Diphenhydramine Hydrochloride Injection, USPRx only
... Reproduction studies have been performed in rats and rabbits at doses up to 5 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to diphenhydramine hydrochloride. There are, however, no adequate and well-controlled studies in pregnant women. Because ani ...
... Reproduction studies have been performed in rats and rabbits at doses up to 5 times the human dose and have revealed no evidence of impaired fertility or harm to the fetus due to diphenhydramine hydrochloride. There are, however, no adequate and well-controlled studies in pregnant women. Because ani ...
Drug Use Among Seniors on Public Drug Programs in Canada
... airway diseases (used for asthma, emphysema and chronic bronchitis). ...
... airway diseases (used for asthma, emphysema and chronic bronchitis). ...
Protocol S1.
... Human glucocerebrosidase has been used successfully for the clinical treatment of Gaucher disease for several years from both natural and recombinant sources (CHO production platform). This is the first trial to utilize a recombinant active form of lysosomal enzyme, glucocerebrosidase, (human prGCD) ...
... Human glucocerebrosidase has been used successfully for the clinical treatment of Gaucher disease for several years from both natural and recombinant sources (CHO production platform). This is the first trial to utilize a recombinant active form of lysosomal enzyme, glucocerebrosidase, (human prGCD) ...
Report to SACATM
... Session 1 looked at the use of zebrafish for screening compounds for cardiovascular activity. Maria Bondesson from the University of Houston introduced the use of Kdr1:GFP transgenic fish (in whom vascular endothelial cells express GFP). In these fish, arsenic causes malformed vasculature along with ...
... Session 1 looked at the use of zebrafish for screening compounds for cardiovascular activity. Maria Bondesson from the University of Houston introduced the use of Kdr1:GFP transgenic fish (in whom vascular endothelial cells express GFP). In these fish, arsenic causes malformed vasculature along with ...
Document Content Authoring and Hybrid Knowledge Bases
... is compatible with both this form and this administration. We can say that drink is a “dead” choice in this context. In order to prevent the author from entering a dead-end, what is really needed is for the system to foresee such possible clashes and to present to the author only those choices which ...
... is compatible with both this form and this administration. We can say that drink is a “dead” choice in this context. In order to prevent the author from entering a dead-end, what is really needed is for the system to foresee such possible clashes and to present to the author only those choices which ...
The Detection and Quantitative Analysis of the Psychoactive
... dosage of 50–200 µg (1,6,11). Psilocybin and mescaline, other commonly abused hallucinogens, have much larger doses of 5 and 100 mg, respectively (11). This supports the contention that salvinorin A is the most potent naturally occurring hallucinogen isolated to date (6). Although the overall experi ...
... dosage of 50–200 µg (1,6,11). Psilocybin and mescaline, other commonly abused hallucinogens, have much larger doses of 5 and 100 mg, respectively (11). This supports the contention that salvinorin A is the most potent naturally occurring hallucinogen isolated to date (6). Although the overall experi ...
Controversial Drug Given to All Guantanamo Detainees Akin to
... forced to take drugs even if they protested. Yund did not return calls for comment. Bradsher declined to respond to a follow-up question about who made the decision to presumptively treat detainees with mefloquine. An April 16, 2002, meeting of the Interagency Working Group for Antimalarial Chemothe ...
... forced to take drugs even if they protested. Yund did not return calls for comment. Bradsher declined to respond to a follow-up question about who made the decision to presumptively treat detainees with mefloquine. An April 16, 2002, meeting of the Interagency Working Group for Antimalarial Chemothe ...
Design of Drug Delivery Methods for the Brain and Central
... committee and for your valuable input during my preliminary exam. I would like to thank Dr. Marvin Rossi for sharing with me his knowledge of the brain and central nervous system, as well as for access to COMSOL software. I would like to thank Prof. Michael Cho, Prof. Urmila Diwekar, and Prof. James ...
... committee and for your valuable input during my preliminary exam. I would like to thank Dr. Marvin Rossi for sharing with me his knowledge of the brain and central nervous system, as well as for access to COMSOL software. I would like to thank Prof. Michael Cho, Prof. Urmila Diwekar, and Prof. James ...
Indonesia - K4Health
... joint statement in 2003 stating that every woman should be offered AMTSL as a means of reducing the incidence of postpartum hemorrhage. The World Health Organization (WHO) Making Pregnancy Safer Technical Update on Prevention of Postpartum Haemorrhage by AMTSL recommends that “AMTSL should be practi ...
... joint statement in 2003 stating that every woman should be offered AMTSL as a means of reducing the incidence of postpartum hemorrhage. The World Health Organization (WHO) Making Pregnancy Safer Technical Update on Prevention of Postpartum Haemorrhage by AMTSL recommends that “AMTSL should be practi ...
Lactic acid- and carbonate-based crosslinked polymeric micelles for drug delivery.
... mPEG114-b-P(CB8-co-LA35-co-MAC2.5) had a higher drug encapsulation efficiency (78.72% 6 0.15%) compared to mPEG114-b- ...
