EMEND (fosaprepitant dimeglumine) for injection
... infusion-site reactions occurred at a higher incidence in patients in the fosaprepitant group (3.0%) compared to those in the aprepitant group (0.5%). The following additional infusion-site reactions occurred in the HEC study and were not reported in the MEC study described above: infusion-site eryt ...
... infusion-site reactions occurred at a higher incidence in patients in the fosaprepitant group (3.0%) compared to those in the aprepitant group (0.5%). The following additional infusion-site reactions occurred in the HEC study and were not reported in the MEC study described above: infusion-site eryt ...
... Fig. 2. – Schematic diagram of the beta2-adrenoceptor and its binding domains for antagonists and agonists. The ligand core is located between 11–18 Å into the receptor. The approximate agonist (✩) and antagonist (✪) binding regions are marked on a shaded background, representing the overlap in agon ...
Use of Antithrombotics in Non-Valvular Atrial Fibrillation
... Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for one-third of hospitalizations due to arrhythmia. Currently, AF affects 2.5 million people in the United States; however, this percentage is expected to increase to an estimated 16 million people by the year 2050, ...
... Atrial fibrillation (AF) is the most common cardiac arrhythmia, and is responsible for one-third of hospitalizations due to arrhythmia. Currently, AF affects 2.5 million people in the United States; however, this percentage is expected to increase to an estimated 16 million people by the year 2050, ...
Salvia divinorum use and phenomenology: results from an online
... admitted to psychiatric services with acute onset of agitation, disorganization, and hallucinations shortly after smoking cannabis (Paulzen and Gründer, 2008). It transpired that her partner had added S. divinorum to the herbal cannabis smoking mixture. A 21-year-old man also presented with symptom ...
... admitted to psychiatric services with acute onset of agitation, disorganization, and hallucinations shortly after smoking cannabis (Paulzen and Gründer, 2008). It transpired that her partner had added S. divinorum to the herbal cannabis smoking mixture. A 21-year-old man also presented with symptom ...
The Effect of an Individual`s Cytochrome CYP3A4 Activity on
... involved in docetaxel metabolism (5). Docetaxel is excreted in the feces with less than 8% excreted unchanged (6). It is highly bound to plasma proteins including AAG. Pharmacokinetic data show significant variation in CL between patients (7). Decrease in total body CL is associated with increased f ...
... involved in docetaxel metabolism (5). Docetaxel is excreted in the feces with less than 8% excreted unchanged (6). It is highly bound to plasma proteins including AAG. Pharmacokinetic data show significant variation in CL between patients (7). Decrease in total body CL is associated with increased f ...
Autonomic Pharmacology
... edrophonium binds reversibly and selectively to the active centre; this reversible binding and its rapid renal elimination result in its short duration of action physostigmine & neostigmine, possessing a carbamyl-ester linkage are hydrolysed by AChE, but at a much slower rate both of these agents ex ...
... edrophonium binds reversibly and selectively to the active centre; this reversible binding and its rapid renal elimination result in its short duration of action physostigmine & neostigmine, possessing a carbamyl-ester linkage are hydrolysed by AChE, but at a much slower rate both of these agents ex ...
Drugs Acting on the Respiratory System
... inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. Th ...
... inflammation causes recurrent episodes of wheezing, breathlessness, chest tightness, and coughing, particularly at night or in the early morning. These episodes are usually associated with widespread but variable airflow obstruction that is often reversible either spontaneously or with treatment. Th ...
Newer Immunosuppressive Drugs: A Review
... acute rejection in cadaveric renal transplantation. A total of 491 patients was enrolled in this multicenter trial with three treatment arms (placebo, MMF 2 g/d, and MMF 3 g/d). This study showed that MMF significantly reduced the rate of biopsy-proven rejection or other treatment failure during the ...
