weight-loss drugs
... office, the risks of these three drugs include primary pulmonary hypertension, valvular heart disease, and neurotoxicity. Under fire from NAAFA and other consumer advocates and following studies which indicated that one-third of users of dexfenfluramine and fenfluramine had contracted valvular hear ...
... office, the risks of these three drugs include primary pulmonary hypertension, valvular heart disease, and neurotoxicity. Under fire from NAAFA and other consumer advocates and following studies which indicated that one-third of users of dexfenfluramine and fenfluramine had contracted valvular hear ...
Document
... α1↓→vasodilation→BP↓ ----↘ α2↓→NA release↑→β↑→heart ↑ ↑ α1D,α1B ↓→ vasodilation→BP↓ α1A↓→smooth muscle of prostate↓ ...
... α1↓→vasodilation→BP↓ ----↘ α2↓→NA release↑→β↑→heart ↑ ↑ α1D,α1B ↓→ vasodilation→BP↓ α1A↓→smooth muscle of prostate↓ ...
Chemistry - Bourbon County Schools
... hybridization models relate to molecular geometry Describe the molecular orbital models for double bonds, triple bonds, and ...
... hybridization models relate to molecular geometry Describe the molecular orbital models for double bonds, triple bonds, and ...
Bath Salts Alert
... Until now easily obtained over the Internet, these bath salts, which have nothing to do with any hygiene product, go by such names as Ivory Wave and Vanilla Sky. The main ingredient in PABS is methylenedioxypyrovalerone, which is structurally related to pyrovalerone and a-pyrrolidinophenone compound ...
... Until now easily obtained over the Internet, these bath salts, which have nothing to do with any hygiene product, go by such names as Ivory Wave and Vanilla Sky. The main ingredient in PABS is methylenedioxypyrovalerone, which is structurally related to pyrovalerone and a-pyrrolidinophenone compound ...
Short Communication PHYSICOCHEMICAL AND PRELIMINARY PHYTOCHEMICAL STUDIES ON THE RHIZOME OF ACORUS CALAMUS AJAY KUMAR MEENA
... The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the rhizome of Acorus calamus Linn. Araceae family. Acorus calamus is a perennial, semi‐aquatic and smelly plant, found in both temperate and sub temperate zones. It is up to ...
... The present communication attempts to evaluate the physicochemical and preliminary phytochemical studies on the rhizome of Acorus calamus Linn. Araceae family. Acorus calamus is a perennial, semi‐aquatic and smelly plant, found in both temperate and sub temperate zones. It is up to ...
Recreational Drugs - Immunodeficiency Clinic
... Key: AUC = area under the concentration-time curve, Cmax = maximum plasma concentration, CYP = cytochrome P450, HAART = highly active antiretroviral therapy, IV = intravenous, PIs = protease inhibitors, sgc = soft gel capsule Please note: This chart summarizes some of the major drug interactions ide ...
... Key: AUC = area under the concentration-time curve, Cmax = maximum plasma concentration, CYP = cytochrome P450, HAART = highly active antiretroviral therapy, IV = intravenous, PIs = protease inhibitors, sgc = soft gel capsule Please note: This chart summarizes some of the major drug interactions ide ...
Report on New Patented Drugs — Olmetec Application of the
... The publication of Summary Reports is part of the PMPRB’s commitment to make its price review process more transparent. Where comparators and dosage regimens are referred to in the Summary Reports, they have been selected by the HDAP for the purpose of carrying out the PMPRB’s regulatory mandate, wh ...
... The publication of Summary Reports is part of the PMPRB’s commitment to make its price review process more transparent. Where comparators and dosage regimens are referred to in the Summary Reports, they have been selected by the HDAP for the purpose of carrying out the PMPRB’s regulatory mandate, wh ...
1. some basic concepts of chemistry
... and pressure. Illustration: H2 combines with O2 to form water vapour according to the equation 2H2(g) + O2(g) → 2H2O(g). If 100 mL of hydrogen combine with 50 mL of oxygen, we get 100 mL of water vapour. Thus, the volumes of hydrogen and oxygen which combine together (i.e. 100 mL and 50 mL) bear a s ...
