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Full-Text PDF

... Besides the involvement of thrombin in developmental processes, there has been evidence of various other functions within the CNS, exerted in a dosage dependent manner [18,19]. At low concentrations thrombin causes neuron and astrocyte modification, induces glial cell proliferation and exerts a neur ...
Local Field Potentials Related to Bimanual Movements in the
Local Field Potentials Related to Bimanual Movements in the

... human motor cortex, studies have addressed the complex sequence of evoked EEG potentials preceding movement (Shibasaki, 1975;Lang et al., 1990;Cui and Deecke, 1999). However, animal research on field potentials in motor cortex has focused on the relationship of synchronous oscillations to movement a ...
Corpus Callosum
Corpus Callosum

... corpus callosum function definition anatomy body maps - the brain is divided into the right and left hemisphere and the two halves are connected by the corpus callosum this bundle of nerve tissue contains over 200, corpus callosum and brain function thoughtco - corpus callosum location directionally ...
Previous results from our laboratory have shown that administration
Previous results from our laboratory have shown that administration

... with volume of consumption (De Bellis et al., 2000). Functional MRI brain scans of adolescents with alcohol-use disorders show less activation of the frontal cortex and cerebellum but more activation of the inferior parietal and temporal regions during a spatial working-memory task, as compared to a ...
sleep disturbances associated with neuropsychiatric disease
sleep disturbances associated with neuropsychiatric disease

Relating normalization to neuronal populations across cortical areas
Relating normalization to neuronal populations across cortical areas

... the same brain area under identical conditions exhibit a range of normalization, ranging from suppression by nonpreferred stimuli (strong normalization) to additive responses to combinations of stimuli (no normalization; for examples, see Lee and Maunsell, 2009; Busse et al., 2009). Normalization ha ...
Motor imagery and higher-level cognition: four hurdles before
Motor imagery and higher-level cognition: four hurdles before

... Belardinelli et al. 2009; Palmiero et al. 2009). As some individuals are better at motor imagery than others, it is possible that these differences in ability will also interact with effects of motor imagery on other cognitive tasks. Additionally, numerous studies have found athletes to be significa ...
NEURAL MECHANISMS SUPPORTING THE LEARNING
NEURAL MECHANISMS SUPPORTING THE LEARNING

... Few brain imaging studies have used functional magnetic resonance imaging (fMRI) to investigate the neural substrates that support conditioned UCR diminution. In this previous research, UCR diminution has been observed within the fMRI signal response of the dorsolateral prefrontal cortex (dlPFC), an ...
Neural mechanism of rapid eye movement sleep generation
Neural mechanism of rapid eye movement sleep generation

... Dement3 used the term “active sleep” to define the same state because the EEG pattern resembled that of an active awake state. Rapid eye movements, low voltage fast waves in the EEG and increased respiration as well as heart rate indicate a behaviourally aroused state, whereas high voltage slow wave ...
stimulant treatment history predicts frontal-striatal
stimulant treatment history predicts frontal-striatal

... Considering  the  substantial  acute  effects  of  a  single  dose  of  methylphenidate   in   the   brain,   it   may   be   expected   that   repeated   exposure   to   stimulants   could   cause   lasting   brain   changes   as   well.   Different   mechanisms   may   underlie   such   lasting   ...
to eat or to sleep? orexin in the regulation of feeding and wakefulness
to eat or to sleep? orexin in the regulation of feeding and wakefulness

... Annu. Rev. Neurosci. 2001.24:429-458. Downloaded from www.annualreviews.org by SCELC Trial on 11/01/10. For personal use only. ...
Psilocybin – Summary of knowledge and new perspectives
Psilocybin – Summary of knowledge and new perspectives

... In humans, psilocybin and psilocin can be found in blood plasma 20–40 min after oral administration of psilocybin, maximum levels of psilocin are achieved between 80 and 105 min and can be detected for up to 6 h (Hasler et al., 1997; Passie et al., 2002). The half-life of psilocin in plasma is 2.5 h ...
NIH Public Access Emotional dysregulation and Attention-Deficit/Hyperactivity Disorder Author Manuscript
NIH Public Access Emotional dysregulation and Attention-Deficit/Hyperactivity Disorder Author Manuscript

... ADHD (82). Likewise, the rapid and accurate recognition of emotions in human faces or voices is central to well-regulated behavior; emotional misperception is linked with aberrant emotional responses and misperception can itself result from emotion dysregulation (83, 84). Studies on emotion labeling ...
The physiological role of orexin/hypocretin neurons in the regulation
The physiological role of orexin/hypocretin neurons in the regulation