... acute rejection in cadaveric renal transplantation. A total of 491 patients was enrolled in this multicenter trial with three treatment arms (placebo, MMF 2 g/d, and MMF 3 g/d). This study showed that MMF significantly reduced the rate of biopsy-proven rejection or other treatment failure during the ...
STUDY OF THE NEUROMODULATORY EFFECTS OF DOPAMINE
... terminals. Moreover, application of a D2 agonist blocked the D1-induced LTPGABA, and coapplication of a G-protein antagonist in the intracellular pipette prevented this D2 mediated ii ...
... terminals. Moreover, application of a D2 agonist blocked the D1-induced LTPGABA, and coapplication of a G-protein antagonist in the intracellular pipette prevented this D2 mediated ii ...
h) Implementation of a Quality Systems Model for Use in
... d) Besides pharmaceutical and biopharmaceutical drugs to treat or prevent disease, medical devices need to enter a regulatory process in order to be approved for use in the United States. Medical devices range from simple tongue depressors and bedpans to complex programmable pacemakers with micro-ch ...
... d) Besides pharmaceutical and biopharmaceutical drugs to treat or prevent disease, medical devices need to enter a regulatory process in order to be approved for use in the United States. Medical devices range from simple tongue depressors and bedpans to complex programmable pacemakers with micro-ch ...
10/15/2014 Caffeine is the Most Widely Used Psychoactive Drug Worldwide
... Caffeine Metabolism Affected by Other Drugs Drugs that prolong half‐life of caffeine (CYP1A2 inhibitors) • Alcohol • Oral contraceptives • Pregnancy hormones • Some SSRIs (Prozac®, Luvox®) ...
... Caffeine Metabolism Affected by Other Drugs Drugs that prolong half‐life of caffeine (CYP1A2 inhibitors) • Alcohol • Oral contraceptives • Pregnancy hormones • Some SSRIs (Prozac®, Luvox®) ...
lactobacillus acidophilus and bulgaricus
... What should I discuss with my healthcare provider before taking lactobacillus acidophilus and bulgaricus? ...
... What should I discuss with my healthcare provider before taking lactobacillus acidophilus and bulgaricus? ...
IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS)
... almost odorless. It mimics some of the actions of dopamine, although not readily metabolized as is dopamine. It is a sympatholytic dopamine D2 receptor agonist exerting an inhibitory effect on the turnover of serotonin in the central nervous system (1); it also acts as an inhibitor of prolactin secr ...
... almost odorless. It mimics some of the actions of dopamine, although not readily metabolized as is dopamine. It is a sympatholytic dopamine D2 receptor agonist exerting an inhibitory effect on the turnover of serotonin in the central nervous system (1); it also acts as an inhibitor of prolactin secr ...
Optimizing orthodontic treatment in patients taking
... up to 1:300 when extractions were performed.50 A retrospective institutional study reported osteonecrosis from oral bisphosphonates occurred frequently after extractions, with a high incidence of 1:20.51 This study also reported that no osteonecrosis was found after 4384 extractions in patients neve ...
... up to 1:300 when extractions were performed.50 A retrospective institutional study reported osteonecrosis from oral bisphosphonates occurred frequently after extractions, with a high incidence of 1:20.51 This study also reported that no osteonecrosis was found after 4384 extractions in patients neve ...
Accelerating antimalarial drug discovery through repositioning Holly
... I certify that this thesis, which I submit to the University of Salford a partial fulfilment of the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due refe ...
... I certify that this thesis, which I submit to the University of Salford a partial fulfilment of the requirements for a Degree of Doctor of Philosophy, is a presentation of my own research work. Wherever contributions of others are involved, every effort is made to indicate this clearly with due refe ...
View PDF - CiteSeerX
... mouse, within the day–time interval of our pharmacological experiments. This protocol allowed us to select 21 of 23 mice with stable spontaneous epileptic activity before starting the treatment (Table 1). Chronic epileptic activity (FIG. 2) was defined by the appearance and recurrence of subclinical ...
