Rational prescribing in the older adult
... ADRs 2-3x higher in elderly cf young – Cusak et al, 1997 ...
... ADRs 2-3x higher in elderly cf young – Cusak et al, 1997 ...
Overview_of_drug_development_cmh_with_animatiions
... “Any chemical agent that affects the processes of living” ...
... “Any chemical agent that affects the processes of living” ...
How Do Drugs Work?
... PROTEINS are tiny molecular machines that perform most of the tasks needed to keep cells alive. These machines are far too small to see, so you might imagine that it is impossible to affect their action. However, drugs can be used to turn proteins on or off. DRUGS are small molecules that bind to pr ...
... PROTEINS are tiny molecular machines that perform most of the tasks needed to keep cells alive. These machines are far too small to see, so you might imagine that it is impossible to affect their action. However, drugs can be used to turn proteins on or off. DRUGS are small molecules that bind to pr ...
Choose the correct answer for questions (1-90: Question 1
... e. Preanesthetic medications 32. Which of the following choices would be most appropriate in treating nausea and vomiting associated with motion sickness? a. Diphenhydramine b. Brompheniramine c. Ondansetron d. Omeprazole e. Ranitidine 33. Which of the following antiulcer medications is most likely ...
... e. Preanesthetic medications 32. Which of the following choices would be most appropriate in treating nausea and vomiting associated with motion sickness? a. Diphenhydramine b. Brompheniramine c. Ondansetron d. Omeprazole e. Ranitidine 33. Which of the following antiulcer medications is most likely ...
Generic Pharmaceutical Products: Same Quality
... Generic drugs are low-cost versions of brand name drugs that are produced by several manufacturers once the patents expire on the brand name versions. In Canada, brand name drugs have 20 years of patent protection. During that time, only the patent holder can produce the drug, but after that, other ...
... Generic drugs are low-cost versions of brand name drugs that are produced by several manufacturers once the patents expire on the brand name versions. In Canada, brand name drugs have 20 years of patent protection. During that time, only the patent holder can produce the drug, but after that, other ...
Basic Nursing: Foundations of Skills and Concepts Chapter 24
... Onset of action (the time it takes for the body to respond to a drug after administration). Peak plasma level (the highest blood concentration of a single drug dose before the elimination rate equals the rate of absorption). Plateau (maintenance of a certain level). ...
... Onset of action (the time it takes for the body to respond to a drug after administration). Peak plasma level (the highest blood concentration of a single drug dose before the elimination rate equals the rate of absorption). Plateau (maintenance of a certain level). ...
1st and 2nd Lectures
... administered with the intention of producing a therapeutic effect” Medicines usually contain other substances (excipients, stabilisers, solvents, etc.) besides the active drug, to make them more convenient to use To count as a drug, the substance must be administered as such, rather than release ...
... administered with the intention of producing a therapeutic effect” Medicines usually contain other substances (excipients, stabilisers, solvents, etc.) besides the active drug, to make them more convenient to use To count as a drug, the substance must be administered as such, rather than release ...
drug interactions
... • Many drugs have the potential to inhibit the metabolism of other drugs • A clinically significant interaction may result and is dependent on 1. the magnitude of decrease in clearance and 2.the consequences of the resulting increase in the steady-state serum concentration of the index drug. • Most ...
... • Many drugs have the potential to inhibit the metabolism of other drugs • A clinically significant interaction may result and is dependent on 1. the magnitude of decrease in clearance and 2.the consequences of the resulting increase in the steady-state serum concentration of the index drug. • Most ...
Generic Drugs and Alzheimer`s Disease In
... Two versions of Namenda are currently available. The “immediate release” version is typically taken twice a day and is available in generic form. The “extended release” version, called Namenda-XR, is used once a day, slowly releasing the drug over the day, but is not currently available in generic f ...
... Two versions of Namenda are currently available. The “immediate release” version is typically taken twice a day and is available in generic form. The “extended release” version, called Namenda-XR, is used once a day, slowly releasing the drug over the day, but is not currently available in generic f ...
AMIRF Drug testing tools for parents how do I ask my teen to take a
... DRUG TESTING TOOLS FOR PARENTS HOW DO I ASK MY TEEN TO TAKE A DRUG TEST? From the time your child reaches Junior High School, let your teens know that you love them too much to let them be involved with drugs. Assure them you will use any tool available to keep them away from drugs, including dr ...
... DRUG TESTING TOOLS FOR PARENTS HOW DO I ASK MY TEEN TO TAKE A DRUG TEST? From the time your child reaches Junior High School, let your teens know that you love them too much to let them be involved with drugs. Assure them you will use any tool available to keep them away from drugs, including dr ...
Prior Authorization Form
... This facsimile transmission contains legally privileged and confidential information intended for the parties identified below. If you have received this transmission in error, please immediately notify us by telephone and return the original message to TennCare Pharmacy Program, c/o Magellan Health ...
... This facsimile transmission contains legally privileged and confidential information intended for the parties identified below. If you have received this transmission in error, please immediately notify us by telephone and return the original message to TennCare Pharmacy Program, c/o Magellan Health ...
Model Description Sheet
... Opium and its derivatives have been used for centuries to treat severe acute or chronic pain by binding to opioid receptors in the body, causing beneficial effects of analgesic and harmful effects. Their addictiveness has led to several opiates becoming recreational drugs such as opium, morphine, an ...
... Opium and its derivatives have been used for centuries to treat severe acute or chronic pain by binding to opioid receptors in the body, causing beneficial effects of analgesic and harmful effects. Their addictiveness has led to several opiates becoming recreational drugs such as opium, morphine, an ...