... and pressure. Illustration: H2 combines with O2 to form water vapour according to the equation 2H2(g) + O2(g) → 2H2O(g). If 100 mL of hydrogen combine with 50 mL of oxygen, we get 100 mL of water vapour. Thus, the volumes of hydrogen and oxygen which combine together (i.e. 100 mL and 50 mL) bear a s ...
R D ESEARCH AND EVELOPMENT
... The ideal solution is when the descriptor is known from the beginning of the development, in preclinical phase. In this case, the drug development is performed along with that of the companion test which can be validated before clinical study start. The study methodology is standard. However, the ma ...
... The ideal solution is when the descriptor is known from the beginning of the development, in preclinical phase. In this case, the drug development is performed along with that of the companion test which can be validated before clinical study start. The study methodology is standard. However, the ma ...
a review on dosage regimen - Indian Journal of Pharmaceutical
... The main objective of individualization is aimed at optimizing the dosage regimen. An inadequate therapeutic response calls for a higher dosage whereas drug related toxicity calls for a reduction in dosage. Thus in order to aid individualization, a drug must be made available in dosage forms of diff ...
... The main objective of individualization is aimed at optimizing the dosage regimen. An inadequate therapeutic response calls for a higher dosage whereas drug related toxicity calls for a reduction in dosage. Thus in order to aid individualization, a drug must be made available in dosage forms of diff ...
COMPARATIVE EVALUATION OF POTATO STARCH AND BANANA POWDER AS
... the grain followed by rapture of tablet core[3]. Banana fruit is economically one of the most important fruit produced and consumed in the world. The soft and sweet fruit of this tropical plant is enjoyed by the people from around the world. The main objective of this study was to utilize banana pow ...
... the grain followed by rapture of tablet core[3]. Banana fruit is economically one of the most important fruit produced and consumed in the world. The soft and sweet fruit of this tropical plant is enjoyed by the people from around the world. The main objective of this study was to utilize banana pow ...
FORMULATION AND EVALUATION OF SINTERED GASTRO RETENTIVE TABLETS OF GLIPIZIDE
... Hydrodynamically Balanced Systems (HBS) with sintering technique is an approach to increase the gastric residence time of drugs in stomach. This system is designed for site specific oral drugs with low bulk density than gastric fluids so as to buoyant the dosage form in stomach to increase the resid ...
... Hydrodynamically Balanced Systems (HBS) with sintering technique is an approach to increase the gastric residence time of drugs in stomach. This system is designed for site specific oral drugs with low bulk density than gastric fluids so as to buoyant the dosage form in stomach to increase the resid ...
The Right Dosage Form and the Right Route of Administration
... the intestine. Figure 8.3 shows an example of an enteric-coated tablet. Controlledrelease tablets are formulated to release the drug over a predetermined period of time to provide more constant levels of the drug in the bloodstream (see Fig. 8.4 for a controlled-release tablet). This may be accompli ...
... the intestine. Figure 8.3 shows an example of an enteric-coated tablet. Controlledrelease tablets are formulated to release the drug over a predetermined period of time to provide more constant levels of the drug in the bloodstream (see Fig. 8.4 for a controlled-release tablet). This may be accompli ...
Press Release English
... “Pharmacoscopy” enables immunomodulatory drug discovery by analyzing immune cell interactions A novel microscopy method allows unprecedented insights into the spatial organization and direct interactions of immune cells within blood and other liquid multi-lineage tissues. The assay, called “Pharmaco ...
... “Pharmacoscopy” enables immunomodulatory drug discovery by analyzing immune cell interactions A novel microscopy method allows unprecedented insights into the spatial organization and direct interactions of immune cells within blood and other liquid multi-lineage tissues. The assay, called “Pharmaco ...
viagra
... Its primary competitors on the market are tadalafil (犀利士) and vardenafil (樂威壯). History Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina ...
... Its primary competitors on the market are tadalafil (犀利士) and vardenafil (樂威壯). History Sildenafil was synthesized by a group of pharmaceutical chemists working at Pfizer's Sandwich, Kent research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina ...
PHA 510 Adult Internal Medicine Advanced Pharmacy Practice
... 1.6.1. Utilize basic science, math, economic and therapeutic principles in selecting and justifying drug therapy for a patient. 1.6.2. Recommend drug therapies based on patient-, drug-, and disease-specific parameters. 1.6.3. Recommend appropriate preventative medicine and non-pharmacologic therapy ...