... mouse, within the day–time interval of our pharmacological experiments. This protocol allowed us to select 21 of 23 mice with stable spontaneous epileptic activity before starting the treatment (Table 1). Chronic epileptic activity (FIG. 2) was defined by the appearance and recurrence of subclinical ...
Doxylamine Succinate Overdose
... autopsies carried out in the Institute of Legal Medicine at Free University Berlin from 19871997, in two cases (0.30%) doxylamine alone was found. In that study doxylamine blood concentration values was less than 165 mg/l (13). It was reported that lethal dosage of doxylamine was less than 1 g (14, ...
... autopsies carried out in the Institute of Legal Medicine at Free University Berlin from 19871997, in two cases (0.30%) doxylamine alone was found. In that study doxylamine blood concentration values was less than 165 mg/l (13). It was reported that lethal dosage of doxylamine was less than 1 g (14, ...
RATIO DERIVATIVE SPECTROPHOTOMETRIC METHOD FOR SIMULTANEOUS ESTIMATION
... recently approved for clinic use as a cholesterol lowering agent11. Atorvastatin calcium (AC) is a potent inhibitor of (HMG-CoA), the rate-limiting enzyme in cholesterol biosynthesis. This synthetic HMG-CoA reductase inhibitor induces a significant reduction in total cholesterol, low-density lipopro ...
... recently approved for clinic use as a cholesterol lowering agent11. Atorvastatin calcium (AC) is a potent inhibitor of (HMG-CoA), the rate-limiting enzyme in cholesterol biosynthesis. This synthetic HMG-CoA reductase inhibitor induces a significant reduction in total cholesterol, low-density lipopro ...
MDMA (Ecstasy) - cloudfront.net
... particular concern during periods of increased physical activity, further complicating these problems. MDMA is rapidly absorbed into the human bloodstream, but once in the body, MDMA metabolites interfere with the body's ability to metabolize, or break down, the drug.8 As a result, additional doses ...
... particular concern during periods of increased physical activity, further complicating these problems. MDMA is rapidly absorbed into the human bloodstream, but once in the body, MDMA metabolites interfere with the body's ability to metabolize, or break down, the drug.8 As a result, additional doses ...
Department for Transport - Over-the
... H 1 -receptor antihistamines, and H 2 -receptor antihistamines. The H 3 -receptors are not associated with any OTC medicine that causes sedation. As histamine is involved with the human sleep-wake mechanism in the brain, any antihistamine that penetrates the blood brain barrier, into the CNS, has th ...
... H 1 -receptor antihistamines, and H 2 -receptor antihistamines. The H 3 -receptors are not associated with any OTC medicine that causes sedation. As histamine is involved with the human sleep-wake mechanism in the brain, any antihistamine that penetrates the blood brain barrier, into the CNS, has th ...
Product Monograph Template - Standard
... FRISIUM can cause respiratory depression, especially if administered in high doses. In elderly patients these effects sometimes persist for a considerable length of time. Therefore, particularly in patients with pre-existing compromised respiratory function (e.g. in patients with bronchial asthma) o ...
... FRISIUM can cause respiratory depression, especially if administered in high doses. In elderly patients these effects sometimes persist for a considerable length of time. Therefore, particularly in patients with pre-existing compromised respiratory function (e.g. in patients with bronchial asthma) o ...
Forensic Toxicology PPT
... Date Rape Drugs • Rohypnot, Ketamine, GHB, Ecstacy. • GHB (depressant) effects can be felt within 15 minutes after ingestion. Mixed with alcohol GHB can cause the central nervous system to shut down, lead to loss of consciousness, and possibly result in a coma or death. • Rohypnol (depressant) effe ...
... Date Rape Drugs • Rohypnot, Ketamine, GHB, Ecstacy. • GHB (depressant) effects can be felt within 15 minutes after ingestion. Mixed with alcohol GHB can cause the central nervous system to shut down, lead to loss of consciousness, and possibly result in a coma or death. • Rohypnol (depressant) effe ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.