Adobe Acrobat version of Pharm Cards for CNS section
... Mech.: Inhib. reuptake of catecholamines (DA, NE, 5HT) → prolonged action. Local anesthetic properties from block of Na+ & Ca2+ channels → ↓ rate of rise of action potential, failure to propagate action potential, eventual conduction block. Smaller, unmyelinated fibers are more easily blocked and re ...
... Mech.: Inhib. reuptake of catecholamines (DA, NE, 5HT) → prolonged action. Local anesthetic properties from block of Na+ & Ca2+ channels → ↓ rate of rise of action potential, failure to propagate action potential, eventual conduction block. Smaller, unmyelinated fibers are more easily blocked and re ...
Methyldopa Methyldopa Description
... Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. If you have a fever and t ...
... Do not take other medicines unless they have been discussed with your doctor. This especially includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure. If you have a fever and t ...
Limitations - HAL
... In the absence of an effective clinical treatment for age-related neuro-degenerative disorder, research has focused on the identification of potential risk factors in order to delay cognitive decline and prolong autonomy. Reversible drug-induced cognitive impairment has been described in clinical st ...
... In the absence of an effective clinical treatment for age-related neuro-degenerative disorder, research has focused on the identification of potential risk factors in order to delay cognitive decline and prolong autonomy. Reversible drug-induced cognitive impairment has been described in clinical st ...
TASTE MASKING TECHNOLOGIES: A REVIEW Review Article SHALINI SHARMA AND SHAILA LEWIS*
... polymers should be such that it prevents the release of active agent in the oral cavity, following per oral intake, but allows it in stomach or small intestine where the drug is expected to be absorbed. Polymers, which mainly insoluble at salivary pH 6.8 but readily, dissolv ...
... polymers should be such that it prevents the release of active agent in the oral cavity, following per oral intake, but allows it in stomach or small intestine where the drug is expected to be absorbed. Polymers, which mainly insoluble at salivary pH 6.8 but readily, dissolv ...
Hypertension Medications
... Options and Progression of Treatment for Hypertension • Long-term success depends on patients understanding the characteristics and diseases that contribute to the issue Demographic characteristics – age, gender, race Coexisting diseases and risk factors – migraine headaches, dysrhythmias, angi ...
... Options and Progression of Treatment for Hypertension • Long-term success depends on patients understanding the characteristics and diseases that contribute to the issue Demographic characteristics – age, gender, race Coexisting diseases and risk factors – migraine headaches, dysrhythmias, angi ...
CHAPTER 1 The Nursing Process and Drug Therapy
... Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. ...
... Mosby items and derived items © 2007, 2005, 2002 by Mosby, Inc., an affiliate of Elsevier Inc. ...
Hard Shell Capsules
... as production of early phase clinical supplies. Quoted production capacities for powder filing range from 6000-8000 capsules/hour up to as high as 15,000 capsules/hour, depending on the capsule size. The rectified capsules are delivered into holes in a split ring (equivalent to the split bushings ab ...
... as production of early phase clinical supplies. Quoted production capacities for powder filing range from 6000-8000 capsules/hour up to as high as 15,000 capsules/hour, depending on the capsule size. The rectified capsules are delivered into holes in a split ring (equivalent to the split bushings ab ...
Cocaine - South Carolina Department of Alcohol and Other Drug
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
... blood tests? The time period during which cocaine use can be detected varies according to the type of test (or “screen”) being used and the limits assigned to each individual test. Generally, cocaine use can be detected for as long as 10 days to five weeks after use by high-dose abusers, and from tw ...
Managing Hypertension
... this region and figures from the Caribbean Epidemiology Centre (CAREC) show that hypertensive disease was the 5th leading cause of death in 2000. It should be noted that the leading causes of death were cerebrovascular disease (including stroke), heart failure and ischaemic heart disease, which are ...
... this region and figures from the Caribbean Epidemiology Centre (CAREC) show that hypertensive disease was the 5th leading cause of death in 2000. It should be noted that the leading causes of death were cerebrovascular disease (including stroke), heart failure and ischaemic heart disease, which are ...
product monograph serc
... evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient group. In general, however, the risk of adverse reactions to any drug may be greater in el ...
... evaluated, therefore its use in this population is not recommended. Geriatrics (> 65 years of age) Limited data from clinical studies suggest that a dosage adjustment is unlikely to be required in this patient group. In general, however, the risk of adverse reactions to any drug may be greater in el ...
Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice
... molecular and biological mechanisms underlying cystic fibrosis (CF) lung disease has resulted in exciting new targets for treatment. Fundamental research focusing on correcting F508del mutant protein can be considered as disease-modifying approaches and would be beneficial for most CF patients. Inde ...
