific ...
... Yes, even though there are no metals present, the ammonium ion is a common polyatomic cation. Are there any monoatomic ions? No, the cation and anion are both polyatomic. Which elements have specific rules? H = +1 because it is attached to a non-metal (N) O = -2 Which elements do not have a specific ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.