rajiv gandhi university of health sciences
... decrease the risk of stroke by 34%, of heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease7. There are many classes of antihypertensive, which lower blood pressure by different means; among the most important and most widely used are ...
... decrease the risk of stroke by 34%, of heart disease by 21%, and reduce the likelihood of dementia, heart failure, and mortality from cardiovascular disease7. There are many classes of antihypertensive, which lower blood pressure by different means; among the most important and most widely used are ...
Drug Use Indicators - Medicines Utilisation Research in Africa
... – To measure the effectiveness of the information given to patients on dosage schedule of drugs they receive – Access to a written prescription or to a patient record against which patients’ knowledge on the dosage schedule can be checked is required – Investigators must be trained to evaluate patie ...
... – To measure the effectiveness of the information given to patients on dosage schedule of drugs they receive – Access to a written prescription or to a patient record against which patients’ knowledge on the dosage schedule can be checked is required – Investigators must be trained to evaluate patie ...
In vitro Nanoparticles Sareh Arjmand, Elham Bidram, Abbas
... component of the lung epithelial lining fluid [3]. AAT has a wide spectrum of anti protease activity inhibiting several serine proteases, but neutrophil elastase is its primary protease target. AAT deficiency predisposes patients to emphysema, juvenile cirrhosis and hepatocellular carcinoma [4; 5]. ...
... component of the lung epithelial lining fluid [3]. AAT has a wide spectrum of anti protease activity inhibiting several serine proteases, but neutrophil elastase is its primary protease target. AAT deficiency predisposes patients to emphysema, juvenile cirrhosis and hepatocellular carcinoma [4; 5]. ...
Chapter 3: The Chemical Basis for Life Lesson 2: Organic Compounds
... identify their differences? The only differences are the positions of some of the atoms. These differences affect the properties of the two monosaccharides. Fructose is found in fruits, whereas glucose generally results from the digestion of other carbohydrates. Glucose is used for energy by the cel ...
... identify their differences? The only differences are the positions of some of the atoms. These differences affect the properties of the two monosaccharides. Fructose is found in fruits, whereas glucose generally results from the digestion of other carbohydrates. Glucose is used for energy by the cel ...
Slide 1
... For acute pain For dose finding during initial treatment of chronic pain For “rescue” dosing Can be used for long-term management in ...
... For acute pain For dose finding during initial treatment of chronic pain For “rescue” dosing Can be used for long-term management in ...
Novel Detoxification from Opiates
... Now, if you apply for an exemption to prescribe, rational detoxification is possible Some will tolerate rapid detoxification (one to two weeks) Some will require stabilization prior to detoxification Buprenorphine is a great detoxification medication ...
... Now, if you apply for an exemption to prescribe, rational detoxification is possible Some will tolerate rapid detoxification (one to two weeks) Some will require stabilization prior to detoxification Buprenorphine is a great detoxification medication ...
introduction into Analytical Chemistry
... In medicine, analytical chemistry is the basis for clinical laboratory tests which help the physicians diagnose disease In industry, analytical chemistry provides the means of testing the raw materials for assuring the quality of finished products whose chemical composition is critical (eg. Drugs ...
... In medicine, analytical chemistry is the basis for clinical laboratory tests which help the physicians diagnose disease In industry, analytical chemistry provides the means of testing the raw materials for assuring the quality of finished products whose chemical composition is critical (eg. Drugs ...
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... the fact that other potentially harmful drugs (including synthetic cathinones, the psychoactive ingredients in “bath salts”) are sometimes sold as ecstasy. These drugs can be neurotoxic or pose other unpredic ...
... the fact that other potentially harmful drugs (including synthetic cathinones, the psychoactive ingredients in “bath salts”) are sometimes sold as ecstasy. These drugs can be neurotoxic or pose other unpredic ...
The importance of inhaler devices in the treatment of COPD
... molecules directly to the target site of action, whilst minimising adverse side-effects. Inhalers therefore play a crucial role in the effective management of patients with COPD and their choice is as important as that of the drug. The three most important factors that influence inhaled drug deposit ...
... molecules directly to the target site of action, whilst minimising adverse side-effects. Inhalers therefore play a crucial role in the effective management of patients with COPD and their choice is as important as that of the drug. The three most important factors that influence inhaled drug deposit ...
Slide 1
... labdanum, the term for a plant extract. He did not know of its addictive properties. In the 19th century, laudanum was used in many patent medicines to "relieve pain... to produce sleep... to allay irritation... to check excessive secretions... to support the system... [and] as a sudorific". The l ...
... labdanum, the term for a plant extract. He did not know of its addictive properties. In the 19th century, laudanum was used in many patent medicines to "relieve pain... to produce sleep... to allay irritation... to check excessive secretions... to support the system... [and] as a sudorific". The l ...
Invention reinvented
... that reinvention. We examine the untapped scope for improving productivity not through scientific innovation, but through better management of R&D and the use of IT in clinical trials. We publish original research on why so many drugs fall out of the development pipeline, and on what makes some labo ...
... that reinvention. We examine the untapped scope for improving productivity not through scientific innovation, but through better management of R&D and the use of IT in clinical trials. We publish original research on why so many drugs fall out of the development pipeline, and on what makes some labo ...
chemical hygiene plan - University of Louisville
... Lab-specific SOP’s providing detailed information relevant to safety and health considerations are required when laboratory work involves the use of highly hazardous chemicals (refer to highly hazardous chemicals in the chemical safety section of the lab safety manual) as defined by OSHA. Considerat ...