... molecular and biological mechanisms underlying cystic fibrosis (CF) lung disease has resulted in exciting new targets for treatment. Fundamental research focusing on correcting F508del mutant protein can be considered as disease-modifying approaches and would be beneficial for most CF patients. Inde ...
neuro 2007 - addiction education home
... profoundly affect the rates of metabolism of these drugs, which in turn can influence drugtaking behaviors. The frequency of these genetic variants differs substantially among ethnic groups, resulting in differing genetic influences, or degrees of risk, among different populations. For many of these ...
... profoundly affect the rates of metabolism of these drugs, which in turn can influence drugtaking behaviors. The frequency of these genetic variants differs substantially among ethnic groups, resulting in differing genetic influences, or degrees of risk, among different populations. For many of these ...
Thorazine (chlorpromazine)
... Thorazine may induce weight gain. It is unclear whether this is due to an underlying metabolic change caused by the antipsychotic or to increased appetite. Weight should be monitored closely during therapy, and if weight gain occurs, an intervention program of diet and exercise should be started. Wh ...
... Thorazine may induce weight gain. It is unclear whether this is due to an underlying metabolic change caused by the antipsychotic or to increased appetite. Weight should be monitored closely during therapy, and if weight gain occurs, an intervention program of diet and exercise should be started. Wh ...
Journal of Science Chemistry IMPACT OF GIVING SILDENAFIL
... studies have been conducted to study the haemodynamic activity of sildenafil in different animal species (rabbit, dog, rat, cat). These studies have demonstrated that sildenafil has vasodilator properties which can, at higher doses, be associated with reductions in blood pressure and accompanied by ...
... studies have been conducted to study the haemodynamic activity of sildenafil in different animal species (rabbit, dog, rat, cat). These studies have demonstrated that sildenafil has vasodilator properties which can, at higher doses, be associated with reductions in blood pressure and accompanied by ...
Herbal Medicines and Perioperative Care
... ginkgo, and ginseng; cardiovascular instability from ephedra; and hypoglycemia from ginseng. Pharmacodynamic herb-drug interactions include potentiation of the sedative effect of anesthetics by kava and valerian. Pharmacokinetic herb-drug interactions include increased metabolism of many drugs used ...
... ginkgo, and ginseng; cardiovascular instability from ephedra; and hypoglycemia from ginseng. Pharmacodynamic herb-drug interactions include potentiation of the sedative effect of anesthetics by kava and valerian. Pharmacokinetic herb-drug interactions include increased metabolism of many drugs used ...
Sterilization of Glucocorticosteroids for Inhalation Delivery
... advantages of the inhalator route over the systemic one is the possibility of delivering the drug directly at the action site, so avoiding any systemic side-effects. Said way of administration allows achieving a more rapid clinical response and a higher therapeutic index. Among the different classes ...
... advantages of the inhalator route over the systemic one is the possibility of delivering the drug directly at the action site, so avoiding any systemic side-effects. Said way of administration allows achieving a more rapid clinical response and a higher therapeutic index. Among the different classes ...
Mood stabilizers
... talk a lot and are active and energetic. They may be happy and feel great or they may be cranky and irritable. In the early stages, they may seem quite productive, but as symptoms worsen, they tend to get more impulsive and start things they do not finish. Their thoughts jump around so fast, it can ...
... talk a lot and are active and energetic. They may be happy and feel great or they may be cranky and irritable. In the early stages, they may seem quite productive, but as symptoms worsen, they tend to get more impulsive and start things they do not finish. Their thoughts jump around so fast, it can ...
VA Medicaid PDL Criteria (effective 01/01/2010)
... LENGTH OF AUTHORIZATIONS: For COX II clinical edit see page (1) ...
... LENGTH OF AUTHORIZATIONS: For COX II clinical edit see page (1) ...
What is Methamphetamine? Pushback Fact Sheet
... disorder, narcolepsy, weight loss and other conditions, although it is rarely used medically, and only at doses much lower than those typically abused. It is classified as a Schedule II drug, meaning it has high potential for abuse and is available only through a prescription that cannot be refilled ...
... disorder, narcolepsy, weight loss and other conditions, although it is rarely used medically, and only at doses much lower than those typically abused. It is classified as a Schedule II drug, meaning it has high potential for abuse and is available only through a prescription that cannot be refilled ...
Pharmacokinetics, toxicity, and cytochrome P450
... properties of plumbagin which result in inadequate systemic drug circulation. Furthermore, results of our previous studies show that both plumbagin and the crude extract of P. indica Linn. are relatively potent inhibitors of CYP450 [9, 10] and this is of concern for the potential herb-drug interacti ...
... properties of plumbagin which result in inadequate systemic drug circulation. Furthermore, results of our previous studies show that both plumbagin and the crude extract of P. indica Linn. are relatively potent inhibitors of CYP450 [9, 10] and this is of concern for the potential herb-drug interacti ...
Full Text - AIMS Press
... Although RLX is rapidly absorbed by the intestine, it will suffer an extensive pre-systemic glucuronide ...
... Although RLX is rapidly absorbed by the intestine, it will suffer an extensive pre-systemic glucuronide ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.