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Uses
Uses

... agents for "atypical" mycobacteria. They have activity against staphylococci but less against streptococci. ...
Your Medication Reference Guide
Your Medication Reference Guide

... The purpose of this tool is to ensure maximum safety and benefit from the medications prescribed for you. ...
Effect of drug type on the degradation rate of PLGA
Effect of drug type on the degradation rate of PLGA

... groups and the drug release parameters. Kiortsis et al. [18] have shown that the % release of drugs from cellulosic polymers, at a fixed time point, depends on the drug solubility in water; it seems reasonable that hydrophilic drugs with high solubility may increase the rate of water diffusion into ...
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ANTIHYPERLIPIDAEMIC DRUGS

... problems). The effects of high cholesterol do not cause problems for many years or even decades. Therefore, if a woman does not take her statin or other cholesterol medications during breastfeeding, it will likely have only a minimal impact on her long-term risks. Therefore, it is best to wait until ...
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Drugs of Abuse: Psychedelic Agents

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Biost 536, Spring 2013 Homework #1 September 26, 2013, Page 1

... trial (96.7%) and requires a relatively small number of confirmatory trials (n=163). 9. The above exercises considered “drug discovery” with randomized clinical trials. What additional issues have to be considered when we are using observational data to explore and try to confirm risk factors for pa ...
Urine Drug Testing Update - American Proficiency Institute
Urine Drug Testing Update - American Proficiency Institute

... treatment. The National Academy of Clinical Biochemistry (NACB) practice guidelines for the use of laboratory tests to support poisoned patients recommend that the clinical laboratory provide two tiers of drug testing: a first tier of qualitative and quantitative tests available on a stat basis to e ...
Drug-Drug Discrimination: Stimulus Properties of Drugs of Abuse
Drug-Drug Discrimination: Stimulus Properties of Drugs of Abuse

... SCHECHTER, M. D. Drug-drug discrimination: Stimulus properties of drugs of abuse upon a serotonergic-dopaminergic continuum. PHARMACOL BIOCHEM BEHAV 56(1) 89–96, 1997.—Ten male N/Nih rats were trained to discriminate between the interoceptive cues produced by the purportedly dopaminergically-mediate ...
Unit 11 Sedative, Hypnotic, Analgesics
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... ● Patients self-medicating with vitamin supplements should be cautioned not to exceed RDA. The effectiveness of megadoses for treatment of various medical conditions is unproved and may cause side effects. ● Advise patient to avoid alcoholic beverages; alcohol impairs the absorption of riboflavin. ...
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Opioid Overdose Costs - Michigan State University College of Nursing

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The mechanism of action of oral antidiabetic drugs: A review of

... tissue. Binding of the PPAR receptor in turn mediates binding to the retinoic-X receptor (RXR-receptor). This heterodimer then binds to a nuclear response element which then switches on gene transcription. Many of the genes that are activated play a central role in carbohydrate and lipid metabolism. ...
Heroin: A Hundred-Year HabitHeroin: A Hundred
Heroin: A Hundred-Year HabitHeroin: A Hundred

... Journal entitled ‘The Heroin Habit Another Curse’, G.E. Pettey declared that of the last 150 people he had treated for drug addiction, eight were dependent on heroin. Nevertheless, other physicians remained reluctant to abandon this highly effective drug. In 1911, J.D. Trawick could still lament in ...
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Drug interaction



A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.
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