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DH 250 - Cypress College
DH 250 - Cypress College

... 2. “A practical definition, useful for the clinician, is any patient who requires daily oral steroids (or very high doses of high-potency inhaled steroids) to minimize the frequency of asthma exacerbations. These patients are considered either steroid-dependent (normal pulmonary function maintained ...
Rationality_OAS - UT Computer Science
Rationality_OAS - UT Computer Science

... Imagine that one of your patients suffers from migraine headaches that last about 3 hours and involve intense pain, nausea, dizziness, and hyper-sensitivity to bright lights and loud noises. The patient usually needs to lie quietly in a dark room until the headache passes. Out of every 365 days (1 y ...
B. Pharm
B. Pharm

... All identification tests for pharmacopoeial inorganic pharmaceuticals and qualitative tests for cations and anions should be covered. ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... A patient is prescribed ibuprofen 200 mg PO every 4 hours as needed for pain. The pharmacy sends up enteric-coated tablets, but the patient refuses the tablets, stating that she cannot swallow pills. What will the nurse do? A. Crush the tablets and mix them with applesauce or ...
WHAT`S SMACK GOT TO DO WITH IT
WHAT`S SMACK GOT TO DO WITH IT

... between your brain and your body. They block physical, mental and emotional responses. Sudden withdrawal from heroin won’t kill you, unless you are using other drugs at the same time, or you are in poor health. It is much less dangerous than withdrawal from drugs like alcohol or benzodiazepines. ...
Over The Counter drugs during Pregnancy
Over The Counter drugs during Pregnancy

... medications used in the United States, and more than 80 percent of pregnant women take OTC or prescription drugs during pregnancy.1,2 Of the new OTC drugs marketed between 1975 and 1994, 30 percent were previously prescription medications. It is estimated that up to 60 percent of patients consult a ...
Itraconazole
Itraconazole

... Absorption is impaired when gastric acidity is reduced. In patients receiving acid neutralizing medicines (e.g. aluminium hydroxide), these should be administered at least 2 hours after the intake of Itraconazole. The drug should be administered after a full meal. Rarely, cases of hepatitis and jaun ...
119 Drug Dose Adjustment in Chronic Renal Diseases
119 Drug Dose Adjustment in Chronic Renal Diseases

... involved in drug metabolism, including the cytochrome P-450 (CYP) enzymes. Although the liver is the main producer of these enzymes, the kidneys may contribute up to 18% of total CYP-activated drug metabolism. In addition, the kidneys have been shown to be involved in the glucuronide, glutathione, a ...
Antipsychotics
Antipsychotics

... last-line therapy because of its increased incidence of agranulocytosis, myocarditis/cardiomyopathy, and convulsion and the need for frequent monitoring ...
product monograph - Novo Nordisk Canada
product monograph - Novo Nordisk Canada

... If glucose control has not been achieved after a suitable trial of combination therapy, consideration should be given to discontinuing these drugs and other antihyperglycemic agents including insulin. Judgments should be based on regular clinical and laboratory evaluations. In initiating treatment f ...
PRODUCT INFORMATION DIFFLAM FORTE ANTI
PRODUCT INFORMATION DIFFLAM FORTE ANTI

... stimulation of the pituitary-adrenal axis. Like other non-steroidal anti-inflammatory agents, benzydamine inhibits the biosynthesis of prostaglandins under certain conditions, but its properties in this respect have not been fully elucidated. The stabilising effect on cellular membranes may also be ...
BAOJ Pharmaceutical Sciences
BAOJ Pharmaceutical Sciences

... Certain agents that enhance drug transport through the skin, including surfactants, bile salts, and fatty acids, have been shown to exert a similar effect on the oral mucosa. Oral drug delivery offers an attractive method of needle-free drug administration. Unfortunately, oral delivery is often hamp ...
PLANT PHENOLICS AS DRUG LEADS с WHAT IS MISSING?
PLANT PHENOLICS AS DRUG LEADS с WHAT IS MISSING?

... biological defense systems, composed of two essential parts: enzymatic (catalase, superoxide dismutase, glutathione peroxidase) and nonenzymatic, to which many plant phenolics can significanty contribute (vitamin E, vitamin C, glutathione, ...
Nexium News: the “Purple Pill” Goes Over-The
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... Proton Pump Inhibitors such as Nexium are seen in workers’ compensation co-prescribed with nonsteroidal anti-inflammatory drugs (NSAIDs: naproxen and ibuprofen are examples) in certain patients considered at high risk for gastrointestinal ulcers. Since ALL PPIs are considered equally effective with ...
Enzyme Kinetics for Clinically Relevant CYP Inhibition
Enzyme Kinetics for Clinically Relevant CYP Inhibition

... should be anticipated and encouraged. Therefore, we would like to, both from theoretic and practical prospective, provide our thoughts on the kinetic mechanisms of CYP inhibitionassociated DDI, which will hopefully enhance the predictability of the findings in DDI studies in vitro. The present paper ...
Angina
Angina