... mPEG114-b-P(CB8-co-LA35-co-MAC2.5) had a higher drug encapsulation efficiency (78.72% 6 0.15%) compared to mPEG114-b- ...
(hons) course year iv june 201
... 2) A cephamycin is a cephalosporin that has a methoxy group at position ‘7’ of the cephem nucleus. 3) The loss of the carboxyl group at position ‘4’ of the cephem nucleus by esterification does not in itself result in any loss of activity of the compound. 4) The cephalosporins owe their cidal effect ...
... 2) A cephamycin is a cephalosporin that has a methoxy group at position ‘7’ of the cephem nucleus. 3) The loss of the carboxyl group at position ‘4’ of the cephem nucleus by esterification does not in itself result in any loss of activity of the compound. 4) The cephalosporins owe their cidal effect ...
APTAMERS ROLE IN BASIC DRUG RESEARCH AND DEVELOPMENT - AN... Review Article STALIN.C*, DINESHKUMAR.P.
... Aptamers in 1990, there has been a steady annual increase in the number of publications related to Aptamers. During the last 10 years Aptamers binding to for example cells, proteins, peptides, low molecular weight molecules (like antibiotics, amino acids, and dyes) or nucleic acids have been isolate ...
... Aptamers in 1990, there has been a steady annual increase in the number of publications related to Aptamers. During the last 10 years Aptamers binding to for example cells, proteins, peptides, low molecular weight molecules (like antibiotics, amino acids, and dyes) or nucleic acids have been isolate ...
投影片 1
... A substituent is alpha when the substituent is below the plane of the molecule. It is represented by a dashed line in a 2D drawing. Examples in this molecule are: H-5, H-9, H-14, etc. A substituent is beta when the substituent is above the plane of the molecule. It is represented by a bold line in ...
... A substituent is alpha when the substituent is below the plane of the molecule. It is represented by a dashed line in a 2D drawing. Examples in this molecule are: H-5, H-9, H-14, etc. A substituent is beta when the substituent is above the plane of the molecule. It is represented by a bold line in ...
Simulation Based Assessment of Limited Sampling Strategies
... and narrow therapeutic ranges [1]. To optimize treatment efficacy and minimize toxicity, appropriate blood samples are collected for the estimation of therapeutic surrogates. The area under the plasma drug concentration-time curve (AUC) is a typical example [1-4]. Many methods have been proposed to ...
... and narrow therapeutic ranges [1]. To optimize treatment efficacy and minimize toxicity, appropriate blood samples are collected for the estimation of therapeutic surrogates. The area under the plasma drug concentration-time curve (AUC) is a typical example [1-4]. Many methods have been proposed to ...
Dow Corning Silicones in Pharmaceutical Applications
... they are not absorbed in the G.I. tract and are excreted without modification, nor are they absorbed through the skin (12). In vitro studies have not indicated mutagenic effects (12). Repeated oral or cutaneous dosages have not indicated effects on different species (12). Inhalation of aerosols of o ...
... they are not absorbed in the G.I. tract and are excreted without modification, nor are they absorbed through the skin (12). In vitro studies have not indicated mutagenic effects (12). Repeated oral or cutaneous dosages have not indicated effects on different species (12). Inhalation of aerosols of o ...
BISMUTH, GERMANIUM and ZIRCONIUM
... metal detoxification.5 Germanium in its organic form is not considered carcinogenic. Studies have shown that the organic germanium (Germanium-132, or Ge-Oxy 132) appears to inhibit cancer development and, in the form of the organic compound, Spirogermanium, to destroy cancer cells.6,7 Germanium comp ...
... metal detoxification.5 Germanium in its organic form is not considered carcinogenic. Studies have shown that the organic germanium (Germanium-132, or Ge-Oxy 132) appears to inhibit cancer development and, in the form of the organic compound, Spirogermanium, to destroy cancer cells.6,7 Germanium comp ...
Committee on Drugs 1998;101;1079 Pediatrics
... not be indicated. Supportive care includes swaddling to decrease sensory stimulation; frequent small feedings of hypercaloric (24 cal/oz) formula to supply the additional caloric requirements; and observation of sleeping habits, temperature stability, weight gain or loss, or change in clinical statu ...
... not be indicated. Supportive care includes swaddling to decrease sensory stimulation; frequent small feedings of hypercaloric (24 cal/oz) formula to supply the additional caloric requirements; and observation of sleeping habits, temperature stability, weight gain or loss, or change in clinical statu ...
Molecular modification
... it was granted on October 19, 1976, and expired in September 1993. Alprazolam is a derivative of an antidepressant similar to other earlier antidepressants such as Librium introduced in 1960. They both have a group called benzodiazepines. At that time, benzodiazepines were thought to be ineffective ...
... it was granted on October 19, 1976, and expired in September 1993. Alprazolam is a derivative of an antidepressant similar to other earlier antidepressants such as Librium introduced in 1960. They both have a group called benzodiazepines. At that time, benzodiazepines were thought to be ineffective ...