... 1.6.1. Utilize basic science, math, economic and therapeutic principles in selecting and justifying drug therapy for a patient. 1.6.2. Recommend drug therapies based on patient-, drug-, and disease-specific parameters. 1.6.3. Recommend appropriate preventative medicine and non-pharmacologic therapy ...
The use of fosmid metagenomic libraries in preliminary screening for
... Background: It is generally believed that there are many natural sources of as yet unknown bioactive compounds with a high biotechnological potential. However, the common method based on the use of cell extracts in the preliminary screening for particular molecules or activities is problematic as am ...
... Background: It is generally believed that there are many natural sources of as yet unknown bioactive compounds with a high biotechnological potential. However, the common method based on the use of cell extracts in the preliminary screening for particular molecules or activities is problematic as am ...
How clinical trials create breakthroughs in care
... • Tumor expression >>> Normal-tissue expression ...
... • Tumor expression >>> Normal-tissue expression ...
A Patient of Poisoning in ICU
... – AC is a highly adsorbent powder made of high surface area porous organic material. Its extensive surface area surface area(2000 m2/g) is covered with a carbon based network which adsorbs chemicals within minutes of contact preventing GI absorption and hence systemic toxicity. – Highest affinity is ...
... – AC is a highly adsorbent powder made of high surface area porous organic material. Its extensive surface area surface area(2000 m2/g) is covered with a carbon based network which adsorbs chemicals within minutes of contact preventing GI absorption and hence systemic toxicity. – Highest affinity is ...
IN TRIHYDRATE Research Article
... swallowing intact or chewing to deliver a precise dosage of medication to patients. The pills, which include tablets and capsules, are able to retain their shapes under moderate pressure. However, some patients, particularly pediatric, geriatric, bedridden, psychiatry and traveling patients have dif ...
... swallowing intact or chewing to deliver a precise dosage of medication to patients. The pills, which include tablets and capsules, are able to retain their shapes under moderate pressure. However, some patients, particularly pediatric, geriatric, bedridden, psychiatry and traveling patients have dif ...
- Warwick WRAP
... polyplexes have all been reported.8-15 Some of the systems are well established and investigated, and are currently in clinical trials.9,16 Most of the formulations in clinical use or trials at the moment are simple monofunctional micellar systems. The next phase of drug delivery research, already w ...
... polyplexes have all been reported.8-15 Some of the systems are well established and investigated, and are currently in clinical trials.9,16 Most of the formulations in clinical use or trials at the moment are simple monofunctional micellar systems. The next phase of drug delivery research, already w ...
inspired by biology, chemists have created a cornucopia of
... he robot moves slowly along its track, pausing regularly to reach out an arm that carefully scoops up a component. The arm connects the component to an elaborate construction on the robot’s back. Then the robot moves forward and repeats the process — systematically stringing the parts together accor ...
... he robot moves slowly along its track, pausing regularly to reach out an arm that carefully scoops up a component. The arm connects the component to an elaborate construction on the robot’s back. Then the robot moves forward and repeats the process — systematically stringing the parts together accor ...
absorption - PHARMACEUTICAL REVIEW
... action. Absorption involves several phases. First, the drug needs to be introduced via some route of administration and in a specific dosage form such as a tablet, capsule, and so on. Absorption is a primary focus in drug development and medicinal chemistry, since the drug must be absorbed before an ...
... action. Absorption involves several phases. First, the drug needs to be introduced via some route of administration and in a specific dosage form such as a tablet, capsule, and so on. Absorption is a primary focus in drug development and medicinal chemistry, since the drug must be absorbed before an ...
macrotys. - David Winston`s Center for Herbal Studies
... statement that" the more acute the disease, the more prompt and decided will be the action of the remedy." The Committee of the American Medical Association, 1848, Dr. N. S. Davis, Chairman, reported that the committee" uniformly found Macrotys to lessen the frequency and force of the pulse, to soot ...
... statement that" the more acute the disease, the more prompt and decided will be the action of the remedy." The Committee of the American Medical Association, 1848, Dr. N. S. Davis, Chairman, reported that the committee" uniformly found Macrotys to lessen the frequency and force of the pulse, to soot ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.