... Lab-specific SOP’s providing detailed information relevant to safety and health considerations are required when laboratory work involves the use of highly hazardous chemicals (refer to highly hazardous chemicals in the chemical safety section of the lab safety manual) as defined by OSHA. Considerat ...
Chapter 34 Antihypertension Drugs
... The physician must establish with certainty that hypertension is persistent and requires treatment and must exclude secondary causes of hypertension that might be treated by definitive surgical procedures. ...
... The physician must establish with certainty that hypertension is persistent and requires treatment and must exclude secondary causes of hypertension that might be treated by definitive surgical procedures. ...
See Jefferies presentation here
... identify forward-looking statements. Forward-looking statements represent management’s present judgment regarding future events and are subject to a number of risk and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. These ris ...
... identify forward-looking statements. Forward-looking statements represent management’s present judgment regarding future events and are subject to a number of risk and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. These ris ...
In Vitro and In Vivo Evaluation of Microparticulate Drug
... time was approximately 180 h and 6 h for Suc-Ch-MMC and CM-Ch-MMC, respectively [58]. As Suc-Ch and CM-Ch are very safe polymers, they were considered to be administered parenterally. These solid conjugates could be made into fine particles using a glass homogenizer with a Teflon pestle. The resulta ...
... time was approximately 180 h and 6 h for Suc-Ch-MMC and CM-Ch-MMC, respectively [58]. As Suc-Ch and CM-Ch are very safe polymers, they were considered to be administered parenterally. These solid conjugates could be made into fine particles using a glass homogenizer with a Teflon pestle. The resulta ...
Harvard-MIT Division of Health Sciences and Technology
... Three components: A thiazolidine ring, the β-lactam ring, and a side chain. The side chain determines in large part to antibacterial spectrum and pharmacologic properties of a particular penicillin. B. Mechanism of Action – surprisingly incompletely understood. 1. Penicillin inhibits bacterial growt ...
... Three components: A thiazolidine ring, the β-lactam ring, and a side chain. The side chain determines in large part to antibacterial spectrum and pharmacologic properties of a particular penicillin. B. Mechanism of Action – surprisingly incompletely understood. 1. Penicillin inhibits bacterial growt ...
Your Title Here - at www.arxiv.org.
... graphical aspects [8]; and a study in which a novel approach was developed for identifying biological functions of chemicals, based on the assumption that interactive chemicals participate in the same metabolic pathways [22]. As evidenced by the range of studies mentioned above, CCI has been used fo ...
... graphical aspects [8]; and a study in which a novel approach was developed for identifying biological functions of chemicals, based on the assumption that interactive chemicals participate in the same metabolic pathways [22]. As evidenced by the range of studies mentioned above, CCI has been used fo ...
Fear - Diwa
... that scientists will be able to “design” drugs or therapies based on a patient’s genetic makeup. To some extent, this is already being done in the United States. There is a family of liver enzymes called Cytochrome P450, which is responsible for breaking down more than 30 different classes of drugs. ...
... that scientists will be able to “design” drugs or therapies based on a patient’s genetic makeup. To some extent, this is already being done in the United States. There is a family of liver enzymes called Cytochrome P450, which is responsible for breaking down more than 30 different classes of drugs. ...
Grapefruit Seed Extract
... glass of grapefruit juice contains typically contains 1-2 mg bergamottin and 2-3 mg DHB. HPLC analysis revealed less than 0.1 mg/g bergamottin and 2.99 mg/g DHB in Pure Encapsulations grapefruit seed extract. The effective dose range for the seed in promoting microbial balance is 2501,000 mg, which ...
... glass of grapefruit juice contains typically contains 1-2 mg bergamottin and 2-3 mg DHB. HPLC analysis revealed less than 0.1 mg/g bergamottin and 2.99 mg/g DHB in Pure Encapsulations grapefruit seed extract. The effective dose range for the seed in promoting microbial balance is 2501,000 mg, which ...
View PDF - Hofstra Law
... drug” was shown to cause serious heart-valve problems in many patients.8 One of the more recently publicized “bad drug” scandals involved the arthritis pain medication drug rofecoxib (known under its brand name—Vioxx).9 Approved by the FDA in 1999,10 rofecoxib was part of a new class of non-steroida ...
... drug” was shown to cause serious heart-valve problems in many patients.8 One of the more recently publicized “bad drug” scandals involved the arthritis pain medication drug rofecoxib (known under its brand name—Vioxx).9 Approved by the FDA in 1999,10 rofecoxib was part of a new class of non-steroida ...
WHAT`S THE NEXT STEP?
... backbone of the PI molecule to make it look less like a peptide, the drug will display less affinity for the CYP3A4 enzyme. The Phe must be maintained in order for the drug’s mechanism of action to proceed; that being, to bind to the virus’ protease and inhibit its function. However, by altering the ...
... backbone of the PI molecule to make it look less like a peptide, the drug will display less affinity for the CYP3A4 enzyme. The Phe must be maintained in order for the drug’s mechanism of action to proceed; that being, to bind to the virus’ protease and inhibit its function. However, by altering the ...
Asia - INCB
... various ways, drug control efforts throughout the region of East and South-East Asia. 384. Significant bilateral efforts are being made, for example, by Myanmar and Thailand, which intend to exchange drug liaison officers, to improve contact between drug control officers along their common border an ...
... various ways, drug control efforts throughout the region of East and South-East Asia. 384. Significant bilateral efforts are being made, for example, by Myanmar and Thailand, which intend to exchange drug liaison officers, to improve contact between drug control officers along their common border an ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.