In vitro available for inhalation from different formulations P.W. Barry, C. O'Callaghan
... prescribed with the Volumatic® spacer, but the Airomir® MDI actuator does not fit the Volumatic®, and the Nebuhaler® was, therefore, assessed as an example of a large volume spacer. It may be that the poor fit of the Ventolin® MDI adapter affected our results. However, we have previously undertaken ...
... prescribed with the Volumatic® spacer, but the Airomir® MDI actuator does not fit the Volumatic®, and the Nebuhaler® was, therefore, assessed as an example of a large volume spacer. It may be that the poor fit of the Ventolin® MDI adapter affected our results. However, we have previously undertaken ...
Herb-drug interactions
... obtained internationally/Internet. Increase in blood pressure, thus contraindicated with antihypertensives and stimulants (e.g. caffeine). Black Cohosh (menopausal symptoms but UIC trial negative) – some hepatotoxicity due to adulteration recently; use cautiously. Ginkgo – 2 case reports of interact ...
... obtained internationally/Internet. Increase in blood pressure, thus contraindicated with antihypertensives and stimulants (e.g. caffeine). Black Cohosh (menopausal symptoms but UIC trial negative) – some hepatotoxicity due to adulteration recently; use cautiously. Ginkgo – 2 case reports of interact ...
1.5.2. Uniformity of tablets content
... Results. Less than 10 % amount Eudragit® of NM 30 D aqueous dispersion did not ensure the formation of granules, because the amount of binder was not enough. The granulation with more than 30 % amount of aqueous polymer dispersion was made by several steps to avoid forming of wet mass which can not ...
... Results. Less than 10 % amount Eudragit® of NM 30 D aqueous dispersion did not ensure the formation of granules, because the amount of binder was not enough. The granulation with more than 30 % amount of aqueous polymer dispersion was made by several steps to avoid forming of wet mass which can not ...
Drug induced gingival enlargement
... Bhardwaj Amit, Bhardwaj Verma Shalu: Gingival enlargement induced by anticonvulsants, calcium channel blockers and immunosuppresants: a review: Int Res J ...
... Bhardwaj Amit, Bhardwaj Verma Shalu: Gingival enlargement induced by anticonvulsants, calcium channel blockers and immunosuppresants: a review: Int Res J ...
Optimized and Validated Spectrophotometric Methods for the
... Three new visible spectrophotometric methods which are simple, sensitive and cost-effective are proposed for the determination of gatifloxacin (GTF) using N-bromosuccinimide (NBS), and three dyes, thymol blue, indigo carmine and methyl orange as reagents. The methods engross the addition of a known ...
... Three new visible spectrophotometric methods which are simple, sensitive and cost-effective are proposed for the determination of gatifloxacin (GTF) using N-bromosuccinimide (NBS), and three dyes, thymol blue, indigo carmine and methyl orange as reagents. The methods engross the addition of a known ...
Drug discovery
In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which new candidate medications are discovered. Historically, drugs were discovered through identifying the active ingredient from traditional remedies or by serendipitous discovery. Later chemical libraries of synthetic small molecules, natural products or extracts were screened in intact cells or whole organisms to identify substances that have a desirable therapeutic effect in a process known as classical pharmacology. Since sequencing of the human genome which allowed rapid cloning and synthesis of large quantities of purified proteins, it has become common practice to use high throughput screening of large compounds libraries against isolated biological targets which are hypothesized to be disease modifying in a process known as reverse pharmacology. Hits from these screens are then tested in cells and then in animals for efficacy.Modern drug discovery involves the identification of screening hits, medicinal chemistry and optimization of those hits to increase the affinity, selectivity (to reduce the potential of side effects), efficacy/potency, metabolic stability (to increase the half-life), and oral bioavailability. Once a compound that fulfills all of these requirements has been identified, it will begin the process of drug development prior to clinical trials. One or more of these steps may, but not necessarily, involve computer-aided drug design. Modern drug discovery is thus usually a capital-intensive process that involves large investments by pharmaceutical industry corporations as well as national governments (who provide grants and loan guarantees). Despite advances in technology and understanding of biological systems, drug discovery is still a lengthy, ""expensive, difficult, and inefficient process"" with low rate of new therapeutic discovery. In 2010, the research and development cost of each new molecular entity (NME) was approximately US$1.8 billion. Drug discovery is done by pharmaceutical companies, with research assistance from universities. The ""final product"" of drug discovery is a patent on the potential drug. The drug requires very expensive Phase I, II and III clinical trials, and most of them fail. Small companies have a critical role, often then selling the rights to larger companies that have the resources to run the clinical trials.Discovering drugs that may be a commercial success, or a public health success, involves a complex interaction between investors, industry, academia, patent laws, regulatory exclusivity, marketing and the need to balance secrecy with communication. Meanwhile, for disorders whose rarity means that no large commercial success or public health effect can be expected, the orphan drug funding process ensures that people who experience those disorders can have some hope of pharmacotherapeutic advances.