... carvedilol, labetalol ...
What`s Cannabis Got To Do With It
What`s Cannabis Got To Do With It

... are no more common now than they were in times when pot was uncommon, so it is not likely that cannabis causes these illnesses. However, if you have emotional or psychological problems, you should know that people who use cannabis have more episodes of their illness and relapse more often. They gene ...
local anaesthetics
local anaesthetics

...  This is because the electron donor substituent increases the binding to the receptor .  Those with amide functional group bind more strongly to receptor site . 95 % of bupivacaine bound to plasma and tissue proteins compared with 55% of prilocaine. ...
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington
Pharmacology and the Nursing Process, 4th ed. Lilley/Harrington

... trimethoprim) ...
FORMULATION AND EVALUATION OF GASTRO RETENTIVE IN
FORMULATION AND EVALUATION OF GASTRO RETENTIVE IN

... compared to conventional liquid dosage form. The gel formed from in-situ gelling system, being lighter than gastric fluids, floats over the stomach contents or adhere to gastric mucosa due to presence of bio adhesive nature of polymer and increase gastric residence time resulting in prolonged drug d ...
Demystifying Analytical Approaches for Urine Drug Testing to
Demystifying Analytical Approaches for Urine Drug Testing to

... adherence monitoring may contribute harm to the provider and patient, specifically by generating unexpected negative results. A commonly cited paper representing nearly one million urine samples collected from chronic pain management patients, that were tested using the traditional two-step model, r ...
COMPARATIVE BIOAVAILABILITY OF TWO LISINOPRIL
COMPARATIVE BIOAVAILABILITY OF TWO LISINOPRIL

... may result in a small increase of serum potassium. In hypertensive patients with normal renal function treated with lisinopril alone for up to 24 weeks, the mean increase in serum potassium was approximately 0.1 meq/L; however, approximately 15% of patients had increases greater than 0.5 meq/L and a ...
PREPARATION AND STANDARDIZATION ANTICANCER FORMULATION
PREPARATION AND STANDARDIZATION ANTICANCER FORMULATION

... and the change in colour was observed. The sample at the concentration of 500 µg/ml showed 28.27 % inhibition. Total reducing capacity of test drug (VM) was presented in Table no. 3. Depending upon the concentration of the test drug (VM) a change in colour was noticed which is due to the conversion ...
Pharmacokinetics
Pharmacokinetics

... efficacy of many drugs when taken orally. For example, more than ninety percent of nitroglycerin is cleared during a single passage through the liver, which is the primary reason why this agent is not administered orally.] Drugs that exhibit high first-pass metabolism should be given in sufficient q ...
PHARMACOTHERAPY OF HYPERTENSION
PHARMACOTHERAPY OF HYPERTENSION

... hypertensive emergency produce controlled hypotension if it is administered continuously release cyanide and latter converted to thiocyanate and cause ...
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Drug interaction



A drug interaction is a situation in which a substance (usually another drug) affects the activity of a drug when both are administered together. This action can be synergistic (when the drug's effect is increased) or antagonistic (when the drug's effect is decreased) or a new effect can be produced that neither produces on its own. Typically, interactions between drugs come to mind (drug-drug interaction). However, interactions may also exist between drugs and foods (drug-food interactions), as well as drugs and medicinal plants or herbs (drug-plant interactions). People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances.It is therefore easy to see the importance of these pharmacological interactions in the practice of medicine. If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. The interaction of the two drugs may also increase the risk that side effects will occur. On the other hand, if the action of a drug is reduced it may cease to have any therapeutic use because of under dosage. Notwithstanding the above, on occasion these interactions may be sought in order to obtain an improved therapeutic effect. Examples of this include the use of codeine with paracetamol to increase its analgesic effect. Or the combination of clavulanic acid with amoxicillin in order to overcome bacterial resistance to the antibiotic. It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions.The pharmaceutical interactions that are of special interest to the practice of medicine are primarily those that have negative effects for an organism. The risk that a pharmacological interaction will appear increases as a function of the number of drugs administered to a patient at the same time.It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. In other situations, the interaction does not involve any effect on the drug. In certain cases, the presence of a drug in an individual's blood may affect certain types of laboratory analysis (analytical interference).It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. Some classic examples of this type of interaction include that Thiopentone and Suxamethonium should not be placed in the same syringe and same is true for Benzylpenicillin and Heparin. These situations will all be discussed under the same heading due to their conceptual similarity.Drug interactions may be the result of various processes. These processes may include alterations in the pharmacokinetics of the drug, such as alterations in the absorption, distribution, metabolism, and excretion (ADME) of a drug. Alternatively, drug interactions may be the result of the pharmacodynamic properties of the drug, e.g. the co-administration of a receptor antagonist and an agonist for the same receptor.
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