Teacher`s Guide
... Tranquilizers slow brain activity through actions on the GABA system. GABA is gamma-amino butyric acid, a neurotransmitter that acts as a natural tranquilizer. Neurotransmitters are chemicals that deliver messages from one nerve cell to another.The chemicals fit into special receptors on the cell me ...
... Tranquilizers slow brain activity through actions on the GABA system. GABA is gamma-amino butyric acid, a neurotransmitter that acts as a natural tranquilizer. Neurotransmitters are chemicals that deliver messages from one nerve cell to another.The chemicals fit into special receptors on the cell me ...
Document
... support a decision, to quantify uncertainty, and to compute a comprehensive benefit-risk profile. We constructed a multi-criteria model for ranking drugs for depression with respect to different benefit and risk criteria. Methods. We analyzed Fluoxetine, Paroxetine, Sertraline, and Venlafaxine accor ...
... support a decision, to quantify uncertainty, and to compute a comprehensive benefit-risk profile. We constructed a multi-criteria model for ranking drugs for depression with respect to different benefit and risk criteria. Methods. We analyzed Fluoxetine, Paroxetine, Sertraline, and Venlafaxine accor ...
Western Washington University Rowing Safety
... This section of the departmental Safety Information Book is intended to bring Western Washington University into compliance with Washington Administrative Code (WAC), Part 29662-500 Hazardous Drugs. The University seeks to protect its employees from avoidable harm at all times and places related to ...
... This section of the departmental Safety Information Book is intended to bring Western Washington University into compliance with Washington Administrative Code (WAC), Part 29662-500 Hazardous Drugs. The University seeks to protect its employees from avoidable harm at all times and places related to ...
Absorption, distribution, metabolism and excretion
... 1-Free form: active, diffusible, available for biotransformation and excretion. 2-Bound form (mainly to albumin): inert, non-diffusible, not available for metabolism and excretion. It acts as a reservoir for drug. Binding to plasma proteins is reversible Drugs highly bound to plasma proteins are i ...
... 1-Free form: active, diffusible, available for biotransformation and excretion. 2-Bound form (mainly to albumin): inert, non-diffusible, not available for metabolism and excretion. It acts as a reservoir for drug. Binding to plasma proteins is reversible Drugs highly bound to plasma proteins are i ...
Definition of the word `Drug`: Drugs are chemicals that prevent
... ¾ Ehrlich coined the term ‘receptive substance’ or ‘receptor’. Receptor: Most drugs combine with specific sites on macromolecules by precise physiochemical and steric interactions between specific chemical groups of the drug. These sites are termed receptors. Types of Receptors: There are severa ...
... ¾ Ehrlich coined the term ‘receptive substance’ or ‘receptor’. Receptor: Most drugs combine with specific sites on macromolecules by precise physiochemical and steric interactions between specific chemical groups of the drug. These sites are termed receptors. Types of Receptors: There are severa ...
Pharmacodynamics and genetics and kinetics
... called a partial agonist. Partial agonists produce an effect if no agonist is present but act as antagonists in the presence of a full agonist. Drugs which bind but do not activate a secondary messenger system are called antagonists. Antagonists can only produce effects by blocking access of the nat ...
... called a partial agonist. Partial agonists produce an effect if no agonist is present but act as antagonists in the presence of a full agonist. Drugs which bind but do not activate a secondary messenger system are called antagonists. Antagonists can only produce effects by blocking access of the nat ...
NUR 312: Pharmacology in Nursing II
... Seratonin Syndrome: Occurs when SSRI’s are administered too close to D/C of MAOl's Confusion, disorientation, mania, restlessness, diaphoresis, shivering. Diarrhea, nausea. DIC all serotonergic drugs, anticonvulsants, Klonapin or Ativan **Do not reintroduce serotonin drugs Only 3 drugs Nardil Pamate ...
... Seratonin Syndrome: Occurs when SSRI’s are administered too close to D/C of MAOl's Confusion, disorientation, mania, restlessness, diaphoresis, shivering. Diarrhea, nausea. DIC all serotonergic drugs, anticonvulsants, Klonapin or Ativan **Do not reintroduce serotonin drugs Only 3 drugs Nardil Pamate ...
DRUG ABSORBPTION
... The lipid partitioning coefficient is a numerical value of how lipid soluble a drug is. ...
... The lipid partitioning coefficient is a numerical value of how lipid soluble a drug is. ...
Document
... The lipid partitioning coefficient is a numerical value of how lipid soluble a ?• .drug is P = [lipid] / ????????????????????????????????????????][water If the concentration of the drug is higher in a lipid medium than in an ?• .aqueous medium, it will have a high P and hence have a high lipid solub ...
... The lipid partitioning coefficient is a numerical value of how lipid soluble a ?• .drug is P = [lipid] / ????????????????????????????????????????][water If the concentration of the drug is higher in a lipid medium than in an ?• .aqueous medium, it will have a high P and hence have a high lipid solub ...
Absorption mechanism of drugs from the GI tract
... (un-dissociated or un-protonated) drug species, therefore, solubility/concentration of the nonionized species at the site of absorption is to be considered and not that of the ionized (protonated or salt) form. For example, drugs such as diltiazem, metoprolol and propranolol are considered highly wa ...
... (un-dissociated or un-protonated) drug species, therefore, solubility/concentration of the nonionized species at the site of absorption is to be considered and not that of the ionized (protonated or salt) form. For example, drugs such as diltiazem, metoprolol and propranolol are considered highly wa ...
Drug interaction
A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.