... The hypothalamus monitors body homeostasis and regulates various behaviors such as feeding, thermogenesis, and sleeping. Orexins (also known as hypocretins) were identified as endogenous ligands for two orphan G-protein-coupled receptors in the lateral hypothalamic area. They were initially recognize ...
A role for sleep in brain plasticity
A role for sleep in brain plasticity

... synchronized bursting in thalamocortical circuits, transient increases of intra-cellular calcium and, in some mammals, the release of somatotropins [13,55,56]. A role for non-REM sleep in developmental cortical plasticity is suggested by maturational changes in non-REM sleep that coincide with perio ...
Emotional experiences of tension and suspense: psychological
Emotional experiences of tension and suspense: psychological

Mechanisms of Sleep Control - UCLA Integrative Center for
Mechanisms of Sleep Control - UCLA Integrative Center for

ATLAS OF FUNCTIONAL NEUROANATOMY
ATLAS OF FUNCTIONAL NEUROANATOMY

... color coding is included after the list of illustrations.) Much of the subject matter’s difficulty is terminology — complex, difficult to spell, sometimes inconsistent, with a Latin base, and sometimes with names of individuals (used often by neurologists, neurosurgeons, and neuroradiologists). A gl ...
What clinical disorders tell us about the neural
What clinical disorders tell us about the neural

... inclusive, attempting to describe features common among a group of patients with similar symptoms, whereas scientific studies tend to be exclusive, focusing on one or a few differences between experimental and control subjects. Finally, basic scientists often study saccades in several species (e.g. ...
Functional Microarchitecture of Cat Primary Visual Cortex
Functional Microarchitecture of Cat Primary Visual Cortex

... We found that preferred direction, preferred orientation, and orientation tuning width were more clustered than would be expected from a random distribution. However, preferred phase, direction selectivity, relative modulation (F1/DC), and spatial frequency preference and tuning width showed no such ...
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model
Apparent Loss and Hypertrophy of Interneurons in a Mouse Model

... objective, counting only neurons with a clearly identifiable nucleus. This value was expressed as the number of detectable neurons per section and corrected by the method of Abercrombie (1946). The same sections were examined under a 1003 objective, and measurements of cross-sectional area were made ...
Zebrafish Get Connected: Investigating Neurotransmission Targets
Zebrafish Get Connected: Investigating Neurotransmission Targets

... Metabotropic receptors are organized into three classes or groups, Group I, Group II, and Group III receptors. Group I receptors include GRM1 and GRM5. Group I receptors classically are coupled to Gq /G11 proteins that activate inositol triphosphate (IP3) second messenger signaling and increase intr ...
DOPAMINERGIC AUGMENTATION of HUMAN FEAR EXTINCTION
DOPAMINERGIC AUGMENTATION of HUMAN FEAR EXTINCTION

... 1.5.1 General .................................................................................................... 17 1.5.2 Associative learning in acquisition of anxiety related disorders............... 19 1.5.3 Treatment of anxiety related disorders ................................................ ...
In 1978 Mountcastle hypothesized that the smallest functional unit of
In 1978 Mountcastle hypothesized that the smallest functional unit of

... (“mosaic”) made up of discrete place-defined macrocolumns – “segregates”– in the region of cat and monkey somatosensory cortex which receives input from forelimb skin, also proposed that discrete place-defined macrocolumns are a common mode of topographic organization throughout somatosensory cortex ...
The Basal Forebrain Cholinergic Projection
The Basal Forebrain Cholinergic Projection

... rat brain beyond the basal forebrain. They are found in the striatum, the medial habenular nucleus, mesopontine tegmentum, cranial nerve motor nuclei and the ventral horn of the spinal cord (for ref. see Semba, 2004). Cholinergic intrinsic neurons are absent in the cortex of the BALB/c ByJ mouse (Ki ...
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Neuroeconomics

Neuroeconomics is an interdisciplinary field that seeks to explain human decision making, the ability to process multiple alternatives and to follow a course of action. It studies how economic behavior can shape our understanding of the brain, and how neuroscientific discoveries can constrain and guide models of economics.It combines research methods from neuroscience, experimental and behavioral economics, and cognitive and social psychology. As research into decision-making behavior becomes increasingly computational, it has also incorporated new approaches from theoretical biology, computer science, and mathematics. Neuroeconomics studies decision making, by using a combination of tools from these fields so as to avoid the shortcomings that arise from a single-perspective approach. In mainstream economics, expected utility (EU), and the concept of rational agents, are still being used. Many economic behaviors are not fully explained by these models, such as heuristics and framing.Behavioral economics emerged to account for these anomalies by integrating social, cognitive, and emotional factors in understanding economic decisions. Neuroeconomics adds another layer by using neuroscientific methods in understanding the interplay between economic behavior and neural mechanisms. By using tools from various fields, some scholars claim that neuroeconomics offers a more integrative way of understanding decision making.
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